13F

Investor

PERCEPTIVE ADVISORS LLC

CIK 0001224962 · filed 2026-05-29 · SEC filing

13F book

$5.12B

Positions

92

18 new · 38 sold

Largest name

12.8%

Praxis Precision Medicines I

Est. mark

$216.9M

Price effect on 74 names still held. Flow −$612.7M.
NameTickerSharesValueWeightEst. markChange
Praxis Precision Medicines I2.04M$656M12.8%$54.8MAdded$67.7M
Celcuity Inc.CELC3.13M$356.9M7.0%$45MCut$41.7M
Ascendis Pharma A/SASND1.53M$350.3M6.8%$16.8MAdded$119.7M
Roivant Sciences Ltd.ROIV8.29M$229.5M4.5%$47.9MAdded$56.2M
Centessa Pharmaceuticals Plc5.26M$208.9M4.1%$42.9MAdded$135.9M
Rhythm Pharmaceuticals, Inc.RYTM2.37M$206.4M4.0%−$47.6MCut−$66.1M
Spyre Therapeutics, Inc.SYRE3.78M$190.8M3.7%$54.3MAdded$90.3M
Nuvalent Inc1.58M$161.9M3.2%$2.94MCut−$5.57M
Edgewise Therapeutics, Inc.EWTX4.42M$139.4M2.7%$29.6MCut$28.7M
Protagonist Therapeutics, IncPTGX1.23M$129.7M2.5%$22.2MCut$11.8M
Apogee Therapeutics, Inc.APGE1.54M$129.7M2.5%$13.4MCut−$46.3M
Travere Therapeutics, Inc.TVTX4.14M$123.1M2.4%−$35.2MCut−$40.4M
Amylyx Pharmaceuticals, Inc.AMLX8.28M$115.2M2.3%$15.1MHeld
Immatics N.V.IMTX10.4M$102.2M2.0%−$6.85MHeld
Relay Therapeutics, Inc.RLAY9.75M$97M1.9%$2.84MAdded$80.9M
Inhibrx Biosciences, Inc.INBX1.44M$97M1.9%−$17MCut−$17.8M
Meiragtx Hldgs Plc10.3M$89.3M1.7%$7.22MHeld
Zymeworks Inc.ZYME3.51M$87.9M1.7%−$4.21MAdded$2.01M
Solid Biosciences Inc.SLDB11.9M$85.7M1.7%$18.5MAdded$19M
Dyne Therapeutics, Inc.DYN4.67M$84.6M1.7%−$4.97MAdded$16.6M
Biocryst Pharmaceuticals IncBCRX7.43M$70.8M1.4%$5.44MAdded$46.1M
Oruka Therapeutics, Inc.ORKA1.4M$68.4M1.3%$26.2MCut$23.7M
Artivion, Inc.AORT1.64M$60M1.2%−$14.7MCut−$18.6M
Nurix Therapeutics, Inc.NRIX3.71M$57.5M1.1%−$12.3MAdded−$9.94M
Nautilus Biotechnology, Inc.NAUT12.6M$48.9M1.0%$24.3MHeld
CytomX Therapeutics, Inc.CTMX10.1M$47.5M0.9%$4.26MAdded$6.23M
Alto Neuroscience, Inc.ANRO2.01M$45.2M0.9%$8.35MAdded$13.4M
Engene Holdings Inc5.83M$39.7M0.8%−$12.9MCut−$13.3M
Immunovant, Inc.IMVT1.6M$39.7M0.8%−$926.5KCut−$11M
Intuitive Surgical IncISRG85.4K$39.4M0.8%−$9MCut−$10.4M
Ionis Pharmaceuticals IncIONS504K$37.8M0.7%New
Day One Biopharmaceuticals I1.76M$37.6M0.7%New
Abivax Sa328.9K$36.6M0.7%−$7.73MCut−$25.2M
Corvus Pharmaceuticals, Inc.CRVS2.29M$33.5M0.7%$4.8MAdded$28.2M
Repligen CorpRGEN280.5K$33.1M0.6%−$12.9MCut−$18.7M
Jazz Pharmaceuticals PlcJAZZ170K$32.1M0.6%$3.24MHeld
Galecto IncDMRA1.22M$31.7M0.6%New
X4 Pharmaceuticals, IncXFOR6.74M$27.8M0.5%$820.9KAdded$2.57M
Guardant Health, Inc.GH300K$27.7M0.5%−$1.56MAdded$11.4M
Bright Minds Biosciences Inc.DRUG377.5K$27.5M0.5%−$1.91MCut−$7.51M
Invivyd, Inc.IVVD20.9M$27.1M0.5%−$24.4MCut−$26.7M
Sionna Therapeutics, Inc.SION658.4K$26.4M0.5%−$691.4KCut−$22.1M
Axsome Therapeutics, Inc.AXSM149.9K$25.3M0.5%−$2.03MAdded−$1.85M
Revolution Medicines Inc258.6K$25.1M0.5%New
Sab Biotherapeutics Inc6.43M$24.6M0.5%$72.3KAdded$21.6M
Belite Bio, IncBLTE152K$24.2M0.5%−$79KCut−$42M
Tenax Therapeutics, Inc.TENX1.45M$23.2M0.5%$1.67MAdded$17.8M
Axogen, Inc.AXGN697.3K$23.1M0.5%$278.9KCut−$2.56M
Viridian Therapeutics Inc1.17M$22.9M0.4%−$13.5MCut−$71.8M
Orchestra Biomed Hldgs Inc5.04M$21.4M0.4%$503.8KCut$133K
Rapport Therapeutics, Inc.RAPP673.9K$21.1M0.4%$640.2KHeld
Dbv Technologies S A964.4K$20.1M0.4%New
Athira Pharma IncLONA1.86M$19.1M0.4%$5.04MHeld
Anteris Technologies Global Corp.AVR3.43M$19M0.4%$938.3KAdded$10.7M
Sutro Biopharma, Inc.STRO715.3K$17.8M0.3%New
Tango Therapeutics, Inc.TNGX808.2K$16.9M0.3%$6.19MAdded$12.4M
Contineum Therapeutics, Inc.CTNM1.26M$16.4M0.3%$2.05MCut−$342.3K
Celcuity Inc.CELC6.5M$15.9M0.3%$1.78MHeld
Palisade Bio, Inc.PALI8.93M$15.6M0.3%−$5.36MCut−$12.7M
Oculis Holding Ag493.8K$13.1M0.3%$3.27MHeld
Irhythm Technologies IncIRTC105K$12.4M0.2%−$6.24MCut−$6.77M
Adagio Med Hldgs Inc9.88M$11M0.2%$740.7KHeld
Evommune, Inc.EVMN448.4K$10.3M0.2%New
Phathom Pharmaceuticals, Inc.PHAT925K$10.3M0.2%New
Neumora Therapeutics, Inc.NMRA5.1M$9.95M0.2%New
Omada Health, Inc.OMDA786.3K$9.88M0.2%−$2.52MCut−$27.9M
Neurocrine Biosciences IncNBIX65K$8.57M0.2%−$656.4KCut−$38.4M
Beta Bionics, Inc.BBNX842.9K$8.45M0.2%−$12.3MAdded−$9.93M
Opus Genetics, Inc.IRD1.84M$8.35M0.2%$4.66MCut−$340.2K
BillionToOne, Inc.BLLN91.8K$7.25M0.1%−$211.2KAdded$1.29M
Twist Bioscience CorpTWST150K$7.13M0.1%New
Surrozen Inc229.4K$6.68M0.1%New
Agomab Therapeutics NvAGMB600K$6.29M0.1%New
Evolus, Inc.EOLS1.29M$5.29M0.1%New
Cogent Biosciences, Inc.COGT121.1K$4.66M0.1%$359.6KHeld
Adma Biologics, Inc.ADMA467.2K$4.21M0.1%−$4.31MCut−$11.9M
Inhibikase Therapeutics, Inc.IKT2.31M$3.89M0.1%−$856.5KCut−$7.23M
Crescent Biopharma, Inc.CBIO206.9K$3.8M0.1%$1.35MCut−$1.58M
Apellis Pharmaceuticals Inc81K$3.26M0.1%New
Outset Med Inc833.3K$3.2M0.1%$108.3KHeld
Edesa Biotech, Inc.EDSA563.2K$2.95M0.1%New
Adaptive Biotechnologies Cor152.5K$2.12M0.0%New
Avalo Therapeutics, Inc.AVTX139.7K$2.09M0.0%−$451.1KHeld
Connect Biopharma Hldgs Ltd792.7K$2.08M0.0%−$158.5KHeld
Corcept Therapeutics IncCORT50K$2.02M0.0%New
Medline Inc.MDLN28K$1.25M0.0%$70KHeld
Palatin Technologies IncPTN61.9K$1.08M0.0%$126.4KCut$2.48K
Cumberland Pharmaceuticals I197K$640.2K0.0%−$143.8KCut−$717.3K
Revolution Medicines Inc250K$447.5K0.0%$212.5KHeld
Exagen Inc.XGN114.9K$344.7K0.0%New
Ensysce Biosciences, Inc.ENSC86.7K$46.7K0.0%−$33.1KHeld
Surrozen Inc166.7K$2.67K0.0%−$666Held

Positions as of Q1 2026. 13F filings arrive up to 45 days after quarter-end and omit shorts. Values are quarter-end marks, as filed. Estimated mark is the price effect on shares still held — not realized P&L or investment advice.