| Fidelity | 9.05M | $234.3M | $690.4K | Added$228.8M |
| Fairmount Funds Management LLC | 8.71M | $225.7M | — | New |
| Avoro Capital Advisors LLC | 3.78M | $98M | — | New |
| VR ADVISER, LLC | 3.6M | $93.3M | — | New |
| FCPM III SERVICES B.V. | 2.44M | $63.2M | — | New |
| RA CAPITAL MANAGEMENT, L.P. | 2.4M | $62.1M | — | New |
| JANUS HENDERSON GROUP PLC | 2.36M | $61.4M | −$40M | Added$21.4M |
| Viking Global | 2.31M | $59.9M | — | New |
| Bellevue Group AG | 2.3M | $59.5M | — | New |
| Remedium Capital Partners, LLC | 2.05M | $53M | $3.12M | Added$53M |
| Commodore Capital LP | 1.94M | $50.2M | — | New |
| Cormorant Asset Management, LP | 1.52M | $39.5M | — | New |
| Balyasny Asset Management L.P. | 1.45M | $37.5M | — | New |
| a16z Capital Management, L.L.C. | 1.24M | $32M | — | New |
| PERCEPTIVE ADVISORS LLC | 1.22M | $31.7M | — | New |
| Point72 Asset Management, L.P. | 1.19M | $30.9M | $315K | Added$28.4M |
| WELLINGTON MANAGEMENT GROUP LLP | 1.06M | $27.4M | — | New |
| Siren, L.L.C. | 900K | $23.3M | — | New |
| BRAIDWELL LP | 894.8K | $23.2M | — | New |
| Vestal Point Capital, LP | 600K | $15.5M | — | New |
| Blackstone Inc. | 503.5K | $13M | — | New |
| MILLENNIUM MANAGEMENT LLC | 471.6K | $12.2M | — | New |
| Affinity Asset Advisors, LLC | 450K | $11.7M | — | New |
| Ikarian Capital, LLC | 335.7K | $8.69M | $825.7K | Added$2.12M |
| Qube Research & Technologies Ltd | 282.4K | $7.32M | — | New |
| ADAR1 Capital Management, LLC | 279K | $7.23M | — | New |
| Nantahala Capital Management, LLC | 278K | $7.2M | — | New |
| GEODE CAPITAL MANAGEMENT, LLC | 241.1K | $6.25M | $33.5K | Added$5.98M |
| BlackRock, Inc. | 222.4K | $5.76M | $21.7K | Added$5.59M |
| VANGUARD CAPITAL MANAGEMENT LLC | 201.8K | $5.23M | — | Held |
| State Street | 183.9K | $4.76M | — | New |
| MARSHALL WACE, LLP | 169.8K | $4.4M | — | New |
| UBS Group AG | 160.4K | $4.15M | $18.5K | Added$4.01M |
| Kalehua Capital Management LLC | 139K | $3.6M | — | New |
| AMERIPRISE FINANCIAL INC | 117.7K | $3.05M | — | New |
| BOOTHBAY FUND MANAGEMENT, LLC | 110.4K | $2.86M | $276.9K | Added$656.1K |
| Seven Fleet Capital Management LP | 101.2K | $2.62M | — | New |
| MORGAN STANLEY | 96.8K | $2.51M | $216.5K | Added$782.7K |
| VANGUARD FIDUCIARY TRUST CO | 96.7K | $2.5M | — | Held |
| GOLDMAN SACHS GROUP INC | 88.3K | $2.29M | — | New |
| Hudson Bay Capital Management LP | 76.3K | $1.98M | — | New |
| Brevan Howard Capital Management LP | 55.2K | $1.43M | — | New |
| NORTHERN TRUST CORP | 38.9K | $1.01M | — | New |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 24.5K | $633.4K | — | New |
| Squarepoint Ops LLC | 23.5K | $607.6K | — | New |
| BARCLAYS PLC | 22K | $570.7K | — | New |
| Catalyst Funds Management Pty Ltd | 17.3K | $447.9K | — | New |
| BANK OF AMERICA CORP /DE/ | 15.6K | $405.3K | $3.55K | Added$377K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 12.5K | $323.8K | — | New |
| JANE STREET GROUP, LLC | 11.4K | $295.8K | — | New |
| CITIGROUP INC | 11.1K | $287.4K | $3.26K | Added$261.4K |
| Schonfeld Strategic Advisors LLC | 10.8K | $280.3K | — | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 9.77K | $253K | — | New |
| XTX Topco Ltd | 9.73K | $252K | — | New |
| Cannon Global Investment Management, LLC | 9.3K | $240.9K | — | New |
| Y-Intercept (Hong Kong) Ltd | 7.92K | $205.2K | — | New |
| Vanguard Global Advisers, LLC | 6.26K | $162.2K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 6.19K | $160.4K | — | New |
| Persistent Asset Partners Ltd | 5.34K | $138.3K | — | New |
| Tower Research Capital LLC (TRC) | 1.42K | $36.7K | $508 | Added$32.7K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 353 | $8.57K | — | New |
| HRT FINANCIAL LP | 72.1K | $1.87K | — | New |
| HARBOUR INVESTMENTS, INC. | 40 | $1.04K | — | New |
| SBI Securities Co., Ltd. | 14 | $363 | $41 | Added$41 |
| ROYAL BANK OF CANADA | 7 | $0 | — | New |