13F

Stock

Ionis Pharmaceuticals Inc

IONS · held by 541 managers

Reported value

$12.9B

Holders

541

+66 new · −115 exited

Holders’ est. mark

$285.1M

Price effect on 218 books still in the name

Largest holder

$1.85B

Fidelity

Notable conviction

Share of each notable manager’s 13F book.

Holder count by quarter

Who holds it

Notable only
InvestorSharesValueEst. markChange
Fidelity31.5M$1.85B$161MCut−$67.5M
Capital World Investors21.2M$1.59B−$72.2MAdded$170M
BlackRock, Inc.29.6M$813M$87.1MCut−$67.8M
VANGUARD PORTFOLIO MANAGEMENT LLC7.81M$586.4MHeld
VANGUARD CAPITAL MANAGEMENT LLC7.12M$534.5MHeld
WELLINGTON MANAGEMENT GROUP LLP20.3M$501M$71.7MCut−$23.7M
TWO SIGMA INVESTMENTS, LP5.86M$439.8M$408.2MAdded$154.1M
State Street15.9M$318.1M$128.2MCut−$34M
GEODE CAPITAL MANAGEMENT, LLC3.98M$305.2M−$7.96MAdded$56M
ROYAL BANK OF CANADA5.96M$288.7M$213.1MAdded$189.6M
DEERFIELD MANAGEMENT COMPANY, L.P.62M$239.3M−$12.7MCut−$12.7M
JPMORGAN CHASE & CO7.68M$179.2M−$104.4MCut−$4.87M
Tweedy, Browne Co LLC2.28M$170.9M−$9.15MCut−$24.1M
Citadel58.9M$158.4M−$163.1MCut−$10.5M
Artisan Partners Limited Partnership2.06M$154.6M−$4.75MAdded$61.1M
BAKER BROS. ADVISORS LP2.05M$153.8M−$7.2MAdded$12M
Deep Track Capital, LP1.95M$146.4M−$6.83MAdded$11.9M
Bellevue Group AG1.82M$136.6M−$7.31MCut−$243.3M
VOYA INVESTMENT MANAGEMENT LLC85.3M$133.8M−$7.1MCut−$24.7M
GOLDMAN SACHS GROUP INC4.16M$131.3M$19.3MAdded$60.5M
AMERICAN CENTURY COMPANIES INC1.66M$124.9M−$6.5MCut−$2.99M
CHARLES SCHWAB INVESTMENT MANAGEMENT INC1.58M$118.9M−$6.2MCut−$3.09M
FRANKLIN RESOURCES INC1.58M$118.3M−$5.31MAdded$13.7M
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC1.48M$110.8M−$5.58MAdded$955.7K
Pictet Asset Management Holding SA1.43M$107.1M−$6.63MCut−$5.4M
SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC1.4M$105.4M−$5.64MCut−$10.3M
Invesco Ltd.1.28M$95.9M$48.5MCut−$6.88M
DLD Asset Management, LP55M$83.1M−$2.26MAdded$40.8M
MILLENNIUM MANAGEMENT LLC1.05M$79M$77.2MAdded$17.1M
MORGAN STANLEY1.12M$77.2M$1.25MCut−$3.72M
VANGUARD FIDUCIARY TRUST CO1.02M$76.9MHeld
BNP PARIBAS ASSET MANAGEMENT Holding S.A.4.04M$72.9M$72.8MAdded$72.8M
Connor, Clark & Lunn Investment Management Ltd.874.1K$65.6M−$3.51MCut−$19.5M
NORTHERN TRUST CORP868.2K$65.2M−$3.4MCut−$1.79M
BANK OF AMERICA CORP /DE/1.82M$64.6M$54.6MCut−$18.7M
Polar Capital Holdings Plc829.5K$62.3M−$3.33MCut−$43.2M
GROUPAMA ASSET MANAGMENT824.5K$61.9M−$3.08MAdded$1.25M
UBS Group AG928.4K$60.9M−$12.6MCut−$21.8M
NOMURA ASSET MANAGEMENT INTERNATIONAL INC.785.3K$59M−$3.16MCut−$9.46M
LMR Partners LLP37.3M$57.3M−$2.52MAdded$12.8M
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP737.9K$55.4M−$2.97MCut−$28.7M
Balyasny Asset Management L.P.35M$52.9M−$4.85MCut−$42.2M
Squarepoint Ops LLC695.3K$52.2M−$1.75MAdded$17.7M
VOLORIDGE INVESTMENT MANAGEMENT, LLC672.9K$50.5M−$2.35MAdded$4.25M
MASSACHUSETTS FINANCIAL SERVICES CO /MA/666.1K$50M−$2.68MCut−$14.3M
AMERIPRISE FINANCIAL INC660.1K$49.6M−$2.41MAdded$2.2M
Nuveen, LLC648.5K$48.7M−$2.61MCut−$3.58M
Eversept Partners, LP632.1K$47.5M−$2.16MAdded$4.89M
BNP PARIBAS FINANCIAL MARKETS7.14M$46.1M−$24.2MAdded$19.6M
EVENTIDE ASSET MANAGEMENT, LLC575K$43.2M−$2.31MCut−$2.31M
TD Asset Management Inc530K$39.8M−$2.13MCut−$21.4M
TEACHER RETIREMENT SYSTEM OF TEXAS523.9K$39.3M−$1.7MAdded$5.89M
Bank of New York Mellon Corp514.6K$38.6M$9.39MCut−$4.21M
PERCEPTIVE ADVISORS LLC504K$37.8MNew
BOONE CAPITAL MANAGEMENT LLC500.5K$37.6M−$1.68MAdded$4.53M
Candriam S.C.A.484.1K$36.3M−$1.95MCut−$17.3M
Alyeska Investment Group, L.P.473.1K$35.5M−$1.9MCut−$2.58M
FIRST TRUST ADVISORS LP468.4K$35.2M−$1.88MCut−$6.38M
NEUBERGER BERMAN GROUP LLC443.3K$33.3M−$434.3KAdded$24.7M
TENOR CAPITAL MANAGEMENT Co., L.P.21.7M$32.9M$1.68MCut−$17.5M
PINNACLE ASSOCIATES LTD436.5K$32.8M−$1.75MCut−$3.77M
D. E. Shaw & Co., Inc.429.6K$32.3M$31.2MCut−$29.1M
ALLIANCEBERNSTEIN L.P.400.7K$31.7M$1Added$4.65M
Davern Capital Partners, LP386.9K$29.1M−$958.7KAdded$10.2M
NEW YORK STATE COMMON RETIREMENT FUND350.4K$26.3M−$972.2KAdded$7.18M
Capital Research Global Investors323K$24.3MNew
BARCLAYS PLC1.85M$24.1M−$28MCut−$45.1M
Universal- Beteiligungs- und Servicegesellschaft mbH4.89M$23.6M$277.3KCut−$1.97M
Renaissance Technologies305.5K$22.9M−$898.9KAdded$5.25M
Swiss National Bank304.5K$22.9M−$1.2MCut−$749.4K
Hudson Bay Capital Management LP295.1K$22.2M−$1.19MCut−$15.4M
Legal & General Group Plc294.7K$22.1M−$1.18MCut−$3.6M
WELLS FARGO & COMPANY/MN5.17M$21.8M−$15.1MCut−$3.68M
Privium Fund Management B.V.290K$21.8M−$968.1KAdded$2.73M
ARK Investment Management LLC288.7K$21.7M−$1.16MCut−$11.8M
Calamos Advisors LLC13.4M$21.7M−$2.16MCut−$2.06M
TimesSquare Capital Management, LLC275.7K$20.7MNew
Focus Partners Wealth5.44M$20.5M−$1.75MCut−$2.49M
DIMENSIONAL FUND ADVISORS LP267.2K$20.1M−$712.9KAdded$6.13M
California Public Employees Retirement System255.5K$19.2M−$857.7KAdded$2.3M
Zurich Insurance Group Ltd/FI239.6K$18M−$963.4KCut−$2.72M
DAVENPORT & Co LLC238.2K$17.9M−$875.9KAdded$651.5K
J. Goldman & Co LP235.3K$17.7M−$271.9KAdded$12.3M
RAYMOND JAMES FINANCIAL INC235.1K$17.7M−$945.2KCut−$2.69M
ExodusPoint Capital Management, LP227.1K$17.1M−$337.2KAdded$10.4M
Orion Investment Co225K$16.9M−$904.6KCut−$916.1K
TOCQUEVILLE ASSET MANAGEMENT L.P.219.2K$16.5M−$819KAdded$344.1K
Trexquant Investment LP213.6K$16M−$531.6KAdded$5.58M
MACKAY SHIELDS LLC10.4M$15.7M−$381.6KCut−$4.66M
Jump Financial, LLC206.7K$15.5MNew
ARISTEIA CAPITAL, L.L.C.10M$15.1M−$833KCut−$833K
NOMURA HOLDINGS INC199.1K$15M−$800.5KCut−$54M
STIFEL FINANCIAL CORP196.7K$14.8M−$790.8KCut−$961.6K
Corient Private Wealth LLC196.6K$14.8M−$790.3KCut−$2.36M
JANE STREET GROUP, LLC191.8K$14.4M−$122.5KAdded$12M
HSBC HOLDINGS PLC186K$14M−$118.2KAdded$11.8M
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM176.5K$13.3M−$579.6KAdded$1.85M
RHUMBLINE ADVISERS173.4K$13M−$697.2KCut−$851.3K
SECTOR GAMMA AS169.5K$12.7M−$681.3KCut−$1.91M
DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main167.7K$12.6M$12.1MCut−$11M
M&G PLC7.35M$12.2M−$645.3KAdded$1.01M
ADAR1 Capital Management, LLC160.3K$12M−$591.5KAdded$400.3K
DEUTSCHE BANK AG\159.9K$12M−$600.8KAdded$183.8K
Sicart Associates LLC159.4K$12M−$640.8KCut−$968.7K
SEI INVESTMENTS CO262.2K$12M$742.6KAdded$2.63M
STATE OF WISCONSIN INVESTMENT BOARD3.1M$11.8M−$503.8KCut−$497.2K
CenterBook Partners LP150.9K$11.3M−$606.7KCut−$846.9K
MANUFACTURERS LIFE INSURANCE COMPANY, THE149.5K$11.2M−$583.7KCut−$876.2K
Aquatic Capital Management LLC147.4K$11.1M−$534KAdded$558.8K
CITIGROUP INC146.5K$11M$10.7MCut−$11.6M
Artia Global Partners LP144.4K$10.8M−$580.4KCut−$580.4K
CAPITAL FUND MANAGEMENT S.A.142.2K$10.7MNew
Fisher Asset Management, LLC141.5K$10.6M−$569KCut−$574.6K
VANGUARD ASSET MANAGEMENT, Ltd137.5K$10.3MHeld
EDMOND DE ROTHSCHILD HOLDING S.A.137.2K$10.3M−$491.2KAdded$635.1K
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM135.9K$10.2M−$546.2KCut−$546.2K
Engineers Gate Manager LP133.8K$10M−$89.2KAdded$8.29M
BRAIDWELL LP130.9K$9.83MNew
Ikarian Capital, LLC127K$9.54M−$510.7KCut−$6.44M
Atle Fund Management AB27.9K$9.4M$7.19MAdded$2.09M
Integral Health Asset Management, LLC125K$9.39MNew
GREAT LAKES ADVISORS, LLC118.9K$8.93M−$478.1KCut−$2.87M
SEB Asset Management AB114.3K$8.59MHeld
Aberdeen Group plc113.8K$8.55M−$116.3KAdded$6.26M
KENNEDY CAPITAL MANAGEMENT LLC111.8K$8.4M−$439.3KCut−$248.7K
Exome Asset Management LLC110.1K$8.26M−$442.5KCut−$952.8K
VICTORY CAPITAL MANAGEMENT INC108.7K$8.17M−$324.5KAdded$1.78M
WINTON GROUP Ltd106.5K$8MNew
ADVENT CAPITAL MANAGEMENT /DE/5.13M$7.77M−$399.3KCut−$284.2K
Empowered Funds, LLC103.1K$7.74MNew
Gotham Asset Management, LLC99K$7.43M−$173.7KAdded$4.01M
Susquehanna Portfolio Strategies, LLC96K$7.21M−$385.8KCut−$385.8K
MARSHALL WACE, LLP96K$7.21M−$385.7KCut−$13.1M
EFG International AG94K$7.06M−$303KAdded$1.1M
ENVESTNET ASSET MANAGEMENT INC93.4K$7.01M−$361.5KCut−$101.4K
Rhenman & Partners Asset Management AB92.9K$6.98M−$373.5KCut−$5.56M
Sumitomo Mitsui Trust Group, Inc.81.9K$6.15M−$329.1KCut−$1.27M
Amova Asset Management Americas, Inc.81.7K$6.13M−$328.4KCut−$1.27M
XTX Topco Ltd80.5K$6.05M−$68KAdded$4.71M
CSS LLC/IL79.1K$5.94M$5.83MCut−$61M
China Universal Asset Management Co., Ltd.77.3K$5.81M−$170.4KAdded$2.45M
Jefferies Financial Group Inc.967.1K$5.81M$3.57MCut−$6.67M
BOOTHBAY FUND MANAGEMENT, LLC76.6K$5.75M−$303.8KCut−$228K
Lisanti Capital Growth, LLC75.7K$5.68M−$131.8KAdded$3.09M
Vanguard Global Advisers, LLC71.9K$5.4MHeld
Hillsdale Investment Management Inc.70.9K$5.32M−$285KCut−$285K
Erste Asset Management GmbH71.8K$5.21M−$535.6KCut−$535.6K
Edgestream Partners, L.P.68.4K$5.13MNew
JANUS HENDERSON GROUP PLC68.2K$5.12M−$275.2KCut−$275.2K
Police & Firemen's Retirement System of New Jersey67.3K$5.06M−$268.7KCut−$233.1K
Walleye Capital LLC65.9K$4.95M−$1.31KAdded$4.93M
Russell Investments Group, Ltd.62.9K$4.72M−$176.6KAdded$1.25M
Orion Porfolio Solutions, LLC61.3K$4.61M−$94.8KAdded$2.74M
Polymer Capital Management (HK) LTD61.2K$4.6MNew
Rafferty Asset Management, LLC60.3K$4.53M−$242.4KCut−$1.32M
Zurcher Kantonalbank (Zurich Cantonalbank)60.2K$4.52M−$196.7KAdded$653.2K
One Capital Management, LLC58.9K$4.43M−$185.4KAdded$777.1K
Future Fund LLC58.7K$4.41M−$184.3KAdded$782.9K
PANAGORA ASSET MANAGEMENT INC57.4K$4.31MNew
DCF Advisers, LLC56K$4.21M−$225.1KCut−$3.94M
Quantinno Capital Management LP55.5K$4.17M−$190.5KAdded$419.6K
FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A.54.3K$4.08M−$218.2KCut−$5.55M
State of New Jersey Common Pension Fund D52.6K$3.95M−$211.4KCut−$385.1K
Creative Planning52.2K$3.92M−$210KCut−$411.4K
BANK OF MONTREAL /CAN/1.29M$3.91M−$942.5KCut−$979.2K
NICOLA WEALTH MANAGEMENT LTD.52K$3.9M−$209KCut−$2.98M
ADAGE CAPITAL PARTNERS GP, L.L.C.50K$3.75M−$201KCut−$7.32M
CAPITAL COUNSEL LLC/NY49.6K$3.72M−$199.3KCut−$201.3K
TUDOR INVESTMENT CORP ET AL48.2K$3.62M−$14.7KAdded$3.33M
SSI INVESTMENT MANAGEMENT LLC2.34M$3.52M−$192KCut−$192K
E Fund Management Co., Ltd.46.7K$3.51MHeld
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO46K$3.46M−$185KCut−$309.1K
Ensign Peak Advisors, Inc46K$3.45M−$184.9KCut−$790.9K
BAMCO INC /NY/45K$3.38M−$144.7KAdded$531.1K
WEST MICHIGAN ADVISORS, LLC44.6K$3.35M−$154.4KAdded$311.2K
GUGGENHEIM CAPITAL LLC44K$3.31M−$151.6KAdded$324.6K
Qube Research & Technologies Ltd42.9K$3.22MNew
ARIZONA STATE RETIREMENT SYSTEM42.3K$3.17M−$169.9KCut−$182.2K
Tetragon Partners GP Ltd41.8K$3.14MNew
Stanley-Laman Group, Ltd.39.3K$2.95M−$146.8KAdded$63K
Arrowpoint Investment Partners (Singapore) Pte. Ltd.39K$2.93M−$100.6KAdded$948.5K
Vanguard Investments Australia, Ltd.38.6K$2.9MHeld
INTECH INVESTMENT MANAGEMENT LLC38.5K$2.89M−$38.6KAdded$2.13M
GRANDFIELD & DODD, LLC37.3K$2.8M−$150.1KCut−$189.2K
PRUDENTIAL FINANCIAL INC35.3K$2.65M−$96.5KAdded$749K
BLB&B Advisors, LLC35.2K$2.64M−$141.4KCut−$2.23M
Raiffeisen Bank International AG36K$2.61M−$225.8KCut−$153.2K
PEAK6 LLC34.4K$2.58M−$123.2KAdded$160.4K
EXCHANGE TRADED CONCEPTS, LLC33.9K$2.55M−$84.8KAdded$879.9K
KLP KAPITALFORVALTNING AS33.9K$2.55M−$134.7KCut−$104.6K
BLAIR WILLIAM & CO/IL33.9K$2.54M−$135.8KCut−$130.6K
Assenagon Asset Management S.A.33.7K$2.53M−$117.9KAdded$209.3K
Tidal Investments LLC34.4K$2.51M−$110.4KAdded$1.09M
Pathstone Holdings, LLC32.8K$2.47M−$132KCut−$248.2K
Swedbank AB32.3K$2.42M−$109.6KAdded$265.9K
LPL Financial LLC31.9K$2.4M−$124.9KCut−$60.1K
Union Bancaire Privee, UBP SA1.85M$2.36M−$106.8KAdded$568.6K
PRELUDE CAPITAL MANAGEMENT, LLC29.7K$2.23M−$119.2KCut−$342.6K
KORNITZER CAPITAL MANAGEMENT INC /KS29.1K$2.19M−$117KCut−$117K
Icahn Capital28.8K$2.16M−$68.5KAdded$684K
STRS OHIO28.8K$2.16M−$15.2KAdded$1.86M
LAZARD ASSET MANAGEMENT LLC16.6M$2.16M−$533KCut−$1.91M
LOOMIS SAYLES & CO L P28.6K$2.15MNew
FRED ALGER MANAGEMENT, LLC28.5K$2.14M−$114.4KCut−$903.2K
MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC28.1K$2.11M−$113.1KCut−$376.7K
WORLDQUANT MILLENNIUM ADVISORS LLC27.9K$2.1M−$70KAdded$719.5K
Man Group plc204K$2.08M−$3.68MCut−$11.5M
DeepCurrents Investment Group LLC27.4K$2.06M$2.02MCut−$67.5M
Entropy Technologies, LP27.2K$2.04MNew
STEMPOINT CAPITAL LP26.4K$1.98MNew
XPONANCE LLC26.4K$1.98M−$92.2KAdded$166.3K
PROFUND ADVISORS LLC26.3K$1.97M−$105.7KCut−$136.2K
Jain Global LLC26.3K$1.97M−$105.7KCut−$26.2M
FLORIDA FINANCIAL ADVISORS, LLC25.9K$1.94MNew
Qsemble Capital Management, LP25.8K$1.93M−$103.5KCut−$247.6K
JONES FINANCIAL COMPANIES LLLP26.7K$1.93M−$45.1KAdded$1.42M
Amundi3.47M$1.8M−$515.1MCut−$542.9M
Voleon Capital Management LP23K$1.73M−$17.2KAdded$1.39M
WOLVERINE ASSET MANAGEMENT LLC22.8K$1.71M$1.65MCut−$3.68M
Informed Momentum Co LLC20.6K$1.55M−$82.8KCut−$2.72M
ALLSTATE CORP20.6K$1.54MNew
READYSTATE ASSET MANAGEMENT LP20.4K$1.53MNew
LANDSCAPE CAPITAL MANAGEMENT, L.L.C.20.1K$1.51M−$81KCut−$398.1K
Boussard & Gavaudan Investment Management LLP1K$1.51M−$81.4KCut−$18.7M
Legato Capital Management LLC19.8K$1.49M−$24.7KAdded$1M
FORA Capital, LLC19.7K$1.48MNew
AlphaCentric Advisors LLC19.6K$1.47M−$74.5KAdded$5.43K
DNB Asset Management AS19.1K$1.43M−$59.6KAdded$257.4K
Dana Investment Advisors, Inc.18.5K$1.39M−$72.5KCut−$37.8K
INCEPTIONR LLC16.8K$1.26M−$67.6KCut−$149K
NORTH STAR ASSET MANAGEMENT INC16.6K$1.25M−$66.8KCut−$66.8K
Caption Management, LLC15.6K$1.17MNew
Kohlberg Kravis Roberts & Co. L.P.760K$1.15M−$63.3KCut−$63.3K
BROWN ADVISORY INC15.1K$1.13M−$60.2KCut−$49.6K
AGF MANAGEMENT LTD750K$1.13M−$61.5KCut−$61.5K
TRUIST FINANCIAL CORP85.8K$1.08M−$40.8KCut−$38.5K
IQ EQ FUND MANAGEMENT (IRELAND) Ltd14.4K$1.08M−$57.8KCut−$119.5K
Bleakley Financial Group, LLC14.3K$1.07M−$55.8KCut−$22.7K
CANADA PENSION PLAN INVESTMENT BOARD14.1K$1.06MNew
Dynasty Wealth Management, LLC14.1K$1.06M−$56.2KCut−$49.5K
PNC Financial Services Group, Inc.13.5K$1.02M−$54.4KCut−$75.9K
Westmount Partners, LLC13K$973.2K−$52.1KCut−$52.1K
HIGHLAND CAPITAL MANAGEMENT, LLC12.8K$962.6KNew
Annis Gardner Whiting Capital Advisors, LLC12.8K$961.2K−$51.5KCut−$51.5K
Allianz Asset Management GmbH12.6K$946.2K−$50.7KCut−$376.2K
SUSQUEHANNA INTERNATIONAL GROUP, LLP12.4K$928K−$49.7KCut−$1.64M
SBI Okasan Asset Management Co.Ltd.12.6K$913.8K−$94KCut−$94K
Alpine Global Management, LLC600$907.2K$859.8KCut−$3.33M
OPPENHEIMER ASSET MANAGEMENT INC.11.9K$890K$776.1KCut−$131.2K
Summit Trail Advisors, LLC11.5K$867.2K−$40KAdded$80.6K

Who left

Positions as of Q1 2026. 13F filings arrive up to 45 days after quarter-end and omit shorts. Values are quarter-end marks, as filed. Estimated mark is the price effect on shares still held — not realized P&L or investment advice.