| EQT Fund Management S.a r.l. | 4.93M | $113.3M | $28.9M | Added$28.9M |
| RA CAPITAL MANAGEMENT, L.P. | 3.49M | $80.3M | $20.3M | Added$21.1M |
| Pivotal bioVenture Partners Investment Advisor LLC | 1.93M | $44.3M | $11.3M | Added$11.3M |
| ANDERA PARTNERS | 1.9M | $43.6M | $11.1M | Added$11.1M |
| RTW INVESTMENTS, LP | 1.5M | $34.5M | $7.54M | Added$12.6M |
| MPM BIOIMPACT LLC | 1.46M | $33.5M | $663.4K | Added$31.5M |
| Nan Fung Group Holdings Ltd | 1.44M | $33.1M | $8.46M | Added$8.46M |
| JPMORGAN CHASE & CO | 1.46M | $32.1M | $6.39M | Added$9.7M |
| SymBiosis Capital Partners, LLC | 1.28M | $29.4M | $7.52M | Added$7.52M |
| EVENTIDE ASSET MANAGEMENT, LLC | 1.21M | $27.8M | $5.64M | Added$11.3M |
| JANUS HENDERSON GROUP PLC | 896.7K | $20.6M | — | New |
| MARSHALL WACE, LLP | 879.7K | $20.2M | $5.16M | Added$3.31M |
| BAKER BROS. ADVISORS LP | 847.4K | $19.5M | — | New |
| Alyeska Investment Group, L.P. | 726.4K | $16.7M | — | New |
| Defilade Capital Management, L.P. | 678.6K | $15.6M | $1.26M | Added$11.9M |
| BlackRock, Inc. | 673.6K | $15.5M | $836.1K | Added$13M |
| Kynam Capital Management, LP | 625.5K | $14.4M | $1.09M | Added$11.2M |
| SECTORAL ASSET MANAGEMENT INC | 589K | $13.5M | $3.46M | Added$3.46M |
| Verition Fund Management LLC | 550K | $12.6M | $3.23M | Added$2.97M |
| AMERICAN CENTURY COMPANIES INC | 492.9K | $11.3M | $2.45M | Added$4.19M |
| VANGUARD CAPITAL MANAGEMENT LLC | 455.1K | $10.5M | — | Held |
| PERCEPTIVE ADVISORS LLC | 448.4K | $10.3M | — | New |
| Velan Capital Investment Management LP | 446.3K | $10.3M | $2.62M | Added$1.58M |
| Freestone Grove Partners LP | 337.3K | $7.75M | — | New |
| GREAT POINT PARTNERS LLC | 325K | $7.47M | $1.91M | Added$1.91M |
| FEDERATED HERMES, INC. | 325K | $7.47M | $1.91M | Added$1.91M |
| UBS Group AG | 298.4K | $6.86M | $20K | Added$6.8M |
| GEODE CAPITAL MANAGEMENT, LLC | 248.6K | $5.72M | $644K | Added$3.84M |
| E Fund Management Co., Ltd. | 243.7K | $5.6M | — | Held |
| Integral Health Asset Management, LLC | 225K | $5.17M | $733.7K | Added$3.03M |
| STEMPOINT CAPITAL LP | 193.8K | $4.39M | $375.8K | Added$3.22M |
| NEXTBio Capital Management LP | 184.1K | $4.23M | $1.08M | Added$323.4K |
| ADAR1 Capital Management, LLC | 184.1K | $4.23M | $1.08M | Added$1.08M |
| State Street | 179.5K | $4.13M | $184.9K | Added$3.59M |
| Monashee Investment Management LLC | 179.3K | $4.12M | $1.05M | Added$986K |
| SEVEN GRAND MANAGERS, LLC | 164.7K | $3.79M | $440.2K | Added$2.5M |
| GOLDMAN SACHS GROUP INC | 154.3K | $3.55M | $362K | Added$2.49M |
| Octagon Capital Advisors LP | 143.5K | $3.3M | $842.2K | Cut−$5.26M |
| Blue Owl Capital Holdings LP | 100K | $2.3M | — | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 94.9K | $2.18M | $368.1K | Added$1.11M |
| ExodusPoint Capital Management, LP | 93.9K | $2.16M | — | New |
| AMERIPRISE FINANCIAL INC | 91.4K | $2.1M | $536.7K | Added$312K |
| NORTHERN TRUST CORP | 79.8K | $1.83M | $132.9K | Added$1.45M |
| SPHERA FUNDS MANAGEMENT LTD. | 78.2K | $1.8M | $459.2K | Cut−$1.05M |
| VANGUARD FIDUCIARY TRUST CO | 72.6K | $1.67M | — | Held |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 61K | $1.4M | — | Held |
| Propel Bio Management, LLC | 55.7K | $1.28M | — | New |
| Eversept Partners, LP | 54.7K | $1.26M | — | New |
| Hudson Bay Capital Management LP | 51.4K | $1.18M | — | New |
| BURKEHILL GLOBAL MANAGEMENT, LP | 50K | $1.15M | $293.5K | Added$293.5K |
| TD Asset Management Inc | 40.2K | $924.4K | $236K | Added$160.3K |
| Point72 Asset Management, L.P. | 36.6K | $840.9K | $201.8K | Added$252.3K |
| BANK OF AMERICA CORP /DE/ | 30.2K | $694.3K | $17.2K | Added$644K |
| Palumbo Wealth Management LLC | 29.9K | $688.1K | — | New |
| MORGAN STANLEY | 25.1K | $576.4K | $49K | Added$433.5K |
| Bank of New York Mellon Corp | 22.1K | $507.9K | — | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 12.8K | $294.5K | $55.9K | Added$115.4K |
| Nuveen, LLC | 12.5K | $286.3K | — | New |
| XTX Topco Ltd | 12K | $276.8K | $70.7K | Cut−$44.7K |
| RHUMBLINE ADVISERS | 11.8K | $271.8K | — | New |
| MetLife Investment Management, LLC | 6.03K | $138.7K | — | New |
| China Universal Asset Management Co., Ltd. | 5K | $115K | $11.7K | Added$80.7K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4.88K | $112.2K | — | New |
| NEW YORK STATE COMMON RETIREMENT FUND | 4.3K | $98.9K | — | New |
| WELLS FARGO & COMPANY/MN | 3.87K | $88.9K | — | New |
| Vanguard Global Advisers, LLC | 3.76K | $86.4K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 3.01K | $69.1K | — | New |
| NATIONAL BANK OF CANADA /FI/ | 2.4K | $55K | $12.9K | Added$17.5K |
| Tower Research Capital LLC (TRC) | 2.25K | $51.7K | $13.2K | Added$4.71K |
| BNP PARIBAS FINANCIAL MARKETS | 2.2K | $50.6K | — | New |
| BARCLAYS PLC | 1.98K | $45.5K | — | New |
| STRS OHIO | 1.8K | $41.4K | — | New |
| Fidelity | 1.72K | $39.5K | — | New |
| Plante Moran Financial Advisors, LLC | 1.15K | $26.4K | — | New |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.12M | $25.7K | $4.59K | Added$12.3K |
| Legal & General Group Plc | 919 | $21.1K | $2.35K | Added$14.3K |
| Ameritas Investment Partners, Inc. | 855 | $19.7K | — | New |
| Russell Investments Group, Ltd. | 788 | $18.1K | — | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 571 | $13.1K | — | New |
| CITIGROUP INC | 518 | $11.9K | — | New |
| Sterling Capital Management LLC | 200 | $4.6K | — | New |
| OSAIC HOLDINGS, INC. | 80 | $1.84K | — | New |
| FIFTH THIRD BANCORP | 21 | $472 | — | New |
| CWM, LLC | 7 | $161 | — | New |