| JANUS HENDERSON GROUP PLC | 1.28M | $93.5M | −$6.66M | Added$2.69M |
| Cormorant Asset Management, LP | 1.06M | $77.3M | −$5.37M | Cut−$5.37M |
| BlackRock, Inc. | 621.9K | $45.4M | −$2M | Added$14.6M |
| Vivo Capital, LLC | 557.2K | $40.7M | −$2.54M | Added$1.51M |
| BRAIDWELL LP | 539.7K | $39.4M | −$1.64M | Added$14.1M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 495.7K | $36.2M | −$2.01M | Added$5.29M |
| Vestal Point Capital, LP | 492.3K | $35.9M | — | New |
| Driehaus Capital Management LLC | 432.5K | $31.6M | −$1.37M | Added$10.5M |
| PERCEPTIVE ADVISORS LLC | 377.5K | $27.5M | −$1.91M | Cut−$7.51M |
| Balyasny Asset Management L.P. | 297.2K | $21.7M | −$1.14M | Added$4.09M |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 283K | $20.7M | — | New |
| RA CAPITAL MANAGEMENT, L.P. | 265K | $19.3M | — | New |
| GREAT POINT PARTNERS LLC | 220K | $16.1M | — | New |
| MPM BIOIMPACT LLC | 212.2K | $15.5M | −$1.08M | Cut−$2.48M |
| Ikarian Capital, LLC | 166.6K | $12.2M | −$808.3K | Cut−$281K |
| WELLINGTON MANAGEMENT GROUP LLP | 136.7K | $9.97M | −$69.4K | Added$8.91M |
| MORGAN STANLEY | 132.8K | $9.69M | −$669.9K | Cut−$623K |
| EVENTIDE ASSET MANAGEMENT, LLC | 130K | $9.49M | −$522.3K | Added$1.45M |
| SEVEN GRAND MANAGERS, LLC | 120K | $8.76M | −$253.5K | Added$4.85M |
| ACUTA CAPITAL PARTNERS, LLC | 112K | $8.17M | −$428.3K | Added$1.58M |
| State Street | 108.2K | $7.9M | −$391.8K | Added$1.87M |
| GEODE CAPITAL MANAGEMENT, LLC | 88.7K | $6.47M | −$322.2K | Added$1.51M |
| Sio Capital Management, LLC | 86.1K | $6.28M | −$415.1K | Cut−$108.7K |
| GOLDMAN SACHS GROUP INC | 74.4K | $5.43M | −$246.1K | Added$1.64M |
| B Group, Inc. | 67.5K | $4.93M | — | New |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 60.5K | $4.41M | — | Held |
| Walleye Capital LLC | 53.7K | $3.92M | −$130.9K | Added$1.9M |
| MILLENNIUM MANAGEMENT LLC | 52.8K | $3.86M | −$267.9K | Cut−$11.3M |
| BOOTHBAY FUND MANAGEMENT, LLC | 51.3K | $3.74M | −$240.8K | Added$36.5K |
| AMERIPRISE FINANCIAL INC | 50K | $3.65M | — | New |
| Woodline Partners LP | 45.7K | $3.33M | — | New |
| Parkman Healthcare Partners LLC | 40.1K | $2.93M | — | New |
| ORBIMED ADVISORS LLC | 40K | $2.92M | — | New |
| Artia Global Partners LP | 38.4K | $2.8M | −$169.4K | Added$195.5K |
| NORTHERN TRUST CORP | 37.4K | $2.73M | −$129.6K | Added$732K |
| ADAR1 Capital Management, LLC | 33.9K | $2.47M | −$17.7K | Added$2.2M |
| KVP Capital Advisors, LP | 31.8K | $2.32M | — | New |
| BANK OF AMERICA CORP /DE/ | 19.4K | $1.42M | −$76.4K | Added$240.8K |
| PLATINUM INVESTMENT MANAGEMENT LTD | 19.1K | $1.4M | −$97K | Cut−$300.1K |
| D. E. Shaw & Co., Inc. | 15.4K | $1.13M | −$19.9K | Added$821.3K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 15.3K | $1.12M | −$63.2K | Added$145K |
| SUPERSTRING CAPITAL MANAGEMENT LP | 13.3K | $971.3K | −$67.5K | Cut−$2.72M |
| UBS Group AG | 13.3K | $969K | −$67.3K | Cut−$108.9K |
| Bank of New York Mellon Corp | 13.3K | $967K | −$50.6K | Added$187.5K |
| Schonfeld Strategic Advisors LLC | 13.2K | $966.4K | −$67.1K | Cut−$1.39M |
| AdvisorShares Investments LLC | 12.6K | $920.4K | −$50.4K | Added$144.3K |
| SEI INVESTMENTS CO | 11.2K | $816.4K | — | New |
| Ghisallo Capital Management LLC | 11K | $802.7K | — | New |
| Informed Momentum Co LLC | 9.19K | $670.5K | — | New |
| Nuveen, LLC | 8.33K | $607.8K | −$30.4K | Added$140.5K |
| RHUMBLINE ADVISERS | 7.76K | $566.4K | −$30.1K | Added$103.1K |
| Trexquant Investment LP | 7.45K | $543.7K | — | New |
| Quadrature Capital Ltd | 6.5K | $474.2K | — | New |
| LPL Financial LLC | 6.5K | $473.9K | −$28.6K | Added$33.4K |
| JANE STREET GROUP, LLC | 6.4K | $467K | −$32.4K | Cut−$236.8K |
| Seven Fleet Capital Management LP | 6.39K | $466.6K | — | New |
| Invesco Ltd. | 6.3K | $459.4K | −$21.3K | Added$131.8K |
| DEUTSCHE BANK AG\ | 6.26K | $456.6K | −$21.6K | Added$124.3K |
| VANGUARD FIDUCIARY TRUST CO | 6.06K | $442.3K | — | Held |
| DNB Asset Management AS | 4.44K | $324.1K | — | New |
| MetLife Investment Management, LLC | 3.91K | $285.4K | −$14.8K | Added$57.7K |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 3.78K | $275.9K | −$19.2K | Cut−$19.2K |
| JPMORGAN CHASE & CO | 3.88K | $265.4K | −$24.1K | Added$69K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 3.26K | $237.9K | −$11.8K | Added$56.6K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 3.14K | $229.2K | — | New |
| BARCLAYS PLC | 3.08K | $224.5K | −$15.6K | Cut−$529.3K |
| Vanguard Global Advisers, LLC | 3.06K | $223.1K | — | Held |
| STRS OHIO | 2.7K | $197K | −$4.56K | Added$126.8K |
| NEW YORK STATE COMMON RETIREMENT FUND | 2.6K | $189.7K | −$13.2K | Cut−$13.2K |
| WELLS FARGO & COMPANY/MN | 2.53K | $184.8K | −$12.8K | Cut−$246.3K |
| Persistent Asset Partners Ltd | 2.31K | $168.6K | — | New |
| Aquatic Capital Management LLC | 2.04K | $149.2K | — | New |
| Police & Firemen's Retirement System of New Jersey | 2.04K | $148.6K | −$7.63K | Added$31.1K |
| BNP PARIBAS FINANCIAL MARKETS | 1.57K | $114.6K | −$7.96K | Cut−$1.89M |
| Russell Investments Group, Ltd. | 882 | $64.4K | −$4.47K | Cut−$8.53K |
| Fidelity | 819 | $59.8K | −$4.15K | Cut−$26.9K |
| Legal & General Group Plc | 616 | $45K | −$3.07K | Added$1.96K |
| Tower Research Capital LLC (TRC) | 597 | $43.6K | −$3.03K | Cut−$40.9K |
| China Universal Asset Management Co., Ltd. | 500 | $36.5K | — | New |
| Ameritas Investment Partners, Inc. | 470 | $34.3K | −$2.38K | Cut−$2.38K |
| ROYAL BANK OF CANADA | 406 | $30K | −$816 | Cut−$10K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 380 | $27.7K | −$1.57K | Added$3.54K |
| CITIGROUP INC | 297 | $21.6K | −$903 | Added$12.4K |
| Sterling Capital Management LLC | 45 | $3.28K | −$152 | Added$943 |
| GAMMA Investing LLC | 33 | $2.41K | — | New |
| CWM, LLC | 11 | $803 | $729 | Added$802 |
| Bell Investment Advisors, Inc | 6 | $438 | — | New |
| SBI Securities Co., Ltd. | 5 | $365 | −$25 | Cut−$25 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4.95K | $361 | −$14 | Added$140 |
| Virtu Financial LLC | 3.13K | $228 | −$15 | Added$2 |
| Allworth Financial LP | 3 | $219 | — | New |
| TWIN PEAKS WEALTH ADVISORS, LLC | 1 | $73 | — | New |
| MAI Capital Management | 1 | $73 | — | New |