| MPM BIOIMPACT LLC | 5.21M | $108.9M | $1.71M | Added$89.8M |
| Vivo Capital, LLC | 2.67M | $55.7M | $4.23M | Added$8.54M |
| Artisan Partners Limited Partnership | 2.22M | $46.4M | $3.82M | Cut−$17.1M |
| Siren, L.L.C. | 1.86M | $38.8M | $3.19M | Added$3.19M |
| BAKER BROS. ADVISORS LP | 1.46M | $30.5M | $2.51M | Added$2.51M |
| ADAR1 Capital Management, LLC | 1.01M | $21.2M | — | New |
| PERCEPTIVE ADVISORS LLC | 964.4K | $20.1M | — | New |
| Patient Square Capital LP | 693.5K | $14.5M | $617.6K | Added$7.6M |
| Octagon Capital Advisors LP | 574.2K | $12M | $987.6K | Added$987.6K |
| Redmile Group, LLC | 491.3K | $10.3M | $845.1K | Cut−$276.3K |
| MILLENNIUM MANAGEMENT LLC | 319K | $6.66M | $548.6K | Cut−$5.62M |
| Atika Capital Management LLC | 271.3K | $5.67M | $355.8K | Added$1.7M |
| Elmind Capital, LP | 265K | $5.54M | — | New |
| Balyasny Asset Management L.P. | 233.4K | $4.88M | $401.5K | Added$370.9K |
| AMERIPRISE FINANCIAL INC | 231.4K | $4.83M | — | New |
| Yiheng Capital Management, L.P. | 170.1K | $3.55M | $292.6K | Cut−$8.71M |
| NEW YORK STATE COMMON RETIREMENT FUND | 168.2K | $3.51M | $289.3K | Cut−$765.2K |
| BOOTHBAY FUND MANAGEMENT, LLC | 163.4K | $3.41M | $281.1K | Added$281.1K |
| MORGAN STANLEY | 146.1K | $3.05M | $210.7K | Added$704.1K |
| Russell Investments Group, Ltd. | 128.6K | $2.69M | — | New |
| Ikarian Capital, LLC | 525K | $2.2M | $114.5K | Added$114.5K |
| Dorsey Wright & Associates | 102.5K | $2.14M | — | New |
| Ishara Investments LP | 102.5K | $2.14M | — | New |
| ENVESTNET ASSET MANAGEMENT INC | 95.7K | $2M | $38.5K | Added$1.57M |
| UBS Group AG | 79.5K | $1.66M | $136.8K | Cut−$3.03M |
| Polymer Capital Management (HK) LTD | 64.5K | $1.35M | $110.9K | Added$110.9K |
| DIVERSIFY WEALTH MANAGEMENT, LLC | 63.7K | $1.29M | — | New |
| LPL Financial LLC | 55.9K | $1.17M | — | New |
| AdvisorShares Investments LLC | 50.3K | $1.05M | — | New |
| XTX Topco Ltd | 42.1K | $878.5K | — | New |
| Qube Research & Technologies Ltd | 37.4K | $781.9K | $23.6K | Added$518.5K |
| NAN FUNG TRINITY (HK) LTD | 37.1K | $774.9K | $63.8K | Added$63.8K |
| Engineers Gate Manager LP | 33K | $690.2K | $43K | Added$211.3K |
| STIFEL FINANCIAL CORP | 30.7K | $642.1K | — | New |
| Cetera Investment Advisers | 25.4K | $529.7K | $22.6K | Added$278.3K |
| Burns Matteson Capital Management, LLC | 22.6K | $472.8K | — | New |
| Atria Investments, Inc | 21.1K | $441.5K | — | New |
| Optiver Holding B.V. | 19K | $397.9K | $32.8K | Cut−$517.1K |
| SEI INVESTMENTS CO | 16.8K | $350.2K | $28.8K | Cut−$921.6K |
| PERSONAL CFO SOLUTIONS, LLC | 12.6K | $264.1K | — | New |
| ExodusPoint Capital Management, LP | 11.5K | $241K | $19.8K | Cut−$280.6K |
| Persistent Asset Partners Ltd | 11.4K | $238K | $10.4K | Added$122.6K |
| JANE STREET GROUP, LLC | 11.3K | $235.7K | — | New |
| Integrated Wealth Concepts LLC | 10.6K | $221.1K | — | New |
| BARCLAYS PLC | 8.08K | $168.8K | — | New |
| RHUMBLINE ADVISERS | 6.1K | $127.4K | $10.5K | Added$4.09K |
| China Universal Asset Management Co., Ltd. | 5K | $104.5K | — | New |
| ROYAL BANK OF CANADA | 4.68K | $98K | $2.69K | Added$64K |
| Truvestments Capital LLC | 3.89K | $81.3K | $6.69K | Added$6.69K |
| GAMMA Investing LLC | 2.9K | $60.6K | $4.61K | Added$9.18K |
| Allworth Financial LP | 1.68K | $35.2K | $2.89K | Added$2.89K |
| OSAIC HOLDINGS, INC. | 1.12K | $23.4K | $591 | Added$16.8K |
| HM PAYSON & CO | 420 | $8.77K | — | New |
| Duquesne Family Office | 383.4K | $8.01K | — | New |
| WELLS FARGO & COMPANY/MN | 300 | $6.27K | $516 | Added$516 |
| HARBOUR INVESTMENTS, INC. | 259 | $5.42K | — | New |
| ORG Wealth Partners, LLC | 259 | $5.41K | — | New |
| Farther Finance Advisors, LLC | 164 | $3.36K | — | New |
| Federation des caisses Desjardins du Quebec | 145 | $3.03K | $249 | Added$249 |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 111 | $2.32K | $191 | Added$191 |
| Caitong International Asset Management Co., Ltd | 67 | $1.4K | — | New |
| Pinnacle Wealth Planning Services, Inc. | 40 | $836 | $69 | Added$69 |
| Advisory Services Network, LLC | 30 | $627 | — | New |
| CURIO WEALTH, LLC | 27 | $564 | $50 | Added$50 |
| HRT FINANCIAL LP | 24.1K | $503 | — | New |
| Bell Investment Advisors, Inc | 21 | $439 | — | New |
| JPMORGAN CHASE & CO | 20 | $391 | $8 | Cut−$543.6K |
| EverSource Wealth Advisors, LLC | 14 | $292 | $24 | Cut−$8.89K |
| TRUST CO OF TOLEDO NA /OH/ | 10 | $209 | $17 | Added$17 |
| BlackRock, Inc. | 2 | $42 | $4 | Added$4 |
| Tower Research Capital LLC (TRC) | 1 | $21 | — | New |