| Frazier Life Sciences Management, L.P. | 12.5M | $138.5M | −$68.3M | Cut−$68.3M |
| Medicxi Ventures Management (Jersey) Ltd | 7.46M | $82.9M | −$40.9M | Cut−$40.9M |
| Invesco Ltd. | 4.32M | $48M | −$21.5M | Cut−$17M |
| BlackRock, Inc. | 4.06M | $45.1M | −$19.5M | Cut−$13.9M |
| MILLENNIUM MANAGEMENT LLC | 4.02M | $44.7M | −$11.4M | Added$10.2M |
| Carlyle Group Inc. | 3.5M | $38.8M | −$19.1M | Cut−$19.1M |
| VANGUARD CAPITAL MANAGEMENT LLC | 2.58M | $28.7M | — | Held |
| NEA Management Company, LLC | 1.96M | $21.8M | −$10.7M | Cut−$10.7M |
| 683 Capital Management, LLC | 1.85M | $20.6M | −$9.78M | Cut−$9.06M |
| Ensign Peak Advisors, Inc | 1.63M | $18.1M | −$8.92M | Cut−$20.9M |
| Catalys Pacific, LLC | 1.49M | $16.6M | −$7.83M | Cut−$7.11M |
| State Street | 1.39M | $15.4M | −$6.3M | Cut−$3.66M |
| WASATCH ADVISORS LP | 1.34M | $14.9M | −$7.3M | Cut−$7.19M |
| GEODE CAPITAL MANAGEMENT, LLC | 1.33M | $14.8M | −$5.88M | Cut−$3.05M |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 1.21M | $13.4M | — | New |
| SummitTX Capital, L.P. | 995.9K | $11.1M | −$2.84M | Added$2.47M |
| FRANKLIN RESOURCES INC | 994.5K | $11M | — | New |
| PERCEPTIVE ADVISORS LLC | 925K | $10.3M | — | New |
| MARSHALL WACE, LLP | 860.7K | $9.56M | — | New |
| Propel Bio Management, LLC | 841.3K | $9.35M | −$4.05M | Cut−$2.94M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 666K | $7.4M | — | Held |
| GOLDMAN SACHS GROUP INC | 626.2K | $6.96M | −$2.15M | Added$453K |
| EcoR1 Capital, LLC | 625K | $6.94M | — | New |
| TWO SIGMA INVESTMENTS, LP | 482.1K | $5.36M | −$316.7K | Added$4.4M |
| StepStone Group LP | 422.1K | $4.69M | −$278.6K | Cut−$278.6K |
| NORTHERN TRUST CORP | 415K | $4.61M | −$1.95M | Cut−$1.3M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 409K | $4.54M | −$2.18M | Cut−$2.06M |
| Citadel | 383.1K | $4.26M | −$1.71M | Cut−$908.9K |
| Woodline Partners LP | 369.1K | $4.1M | −$1.03M | Added$993K |
| UBS Group AG | 360.4K | $4M | −$1.67M | Cut−$1.05M |
| VANGUARD FIDUCIARY TRUST CO | 338.7K | $3.76M | — | Held |
| Renaissance Technologies | 305.8K | $3.4M | — | New |
| Trexquant Investment LP | 293.3K | $3.26M | −$749.8K | Added$988.7K |
| Squarepoint Ops LLC | 275.2K | $3.06M | — | New |
| JPMORGAN CHASE & CO | 287.4K | $3.03M | −$1.74M | Cut−$1.9M |
| Susquehanna Portfolio Strategies, LLC | 268K | $2.98M | −$1.47M | Cut−$1.47M |
| Simplify Asset Management Inc. | 262.4K | $2.92M | −$1.44M | Cut−$2.43M |
| AMERIPRISE FINANCIAL INC | 254.2K | $2.82M | −$1.02M | Cut−$257.1K |
| Avidity Partners Management LP | 249.4K | $2.77M | −$1.13M | Cut−$648.1K |
| Catalio Capital Management, LP | 247.8K | $2.75M | −$1.36M | Cut−$8.84M |
| BANK OF AMERICA CORP /DE/ | 208.1K | $2.31M | −$1.14M | Cut−$1.98M |
| Birchview Capital, LP | 195K | $2.17M | −$1.07M | Cut−$1.07M |
| XTX Topco Ltd | 160.5K | $1.78M | −$215.9K | Added$1.13M |
| Hennion & Walsh Asset Management, Inc. | 145.9K | $1.62M | −$630.1K | Cut−$286.2K |
| GILDER GAGNON HOWE & CO LLC | 139.9K | $1.55M | −$766.6K | Cut−$854.3K |
| D. E. Shaw & Co., Inc. | 132.5K | $1.47M | −$725.9K | Cut−$2.86M |
| Bank of New York Mellon Corp | 124K | $1.38M | −$673.9K | Cut−$662.2K |
| Nuveen, LLC | 117.3K | $1.3M | −$596.5K | Cut−$502.5K |
| WELLINGTON MANAGEMENT GROUP LLP | 111.8K | $1.24M | −$612.4K | Cut−$990.6K |
| Stratos Wealth Partners, LTD. | 100K | $1.11M | −$275.6K | Added$276.5K |
| Balyasny Asset Management L.P. | 95.3K | $1.06M | −$522.2K | Cut−$2.38M |
| Brevan Howard Capital Management LP | 94.6K | $1.05M | −$518.6K | Cut−$3.54M |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 93K | $1.03M | −$509.5K | Cut−$8.08M |
| Swiss National Bank | 92.6K | $1.03M | −$460.3K | Cut−$364.8K |
| Russell Investments Group, Ltd. | 85.7K | $951.9K | −$36.4K | Added$841.7K |
| Freestone Grove Partners LP | 84.6K | $939.6K | — | New |
| HUSSMAN STRATEGIC ADVISORS, INC. | 84K | $933.2K | −$460.3K | Cut−$1.51M |
| MORGAN STANLEY | 76.7K | $851.9K | −$420.2K | Cut−$1.1M |
| BURKEHILL GLOBAL MANAGEMENT, LP | 75K | $833.3K | — | New |
| Engineers Gate Manager LP | 73.8K | $820.5K | −$242.5K | Added$86.2K |
| ALLIANCEBERNSTEIN L.P. | 49.4K | $819.4K | $0 | Held |
| Creative Planning | 70.2K | $779.8K | −$384.7K | Cut−$560.1K |
| Penn Mutual Asset Management | 62.8K | $697.7K | −$344.2K | Cut−$344.2K |
| Campbell & CO Investment Adviser LLC | 62K | $689.1K | −$339.9K | Cut−$1.22M |
| Virtus Investment Advisers, LLC | 58K | $644.2K | −$257.2K | Cut−$134.5K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 55.8K | $619.8K | −$167.9K | Added$111.6K |
| Icahn Capital | 55.5K | $616.2K | −$298.4K | Cut−$287K |
| RHUMBLINE ADVISERS | 55.4K | $615.9K | −$285.5K | Cut−$248.3K |
| DIADEMA PARTNERS LP | 54.6K | $607.2K | — | New |
| STIFEL FINANCIAL CORP | 54K | $600.4K | −$283.1K | Cut−$256.7K |
| Stonepine Capital Management, LLC | 50K | $555.6K | — | New |
| WELLS FARGO & COMPANY/MN | 46.1K | $512.3K | −$252.7K | Cut−$616.1K |
| STATE OF WISCONSIN INVESTMENT BOARD | 44K | $488.9K | −$83.8K | Added$235.3K |
| ADAR1 Capital Management, LLC | 42.9K | $476.6K | −$235.1K | Cut−$235.1K |
| Aquatic Capital Management LLC | 40.9K | $453.9K | — | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 40.2K | $446.9K | −$220K | Cut−$219.1K |
| VARCOV Co. | 39.2K | $435.2K | −$214.7K | Cut−$1M |
| TUDOR INVESTMENT CORP ET AL | 38.2K | $424.7K | −$156.5K | Cut−$49K |
| DEUTSCHE BANK AG\ | 36.5K | $405.1K | −$182.9K | Cut−$148.7K |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 35.2K | $391.1K | −$190.2K | Cut−$184.6K |
| ALLSTATE CORP | 32.7K | $363.2K | — | New |
| COMMONWEALTH EQUITY SERVICES, LLC | 32.2K | $358.1K | −$169.5K | Cut−$155.2K |
| Legal & General Group Plc | 32K | $355.9K | −$175.6K | Cut−$212.3K |
| Man Group plc | 30.4K | $337.2K | — | New |
| CITIGROUP INC | 29.4K | $326.3K | −$156K | Cut−$145.8K |
| VANGUARD ASSET MANAGEMENT, Ltd | 28.5K | $316.7K | — | Held |
| Kera Capital Partners, Inc. | 26.8K | $298K | −$62.1K | Cut−$33.5K |
| Persistent Asset Partners Ltd | 26.8K | $297.4K | −$70.8K | Added$83.1K |
| Vanguard Global Advisers, LLC | 26.5K | $294.5K | — | Held |
| Jump Financial, LLC | 26.4K | $293.8K | −$95.4K | Added$5K |
| RAYMOND JAMES FINANCIAL INC | 26.3K | $292.5K | −$133.7K | Cut−$112.1K |
| MetLife Investment Management, LLC | 25.8K | $287.1K | −$141.6K | Cut−$141.6K |
| BARCLAYS PLC | 25.4K | $281.7K | −$139K | Cut−$1.13M |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 25K | $277.7K | −$109K | Cut−$52.3K |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 24.7K | $274.1K | −$54.3K | Cut−$170.7K |
| Summit Financial Wealth Advisors, LLC | 22.1K | $246K | −$121.3K | Cut−$121.3K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 21.7K | $241.4K | −$101.2K | Cut−$64.8K |
| JANUS HENDERSON GROUP PLC | 21.5K | $239.4K | −$117.2K | Cut−$117.2K |
| INSPIRION WEALTH ADVISORS, LLC | 19.9K | $221.2K | −$108.6K | Cut−$107.5K |
| Jain Global LLC | 18.3K | $202.9K | −$100.1K | Cut−$157.7K |
| Fiduciary Trust Co | 18.1K | $200.7K | −$87.9K | Cut−$65.4K |
| DARK FOREST CAPITAL MANAGEMENT LP | 17.5K | $194K | −$95.7K | Cut−$838.7K |
| LPL Financial LLC | 17.2K | $191.2K | — | New |
| GROUP ONE TRADING LLC | 16.9K | $188.2K | −$92.8K | Cut−$1.53M |
| PROFUND ADVISORS LLC | 16.5K | $183.1K | −$85.3K | Cut−$75K |
| NewEdge Advisors, LLC | 183K | $183K | −$2.7M | Cut−$2.98M |
| State of New Jersey Common Pension Fund D | 16K | $177.7K | — | New |
| DRW Securities, LLC | 15.9K | $176.9K | — | New |
| Schonfeld Strategic Advisors LLC | 15.6K | $173.5K | −$85.6K | Cut−$339.9K |
| Pathstone Holdings, LLC | 15K | $166.7K | −$81.7K | Cut−$80.5K |
| Bridgefront Capital, LLC | 15K | $166.1K | −$81.9K | Cut−$115.6K |
| LAZARD ASSET MANAGEMENT LLC | 14.7K | $163K | — | New |
| KLP KAPITALFORVALTNING AS | 14K | $155.5K | −$76.7K | Cut−$76.7K |
| China Universal Asset Management Co., Ltd. | 14K | $155.4K | −$63.5K | Cut−$37K |
| ExodusPoint Capital Management, LP | 13.3K | $147.7K | −$72.8K | Cut−$223.9K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 12.9K | $143.4K | −$68.2K | Cut−$62.9K |
| ARIZONA STATE RETIREMENT SYSTEM | 12.9K | $142.8K | −$65K | Cut−$54K |
| Dynamic Technology Lab Private Ltd | 12.1K | $134.6K | — | New |
| Quadrature Capital Ltd | 12.1K | $134.2K | — | New |
| Police & Firemen's Retirement System of New Jersey | 11.9K | $132.5K | −$65.3K | Cut−$65.3K |
| Quantinno Capital Management LP | 11.5K | $128.2K | — | New |
| PRIMORIS WEALTH ADVISORS, LLC | 11.4K | $127.2K | — | New |
| INTECH INVESTMENT MANAGEMENT LLC | 11.3K | $126.1K | −$62.2K | Cut−$190K |
| BNP PARIBAS FINANCIAL MARKETS | 11.3K | $125.9K | −$53.6K | Cut−$36.5K |
| Vanguard Investments Australia, Ltd. | 11.3K | $125.3K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 10.8K | $119.7K | −$59K | Cut−$573.1K |
| Allworth Financial LP | 10.5K | $117.1K | −$57.3K | Cut−$56.3K |
| ProShare Advisors LLC | 10.2K | $113.8K | −$56.1K | Cut−$58.3K |
| Private Advisor Group, LLC | 10.2K | $113.1K | −$55.8K | Cut−$128.8K |
| Fidelity | 7.03K | $78K | −$38.5K | Cut−$41.1K |
| ROYAL BANK OF CANADA | 5.77K | $64K | −$31.6K | Cut−$310K |
| State of Wyoming | 4.94K | $54.8K | — | New |
| Mirae Asset Global Investments Co., Ltd. | 4.11K | $45.7K | −$18.9K | Cut−$11.7K |
| Rockefeller Capital Management L.P. | 4.09K | $45.5K | −$849 | Added$42.9K |
| Ameritas Investment Partners, Inc. | 3.53K | $39.2K | −$19.3K | Cut−$19.3K |
| JONES FINANCIAL COMPANIES LLLP | 3.53K | $37.3K | −$17.3K | Cut−$10.3K |
| SUMMIT SECURITIES GROUP LLC | 3.05K | $33.9K | — | New |
| HUNTINGTON NATIONAL BANK | 2.3K | $25.6K | −$10.9K | Cut−$7.35K |
| OSAIC HOLDINGS, INC. | 2.3K | $25.6K | −$12.6K | Cut−$81.4K |
| NISA INVESTMENT ADVISORS, LLC | 2.29K | $25.4K | −$3.11K | Added$16K |
| Tower Research Capital LLC (TRC) | 1.94K | $21.6K | −$6.01K | Added$3.37K |
| CWM, LLC | 1.86K | $20.7K | $20.7K | Added$20.7K |
| Larson Financial Group LLC | 1.77K | $19.6K | −$3.55K | Added$8.9K |
| GF FUND MANAGEMENT CO. LTD. | 1.59K | $17.6K | −$7.66K | Cut−$5.53K |
| GW&K Investment Management, LLC | 1.42M | $15.8K | −$7.16K | Cut−$5.89K |
| PNC Financial Services Group, Inc. | 1.39K | $15.4K | −$7.6K | Cut−$8.17K |
| Sterling Capital Management LLC | 1.2K | $13.3K | −$6.56K | Cut−$15.7K |
| QUADRANT CAPITAL GROUP LLC | 1.09K | $12.1K | −$5.88K | Cut−$5.68K |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 889 | $9.88K | $6.7K | Added$9.87K |
| C M BIDWELL & ASSOCIATES LTD | 590 | $6.55K | −$3.23K | Cut−$7.6K |
| MassMutual Private Wealth & Trust, FSB | 459 | $5.1K | −$1.75K | Cut−$210 |
| GAMMA Investing LLC | 438 | $4.87K | −$1.66K | Cut−$161 |
| Farther Finance Advisors, LLC | 349 | $3.89K | −$1.86K | Cut−$1.79K |
| US BANCORP \DE\ | 295 | $3.28K | −$1.52K | Cut−$1.32K |
| Optiver Holding B.V. | 282 | $3.13K | −$1.09K | Cut−$152 |
| SIGNATUREFD, LLC | 239 | $2.65K | −$220 | Added$1.99K |
| Truvestments Capital LLC | 225 | $2.5K | — | New |
| Parallel Advisors, LLC | 100 | $1.11K | −$548 | Cut−$548 |
| GSA CAPITAL PARTNERS LLP | 97.1K | $1.08K | −$453 | Cut−$293 |
| True Wealth Design, LLC | 88 | $978 | −$483 | Cut−$599 |
| KBC Group NV | 77.1K | $857 | — | New |
| PRICE T ROWE ASSOCIATES INC /MD/ | 52.5K | $583 | −$204 | Cut−$33 |
| ALGERT GLOBAL LLC | 39.4K | $438 | — | New |
| Rachor Investment Advisory Services, LLC | 25 | $278 | −$137 | Cut−$137 |
| MAI Capital Management | 23 | $256 | — | New |
| ELEVATION WEALTH PARTNERS, LLC | 20 | $223 | −$109 | Cut−$109 |
| EverSource Wealth Advisors, LLC | 12 | $134 | −$27 | Added$51 |
| Root Financial Partners, LLC | 11 | $122 | — | New |
| Stone House Investment Management, LLC | 8 | $89 | — | New |
| CANADA LIFE ASSURANCE Co | 6.82K | $76 | −$37 | Cut−$37 |
| Strategic Wealth Advisors LLC | 1K | $11 | −$5 | Cut−$5 |
| IFP Advisors, Inc | 1 | $11 | −$6 | Cut−$6 |
| Hughes Financial Services, LLC | 1 | $11 | — | New |
| Covestor Ltd | 8 | $0 | $0 | Held |