| SUVRETTA CAPITAL MANAGEMENT, LLC | 2.84M | $37.1M | $4.63M | Added$4.63M |
| JANUS HENDERSON GROUP PLC | 2.73M | $35.6M | $3.97M | Added$7.69M |
| JOHNSON & JOHNSON | 1.98M | $25.8M | $3.23M | Added$3.23M |
| FRANKLIN RESOURCES INC | 1.84M | $24M | $3M | Added$2.54M |
| Balyasny Asset Management L.P. | 1.69M | $22M | $2.75M | Added$951.2K |
| MILLENNIUM MANAGEMENT LLC | 1.54M | $20.1M | $1.35M | Added$10.6M |
| BAKER BROS. ADVISORS LP | 1.42M | $18.6M | $2.32M | Added$2.32M |
| RA CAPITAL MANAGEMENT, L.P. | 1.3M | $16.9M | $2.11M | Cut−$7.99M |
| PERCEPTIVE ADVISORS LLC | 1.26M | $16.4M | $2.05M | Cut−$342.3K |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.21M | $15.9M | — | Held |
| Fidelity | 814.9K | $10.6M | $1.33M | Added$1.33M |
| Ikarian Capital, LLC | 807.9K | $10.6M | $461.1K | Added$7.32M |
| GREAT POINT PARTNERS LLC | 800.2K | $10.5M | $1.3M | Added$1.31M |
| Longaeva Partners L.P. | 732.1K | $9.56M | $766.1K | Added$4.19M |
| SECTORAL ASSET MANAGEMENT INC | 727.6K | $9.5M | $1.19M | Added$349.3K |
| HHLR ADVISORS, LTD. | 669.3K | $8.74M | $1.09M | Added$1.09M |
| BlackRock, Inc. | 669.1K | $8.74M | $873.9K | Added$2.61M |
| RED TREE MANAGEMENT, LLC | 638.2K | $8.33M | $1.04M | Added$1.04M |
| Versant Venture Management, LLC | 542.6K | $7.09M | $884.5K | Added$884.5K |
| Jones Hill Capital LP | 513.1K | $6.7M | — | Held |
| Boxer Capital Management, LLC | 494K | $6.45M | $805.2K | Added$805.2K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 371.6K | $4.85M | $433.2K | Added$1.82M |
| Citadel | 350.2K | $4.57M | — | New |
| GOLDMAN SACHS GROUP INC | 307.1K | $4.01M | $172.1K | Added$2.8M |
| SILVERARC CAPITAL MANAGEMENT, LLC | 301.7K | $3.94M | $491.8K | Added$425.4K |
| GEODE CAPITAL MANAGEMENT, LLC | 282K | $3.69M | $349K | Added$1.24M |
| ADAR1 Capital Management, LLC | 276.7K | $3.61M | $451K | Added$424.7K |
| Qube Research & Technologies Ltd | 232.5K | $3.04M | $70.2K | Added$2.54M |
| UBS Group AG | 230.4K | $3.01M | $325K | Added$730.1K |
| MARSHALL WACE, LLP | 226.3K | $2.96M | $294.7K | Added$888.9K |
| BOOTHBAY FUND MANAGEMENT, LLC | 222.3K | $2.9M | $118.2K | Added$2.08M |
| SPHERA FUNDS MANAGEMENT LTD. | 173.5K | $2.27M | $282.8K | Added$282.8K |
| VANGUARD FIDUCIARY TRUST CO | 153.9K | $2.01M | — | Held |
| Casdin Capital, LLC | 148.3K | $1.94M | $241.8K | Added$241.8K |
| Eversept Partners, LP | 146.4K | $1.91M | $224.1K | Added$340.6K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 144K | $1.88M | $179.4K | Added$622.8K |
| Ishara Investments LP | 142K | $1.85M | — | New |
| JANE STREET GROUP, LLC | 107.4K | $1.4M | $45.6K | Added$1.08M |
| State Street | 101.3K | $1.32M | $137.6K | Added$357.7K |
| Verdad Advisers, LP | 86K | $1.12M | — | New |
| Point72 Asset Management, L.P. | 84.9K | $1.11M | $138.4K | Cut−$7.57M |
| MORGAN STANLEY | 70.8K | $924.7K | $115.4K | Cut−$495.9K |
| Renaissance Technologies | 69.4K | $906.4K | $93.1K | Added$253.7K |
| NORTHERN TRUST CORP | 65.9K | $861K | $87.8K | Added$245.2K |
| DIMENSIONAL FUND ADVISORS LP | 59.9K | $782.1K | — | New |
| Squarepoint Ops LLC | 59.8K | $781.6K | — | New |
| WELLINGTON MANAGEMENT GROUP LLP | 55.6K | $726.3K | — | New |
| 683 Capital Management, LLC | 55K | $718.3K | $89.7K | Cut−$326.9K |
| Strategies Wealth Advisors, LLC | 50K | $653K | $81.5K | Added$81.5K |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 49.3K | $643.6K | $80.3K | Added$80.3K |
| Trexquant Investment LP | 47.7K | $623.6K | $77.8K | Cut−$51.2K |
| BANK OF AMERICA CORP /DE/ | 47.4K | $619.7K | $15.1K | Added$513.7K |
| BARCLAYS PLC | 44K | $574.1K | $71.7K | Cut−$106.1K |
| Hudson Bay Capital Management LP | 42.8K | $559.2K | $42.3K | Added$262.7K |
| Brevan Howard Capital Management LP | 42.2K | $550.8K | $31.7K | Added$328.8K |
| BNP PARIBAS FINANCIAL MARKETS | 39.9K | $520.8K | $65K | Cut−$213.3K |
| TWO SIGMA INVESTMENTS, LP | 37.9K | $495.2K | $61.8K | Added$61.8K |
| XTX Topco Ltd | 35.8K | $468.1K | — | New |
| AMERICAN CENTURY COMPANIES INC | 35.7K | $466K | $31.8K | Added$242.9K |
| Seven Fleet Capital Management LP | 27.1K | $353.3K | — | New |
| INDEPENDENT FINANCIAL GROUP, LLC | 27K | $352.9K | $44K | Added$44K |
| Jain Global LLC | 23K | $300.2K | — | New |
| CANADA PENSION PLAN INVESTMENT BOARD | 20.6K | $269K | — | New |
| RBF Capital, LLC | 20K | $261.2K | $32.6K | Added$32.6K |
| Quarry LP | 16K | $209K | — | New |
| Engineers Gate Manager LP | 15K | $195.3K | — | New |
| OMERS ADMINISTRATION Corp | 14.2K | $185.5K | $23.1K | Cut−$213.5K |
| China Universal Asset Management Co., Ltd. | 13.5K | $176.3K | $6.13K | Added$133.3K |
| Cannon Global Investment Management, LLC | 13K | $169.8K | — | New |
| Quadrature Capital Ltd | 12.8K | $167.2K | $20.9K | Cut−$100K |
| ExodusPoint Capital Management, LP | 12.4K | $161.7K | $20.2K | Cut−$421.5K |
| Diametric Capital, LP | 10.7K | $140.1K | — | New |
| Vanguard Global Advisers, LLC | 10.3K | $134.1K | — | Held |
| CITIGROUP INC | 8.86K | $115.7K | $14.4K | Cut−$25.2K |
| ROYAL BANK OF CANADA | 5.79K | $76K | $5.81K | Added$38K |
| JPMORGAN CHASE & CO | 2.49K | $31K | $1.84K | Added$10.5K |
| Mirae Asset Global Investments Co., Ltd. | 1.59K | $20.7K | $1.83K | Added$7.92K |
| Federation des caisses Desjardins du Quebec | 1.28K | $16.7K | $2.09K | Cut−$12.5K |
| CWM, LLC | 1.15K | $15K | $14.9K | Added$14.9K |
| Tower Research Capital LLC (TRC) | 731 | $9.55K | $202 | Added$8.13K |
| GF FUND MANAGEMENT CO. LTD. | 513 | $6.7K | $740 | Added$1.51K |
| Torren Management, LLC | 254 | $3.32K | $414 | Cut−$14.5K |
| Banque Transatlantique SA | 220 | $2.95K | $432 | Added$432 |
| US BANCORP \DE\ | 123 | $1.61K | — | New |
| Cornerstone Financial Management LLC | 64 | $836 | $104 | Added$104 |
| ACADIAN ASSET MANAGEMENT LLC | 54.1K | $703 | $89 | Cut−$32 |
| HRT FINANCIAL LP | 22.2K | $289 | — | New |
| PRICE T ROWE ASSOCIATES INC /MD/ | 11.3K | $148 | $18 | Added$18 |
| OSAIC HOLDINGS, INC. | 6 | $78 | — | New |
| Caitong International Asset Management Co., Ltd | 1 | $13 | — | New |