| EcoR1 Capital, LLC | 23M | $575.2M | −$29.6M | Cut−$29.6M |
| Rubric Capital Management LP | 7M | $175.3M | −$7.42M | Added$23.9M |
| BlackRock, Inc. | 4.55M | $114M | −$5.87M | Cut−$6.97M |
| BVF INC/IL | 3.73M | $93.5M | −$4.82M | Cut−$10.2M |
| PERCEPTIVE ADVISORS LLC | 3.51M | $87.9M | −$4.21M | Added$2.01M |
| MORGAN STANLEY | 2.48M | $62.1M | −$3.2M | Cut−$6.16M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1.91M | $47.8M | $45.6M | Added$47.7M |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.71M | $42.7M | — | Held |
| Citadel | 1.15M | $28.8M | −$329.4K | Added$22.1M |
| DIMENSIONAL FUND ADVISORS LP | 1.14M | $28.5M | −$1.48M | Cut−$2M |
| Nextech Invest, Ltd. | 1.11M | $27.9M | −$1.44M | Cut−$1.44M |
| State Street | 1.01M | $25.3M | −$1.31M | Cut−$1.99M |
| Capricorn Fund Managers Ltd | 1.01M | $25.2M | −$1.3M | Cut−$1.71M |
| DEUTSCHE BANK AG\ | 921.3K | $23.1M | −$1.19M | Cut−$19M |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 743.9K | $18.6M | −$903K | Added$196.2K |
| Assenagon Asset Management S.A. | 728K | $18.2M | −$835.1K | Added$1.18M |
| Fidelity | 667.2K | $16.7M | −$722.5K | Added$1.96M |
| GEODE CAPITAL MANAGEMENT, LLC | 659.9K | $16.5M | −$835.8K | Cut−$536.1K |
| Nuveen, LLC | 651.7K | $16.3M | −$836.3K | Cut−$752.8K |
| GOLDMAN SACHS GROUP INC | 599.5K | $15M | −$542.1K | Added$3.95M |
| MPM BIOIMPACT LLC | 565.2K | $14.2M | — | New |
| Prosight Management, LP | 539K | $13.5M | −$684.2K | Cut−$467.5K |
| Qube Research & Technologies Ltd | 511.9K | $12.8M | −$611.8K | Added$330.8K |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 499.9K | $12.5M | — | Held |
| Redmile Group, LLC | 491.7K | $12.3M | −$634.2K | Cut−$634.2K |
| Hillsdale Investment Management Inc. | 345.6K | $8.65M | −$306.9K | Added$2.39M |
| SummitTX Capital, L.P. | 321.4K | $8.05M | −$289.3K | Added$2.14M |
| NORTHERN TRUST CORP | 320.2K | $8.02M | −$397.3K | Cut−$91K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 319.4K | $8M | −$412K | Cut−$435.1K |
| ROYCE & ASSOCIATES LP | 299.2K | $7.49M | — | New |
| PICTON MAHONEY ASSET MANAGEMENT | 256.7K | $6.43M | −$315.8K | Cut−$18K |
| Granahan Investment Management, LLC | 250.8K | $6.28M | −$289.5K | Added$370.7K |
| BANK OF AMERICA CORP /DE/ | 236.8K | $5.93M | −$115.5K | Added$3.57M |
| D. E. Shaw & Co., Inc. | 235.6K | $5.9M | −$288.7K | Added$7.67K |
| JANE STREET GROUP, LLC | 227K | $5.68M | −$90.9K | Added$3.83M |
| PANAGORA ASSET MANAGEMENT INC | 206.9K | $5.18M | −$101.1K | Added$3.12M |
| Man Group plc | 189.9K | $4.75M | −$97.2K | Added$2.77M |
| WELLS FARGO & COMPANY/MN | 189.6K | $4.75M | −$244.6K | Cut−$736.4K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 185.1K | $4.64M | −$238.8K | Cut−$1.18M |
| FEDERATED HERMES, INC. | 182.4K | $4.57M | −$197K | Added$547.2K |
| RAYMOND JAMES FINANCIAL INC | 176.4K | $4.42M | −$227.6K | Cut−$524.4K |
| UBS Group AG | 171.8K | $4.3M | −$221.6K | Cut−$3.04M |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 163.6K | $4.1M | −$211.1K | Cut−$688.8K |
| KENNEDY CAPITAL MANAGEMENT LLC | 148.2K | $3.71M | −$187.7K | Cut−$120.3K |
| XTX Topco Ltd | 143.9K | $3.6M | −$120.6K | Added$1.14M |
| DIADEMA PARTNERS LP | 142.1K | $3.56M | — | New |
| WELLINGTON MANAGEMENT GROUP LLP | 138.7K | $3.47M | −$178.9K | Cut−$1.31M |
| Invesco Ltd. | 125.6K | $3.15M | −$162.1K | Cut−$3.64M |
| Bank of New York Mellon Corp | 124.1K | $3.11M | −$160.1K | Cut−$266.1K |
| CITIGROUP INC | 114.3K | $2.86M | −$143.5K | Cut−$65.3K |
| JPMORGAN CHASE & CO | 114.1K | $2.76M | −$74.2K | Added$1.84M |
| PLATINUM INVESTMENT MANAGEMENT LTD | 105.2K | $2.63M | −$135.7K | Cut−$135.7K |
| TEMA ETFS LLC | 104.9K | $2.63M | −$98K | Added$627K |
| Tidal Investments LLC | 104.9K | $2.63M | — | New |
| Fisher Asset Management, LLC | 101.4K | $2.54M | −$88K | Added$744.4K |
| Susquehanna Portfolio Strategies, LLC | 99.8K | $2.5M | −$128.7K | Cut−$128.7K |
| Icahn Capital | 90.7K | $2.27M | −$117K | Cut−$127.7K |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 88.8K | $2.22M | −$114.6K | Cut−$114.6K |
| VANGUARD FIDUCIARY TRUST CO | 84.4K | $2.11M | — | Held |
| Squarepoint Ops LLC | 83.1K | $2.08M | — | New |
| MACKENZIE FINANCIAL CORP | 82.7K | $2.07M | −$65.8K | Added$867.3K |
| Verdad Advisers, LP | 82.7K | $2.07M | — | New |
| PRINCIPAL FINANCIAL GROUP INC | 78.5K | $1.97M | — | New |
| FRANKLIN RESOURCES INC | 77.7K | $1.94M | −$76.1K | Added$391.5K |
| STIFEL FINANCIAL CORP | 76.8K | $1.92M | −$97.8K | Cut−$75.1K |
| RHUMBLINE ADVISERS | 75.4K | $1.89M | −$97.3K | Cut−$99.9K |
| CREDIT AGRICOLE S A | 75K | $1.88M | −$96.7K | Cut−$96.8K |
| AMERIPRISE FINANCIAL INC | 74.2K | $1.86M | −$95.7K | Cut−$1.12M |
| Swiss National Bank | 74.2K | $1.86M | −$95.7K | Cut−$95.7K |
| AMERICAN CENTURY COMPANIES INC | 70.9K | $1.77M | −$75.9K | Added$225.1K |
| STATE OF WISCONSIN INVESTMENT BOARD | 66.1K | $1.66M | −$85.3K | Cut−$334.4K |
| ALLIANCEBERNSTEIN L.P. | 55.9K | $1.47M | $0 | Added$154.5K |
| Dana Investment Advisors, Inc. | 56.1K | $1.4M | −$62.3K | Added$132.7K |
| Campbell & CO Investment Adviser LLC | 54.9K | $1.37M | −$43.3K | Added$489.9K |
| Russell Investments Group, Ltd. | 47.5K | $1.19M | −$61.2K | Cut−$348.2K |
| ROYAL BANK OF CANADA | 47.4K | $1.19M | −$60.3K | Cut−$263K |
| SEGALL BRYANT & HAMILL, LLC | 45.7K | $1.14M | — | New |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 42.8K | $1.07M | — | New |
| VICTORY CAPITAL MANAGEMENT INC | 42.4K | $1.06M | −$54.7K | Cut−$67.9K |
| ENVESTNET ASSET MANAGEMENT INC | 40.4K | $1.01M | −$52.1K | Cut−$62.5K |
| Manatuck Hill Partners, LLC | 40K | $1M | — | New |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 39.8K | $995.3K | $2.29K | Added$987.9K |
| Quantinno Capital Management LP | 39.6K | $992.6K | −$37.3K | Added$232.1K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 39.4K | $985.4K | −$26.3K | Added$447.8K |
| Connor, Clark & Lunn Investment Management Ltd. | 37.9K | $949.5K | — | New |
| HSBC HOLDINGS PLC | 37.8K | $940.1K | −$31.5K | Added$463.9K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37.4K | $936.2K | −$48.2K | Cut−$58K |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 37.1K | $929.7K | −$47.9K | Cut−$203.8K |
| TUDOR INVESTMENT CORP ET AL | 36.9K | $923.4K | −$39.1K | Added$124.9K |
| HighTower Advisors, LLC | 36.3K | $908K | — | New |
| Persistent Asset Partners Ltd | 35.9K | $899.8K | −$9.48K | Added$706.4K |
| HighVista Strategies LLC | 34.1K | $853.5K | — | New |
| Vinva Investment Management Ltd | 24.1K | $850.8K | −$52.4K | Added$366.9K |
| MARTINGALE ASSET MANAGEMENT L P | 32.8K | $820.4K | — | New |
| Creative Planning | 32.4K | $811.1K | −$36.5K | Added$66.2K |
| MARSHALL WACE, LLP | 32.2K | $806.9K | — | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 31.6K | $791.1K | −$22.5K | Added$332.1K |
| Engineers Gate Manager LP | 31.5K | $790K | — | New |
| SBI Okasan Asset Management Co.Ltd. | 32K | $774.7K | −$81K | Cut−$81K |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 30.4K | $762K | −$39.3K | Cut−$102K |
| STRS OHIO | 30.1K | $753.7K | −$34.3K | Added$53.3K |
| MetLife Investment Management, LLC | 29.7K | $742.5K | −$36.9K | Cut−$11.3K |
| JOURNEY STRATEGIC WEALTH LLC | 29.1K | $727.4K | −$37.5K | Cut−$37.5K |
| BNP PARIBAS FINANCIAL MARKETS | 28.1K | $704.1K | −$30.1K | Added$90.7K |
| OXFORD ASSET MANAGEMENT LLP | 27.8K | $696.4K | — | New |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 28.3K | $686.3K | −$66.1K | Cut−$1.91M |
| ExodusPoint Capital Management, LP | 27.4K | $685.4K | — | New |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 27.4K | $684.9K | −$35.3K | Cut−$54.5K |
| VANGUARD ASSET MANAGEMENT, Ltd | 26.3K | $658K | — | Held |
| Legal & General Group Plc | 26.2K | $656.3K | −$33.8K | Cut−$190.2K |
| COMMONWEALTH EQUITY SERVICES, LLC | 26K | $651.8K | −$33.6K | Cut−$35.3K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 24.4K | $611.5K | −$31.5K | Cut−$4.02M |
| RITHOLTZ WEALTH MANAGEMENT | 24.2K | $607K | −$31.3K | Cut−$33.8K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 23.4K | $585.3K | −$29.8K | Cut−$23.2K |
| Headlands Technologies LLC | 22.8K | $572K | — | New |
| Duncan Williams Asset Management, LLC | 22.1K | $553.3K | $42.6K | Added$42.6K |
| PRUDENTIAL FINANCIAL INC | 22K | $550.1K | −$16.5K | Added$214.3K |
| BARCLAYS PLC | 18.4K | $460.1K | −$23.7K | Cut−$1.65M |
| JANUS HENDERSON GROUP PLC | 18.2K | $455.8K | −$23.3K | Cut−$23.3K |
| BANK OF MONTREAL /CAN/ | 17.5K | $437.4K | −$22.5K | Cut−$22.5K |
| NEW YORK STATE COMMON RETIREMENT FUND | 17.4K | $435K | −$22.4K | Cut−$22.4K |
| State of Wyoming | 17.1K | $429.4K | −$14K | Added$143K |
| Quadrature Capital Ltd | 16.7K | $419K | −$21.6K | Cut−$187K |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 15.3K | $384.1K | −$19.8K | Cut−$19.8K |
| AGF MANAGEMENT LTD | 15K | $375.6K | −$19.3K | Cut−$19.4K |
| Amundi | 14.1K | $352.7K | — | New |
| Police & Firemen's Retirement System of New Jersey | 13.7K | $343.1K | −$17.7K | Cut−$17.7K |
| China Universal Asset Management Co., Ltd. | 13.3K | $332.5K | −$15.7K | Added$11.4K |
| Freestone Grove Partners LP | 12.9K | $324.1K | — | New |
| State of New Jersey Common Pension Fund D | 12.8K | $320.2K | — | New |
| Northwest & Ethical Investments L.P. | 12.2K | $316.4K | −$8.43K | Cut−$3.26K |
| INTECH INVESTMENT MANAGEMENT LLC | 12.5K | $314K | −$16.2K | Cut−$221.3K |
| Abacus Wealth Partners, LLC | 11.7K | $292.2K | −$13.2K | Added$23K |
| JAMES INVESTMENT RESEARCH, INC. | 10.9K | $273.6K | −$14.1K | Cut−$14.1K |
| Ewing Morris & Co. Investment Partners Ltd. | 10.8K | $271.7K | −$17.5K | Cut−$17.5K |
| Virtus Investment Advisers, LLC | 10.7K | $268K | −$13.5K | Cut−$6.93K |
| LAZARD ASSET MANAGEMENT LLC | 10.6K | $265.5K | −$13.7K | Cut−$97.2K |
| ProShare Advisors LLC | 10.6K | $264.8K | −$13.6K | Cut−$61.4K |
| ARIZONA STATE RETIREMENT SYSTEM | 10.3K | $257.3K | −$13.3K | Cut−$16.4K |
| Soleus Capital Management, L.P. | 10K | $250.4K | −$12.9K | Cut−$2.38M |
| PSP Research LLC | 10K | $250.4K | −$12.9K | Cut−$284.4K |
| Pictet Asset Management Holding SA | 9.26K | $231.8K | −$15.4K | Cut−$1.73M |
| VOYA INVESTMENT MANAGEMENT LLC | 8.99K | $225.2K | −$11.6K | Cut−$17.9K |
| Allspring Global Investments Holdings, LLC | 8.51K | $220.7K | −$5.24K | Added$15.5K |
| Vanguard Investments Australia, Ltd. | 8.8K | $220.4K | — | Held |
| WINTON GROUP Ltd | 8.4K | $210.3K | −$10.8K | Cut−$84K |
| KLP KAPITALFORVALTNING AS | 8K | $200.3K | −$10.3K | Cut−$10.3K |
| CWM, LLC | 6.96K | $174.2K | $174K | Added$174K |
| Vanguard Global Advisers, LLC | 5.46K | $136.7K | — | Held |
| Tower Research Capital LLC (TRC) | 4.87K | $121.9K | −$1.74K | Added$86.3K |
| Ameritas Investment Partners, Inc. | 4.16K | $104.3K | −$5.37K | Cut−$5.37K |
| Mirae Asset Global Investments Co., Ltd. | 3.9K | $97.7K | −$4.69K | Added$1.97K |
| GF FUND MANAGEMENT CO. LTD. | 1.68K | $42.1K | −$1.9K | Added$3.39K |
| Global Wealth Strategies & Associates | 1.64K | $40.9K | — | New |
| Sofinnova Investments, Inc. | 1.61K | $40.3K | — | New |
| TD Waterhouse Canada Inc. | 1.44K | $37.2K | −$153 | Added$29K |
| SIMPLEX TRADING, LLC | 1.34K | $33.5K | −$1.72K | Cut−$1.23M |
| Aviso Financial Inc. | 1.15K | $28.7K | — | New |
| GAMMA Investing LLC | 1.1K | $27.5K | −$1.27K | Added$1.53K |
| PNC Financial Services Group, Inc. | 987 | $24.7K | −$1.01K | Added$4.15K |
| NISA INVESTMENT ADVISORS, LLC | 971 | $24.3K | −$1.25K | Cut−$1.17K |
| Steward Partners Investment Advisory, LLC | 971 | $24.3K | −$68 | Added$22.9K |
| Optiver Holding B.V. | 958 | $24K | −$1.3K | Cut−$6.32K |
| OSAIC HOLDINGS, INC. | 882 | $22.1K | −$1.14K | Cut−$44K |
| NBC SECURITIES, INC. | 623 | $15.6K | −$804 | Cut−$804 |
| Federation des caisses Desjardins du Quebec | 570 | $14.3K | −$729 | Cut−$729 |
| NATIONAL BANK OF CANADA /FI/ | 554 | $13.9K | −$697 | Cut−$472 |
| UMB Bank, n.a. | 466 | $11.7K | −$601 | Cut−$601 |
| JONES FINANCIAL COMPANIES LLLP | 465 | $11.2K | −$43 | Added$10.7K |
| US BANCORP \DE\ | 352 | $8.81K | −$370 | Added$1.26K |
| Parallel Advisors, LLC | 352 | $8.81K | −$425 | Added$151 |
| HUNTINGTON NATIONAL BANK | 343 | $8.59K | −$442 | Cut−$995 |
| Sterling Capital Management LLC | 324 | $8.11K | −$418 | Cut−$602 |
| HRT FINANCIAL LP | 237.9K | $5.96K | −$156 | Added$2.77K |
| EverSource Wealth Advisors, LLC | 218 | $5.46K | −$236 | Added$665 |
| Caitong International Asset Management Co., Ltd | 216 | $5.41K | −$278 | Cut−$31.4K |
| Allworth Financial LP | 109 | $2.73K | −$141 | Cut−$1.11K |
| IFP Advisors, Inc | 96 | $2.4K | −$124 | Cut−$124 |
| HighMark Wealth Management LLC | 80 | $2K | −$103 | Cut−$4.05K |
| ROTHSCHILD INVESTMENT LLC | 80 | $2K | −$72 | Added$529 |
| Walleye Capital LLC | 78 | $1.95K | −$101 | Cut−$357.9K |
| SIGNATUREFD, LLC | 77 | $1.93K | −$54 | Added$822 |
| FIFTH THIRD BANCORP | 67 | $1.68K | — | New |
| Kilter Group LLC | 66 | $1.65K | −$85 | Cut−$85 |
| Bare Financial Services, Inc | 64 | $1.6K | −$82 | Cut−$82 |
| Rockefeller Capital Management L.P. | 61 | $1.53K | — | New |
| Farther Finance Advisors, LLC | 57 | $1.48K | −$22 | Cut−$5.87K |
| True Wealth Design, LLC | 58 | $1.45K | −$75 | Cut−$75 |
| Physician Wealth Advisors, Inc. | 51 | $1.28K | −$65 | Cut−$65 |
| North Growth Management Ltd. | 46K | $1.14K | −$68 | Cut−$43 |
| Versant Capital Management, Inc | 45 | $1.13K | — | New |
| PRICE T ROWE ASSOCIATES INC /MD/ | 35.5K | $889 | −$37 | Added$131 |
| Sunbelt Securities, Inc. | 27 | $676 | −$35 | Cut−$35 |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 25 | $649 | −$9 | Cut−$9 |
| GSA CAPITAL PARTNERS LLP | 20.5K | $514 | — | New |
| TWIN PEAKS WEALTH ADVISORS, LLC | 20 | $501 | — | New |
| Aster Capital Management (DIFC) Ltd | 42 | $500 | — | New |
| Jackson Creek Investment Advisors LLC | 18.7K | $468 | — | New |
| CoreCap Advisors, LLC | 18 | $451 | −$23 | Cut−$23 |
| Essential Partners LLC | 12 | $300 | −$16 | Cut−$16 |
| Root Financial Partners, LLC | 12 | $300 | — | New |
| Smartleaf Asset Management LLC | 12 | $291 | −$27 | Cut−$27 |
| Janney Montgomery Scott LLC | 11.5K | $288 | −$14 | Cut−$3 |
| SBI Securities Co., Ltd. | 11 | $275 | −$15 | Cut−$15 |
| SG Americas Securities, LLC | 10.4K | $261 | −$13 | Cut−$201 |
| Cygnus Capital Advisors, LLC | 8.2K | $205 | −$8 | Added$47 |
| MAI Capital Management | 7 | $176 | −$6 | Added$44 |
| Larson Financial Group LLC | 6 | $150 | −$8 | Cut−$8 |
| Hughes Financial Services, LLC | 4 | $100 | — | New |
| DekaBank Deutsche Girozentrale | 3.84K | $96 | $61 | Added$61 |
| Covestor Ltd | 28 | $1 | $0 | Held |