| Darwin Global Management, Ltd. | 3.06M | $456.1M | −$35.2M | Cut−$30.8M |
| Paradigm Biocapital Advisors LP | 1.11M | $177.7M | — | New |
| UBS Group AG | 768.4K | $122.5M | −$67K | Added$101.9M |
| RTW INVESTMENTS, LP | 715.3K | $114.1M | −$372K | Cut−$372K |
| MILLENNIUM MANAGEMENT LLC | 570.1K | $90.9M | −$290.6K | Added$1.5M |
| Holocene Advisors, LP | 494.5K | $78.8M | −$43.7K | Added$65.4M |
| EVENTIDE ASSET MANAGEMENT, LLC | 357.6K | $57M | −$186K | Cut−$4.26M |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 304K | $48.5M | −$121.6K | Added$11.1M |
| MORGAN STANLEY | 201.4K | $32.1M | −$14.6K | Added$27.6M |
| PERCEPTIVE ADVISORS LLC | 152K | $24.2M | −$79K | Cut−$42M |
| Patient Square Capital LP | 116.7K | $18.6M | — | New |
| GOLDMAN SACHS GROUP INC | 105.5K | $16.8M | −$23.2K | Added$9.69M |
| MPM BIOIMPACT LLC | 88K | $14M | −$45.6K | Cut−$195 |
| Affinity Asset Advisors, LLC | 65K | $10.4M | −$10.4K | Added$7.16M |
| FRED ALGER MANAGEMENT, LLC | 62.6K | $9.98M | −$32.5K | Cut−$2.72M |
| PFM Health Sciences, LP | 59.4K | $9.48M | −$10.3K | Added$6.3M |
| Renaissance Technologies | 52K | $8.29M | — | New |
| Longaeva Partners L.P. | 33.5K | $5.34M | — | New |
| TD Asset Management Inc | 33.4K | $5.33M | — | New |
| BNP PARIBAS FINANCIAL MARKETS | 32.5K | $5.19M | −$1.27K | Added$4.79M |
| ADAR1 Capital Management, LLC | 26.9K | $4.29M | −$14K | Cut−$2.09M |
| Artia Global Partners LP | 25K | $3.98M | −$9.35K | Added$1.11M |
| Quadrature Capital Ltd | 23.7K | $3.78M | −$12.3K | Cut−$192.1K |
| Aquatic Capital Management LLC | 20.3K | $3.24M | — | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 19.6K | $3.13M | — | New |
| Squarepoint Ops LLC | 17K | $2.71M | — | New |
| State Street | 16K | $2.56M | −$8.18K | Added$40.9K |
| BANK OF MONTREAL /CAN/ | 16K | $2.55M | −$21.4K | Added$49.2K |
| Trexquant Investment LP | 15.1K | $2.4M | — | New |
| XTX Topco Ltd | 15.1K | $2.4M | — | New |
| BALANCE CAPITAL PARTNERS L.P. | 14.5K | $2.31M | — | New |
| Verdad Advisers, LP | 13.8K | $2.2M | — | New |
| JANE STREET GROUP, LLC | 12.2K | $1.95M | −$6.36K | Cut−$3.22M |
| Blackstone Inc. | 10.7K | $1.7M | — | New |
| GEODE CAPITAL MANAGEMENT, LLC | 10.4K | $1.66M | −$5.42K | Cut−$8.3K |
| HighVista Strategies LLC | 8.03K | $1.28M | — | New |
| Voleon Capital Management LP | 7.88K | $1.26M | — | New |
| BARCLAYS PLC | 6.82K | $1.09M | −$2.17K | Added$419.7K |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 6K | $957.3K | −$1.59K | Added$469.6K |
| Amundi | 4.21K | $671.2K | — | New |
| SmartHarvest Portfolios, LLC | 4.19K | $667.6K | −$2.18K | Cut−$1.7K |
| BANK OF AMERICA CORP /DE/ | 3.78K | $602.4K | −$963 | Added$306.1K |
| High Net Worth Advisory Group LLC | 3.5K | $558K | −$1.82K | Cut−$1.82K |
| Convergence Financial, LLC | 2.97K | $473.2K | — | New |
| AMERIPRISE FINANCIAL INC | 2.77K | $441.2K | −$1.44K | Cut−$1.67M |
| Engineers Gate Manager LP | 2.49K | $396.8K | — | New |
| AXQ CAPITAL, LP | 2.37K | $378.2K | — | New |
| ROYAL BANK OF CANADA | 2.26K | $360K | −$318 | Added$26K |
| Citadel | 2.01K | $320.2K | −$1.04K | Cut−$488.4K |
| Virtus Investment Advisers, LLC | 1.93K | $307.6K | −$979 | Added$6.51K |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. | 1.9K | $302.9K | — | New |
| GAMMA Investing LLC | 1.71K | $272.2K | −$888 | Cut−$12.4K |
| EverSource Wealth Advisors, LLC | 1.61K | $256.4K | −$831 | Added$763 |
| TUDOR INVESTMENT CORP ET AL | 1.6K | $254.5K | — | New |
| Merit Financial Group, LLC | 1.42K | $225.6K | — | New |
| Independent Advisor Alliance | 1.32K | $210.3K | −$686 | Cut−$686 |
| FARALLON CAPITAL MANAGEMENT LLC | 1.3K | $207.3K | — | New |
| Mirae Asset Global Investments Co., Ltd. | 657 | $104.8K | −$335 | Added$1.58K |
| Caitong International Asset Management Co., Ltd | 349 | $55.6K | −$181 | Cut−$32.2K |
| PRICE T ROWE ASSOCIATES INC /MD/ | 281.8K | $44.9K | — | New |
| WELLS FARGO & COMPANY/MN | 124 | $19.8K | −$52 | Added$3.77K |
| Duquesne Family Office | 106.1K | $16.9K | — | New |
| E Fund Management (Hong Kong) Co., Ltd. | 83 | $13.2K | — | New |
| TD Waterhouse Canada Inc. | 70 | $11.7K | $511 | Added$511 |
| Rossby Financial, LCC | 55 | $9.2K | $95 | Added$7.12K |
| SBI Securities Co., Ltd. | 22 | $3.51K | −$11 | Cut−$4.49K |
| Farther Finance Advisors, LLC | 15 | $2.51K | $110 | Cut−$13.6K |
| NISA INVESTMENT ADVISORS, LLC | 13 | $2.07K | — | New |
| HRT FINANCIAL LP | 10.9K | $1.74K | −$4 | Added$436 |
| JONES FINANCIAL COMPANIES LLLP | 6 | $912 | −$48 | Cut−$48 |
| Bell Investment Advisors, Inc | 4 | $638 | — | New |
| JPMORGAN CHASE & CO | 3 | $448 | −$32 | Cut−$32 |
| SG Americas Securities, LLC | 2.14K | $342 | −$1 | Cut−$99 |
| GSA CAPITAL PARTNERS LLP | 1.65K | $262 | −$1 | Added$28 |
| CITIGROUP INC | 1 | $159 | −$1 | Cut−$341.7K |