| PERCEPTIVE ADVISORS LLC | 11.9M | $85.7M | $18.5M | Added$19M |
| Bain Capital Life Sciences Investors, LLC | 9.81M | $70.6M | $12.3M | Added$26M |
| RA CAPITAL MANAGEMENT, L.P. | 9.34M | $67.2M | $9.07M | Added$34.5M |
| Siren, L.L.C. | 7.69M | $55.4M | $12M | Added$12M |
| Vestal Point Capital, LP | 5M | $36M | $7.8M | Added$3.2M |
| BlackRock, Inc. | 4.96M | $35.7M | $7.6M | Added$8.24M |
| JANUS HENDERSON GROUP PLC | 4.01M | $28.9M | — | New |
| Fidelity | 3.61M | $26M | $3.17M | Added$14.5M |
| Deep Track Capital, LP | 3.57M | $25.7M | — | New |
| ARMISTICE CAPITAL, LLC | 3.2M | $23M | $4.07M | Added$8.31M |
| VANGUARD CAPITAL MANAGEMENT LLC | 2.67M | $19.3M | — | Held |
| Citadel | 2.6M | $18.7M | $4.05M | Added$3.67M |
| AMERIPRISE FINANCIAL INC | 2.44M | $17.6M | — | New |
| Alyeska Investment Group, L.P. | 2.28M | $16.4M | $2.61M | Added$6.91M |
| FRANKLIN RESOURCES INC | 2.19M | $15.8M | $2.49M | Added$6.77M |
| Point72 Asset Management, L.P. | 2.05M | $14.8M | $3.2M | Added$1.14M |
| Redmile Group, LLC | 2.01M | $14.5M | $2.9M | Added$3.99M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.76M | $12.6M | $2.18M | Added$4.75M |
| Monashee Investment Management LLC | 1.42M | $10.2M | $2.11M | Added$2.61M |
| GEODE CAPITAL MANAGEMENT, LLC | 1.3M | $9.33M | $1.98M | Added$2.18M |
| Nantahala Capital Management, LLC | 1.17M | $8.39M | $1.82M | Cut−$654.3K |
| State Street | 1.13M | $8.1M | $1.7M | Added$1.97M |
| DIMENSIONAL FUND ADVISORS LP | 956.1K | $6.88M | $1.05M | Added$3.05M |
| GOLDMAN SACHS GROUP INC | 935.5K | $6.74M | $1.46M | Added$1.06M |
| Ally Bridge Group (NY) LLC | 767K | $5.52M | $645.3K | Added$3.19M |
| BLAIR WILLIAM & CO/IL | 651.2K | $4.69M | — | New |
| Birchview Capital, LP | 626K | $4.51M | $976.5K | Added$525.5K |
| Woodline Partners LP | 495.1K | $3.56M | $494.2K | Added$1.78M |
| NORTHERN TRUST CORP | 418.2K | $3.01M | $643.9K | Added$683K |
| Nuveen, LLC | 400.3K | $2.88M | $616.2K | Added$654.4K |
| BANK OF AMERICA CORP /DE/ | 386.8K | $2.78M | $537.1K | Added$843.1K |
| MILLENNIUM MANAGEMENT LLC | 363.7K | $2.62M | $181.9K | Added$1.96M |
| Invesco Ltd. | 340.9K | $2.45M | $237.3K | Added$1.6M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 338.6K | $2.44M | — | Held |
| VANGUARD FIDUCIARY TRUST CO | 326K | $2.35M | — | Held |
| MOORE CAPITAL MANAGEMENT, LP | 324.7K | $2.34M | — | New |
| Parkman Healthcare Partners LLC | 308.8K | $2.22M | $481.8K | Cut−$135.9K |
| Boxer Capital Management, LLC | 300K | $2.16M | $468K | Added$468K |
| J. Goldman & Co LP | 284.5K | $2.05M | — | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 269.7K | $1.94M | $420.8K | Cut−$874K |
| Ikarian Capital, LLC | 264.4K | $1.9M | $250.2K | Added$999K |
| MORGAN STANLEY | 261.1K | $1.88M | $407.4K | Cut−$343.5K |
| JPMORGAN CHASE & CO | 276.4K | $1.79M | $27K | Added$1.61M |
| BNP PARIBAS FINANCIAL MARKETS | 217.2K | $1.56M | $116.4K | Added$1.14M |
| Susquehanna Portfolio Strategies, LLC | 197.6K | $1.42M | $308.2K | Added$297.7K |
| STEMPOINT CAPITAL LP | 195.4K | $1.41M | — | New |
| Balyasny Asset Management L.P. | 178.3K | $1.2M | $197K | Cut−$833.3K |
| WELLINGTON MANAGEMENT GROUP LLP | 161.3K | $1.16M | $251.6K | Added$114K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 160.7K | $1.16M | $250.7K | Added$246.2K |
| Apis Capital Advisors, LLC | 160K | $1.15M | $249.6K | Added$46.6K |
| Icahn Capital | 151.5K | $1.09M | $205.9K | Added$346.9K |
| Bank of New York Mellon Corp | 137.9K | $993.2K | $215.2K | Added$177.1K |
| D. E. Shaw & Co., Inc. | 128.3K | $924.1K | $200.1K | Added$200.7K |
| Renaissance Technologies | 124.3K | $894.8K | $82.4K | Added$597K |
| Trexquant Investment LP | 123.9K | $892.1K | — | New |
| AMERICAN CENTURY COMPANIES INC | 114.4K | $823.6K | $151.8K | Added$274.7K |
| Fisher Asset Management, LLC | 103.5K | $745.1K | $161.4K | Added$161.4K |
| UBS Group AG | 99K | $712.6K | $154.4K | Cut−$4.43M |
| JANE STREET GROUP, LLC | 97K | $698.3K | $151.3K | Cut−$505.3K |
| TWO SIGMA INVESTMENTS, LP | 92.2K | $663.9K | $143.8K | Cut−$201.3K |
| PANAGORA ASSET MANAGEMENT INC | 91.1K | $655.9K | $142.1K | Cut−$623K |
| Quantum Private Wealth, LLC | 90.2K | $649.7K | $140.8K | Added$118.2K |
| BOOTHBAY FUND MANAGEMENT, LLC | 87K | $626.8K | $82.4K | Added$329K |
| RHUMBLINE ADVISERS | 82.1K | $591.1K | $128.1K | Added$125.4K |
| XTX Topco Ltd | 76.5K | $550.7K | $55.6K | Added$349.7K |
| CITIGROUP INC | 69.4K | $499.5K | $5.47K | Added$479.7K |
| BARCLAYS PLC | 58.9K | $423.9K | $91.8K | Cut−$355.2K |
| ALLIANCEBERNSTEIN L.P. | 69.3K | $390.6K | −$0 | Cut−$70.9K |
| Knott David M Jr | 47.1K | $339.4K | $73.5K | Cut−$576.7K |
| DEUTSCHE BANK AG\ | 46.3K | $333.2K | $62.3K | Added$107.8K |
| STATE OF WISCONSIN INVESTMENT BOARD | 45.6K | $328.4K | $46.8K | Added$159.1K |
| Squarepoint Ops LLC | 44.8K | $322.3K | $69.8K | Added$40K |
| HSBC HOLDINGS PLC | 39.5K | $284.5K | $32.8K | Added$157.8K |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 37.4K | $269.4K | — | New |
| Vanguard Global Advisers, LLC | 36.4K | $262.1K | — | Held |
| Creative Planning | 34.6K | $248.9K | $38.8K | Added$108.5K |
| CIBC Bancorp USA Inc. | 33.6K | $241.7K | — | Held |
| WELLS FARGO & COMPANY/MN | 32.3K | $232.4K | $50.4K | Cut−$196.8K |
| Schonfeld Strategic Advisors LLC | 30.5K | $219.5K | $47.6K | Cut−$811.8K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 28K | $201.8K | $42.7K | Added$47.6K |
| Persistent Asset Partners Ltd | 28K | $201.5K | — | New |
| MetLife Investment Management, LLC | 26.5K | $190.7K | $41.3K | Added$3.42K |
| Brooklyn Investment Group | 25.8K | $185.8K | — | New |
| FOX RUN MANAGEMENT, L.L.C. | 27.2K | $176.7K | $21.3K | Added$35.7K |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 23.5K | $168.9K | $36.6K | Added$36.6K |
| SFMG, LLC | 22.2K | $159.5K | — | New |
| Engineers Gate Manager LP | 21.5K | $154.8K | — | New |
| Scientech Research LLC | 20.4K | $146.9K | — | New |
| MIRABELLA FINANCIAL SERVICES LLP | 19.9K | $143.3K | — | New |
| Police & Firemen's Retirement System of New Jersey | 17.4K | $125.2K | $27.1K | Added$27.1K |
| INTECH INVESTMENT MANAGEMENT LLC | 16.6K | $119.4K | $25.9K | Cut−$75.1K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16.3K | $117.2K | $25.4K | Added$14.2K |
| Lido Advisors, LLC | 16K | $115.2K | $16.5K | Cut−$9.28K |
| SIMPLEX TRADING, LLC | 15.1K | $108.7K | $23.6K | Cut−$232.7K |
| Verdad Advisers, LP | 14.9K | $107.1K | — | New |
| Brevan Howard Capital Management LP | 14.5K | $104.6K | — | New |
| China Universal Asset Management Co., Ltd. | 13.8K | $99.5K | $19.8K | Added$27.9K |
| US BANCORP \DE\ | 13.2K | $95.2K | $468 | Added$93.5K |
| SEI INVESTMENTS CO | 13.1K | $94.2K | $20.4K | Added$20.4K |
| Hudson Bay Capital Management LP | 12.7K | $91.1K | — | New |
| ProShare Advisors LLC | 12K | $86.6K | $18.8K | Added$6.45K |
| Vanguard Personalized Indexing Management, LLC | 11.1K | $79.9K | — | New |
| VOYA INVESTMENT MANAGEMENT LLC | 10.7K | $76.9K | $16.7K | Added$14K |
| MARTINGALE ASSET MANAGEMENT L P | 10.6K | $76.1K | $16.5K | Added$16.5K |
| Russell Investments Group, Ltd. | 8.89K | $64K | $11.2K | Added$23.4K |
| NEW YORK STATE COMMON RETIREMENT FUND | 7.1K | $51.1K | $11.1K | Added$11.1K |
| NISA INVESTMENT ADVISORS, LLC | 5.44K | $39.1K | $7.54K | Added$11.9K |
| CWM, LLC | 5.29K | $38.1K | $32.3K | Added$38.1K |
| Legal & General Group Plc | 5.27K | $37.9K | $8.22K | Added$8.22K |
| Steward Partners Investment Advisory, LLC | 4.96K | $35.7K | $7.73K | Added$7.73K |
| Ameritas Investment Partners, Inc. | 4.93K | $35.5K | $7.68K | Added$7.68K |
| Mirae Asset Global Investments Co., Ltd. | 4.06K | $29.3K | $5.91K | Added$7.91K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3.19K | $23K | $4.98K | Added$2.49K |
| Tower Research Capital LLC (TRC) | 2.78K | $20K | $4.33K | Cut−$40.2K |
| ROYAL BANK OF CANADA | 2.67K | $19K | $4.11K | Cut−$5K |
| Rockefeller Capital Management L.P. | 2.59K | $18.6K | $537 | Added$16.7K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 2.13K | $15.4K | $779 | Added$12.5K |
| Sterling Capital Management LLC | 1.95K | $14.1K | $3.05K | Cut−$5.1K |
| GF FUND MANAGEMENT CO. LTD. | 1.74K | $12.5K | $2.39K | Added$3.89K |
| OSAIC HOLDINGS, INC. | 1.46K | $10.5K | $2.28K | Cut−$842 |
| GAMMA Investing LLC | 1.12K | $8.04K | $377 | Added$6.68K |
| Quantbot Technologies LP | 1K | $7.2K | — | New |
| SBI Securities Co., Ltd. | 877 | $6.31K | $1.18K | Added$2.05K |
| PNC Financial Services Group, Inc. | 682 | $4.91K | $1.02K | Added$1.21K |
| Larson Financial Group LLC | 630 | $4.54K | $346 | Added$3.28K |
| True Wealth Design, LLC | 582 | $4.19K | $908 | Added$908 |
| Optiver Holding B.V. | 560 | $4.03K | $474 | Added$2.32K |
| Osbon Capital Management LLC | 501 | $3.61K | $781 | Added$781 |
| Allworth Financial LP | 418 | $3.01K | $641 | Added$691 |
| Physician Wealth Advisors, Inc. | 312 | $2.25K | $487 | Added$487 |
| IFP Advisors, Inc | 298 | $2.15K | $465 | Added$465 |
| QUADRANT CAPITAL GROUP LLC | 278 | $2K | $434 | Cut−$7.05K |
| Parkside Financial Bank & Trust | 135 | $971 | $209 | Added$209 |
| MAI Capital Management | 123 | $886 | $192 | Added$192 |
| HRT FINANCIAL LP | 86.9K | $625 | $23 | Added$541 |
| ALGERT GLOBAL LLC | 72.7K | $523 | — | New |
| Virtu Financial LLC | 59.7K | $430 | — | New |
| PRICE T ROWE ASSOCIATES INC /MD/ | 40.3K | $291 | $55 | Added$93 |
| Keating Financial Advisory Services, Inc. | 33 | $238 | — | New |
| GSA CAPITAL PARTNERS LLP | 29.6K | $213 | — | New |
| HANTZ FINANCIAL SERVICES, INC. | 1K | $7 | $1 | Added$1 |
| Activest Wealth Management | 0 | $0 | — | New |