13F

Stock

Rhythm Pharmaceuticals, Inc.

RYTM · held by 285 managers

Reported value

$6.24B

Holders

285

+55 new · −51 exited

Holders’ est. mark

−$1.11B

Price effect on 197 books still in the name

Largest holder

$579.8M

RA CAPITAL MANAGEMENT, L.P.

Notable conviction

Share of each notable manager’s 13F book.

Holder count by quarter

Who holds it

Notable only
InvestorSharesValueEst. markChange
RA CAPITAL MANAGEMENT, L.P.6.67M$579.8M−$133.8MCut−$133.8M
BlackRock, Inc.6.24M$542.4M−$125.2MCut−$131.6M
BAKER BROS. ADVISORS LP5.6M$487.4M−$112.5MCut−$112.5M
PRIMECAP MANAGEMENT CO/CA/3.42M$297.2M−$68.6MCut−$75.1M
VANGUARD PORTFOLIO MANAGEMENT LLC3.04M$264.5MHeld
VANGUARD CAPITAL MANAGEMENT LLC2.97M$258.1MHeld
PERCEPTIVE ADVISORS LLC2.37M$206.4M−$47.6MCut−$66.1M
State Street2.27M$197.6M−$44.1MCut−$37.8M
GOLDMAN SACHS GROUP INC1.97M$170.9M−$36.7MCut−$25M
WESTFIELD CAPITAL MANAGEMENT CO LP1.93M$167.8M−$25.4MAdded$32.1M
Fidelity1.69M$147M−$33.9MCut−$35.7M
Polar Capital Holdings Plc1.62M$140.5M−$23.8MAdded$13.6M
Citadel1.42M$123.4M−$3.08MAdded$107M
GEODE CAPITAL MANAGEMENT, LLC1.42M$123.2M−$27.6MCut−$24.1M
JPMORGAN CHASE & CO1.55M$120M−$42.4MCut−$32.4M
FEDERATED HERMES, INC.1.29M$111.9M−$25.8MCut−$61.9M
Checkpoint Capital L.P.1.23M$106.7M−$19.9MAdded$524.5K
ALLIANCEBERNSTEIN L.P.910.4K$97.5M$1Cut−$2.12M
Capital Research Global Investors1.12M$97M−$19.8MCut−$8.43M
JANUS HENDERSON GROUP PLC918.2K$79.9M−$18.4MCut−$40.7M
Point72 Asset Management, L.P.846.8K$73.6M−$8.62MAdded$27.7M
Woodline Partners LP758.9K$66M−$13.8MCut−$7.73M
ADAGE CAPITAL PARTNERS GP, L.L.C.725.7K$63.1M−$12.5MCut−$3.42M
Siren, L.L.C.725.5K$63.1M−$10MAdded$9.58M
MORGAN STANLEY704K$61.2M−$13.1MCut−$8.5M
Rock Springs Capital Management LP689.7K$60M−$13.8MCut−$14.4M
Pictet Asset Management Holding SA667K$57.3M−$13.4MCut−$8.86M
BANK OF AMERICA CORP /DE/628.7K$54.7M−$4.51MAdded$30.6M
FRANKLIN RESOURCES INC626.8K$54.5M−$12.6MCut−$20M
Clearbridge Investments, LLC609.4K$53M−$10.2MCut−$1.17M
Integral Health Asset Management, LLC600K$52.2M−$9.53MAdded$1.34M
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC541.5K$47.1M−$10.9MCut−$11.7M
CHARLES SCHWAB INVESTMENT MANAGEMENT INC526.5K$45.8M−$10.6MCut−$11.2M
NORTHERN TRUST CORP498.5K$43.4M−$9.8MCut−$8.9M
LOOMIS SAYLES & CO L P465.1K$40.4M−$9.33MCut−$13.5M
Candriam S.C.A.464.3K$40.4M−$5.78MAdded$9.56M
MILLENNIUM MANAGEMENT LLC451.8K$39.3M−$3.75MAdded$19.3M
Sofinnova Investments, Inc.450.1K$39.1M−$5.45MAdded$10.1M
Logos Global Management LP450K$39.1M−$3.81MAdded$18.8M
Driehaus Capital Management LLC436.5K$38M−$8.76MCut−$99.6M
VANGUARD FIDUCIARY TRUST CO421.9K$36.7MHeld
Opaleye Management Inc.123K$35.3M$22.2MHeld
Artisan Partners Limited Partnership390.7K$34M−$5.29MAdded$5.76M
AMERIPRISE FINANCIAL INC384K$33.4M−$5.24MAdded$5.44M
Invesco Ltd.364.3K$31.7M−$5.84MAdded$519K
ORBIMED ADVISORS LLC314.1K$27.3M−$4.81MAdded$1.65M
BRAIDWELL LP310.6K$27MNew
SILVERARC CAPITAL MANAGEMENT, LLC306K$26.6M−$2.73MAdded$12.1M
Bank of New York Mellon Corp293.3K$25.5M−$5.89MCut−$6.72M
Qube Research & Technologies Ltd277.9K$24.2M−$5.58MCut−$9.11M
WELLINGTON MANAGEMENT GROUP LLP273.8K$23.8M−$5.02MCut−$2.97M
Squarepoint Ops LLC263K$22.9M−$658.9KAdded$19.4M
Renaissance Technologies258K$22.4M−$5.18MCut−$14.1M
BNP PARIBAS FINANCIAL MARKETS247.9K$21.6M−$3.3MAdded$3.94M
Hood River Capital Management LLC239.9K$20.9M−$4.76MCut−$4.51M
VOYA INVESTMENT MANAGEMENT LLC233.8K$20.3M−$4.69MCut−$6.41M
UBS Group AG231.7K$20.1M−$4.65MCut−$25.6M
ADAR1 Capital Management, LLC211.4K$18.4M−$1.03MAdded$12.9M
SummitTX Capital, L.P.165.6K$14.4M−$1.62MAdded$5.76M
Connor, Clark & Lunn Investment Management Ltd.151.8K$13.2M−$3MCut−$2.78M
DEUTSCHE BANK AG\141.6K$12.3M−$2.59MCut−$1.51M
M&G PLC138.6K$12.1M−$2.74MCut−$2.61M
PFM Health Sciences, LP136.6K$11.9M−$807KAdded$7.58M
NEXTBio Capital Management LP126.1K$11M−$1.36MAdded$3.73M
NEW YORK STATE COMMON RETIREMENT FUND125.2K$10.9M−$1.88MAdded$862.1K
Nuveen, LLC117.4K$10.2M−$2.33MCut−$2.2M
SCHRODER INVESTMENT MANAGEMENT GROUP131.7K$10.2MNew
Russell Investments Group, Ltd.115.7K$10.1M−$2.32MCut−$4.3M
Capital World Investors115.7K$10.1M−$2.32MCut−$2.32M
Swiss National Bank112.2K$9.76M−$2.23MCut−$2.16M
AXIOM INVESTORS LLC /DE91.7K$7.98M−$1.68MCut−$964.2K
First Light Asset Management, LLC87.2K$7.58M−$1.75MCut−$24.1M
FIRST TRUST ADVISORS LP85.5K$7.44M−$1.72MCut−$2.04M
Aberdeen Group plc79.4K$6.9MNew
Granahan Investment Management, LLC77.7K$6.76M−$1.07MAdded$1.04M
NEUBERGER BERMAN GROUP LLC73.4K$6.39M−$1.47MCut−$1.49M
WCM INVESTMENT MANAGEMENT, LLC80.6K$6.23M−$1.32MAdded$1.44M
RHUMBLINE ADVISERS69.9K$6.08M−$1.4MCut−$1.55M
KENNEDY CAPITAL MANAGEMENT LLC65.8K$5.72M−$800.5KAdded$1.45M
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM65.8K$5.72M−$1.07MCut−$7.45K
Universal- Beteiligungs- und Servicegesellschaft mbH62.9K$5.47M−$1.26MCut−$7.74M
Blue Owl Capital Holdings LP61.5K$5.34MNew
XTX Topco Ltd59.5K$5.17M−$209.4KAdded$4.06M
Icahn Capital59.3K$5.16M−$1.19MCut−$2.34M
Atom Investors LP57K$4.96M−$460.2KAdded$2.5M
Balyasny Asset Management L.P.53K$4.61M−$1.06MCut−$3.13M
CASTLEARK MANAGEMENT LLC52.3K$4.55M−$1.05MCut−$2.36M
SUSQUEHANNA INTERNATIONAL GROUP, LLP50.8K$4.42M−$82.2KAdded$3.98M
MANUFACTURERS LIFE INSURANCE COMPANY, THE50.8K$4.42M−$1.01MCut−$1.96M
PICTON MAHONEY ASSET MANAGEMENT50.4K$4.38MNew
Rafferty Asset Management, LLC50.1K$4.36M−$1.01MCut−$1.59M
RAYMOND JAMES FINANCIAL INC49.9K$4.34M−$825.2KCut−$59.4K
VANGUARD ASSET MANAGEMENT, Ltd49.7K$4.32MHeld
Nan Fung Group Holdings Ltd49.1K$4.27M−$985.8KCut−$985.8K
Harvest Investment Services, LLC48.5K$4.22M−$882.1KCut−$489.5K
Legal & General Group Plc47K$4.09M−$943.9KCut−$1.8M
SILVERCREST ASSET MANAGEMENT GROUP LLC46.9K$4.08M−$684.9KAdded$424.8K
BNP PARIBAS ASSET MANAGEMENT Holding S.A.43.9K$3.82M$209.8KAdded$3.82M
Utah Retirement Systems42.2K$3.67MNew
SEI INVESTMENTS CO40.7K$3.54M−$751.3KCut−$468.4K
Exome Asset Management LLC40.6K$3.53MNew
Hillsdale Investment Management Inc.40.3K$3.5M−$808.8KCut−$1.02M
TD Asset Management Inc38.8K$3.37M−$778.3KCut−$2.52M
STATE OF WISCONSIN INVESTMENT BOARD36.6K$3.18M−$724.1KCut−$681.3K
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.34.7K$2.98M−$729.6KCut−$753.5K
EFG International AG34.2K$2.98M−$588.2KCut−$159.7K
WELLS FARGO & COMPANY/MN34.1K$2.97M−$684.5KCut−$4.81M
ASPIRIANT, LLC33K$2.87MNew
LAZARD ASSET MANAGEMENT LLC32.9K$2.86M−$513.2KAdded$123.1K
D. E. Shaw & Co., Inc.32.7K$2.84M−$629.3KCut−$516.6K
Alyeska Investment Group, L.P.32.6K$2.83MNew
PRUDENTIAL FINANCIAL INC30.2K$2.63M−$605.9KCut−$3.06M
Vanguard Global Advisers, LLC29.7K$2.58MHeld
Aquatic Capital Management LLC29.7K$2.58MNew
STRS OHIO28.9K$2.51M−$240.8KAdded$1.23M
MetLife Investment Management, LLC28.9K$2.51M−$579.8KCut−$610.3K
PDT Partners, LLC27.2K$2.37M−$546.5KCut−$3.99M
WEDGE CAPITAL MANAGEMENT L L P/NC24.5K$2.13M−$386.3KAdded$73.6K
PROFUND ADVISORS LLC22.8K$1.98M−$422.4KCut−$271K
MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC22.5K$1.96MNew
Creative Planning21.1K$1.83M−$423.2KCut−$864.3K
Liberty Mutual Group Asset Management Inc.20.5K$1.78MNew
VICTORY CAPITAL MANAGEMENT INC20.5K$1.78M−$411.5KCut−$3.07M
TUDOR INVESTMENT CORP ET AL19.6K$1.71MNew
State of New Jersey Common Pension Fund D19.4K$1.69M−$386.7KCut−$376.7K
DIMENSIONAL FUND ADVISORS LP19.2K$1.67M−$384.4KCut−$1.76M
Advisors Asset Management, Inc.18.7K$1.63M−$371.8KCut−$354.9K
CAPTRUST FINANCIAL ADVISORS18.1K$1.58M−$364.2KCut−$383.3K
ExodusPoint Capital Management, LP17.8K$1.55M−$356.7KCut−$6.5M
HighVista Strategies LLC16.8K$1.46M−$337.1KCut−$3.13M
GUGGENHEIM CAPITAL LLC16.6K$1.44M−$248.9KAdded$112.3K
Zurcher Kantonalbank (Zurich Cantonalbank)15.6K$1.36M−$249.6KAdded$25.5K
Knights of Columbus Asset Advisors LLC15.6K$1.36M−$207KAdded$251.8K
ARIZONA STATE RETIREMENT SYSTEM15.6K$1.36M−$312.7KCut−$332.1K
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM14.7K$1.27M−$294KCut−$294K
Police & Firemen's Retirement System of New Jersey14.6K$1.27M−$284.7KCut−$248.9K
HSBC HOLDINGS PLC14.3K$1.22MNew
Vanguard Investments Australia, Ltd.13.9K$1.21MHeld
Jasper Ridge Partners, L.P.13.8K$1.2M−$113.2KAdded$600.5K
INTECH INVESTMENT MANAGEMENT LLC13.7K$1.19M−$275.7KCut−$1.09M
KLP KAPITALFORVALTNING AS12.5K$1.09M−$240.8KCut−$197.4K
Bridgefront Capital, LLC12.5K$1.09MNew
STIFEL FINANCIAL CORP12.3K$1.07M−$247.6KCut−$344.8K
CITIGROUP INC12.3K$1.07M−$247.6KCut−$288.7K
China Universal Asset Management Co., Ltd.12.1K$1.05M−$218.3KCut−$110.2K
DNB Asset Management AS11.2K$973.6K−$224KCut−$221.3K
ProShare Advisors LLC10.7K$932.3K−$215.2KCut−$418.7K
BARCLAYS PLC10.7K$926.4K−$213.8KCut−$13.1M
Entropy Technologies, LP10.3K$897.4K−$50KAdded$630.6K
TOTH FINANCIAL ADVISORY CORP10K$869.7K−$200.7KCut−$200.7K
Cannon Financial Strategists, Inc.10K$869.7K−$200.7KCut−$200.7K
MARSHALL WACE, LLP9.63K$837.3KNew
AlphaCentric Advisors LLC9.3K$808.6K−$101.4KAdded$267.8K
LOS ANGELES CAPITAL MANAGEMENT LLC9.22K$801.8K−$229KCut−$1.92M
Hudson Bay Capital Management LP9.12K$793.2KNew
HighTower Advisors, LLC9.06K$787.8KNew
CenterBook Partners LP9.03K$785KNew
EXCHANGE TRADED CONCEPTS, LLC8.46K$736K−$122KAdded$85.2K
PRELUDE CAPITAL MANAGEMENT, LLC8.37K$728.1KNew
Tower Research Capital LLC (TRC)7.71K$671K−$59.4KAdded$353.9K
Virtus Investment Advisers, LLC7.43K$646.5K−$120.8KAdded$2.48K
TEACHER RETIREMENT SYSTEM OF TEXAS7.33K$637.5K−$147.1KCut−$257.3K
PNC Financial Services Group, Inc.6.94K$603.4K−$93.5KAdded$104.7K
IMC-Chicago, LLC6.7K$582.4KNew
E Fund Management Co., Ltd.6.45K$561.2KHeld
LPL Financial LLC6.2K$539K−$108.9KCut−$41.9K
Campbell & CO Investment Adviser LLC5.96K$518.2KNew
Blueshift Asset Management, LLC5.79K$503.3K−$57.8KAdded$194.9K
PRINCIPAL FINANCIAL GROUP INC5.64K$490.3K−$113.1KCut−$173.2K
FIFTH THIRD BANCORP5.26K$457.5KNew
XPONANCE LLC4.99K$434K−$85.7KCut−$23K
Gotham Asset Management, LLC4.85K$421.6K−$97.3KCut−$97.6K
Rockefeller Capital Management L.P.4.84K$421.3K−$97.2KCut−$838.7K
Avior Wealth Management, LLC4.65K$404.4K−$71.7KAdded$22.1K
E. Ohman J:or Asset Management AB4.41K$383.5K−$88.5KCut−$321.8K
INCEPTIONR LLC4.38K$380.8KNew
Ameritas Investment Partners, Inc.4.37K$379.6K−$87.6KCut−$87.6K
TWO SIGMA INVESTMENTS, LP4.3K$374KNew
JONES FINANCIAL COMPANIES LLLP4.92K$372.9K−$7.21KAdded$348.2K
Man Group plc4.02K$349.8K−$80.7KCut−$673.3K
Amundi4.02K$349.4KNew
Abel Hall, LLC4.01K$349.2K−$42.9KAdded$120.1K
Centiva Capital, LP4K$347.9KNew
FOX RUN MANAGEMENT, L.L.C.4.5K$347.5KNew
Ensign Peak Advisors, Inc3.86K$335.6K−$77.5KCut−$77.5K
Quantinno Capital Management LP3.85K$334.9K−$76.9KCut−$75.1K
BANK OF MONTREAL /CAN/3.8K$330.6KNew
Brevan Howard Capital Management LP3.78K$328.5KNew
Freestone Capital Holdings, LLC3.7K$321.8K−$74.3KCut−$74.3K
Mirae Asset Global Investments Co., Ltd.3.56K$309.8K−$65.1KCut−$37.3K
Swiss Life Asset Management Ltd3.34K$290.6K−$53.2KAdded$6.59K
Marex Group plc3.29K$286KNew
Cerity Partners LLC3.21K$279.6K−$64.5KCut−$112.6K
Vanguard Personalized Indexing Management, LLC3.1K$269.8K−$47.7KAdded$15.1K
Leo Wealth, LLC3.09K$268.6K−$62KCut−$475.6K
Chicago Partners Investment Group LLC3.13K$266.2K−$48.5KCut−$15.6K
Ethic Inc.3K$261.2KNew
Allianz Asset Management GmbH3K$260.9K−$60.2KCut−$595.4K
CIM INVESTMENT MANAGEMENT INC2.99K$260.3K−$60.1KCut−$60.1K
CIBC Asset Management Inc2.85K$247.7K−$57.2KCut−$57.2K
MAI Capital Management2.71K$235.7K−$41Added$235.5K
CIBC Bancorp USA Inc.2.66K$231.6KHeld
Blackstone Inc.2.6K$226.1KNew
DRW Securities, LLC2.56K$222.8KNew
TWO SIGMA SECURITIES, LLC2.54K$221.3K−$51.1KCut−$307.8K
CWM, LLC2.54K$220.6K$220.3KAdded$220.3K
Northwest & Ethical Investments L.P.2.49K$216.6KNew
Integrated Wealth Concepts LLC2.48K$215.7KNew
CORNERSTONE PARTNERS CAPITAL MANAGEMENT, LLC2.46K$214.1KNew
Verdad Advisers, LP2.44K$212.6KNew
ELEVATION WEALTH PARTNERS, LLC1.97K$171.4K−$39.6KCut−$39.6K
WHITTIER TRUST CO1.81K$157.5K−$22.6KCut−$22.6K
PRICE T ROWE ASSOCIATES INC /MD/1.65M$143.9K−$31.3KCut−$23.1K
GF FUND MANAGEMENT CO. LTD.1.5K$130.3K−$26.3KCut−$9.94K
Quantbot Technologies LP1.36K$118.5KNew
NISA INVESTMENT ADVISORS, LLC1.14K$99K−$22.8KCut−$1.31M
US BANCORP \DE\1.04K$90.5K−$19.1KCut−$11.5K
Bellevue Group AG1.02K$88.4K−$20.4KCut−$714.9K
OSAIC HOLDINGS, INC.939$81.7K−$18.8KCut−$29.6K
Farther Finance Advisors, LLC645$56.8K−$12.1KCut−$11.9K
Kemnay Advisory Services Inc.562$48.9K−$4.15KAdded$26.7K
EverSource Wealth Advisors, LLC549$47.7K−$5.34KAdded$19.3K
Arax Advisory Partners368$32.1K−$7.34KCut−$8.73K
LORD, ABBETT & CO. LLC349K$30.3K−$7KCut−$36K
Sterling Capital Management LLC343$29.8K−$6.88KCut−$6.99K
SBI Securities Co., Ltd.302$26.3K−$6.06KCut−$10.4K
GAMMA Investing LLC267$23.2K−$5.36KCut−$15.4K
Smartleaf Asset Management LLC264$20.4K−$7.79KCut−$22.2K
SIGNATUREFD, LLC224$19.5K−$4.5KCut−$5.35K
E Fund Management (Hong Kong) Co., Ltd.154$13.4KNew
True Wealth Design, LLC147$12.8K−$2.95KCut−$2.95K
Truvestments Capital LLC138$12K−$2.77KCut−$2.77K
Essential Partners LLC120$10.4K−$2.41KCut−$13.4K
Sound Income Strategies, LLC114$10KNew
DANSKE BANK A/S100$8.7K−$2.01KCut−$109K
Cassaday & Co Wealth Management LLC93$8.09KNew
ROTHSCHILD INVESTMENT LLC86$7.48K−$1.73KCut−$2.26K
Allworth Financial LP83$7.22K−$1.67KCut−$4.45K
WPG Advisers, LLC60$5.22K−$1.2KCut−$1.2K
HARBOUR INVESTMENTS, INC.60$5.22K−$1.2KCut−$1.2K
EASTERN BANK59$5.13K−$1.18KCut−$1.18K
ALGERT GLOBAL LLC58.5K$5.09K−$1.17KCut−$4.36K
ROYAL BANK OF CANADA62$5K−$1.66KCut−$175K
Larson Financial Group LLC52$4.52K−$1.04KCut−$3.72K
Cedar Mountain Advisors, LLC51$4.43KNew
Optiver Holding B.V.50$4.35K−$1KCut−$5.5K
IFP Advisors, Inc46$4K−$722Added$148
Advisory Services Network, LLC37$3.22KNew
Golden State Equity Partners37$3.22KNew
Versant Capital Management, Inc36$3.13K−$722Cut−$722

Who left

Positions as of Q1 2026. 13F filings arrive up to 45 days after quarter-end and omit shorts. Values are quarter-end marks, as filed. Estimated mark is the price effect on shares still held — not realized P&L or investment advice.