| ORBIMED ADVISORS LLC | 7.17M | $104.8M | $49.7M | Added$49.7M |
| BlackRock, Inc. | 6.16M | $90.1M | $35M | Added$51.2M |
| State Street | 3.57M | $52.2M | $19.3M | Added$30.7M |
| ADAMS STREET PARTNERS LLC | 3.28M | $47.9M | $22.7M | Added$22.7M |
| VANGUARD CAPITAL MANAGEMENT LLC | 3.23M | $47.3M | — | Held |
| Vivo Capital, LLC | 2.81M | $41M | $15.5M | Added$23.8M |
| MORGAN STANLEY | 2.5M | $36.6M | $17.3M | Added$9.08M |
| Deep Track Capital, LP | 2.49M | $36.5M | — | New |
| WELLINGTON MANAGEMENT GROUP LLP | 2.32M | $33.9M | $2.18M | Added$31.5M |
| PERCEPTIVE ADVISORS LLC | 2.29M | $33.5M | $4.8M | Added$28.2M |
| Commodore Capital LP | 2.26M | $33M | — | New |
| Foresite Capital Management VI LLC | 1.83M | $26.8M | $9.57M | Added$16.2M |
| BRAIDWELL LP | 1.75M | $25.6M | — | New |
| GEODE CAPITAL MANAGEMENT, LLC | 1.71M | $25.1M | $10.2M | Added$13.7M |
| MPM BIOIMPACT LLC | 1.67M | $24.5M | $11.6M | Added$3.38M |
| GOLDMAN SACHS GROUP INC | 1.54M | $22.5M | $3.83M | Added$18.3M |
| Hood River Capital Management LLC | 1.34M | $19.5M | — | New |
| Boxer Capital Management, LLC | 1.1M | $16.1M | — | New |
| Polar Capital Holdings Plc | 1.07M | $15.7M | — | New |
| Catalio Capital Management, LP | 891.9K | $13M | — | New |
| MILLENNIUM MANAGEMENT LLC | 866.4K | $12.7M | $4.77M | Added$7.37M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 750K | $11M | — | New |
| EMERALD ADVISERS, LLC | 686.2K | $10M | — | New |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 669.9K | $9.8M | — | Held |
| DCF Advisers, LLC | 637.5K | $9.33M | $4.42M | Added$3.71M |
| EVENTIDE ASSET MANAGEMENT, LLC | 550K | $8.05M | — | New |
| MARSHALL WACE, LLP | 548.3K | $8.02M | $1.5M | Added$6.36M |
| Blue Owl Capital Holdings LP | 545K | $7.97M | — | New |
| TWO SIGMA INVESTMENTS, LP | 539.9K | $7.9M | $995.1K | Added$6.79M |
| NORTHERN TRUST CORP | 506.1K | $7.4M | $2.98M | Added$4.1M |
| VANGUARD FIDUCIARY TRUST CO | 504.6K | $7.38M | — | Held |
| EMERALD MUTUAL FUND ADVISERS TRUST | 459.3K | $6.72M | — | New |
| RA CAPITAL MANAGEMENT, L.P. | 450K | $6.58M | — | New |
| Logos Global Management LP | 450K | $6.58M | $3.12M | Added$2.73M |
| Nextech Invest, Ltd. | 450K | $6.58M | — | New |
| Citadel | 442.5K | $6.47M | $1.44M | Added$4.87M |
| UBS Group AG | 289.1K | $4.23M | $1.47M | Added$2.6M |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 278K | $4.07M | — | New |
| SPHERA FUNDS MANAGEMENT LTD. | 248K | $3.63M | $1.72M | Added$488.3K |
| DIADEMA PARTNERS LP | 244.8K | $3.58M | — | New |
| BARCLAYS PLC | 243.8K | $3.57M | $1.69M | Added$526.7K |
| BANK OF AMERICA CORP /DE/ | 237K | $3.47M | $1.64M | Added$1.65M |
| Spruce Street Capital LP | 231.6K | $3.39M | — | New |
| SEB Asset Management AB | 226.8K | $3.32M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 188.1K | $2.75M | $1.19M | Added$1.43M |
| Bank of New York Mellon Corp | 185.3K | $2.71M | $912.2K | Added$1.7M |
| Polymer Capital Management (HK) LTD | 183.2K | $2.68M | — | New |
| Brevan Howard Capital Management LP | 168K | $2.46M | — | New |
| Nuveen, LLC | 149.1K | $2.18M | $471.7K | Added$1.66M |
| Jump Financial, LLC | 147.8K | $2.16M | — | New |
| Informed Momentum Co LLC | 138.1K | $2.02M | — | New |
| JPMORGAN CHASE & CO | 145.2K | $1.95M | $174.7K | Added$1.71M |
| VICTORY CAPITAL MANAGEMENT INC | 128.4K | $1.88M | — | New |
| Squarepoint Ops LLC | 123.9K | $1.81M | $726.4K | Added$1.01M |
| TD Asset Management Inc | 123.7K | $1.81M | — | New |
| Avidity Partners Management LP | 115K | $1.68M | — | New |
| Rafferty Asset Management, LLC | 112.6K | $1.65M | $691.1K | Added$879.6K |
| Tidal Investments LLC | 107.8K | $1.58M | — | New |
| TEMA ETFS LLC | 107.8K | $1.58M | $552.3K | Added$963.1K |
| Aquatic Capital Management LLC | 102.4K | $1.5M | — | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 101.8K | $1.49M | $121.3K | Added$1.35M |
| F/m Investments LLC | 100K | $1.46M | — | New |
| RAYMOND JAMES FINANCIAL INC | 99.9K | $1.46M | $692.2K | Added$528.4K |
| VOYA INVESTMENT MANAGEMENT LLC | 99.6K | $1.46M | $191.7K | Added$1.24M |
| ADAR1 Capital Management, LLC | 87.9K | $1.29M | $609.2K | Cut−$2.3M |
| Propel Bio Management, LLC | 85.8K | $1.25M | — | New |
| Connor, Clark & Lunn Investment Management Ltd. | 83.9K | $1.23M | $194.9K | Added$1.01M |
| Seven Fleet Capital Management LP | 82.9K | $1.21M | — | New |
| Renaissance Technologies | 81.3K | $1.19M | — | New |
| RHUMBLINE ADVISERS | 76.5K | $1.12M | $490.1K | Added$574.8K |
| TOWERVIEW LLC | 70K | $1.02M | $485.1K | Cut−$53.9K |
| ALPS ADVISORS INC | 68.2K | $997.7K | $424.9K | Added$525.5K |
| JACKSON SQUARE CAPITAL, LLC | 63.8K | $933K | $441.9K | Added$441.9K |
| Persistent Asset Partners Ltd | 62.1K | $907.8K | — | New |
| SEI INVESTMENTS CO | 60.8K | $890.2K | — | New |
| Ancora Advisors LLC | 54.8K | $801.3K | $330.3K | Added$434.2K |
| DEUTSCHE BANK AG\ | 54.5K | $797K | $377.5K | Added$365.5K |
| PROFUND ADVISORS LLC | 50.2K | $734.9K | $256.8K | Added$449.6K |
| SEVEN GRAND MANAGERS, LLC | 50K | $731.5K | — | New |
| Vanguard Global Advisers, LLC | 47.7K | $697.7K | — | Held |
| JANE STREET GROUP, LLC | 44.5K | $650.6K | $308.2K | Cut−$2.26M |
| Creative Planning | 43K | $629.6K | $271.5K | Added$327.9K |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 41.4K | $605.9K | — | New |
| FRANKLIN RESOURCES INC | 39.1K | $571.8K | — | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 38.6K | $565.2K | $267.7K | Added$89.7K |
| Invesco Ltd. | 38.2K | $559K | $264.8K | Added$223.5K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 38.2K | $548.4K | $217.5K | Added$300K |
| SIMPLEX TRADING, LLC | 34.7K | $508K | — | New |
| XTX Topco Ltd | 34.3K | $501.9K | — | New |
| Qube Research & Technologies Ltd | 33.2K | $486.1K | $230.3K | Cut−$395.5K |
| AVITY INVESTMENT MANAGEMENT INC. | 33.2K | $485.7K | $226.5K | Added$234.1K |
| MetLife Investment Management, LLC | 33.1K | $484.3K | $213.3K | Added$247.2K |
| Virtus Investment Advisers, LLC | 32.6K | $476.6K | $220.3K | Added$231.9K |
| ALLIANCEBERNSTEIN L.P. | 61.7K | $475.4K | $0 | Added$343.6K |
| Composition Wealth, LLC | 30K | $438.9K | — | New |
| Optimize Financial Inc | 28.1K | $410.5K | — | New |
| TUDOR INVESTMENT CORP ET AL | 27.5K | $402.2K | — | New |
| China Universal Asset Management Co., Ltd. | 27.2K | $397.3K | $125.9K | Added$257.4K |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 26.7K | $390.6K | $185K | Added$185K |
| WINTON GROUP Ltd | 26.6K | $389.5K | — | New |
| INTECH INVESTMENT MANAGEMENT LLC | 23.4K | $342.1K | $162K | Added$65.1K |
| WELLS FARGO & COMPANY/MN | 23.4K | $341.9K | $161.9K | Cut−$140.3K |
| Quantinno Capital Management LP | 23K | $336.2K | — | New |
| Three Bridge Wealth Advisors, LLC | 22.4K | $327.3K | $155K | Added$155K |
| BNP PARIBAS FINANCIAL MARKETS | 21.3K | $311.8K | $45.5K | Added$261.3K |
| Simplify Asset Management Inc. | 20.2K | $296.1K | — | New |
| BURKEHILL GLOBAL MANAGEMENT, LP | 20K | $292.6K | — | New |
| Corient Private Wealth LLC | 19.8K | $289.6K | — | New |
| NEW YORK STATE COMMON RETIREMENT FUND | 18.1K | $264.8K | $125.4K | Added$120K |
| Police & Firemen's Retirement System of New Jersey | 18K | $263.6K | $107.6K | Added$144K |
| Sowell Financial Services LLC | 15K | $219.4K | $104K | Added$88.5K |
| CITIGROUP INC | 14.8K | $217.2K | $102.9K | Added$102.8K |
| E Fund Management Co., Ltd. | 14.2K | $207.1K | — | Held |
| AXQ CAPITAL, LP | 13.7K | $200.9K | $87.3K | Added$103.9K |
| ProShare Advisors LLC | 13K | $190.6K | $90.3K | Added$84.6K |
| SHELTON WEALTH MANAGEMENT, LLC | 12.3K | $179.5K | $85K | Added$59.1K |
| PRUDENTIAL FINANCIAL INC | 11.7K | $170.8K | — | New |
| OneDigital Investment Advisors LLC | 10.7K | $156.8K | $69.3K | Added$79.8K |
| DRW Securities, LLC | 10.6K | $154.8K | $73.3K | Cut−$25.2K |
| Truvestments Capital LLC | 10.3K | $150.1K | $71.1K | Added$71.1K |
| WHITTIER TRUST CO OF NEVADA INC | 10.2K | $150K | $81.9K | Added$75.2K |
| Ghisallo Capital Management LLC | 10K | $146.3K | — | New |
| Caitong International Asset Management Co., Ltd | 9.98K | $146.1K | $796 | Added$145.2K |
| Tower Research Capital LLC (TRC) | 9.36K | $137K | $4.37K | Added$132.1K |
| ROTHSCHILD INVESTMENT LLC | 7.5K | $109.7K | $48.5K | Added$55.8K |
| Russell Investments Group, Ltd. | 6.79K | $99.4K | $46.2K | Added$48.1K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 6.12K | $89.5K | $5.02K | Added$83.9K |
| Legal & General Group Plc | 5.68K | $83.1K | $39.4K | Added$38.5K |
| Ameritas Investment Partners, Inc. | 4.75K | $69.5K | $32.9K | Added$28.3K |
| Mirae Asset Global Investments Co., Ltd. | 4.31K | $63K | $25.1K | Added$35.1K |
| Fidelity | 3.56K | $52.1K | $15.9K | Added$34.5K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3.5K | $51.2K | $24.2K | Added$24K |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2.92M | $42.7K | $236 | Added$42.4K |
| NISA INVESTMENT ADVISORS, LLC | 2.6K | $38.1K | — | New |
| Western Pacific Wealth Management, LP | 2K | $29.3K | $13.9K | Added$13.9K |
| GF FUND MANAGEMENT CO. LTD. | 1.67K | $24.4K | $10.2K | Added$13.1K |
| CWM, LLC | 1.24K | $18.1K | $3K | Added$18.1K |
| US BANCORP \DE\ | 1.1K | $16.1K | — | New |
| SBI Securities Co., Ltd. | 1K | $14.7K | $6.96K | Added$6.96K |
| MEEDER ASSET MANAGEMENT INC | 754 | $11K | — | New |
| OSAIC HOLDINGS, INC. | 735 | $10.8K | $5.09K | Cut−$512.8K |
| GAMMA Investing LLC | 600 | $8.78K | $991 | Added$7.68K |
| Sterling Capital Management LLC | 418 | $6.12K | $2.72K | Added$3.1K |
| QUADRANT CAPITAL GROUP LLC | 265 | $3.88K | — | New |
| Physician Wealth Advisors, Inc. | 177 | $2.59K | $1.23K | Added$1.23K |
| PNC Financial Services Group, Inc. | 137 | $2K | $949 | Added$949 |
| SIGNATUREFD, LLC | 136 | $1.99K | $527 | Added$1.41K |
| Fortitude Family Office, LLC | 99 | $1.45K | — | New |
| ACADIAN ASSET MANAGEMENT LLC | 69.2K | $1.01K | — | New |
| ROYAL BANK OF CANADA | 79 | $1K | $416 | Cut−$11K |
| Larson Financial Group LLC | 65 | $951 | — | New |
| Allworth Financial LP | 62 | $908 | $118 | Added$777 |
| Clearstead Advisors, LLC | 50 | $732 | $346 | Cut−$834 |
| Hikari Power Ltd | 50K | $731 | $346 | Added$346 |
| Farther Finance Advisors, LLC | 39 | $563 | $263 | Cut−$1.92K |
| SG Americas Securities, LLC | 35.4K | $518 | $139 | Added$364 |
| Sunrise Financial Services, LLC | 30 | $439 | — | New |
| Versant Capital Management, Inc | 28 | $410 | — | New |
| FIFTH THIRD BANCORP | 21 | $307 | — | New |
| Virtu Financial LLC | 12K | $175 | — | New |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 8K | $117 | — | New |
| MAI Capital Management | 7 | $103 | — | New |
| TWIN PEAKS WEALTH ADVISORS, LLC | 7 | $102 | — | New |
| Advisory Services Network, LLC | 1 | $15 | — | New |