| JANUS HENDERSON GROUP PLC | 13.6M | $247.4M | −$19.5M | Cut−$24.2M |
| BlackRock, Inc. | 11.7M | $212.1M | −$16M | Cut−$6.77M |
| Atlas Venture Life Science Advisors, LLC | 9.13M | $165.5M | −$13.1M | Cut−$13.1M |
| Fidelity | 8.91M | $161.5M | −$9.39M | Added$33M |
| Orbis Allan Gray Ltd | 6.76M | $122.6M | −$6.87M | Added$28.7M |
| State Street | 6.65M | $120.6M | −$9.51M | Cut−$10.3M |
| VANGUARD CAPITAL MANAGEMENT LLC | 6.41M | $116.1M | — | Held |
| PERCEPTIVE ADVISORS LLC | 4.67M | $84.6M | −$4.97M | Added$16.6M |
| FCPM III SERVICES B.V. | 4.64M | $84.2M | −$6.64M | Cut−$22.7M |
| TCG Crossover Management, LLC | 4.62M | $83.7M | −$6.6M | Cut−$6.6M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 4.16M | $75.5M | — | Held |
| Vestal Point Capital, LP | 4M | $72.5M | −$171.6K | Added$70.2M |
| GEODE CAPITAL MANAGEMENT, LLC | 3.5M | $63.5M | −$4.67M | Cut−$301.8K |
| ARMISTICE CAPITAL, LLC | 3.18M | $57.6M | −$4.54M | Cut−$6M |
| Frazier Life Sciences Management, L.P. | 3.15M | $57.2M | −$4.51M | Cut−$4.51M |
| JPMORGAN CHASE & CO | 3.25M | $55.6M | −$8.04M | Cut−$13.8M |
| ORBIMED ADVISORS LLC | 2.92M | $52.9M | −$3.15M | Added$9.83M |
| Siren, L.L.C. | 2.23M | $40.4M | −$3.19M | Cut−$28.1M |
| VR ADVISER, LLC | 2.17M | $39.4M | −$3.11M | Cut−$3.11M |
| FRANKLIN RESOURCES INC | 2.01M | $36.4M | −$2.87M | Cut−$2.83M |
| Deep Track Capital, LP | 2M | $36.3M | −$2.86M | Cut−$15.6M |
| SAMLYN CAPITAL, LLC | 1.92M | $34.9M | −$2.14M | Added$5.65M |
| GOLDMAN SACHS GROUP INC | 1.72M | $31.2M | −$2.46M | Cut−$13.4M |
| BRAIDWELL LP | 1.68M | $30.5M | −$2.11M | Added$1.58M |
| Palo Alto Investors LP | 1.65M | $30M | −$2.11M | Added$1.17M |
| Sofinnova Investments, Inc. | 1.63M | $29.6M | −$2.34M | Cut−$14.5M |
| Vivo Capital, LLC | 1.56M | $28.2M | −$2.23M | Cut−$22.9M |
| BANK OF AMERICA CORP /DE/ | 1.44M | $26.2M | −$1.26M | Added$8.9M |
| Aberdeen Group plc | 1.43M | $25.9M | −$1.58M | Added$4.26M |
| MPM BIOIMPACT LLC | 1.41M | $25.5M | −$2.01M | Cut−$1.96M |
| Logos Global Management LP | 1.4M | $25.4M | −$1.79M | Added$932K |
| Fiera Capital Corp | 1.38M | $25M | — | New |
| Polar Capital Holdings Plc | 1.36M | $24.6M | −$1.81M | Cut−$182.5K |
| NORTHERN TRUST CORP | 1.2M | $21.7M | −$1.56M | Added$371.7K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1.16M | $21M | −$1.65M | Cut−$1.52M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1M | $18.1M | −$1.43M | Cut−$83M |
| Rock Springs Capital Management LP | 972.2K | $17.6M | −$1.31M | Cut−$231.4K |
| Saturn V Capital Management LP | 966.6K | $17.5M | −$1.38M | Cut−$17.5M |
| DIMENSIONAL FUND ADVISORS LP | 951.6K | $17.2M | −$141.1K | Added$15.3M |
| VANGUARD FIDUCIARY TRUST CO | 947.4K | $17.2M | — | Held |
| MORGAN STANLEY | 929K | $16.8M | −$1.33M | Cut−$6.89M |
| Squarepoint Ops LLC | 834.2K | $15.1M | −$364.9K | Added$10.1M |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 821.8K | $14.9M | −$1.18M | Cut−$7.38M |
| BAKER BROS. ADVISORS LP | 813.4K | $14.7M | −$1.16M | Cut−$1.16M |
| Nuveen, LLC | 718.3K | $13M | −$888.5K | Added$870.6K |
| ArrowMark Colorado Holdings LLC | 673.9K | $12.2M | −$963.7K | Cut−$1.49M |
| Artisan Partners Limited Partnership | 619.5K | $11.2M | −$885.8K | Cut−$1.48M |
| Renaissance Technologies | 533.6K | $9.67M | −$673K | Added$468.4K |
| TD Asset Management Inc | 529.3K | $9.6M | −$600.3K | Added$1.39M |
| STEMPOINT CAPITAL LP | 506.1K | $9.18M | −$723.7K | Cut−$7.16M |
| Ensign Peak Advisors, Inc | 496.6K | $9M | −$710.1K | Cut−$710.1K |
| University of Wisconsin Foundation | 484.7K | $8.79M | −$596K | Added$636.8K |
| RAYMOND JAMES FINANCIAL INC | 451.6K | $8.19M | −$645.9K | Cut−$2.19M |
| WASATCH ADVISORS LP | 443.7K | $8.04M | −$582K | Added$83.6K |
| Clearbridge Investments, LLC | 403.2K | $7.31M | −$576.6K | Cut−$666K |
| Bank of New York Mellon Corp | 401.6K | $7.28M | −$505.5K | Added$366.9K |
| UBS Group AG | 380.6K | $6.9M | −$544.2K | Cut−$552.4K |
| NEW YORK STATE COMMON RETIREMENT FUND | 333.5K | $6.05M | −$113.3K | Added$4.5M |
| Fisher Asset Management, LLC | 323.1K | $5.86M | −$357.6K | Added$965.6K |
| Catalio Capital Management, LP | 283K | $5.13M | −$404.6K | Cut−$5.04M |
| Tetragon Partners GP Ltd | 258.1K | $4.68M | −$354.6K | Cut−$170.9K |
| Qube Research & Technologies Ltd | 253.2K | $4.59M | −$362K | Cut−$3.48M |
| Invesco Ltd. | 248.9K | $4.51M | −$196.9K | Added$1.82M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 239.3K | $4.34M | −$306.7K | Added$142.8K |
| Swiss National Bank | 228.1K | $4.14M | −$318.2K | Cut−$216.6K |
| DEUTSCHE BANK AG\ | 221.1K | $4.01M | −$280.4K | Added$173.6K |
| Citadel | 201.1K | $3.65M | −$287.6K | Cut−$19.3M |
| SummitTX Capital, L.P. | 196.2K | $3.56M | −$280.5K | Cut−$1.2M |
| RHUMBLINE ADVISERS | 187.2K | $3.39M | −$250.3K | Cut−$29K |
| PDT Partners, LLC | 183K | $3.32M | −$261.7K | Cut−$261.7K |
| Rafferty Asset Management, LLC | 183K | $3.32M | −$261.7K | Cut−$1.26M |
| HighVista Strategies LLC | 182.9K | $3.32M | −$85.3K | Added$2.15M |
| Neo Ivy Capital Management | 168.8K | $3.06M | −$241.3K | Cut−$1.59M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 164.9K | $2.99M | $2.99M | Added$2.99M |
| AMERIPRISE FINANCIAL INC | 163K | $2.95M | −$233.1K | Cut−$912.2K |
| SPHERA FUNDS MANAGEMENT LTD. | 160.6K | $2.91M | −$229.6K | Cut−$4.77M |
| MILLENNIUM MANAGEMENT LLC | 158.5K | $2.87M | −$226.7K | Cut−$14.8M |
| BURKEHILL GLOBAL MANAGEMENT, LP | 155K | $2.81M | −$221.6K | Cut−$221.7K |
| Darwin Wealth Management, LLC | 154.9K | $2.81M | −$164.8K | Added$553K |
| Woodline Partners LP | 149.4K | $2.71M | −$172.7K | Added$345.8K |
| ALLIANCEBERNSTEIN L.P. | 135.9K | $2.66M | −$1 | Added$32.9K |
| WELLS FARGO & COMPANY/MN | 145.5K | $2.64M | −$208.1K | Cut−$253.5K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 139.7K | $2.53M | −$172.7K | Added$169.2K |
| Aegis Wealth Management LLC | 135K | $2.45M | −$108.5K | Added$963.3K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 108.7K | $1.97M | −$140.4K | Added$50.1K |
| Legal & General Group Plc | 96.5K | $1.75M | −$137.9K | Cut−$561.6K |
| Man Group plc | 95.7K | $1.73M | — | New |
| VOYA INVESTMENT MANAGEMENT LLC | 86.6K | $1.57M | −$123.6K | Cut−$120.5K |
| Icahn Capital | 84.2K | $1.53M | −$101K | Added$145.1K |
| MARSHALL WACE, LLP | 83.1K | $1.51M | −$118.9K | Cut−$11.7M |
| PROFUND ADVISORS LLC | 82.1K | $1.49M | −$117.5K | Cut−$207.6K |
| MOORE CAPITAL MANAGEMENT, LP | 78.8K | $1.43M | — | New |
| TUDOR INVESTMENT CORP ET AL | 77K | $1.4M | −$110.2K | Cut−$1.49M |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 75.5K | $1.35M | −$109.6K | Cut−$32.8K |
| VANGUARD ASSET MANAGEMENT, Ltd | 73.3K | $1.33M | — | Held |
| MetLife Investment Management, LLC | 72.8K | $1.32M | −$99.5K | Cut−$40.7K |
| CIBC WORLD MARKET INC. | 69.2K | $1.25M | −$98.3K | Cut−$90.2K |
| STATE OF WISCONSIN INVESTMENT BOARD | 68.6K | $1.24M | −$91K | Cut−$1.86K |
| ENVESTNET ASSET MANAGEMENT INC | 68.4K | $1.24M | — | New |
| ROYAL BANK OF CANADA | 68.2K | $1.24M | −$26.8K | Added$873K |
| Y-Intercept (Hong Kong) Ltd | 65.2K | $1.18M | −$93.2K | Cut−$5.54M |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 63.9K | $1.16M | −$91.3K | Cut−$162.8K |
| Blackstone Inc. | 57.1K | $1.04M | — | New |
| Vanguard Global Advisers, LLC | 56.4K | $1.02M | — | Held |
| FIFTH THIRD BANCORP | 54.2K | $983.2K | — | New |
| VICTORY CAPITAL MANAGEMENT INC | 53K | $960.5K | −$73.6K | Cut−$46.5K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 52.2K | $945.5K | −$53.3K | Added$215.8K |
| ARCADIA INVESTMENT MANAGEMENT CORP/MI | 49.5K | $897K | −$68.5K | Cut−$39.5K |
| WELLINGTON MANAGEMENT GROUP LLP | 48.9K | $886.2K | −$67.3K | Cut−$35K |
| MANGROVE PARTNERS IM, LLC | 47.9K | $868.9K | — | New |
| ADAR1 Capital Management, LLC | 47.5K | $860.5K | −$61K | Added$25.8K |
| SEI INVESTMENTS CO | 45K | $815.4K | −$64.3K | Cut−$333.9K |
| XTX Topco Ltd | 42.7K | $774.3K | −$61.1K | Cut−$334K |
| Russell Investments Group, Ltd. | 40K | $725.9K | −$57.3K | Cut−$3.81M |
| State of New Jersey Common Pension Fund D | 39.4K | $714.1K | −$45.1K | Added$96.8K |
| BNP PARIBAS FINANCIAL MARKETS | 39.2K | $711.3K | −$35K | Added$232K |
| CITIGROUP INC | 37.8K | $685.3K | −$52.4K | Cut−$31.8K |
| Brevan Howard Capital Management LP | 37.2K | $674.7K | −$53.2K | Cut−$2.42M |
| BARCLAYS PLC | 36.6K | $663K | −$52.3K | Cut−$8.11M |
| Police & Firemen's Retirement System of New Jersey | 36.3K | $658.2K | −$48K | Added$2.01K |
| SEVEN GRAND MANAGERS, LLC | 35K | $634.5K | −$50K | Cut−$50K |
| ARIZONA STATE RETIREMENT SYSTEM | 31.7K | $574K | −$44.9K | Cut−$40.5K |
| ASSETMARK, INC | 31.1K | $563.2K | — | New |
| T. Rowe Price Investment Management, Inc. | 30.8M | $558.1K | −$25.1K | Added$215.1K |
| Creative Planning | 29.9K | $542.9K | −$28.3K | Added$156.2K |
| INTECH INVESTMENT MANAGEMENT LLC | 29.6K | $536.6K | −$42.3K | Cut−$329.6K |
| China Universal Asset Management Co., Ltd. | 29.2K | $529.7K | −$33.3K | Added$74.5K |
| Vanguard Investments Australia, Ltd. | 27.7K | $502.7K | — | Held |
| Trexquant Investment LP | 27.6K | $501.1K | −$39.5K | Cut−$1.47M |
| Orion Porfolio Solutions, LLC | 27K | $490.4K | — | New |
| ProShare Advisors LLC | 26.7K | $483.8K | −$38.2K | Cut−$82K |
| MARTINGALE ASSET MANAGEMENT L P | 25.7K | $465.1K | −$36K | Cut−$26.9K |
| KLP KAPITALFORVALTNING AS | 25.4K | $460.5K | −$36.3K | Cut−$36.3K |
| Elevate Capital Advisors, LLC | 24.6K | $446K | −$34.5K | Cut−$25.7K |
| Engineers Gate Manager LP | 24.4K | $442.7K | −$30.9K | Added$19.9K |
| Atom Investors LP | 24.1K | $436.5K | — | New |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 24K | $435.5K | −$29.5K | Added$32.5K |
| E Fund Management Co., Ltd. | 23K | $417K | — | Held |
| PRUDENTIAL FINANCIAL INC | 20.6K | $373K | — | New |
| PSP Research LLC | 20K | $362.6K | −$28.6K | Cut−$58.6K |
| Pictet Asset Management Holding SA | 19.4K | $351.2K | −$18.5K | Added$97.7K |
| Quantinno Capital Management LP | 19.3K | $349.9K | −$18K | Added$103.5K |
| Z3 Capital Partners, LLC | 19.1K | $346.7K | −$21.5K | Added$52.4K |
| LPL Financial LLC | 18.4K | $332.9K | −$21.8K | Added$34.6K |
| Lion Point Capital, LP | 18K | $326.3K | −$25.7K | Cut−$25.7K |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 17.2K | $312.1K | −$20.6K | Added$30.7K |
| Mariner, LLC | 16.1K | $291.7K | — | New |
| STIFEL FINANCIAL CORP | 16K | $290.6K | — | New |
| Rockefeller Capital Management L.P. | 15.2K | $274.9K | −$20.4K | Cut−$4.21K |
| Allianz Asset Management GmbH | 15K | $271.9K | −$21.4K | Cut−$21.4K |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 14.8K | $268.3K | −$21.2K | Cut−$46.1K |
| Virtus Investment Advisers, LLC | 14.2K | $256.5K | −$19.7K | Cut−$13.5K |
| Graham Capital Management, L.P. | 13.2K | $238.8K | −$18.8K | Cut−$468.6K |
| GUGGENHEIM CAPITAL LLC | 12.2K | $221.8K | −$15.8K | Added$5.29K |
| XPONANCE LLC | 12.2K | $221.3K | — | New |
| Inspire Advisors, LLC | 11.8K | $214.7K | — | New |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 11.8K | $214K | −$16.9K | Cut−$67.7K |
| Tower Research Capital LLC (TRC) | 11.6K | $210.8K | −$1.04K | Added$196.5K |
| CAPSTONE INVESTMENT ADVISORS, LLC | 11.2K | $203.4K | −$16K | Cut−$45K |
| Ameritas Investment Partners, Inc. | 10.9K | $197.7K | −$14.9K | Cut−$6.5K |
| Jump Financial, LLC | 10.6K | $192.4K | −$15.2K | Cut−$497.3K |
| Scientech Research LLC | 10.6K | $191.5K | — | New |
| Caitong International Asset Management Co., Ltd | 10.4K | $188.6K | — | New |
| STEPHENS INC /AR/ | 10.1K | $183.4K | — | New |
| FARALLON CAPITAL MANAGEMENT LLC | 10K | $181.3K | −$14.3K | Cut−$14.3K |
| Inspire Investing, LLC | 9.3K | $168.7K | — | New |
| Mirae Asset Global Investments Co., Ltd. | 8.59K | $155.7K | −$9.92K | Added$20K |
| Caption Management, LLC | 7.89K | $143.1K | −$3.58K | Added$94.2K |
| Steward Partners Investment Advisory, LLC | 6.88K | $124.7K | −$6.98K | Added$29.3K |
| Keating Financial Advisory Services, Inc. | 5.09K | $92.3K | −$7.15K | Cut−$5.46K |
| CWM, LLC | 4.43K | $80.3K | $72.9K | Added$80.2K |
| JONES FINANCIAL COMPANIES LLLP | 4.48K | $76.8K | −$2.9K | Added$53.3K |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 4.15K | $72.5K | — | New |
| IFP Advisors, Inc | 3.77K | $68.3K | −$136 | Added$66.4K |
| Sterling Capital Management LLC | 3.28K | $59.5K | −$4.69K | Cut−$41.6K |
| GF FUND MANAGEMENT CO. LTD. | 3.21K | $58.2K | −$4.01K | Added$3.28K |
| NISA INVESTMENT ADVISORS, LLC | 2.97K | $53.9K | −$4.25K | Cut−$151.5K |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2.33M | $42.2K | −$3.32K | Cut−$3.24K |
| Allworth Financial LP | 2.33K | $42.2K | −$800 | Added$31.3K |
| Chung Wu Investment Group, LLC | 2K | $36.3K | −$2.86K | Cut−$18.5K |
| SIMPLEX TRADING, LLC | 1.73K | $31.4K | −$2.48K | Cut−$148.2K |
| Hilton Head Capital Partners, LLC | 1.45K | $26.2K | — | New |
| OSAIC HOLDINGS, INC. | 1.29K | $23.4K | −$908 | Added$11K |
| Kemnay Advisory Services Inc. | 1.19K | $21.5K | — | New |
| Quantbot Technologies LP | 1.1K | $19.9K | — | New |
| GROUP ONE TRADING LLC | 1.07K | $19.5K | −$930 | Added$6.74K |
| GAMMA Investing LLC | 1.05K | $19K | −$1.2K | Added$2.57K |
| US BANCORP \DE\ | 965 | $17.5K | −$572 | Added$9.67K |
| PNC Financial Services Group, Inc. | 921 | $16.7K | −$597 | Added$8.52K |
| Versant Capital Management, Inc | 859 | $15.6K | −$1.23K | Cut−$1.23K |
| Larson Financial Group LLC | 796 | $14.4K | −$31 | Added$14K |
| Quarry LP | 750 | $13.6K | — | New |
| Smartleaf Asset Management LLC | 769 | $13.1K | −$1.17K | Added$2.49K |
| Geneos Wealth Management Inc. | 691 | $12.5K | −$197 | Added$9.83K |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 612 | $11.1K | −$3.32K | Cut−$311.4K |
| ALGERT GLOBAL LLC | 454.5K | $8.24K | −$389 | Added$2.93K |
| Essential Partners LLC | 445 | $8.07K | −$636 | Cut−$636 |
| FIRST HORIZON CORP | 409 | $7.42K | −$546 | Cut−$57 |
| Truvestments Capital LLC | 295 | $5.35K | −$422 | Cut−$422 |
| SIGNATUREFD, LLC | 278 | $5.04K | −$398 | Cut−$1.22K |
| MassMutual Private Wealth & Trust, FSB | 243 | $4.41K | −$347 | Cut−$347 |
| Western Wealth Management, LLC | 240 | $4.35K | — | New |
| Aspect Partners, LLC | 225 | $4.08K | −$322 | Cut−$322 |
| ROTHSCHILD INVESTMENT LLC | 210 | $3.81K | −$243 | Added$482 |
| NATIONAL BANK OF CANADA /FI/ | 200 | $3.62K | −$286 | Cut−$286 |
| SBI Securities Co., Ltd. | 159 | $2.88K | −$214 | Cut−$51 |
| WHITTIER TRUST CO OF NEVADA INC | 150 | $2.75K | — | New |
| Aster Capital Management (DIFC) Ltd | 226 | $2.36K | −$2.06K | Cut−$81.9K |
| EverSource Wealth Advisors, LLC | 115 | $2.08K | −$139 | Added$187 |
| MAI Capital Management | 113 | $2.05K | — | New |
| SG Americas Securities, LLC | 112.6K | $2.04K | −$161 | Cut−$3.15K |
| QUADRANT CAPITAL GROUP LLC | 67 | $1.22K | −$96 | Cut−$96 |
| DekaBank Deutsche Girozentrale | 60K | $1.09K | −$769 | Cut−$769 |
| Park Place Capital Corp | 47 | $852 | — | New |
| Cornerstone Financial Management LLC | 40 | $725 | −$57 | Cut−$57 |
| Advisory Services Network, LLC | 29 | $526 | — | New |
| Bare Financial Services, Inc | 28 | $508 | — | New |
| Parallel Advisors, LLC | 27 | $490 | −$38 | Cut−$38 |
| Fortitude Family Office, LLC | 25 | $453 | — | New |
| Farther Finance Advisors, LLC | 24 | $434 | −$26 | Added$101 |
| STONERIDGE INVESTMENT PARTNERS LLC | 16.6K | $301 | — | New |
| TWIN PEAKS WEALTH ADVISORS, LLC | 14 | $254 | — | New |
| True Wealth Design, LLC | 13 | $236 | −$19 | Cut−$19 |
| CREATIVE FINANCIAL DESIGNS INC /ADV | 10 | $181 | — | New |
| Hughes Financial Services, LLC | 6 | $109 | — | New |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 5.74K | $104 | −$8 | Cut−$8 |
| KBC Group NV | 3.4K | $62 | −$4 | Added$1 |