| Medicxi Ventures Management (Jersey) Ltd | 20M | $792.9M | $293.7M | Added$293.7M |
| Avoro Capital Advisors LLC | 11.4M | $454M | $168.1M | Added$90M |
| Index Venture Life Associates VI Ltd | 9.96M | $395.7M | $146.5M | Added$146.5M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 8.93M | $354.5M | $131.3M | Added$72.3M |
| Pentwater Capital Management LP | 8.17M | $324.5M | — | New |
| Fidelity | 6.85M | $272.2M | $100.8M | Added$48M |
| EcoR1 Capital, LLC | 6M | $238.3M | $45.8M | Added$160.4M |
| PERCEPTIVE ADVISORS LLC | 5.26M | $208.9M | $42.9M | Added$135.9M |
| Capital World Investors | 4.83M | $191.9M | $17M | Added$163M |
| FARALLON CAPITAL MANAGEMENT LLC | 4.81M | $191M | $70.7M | Added$56.5M |
| TCG Crossover Management, LLC | 4.29M | $170.3M | $63.1M | Added$63.1M |
| MORGAN STANLEY | 4.27M | $169.5M | $16.3M | Added$141.8M |
| Paradigm Biocapital Advisors LP | 3.57M | $142M | — | New |
| JANUS HENDERSON GROUP PLC | 3.49M | $138.7M | $51.4M | Added$36.3M |
| Deep Track Capital, LP | 3.16M | $125.4M | $29.4M | Added$75.4M |
| Logos Global Management LP | 2.13M | $84.4M | $2.94M | Added$79.4M |
| RTW INVESTMENTS, LP | 2.05M | $81.6M | $26.3M | Added$36.8M |
| FEDERATED HERMES, INC. | 2.05M | $81.4M | $30.1M | Added$22.8M |
| BRAIDWELL LP | 1.99M | $78.9M | $29.2M | Added$24.2M |
| BANK OF AMERICA CORP /DE/ | 1.93M | $76.8M | $14M | Added$53M |
| MAVERICK CAPITAL LTD | 1.85M | $73.7M | $24.2M | Added$32.6M |
| First Light Asset Management, LLC | 1.56M | $62M | $23M | Added$5.01M |
| Affinity Asset Advisors, LLC | 1.4M | $55.6M | $8.83M | Added$40.6M |
| Foresite Capital Management VI LLC | 1.36M | $54.2M | $20.1M | Added$20.1M |
| GENERAL ATLANTIC, L.P. | 1.35M | $53.8M | $19.9M | Cut−$99.2M |
| GOLDMAN SACHS GROUP INC | 1.14M | $45.5M | $11.5M | Added$26M |
| Siren, L.L.C. | 1.05M | $41.8M | $15.5M | Cut−$58.9M |
| Cormorant Asset Management, LP | 1.05M | $41.7M | $15.4M | Added$8.57M |
| ALPINE ASSOCIATES MANAGEMENT INC. | 865.5K | $34.4M | — | New |
| Woodline Partners LP | 859.1K | $34.1M | $8.51M | Added$19.7M |
| Balyasny Asset Management L.P. | 852.8K | $33.9M | $6.9M | Added$22.1M |
| Octagon Capital Advisors LP | 750K | $29.8M | $11M | Added$11M |
| MILLENNIUM MANAGEMENT LLC | 722.1K | $28.7M | $10.6M | Cut−$18.1M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 702.3K | $27.9M | — | New |
| AMERICAN CENTURY COMPANIES INC | 687.4K | $27.3M | $10.1M | Cut−$950.6K |
| FRANKLIN RESOURCES INC | 684.5K | $27.2M | $10.1M | Cut−$32M |
| BAKER BROS. ADVISORS LP | 670.8K | $26.6M | $9.87M | Added$9.87M |
| EVENTIDE ASSET MANAGEMENT, LLC | 668.1K | $26.5M | — | New |
| TORONTO DOMINION BANK | 654.9K | $26M | — | New |
| TIG Advisors, LLC | 648.3K | $25.8M | — | New |
| D. E. Shaw & Co., Inc. | 643.8K | $25.6M | $9.47M | Added$4.77M |
| Bain Capital Life Sciences Investors, LLC | 635K | $25.2M | — | New |
| Qube Research & Technologies Ltd | 628K | $24.9M | $5.57M | Added$15.5M |
| BlackRock, Inc. | 625.4K | $24.8M | $8.72M | Added$10M |
| Citadel | 598.2K | $23.8M | $7.65M | Added$10.8M |
| 5AM Venture Management, LLC | 580.9K | $23.1M | $8.55M | Added$8.55M |
| PFM Health Sciences, LP | 528.2K | $21M | $7.77M | Added$6.19M |
| Weiss Asset Management LP | 510.4K | $20.3M | — | New |
| Spruce Street Capital LP | 489.8K | $19.5M | $1.15M | Added$17.5M |
| SILVERARC CAPITAL MANAGEMENT, LLC | 466.3K | $18.5M | $6.74M | Added$7.06M |
| Trexquant Investment LP | 391K | $15.5M | $2.16M | Added$11.9M |
| UBS Group AG | 359.9K | $14.3M | $5.29M | Added$853.5K |
| Rock Springs Capital Management LP | 351.8K | $14M | $4.77M | Added$5.87M |
| JPMORGAN CHASE & CO | 477.6K | $13.2M | $209.4K | Added$11.1M |
| Alyeska Investment Group, L.P. | 320.4K | $12.7M | — | New |
| Point72 Asset Management, L.P. | 307.4K | $12.2M | — | New |
| ROYCE & ASSOCIATES LP | 278.1K | $11M | $4.09M | Added$1.97M |
| Caption Management, LLC | 274.1K | $10.9M | — | New |
| Nantahala Capital Management, LLC | 254.8K | $10.1M | $3.75M | Added$3.75M |
| TD Asset Management Inc | 242K | $9.61M | $3.56M | Added$201.6K |
| HighMark Wealth Management LLC | 236.8K | $9.41M | $3.48M | Added$3.48M |
| Eagle Health Investments LP | 214.3K | $8.51M | $1.52M | Added$5.93M |
| SummitTX Capital, L.P. | 206.8K | $8.22M | $3.04M | Cut−$105.1K |
| DEUTSCHE BANK AG\ | 190K | $7.55M | $2.3M | Added$3.64M |
| Renaissance Technologies | 185K | $7.35M | $2.72M | Added$362.9K |
| Schonfeld Strategic Advisors LLC | 171.9K | $6.83M | — | New |
| MARSHALL WACE, LLP | 168.2K | $6.68M | $2.47M | Added$1.27M |
| FRED ALGER MANAGEMENT, LLC | 168.2K | $6.68M | $2.39M | Added$2.62M |
| Holocene Advisors, LP | 160.9K | $6.39M | $1.49M | Added$3.85M |
| Atom Investors LP | 158.5K | $6.3M | $269.9K | Added$5.84M |
| BURKEHILL GLOBAL MANAGEMENT, LP | 150K | $5.96M | $2.21M | Added$2.21M |
| PLATINUM INVESTMENT MANAGEMENT LTD | 137.7K | $5.47M | $2.03M | Added$1.59M |
| LMR Partners LLP | 125K | $4.96M | — | New |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 112K | $4.45M | $1.65M | Cut−$4.26M |
| Freestone Grove Partners LP | 109.3K | $4.34M | — | New |
| Legal & General Group Plc | 110.2K | $4.32M | $1.5M | Added$1.68M |
| GEODE CAPITAL MANAGEMENT, LLC | 107.8K | $4.28M | $1.29M | Added$2.09M |
| AQR Arbitrage LLC | 98K | $3.89M | — | New |
| Y-Intercept (Hong Kong) Ltd | 96.4K | $3.83M | $168.3K | Added$3.54M |
| Caitong International Asset Management Co., Ltd | 93.7K | $3.72M | $47.3K | Added$3.64M |
| HARVEST MANAGEMENT LLC | 80K | $3.18M | — | New |
| CITIGROUP INC | 74.3K | $2.95M | $39.6K | Added$2.88M |
| Jain Global LLC | 71.5K | $2.84M | $1.05M | Cut−$20.1M |
| Pictet Asset Management Holding SA | 96.9K | $2.67M | — | New |
| TWO SIGMA INVESTMENTS, LP | 59.8K | $2.38M | $845K | Added$940.3K |
| Squarepoint Ops LLC | 50.6K | $2.01M | $744.4K | Cut−$36K |
| WATER ISLAND CAPITAL LLC | 41K | $1.63M | — | New |
| JANE STREET GROUP, LLC | 41K | $1.63M | $602.6K | Cut−$10.4M |
| BOOTHBAY FUND MANAGEMENT, LLC | 39.7K | $1.58M | $478.2K | Added$762.1K |
| Knott David M Jr | 39K | $1.55M | $58.8K | Added$1.45M |
| Russell Investments Group, Ltd. | 38.8K | $1.54M | $570.9K | Cut−$329.6K |
| ADAR1 Capital Management, LLC | 38.6K | $1.53M | $567.3K | Added$567.3K |
| Candriam S.C.A. | 36.3K | $1.44M | $533.3K | Cut−$8.45M |
| Buckland Partners Management Co LLC | 30K | $1.19M | — | New |
| VOYA INVESTMENT MANAGEMENT LLC | 29.7K | $1.18M | $436.4K | Added$436.4K |
| Cinctive Capital Management LP | 25.4K | $1.01M | $372.9K | Cut−$814.6K |
| Voleon Capital Management LP | 24.2K | $960.2K | $355.6K | Cut−$1.02M |
| Yakira Capital Management, Inc. | 24K | $953.3K | — | New |
| China Universal Asset Management Co., Ltd. | 21.2K | $843.1K | $231.3K | Added$449.9K |
| JBF Capital, Inc. | 20.9K | $829.6K | — | New |
| TORNO CAPITAL, LLC | 20K | $794.4K | — | New |
| Fortress Investment Group LLC | 20K | $794.4K | — | New |
| Crossmark Global Holdings, Inc. | 19.4K | $772K | — | New |
| Ikarian Capital, LLC | 18.1K | $719.4K | — | New |
| Meridian Wealth Partners, LLC | 18.1K | $719K | $266.3K | Added$266.3K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 17.7K | $704.5K | $170.1K | Added$415.3K |
| GABELLI FUNDS LLC | 17.6K | $699.1K | — | New |
| CSS LLC/IL | 17K | $675.2K | — | New |
| AMERIPRISE FINANCIAL INC | 16.9K | $671K | $248.5K | Cut−$6.33M |
| TD Waterhouse Canada Inc. | 15.6K | $621.9K | $14.9K | Added$596.9K |
| Greenland Capital Management LP | 15K | $595.8K | — | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 14K | $554.7K | $208.9K | Cut−$4.68M |
| Coastal Bridge Advisors, LLC | 13.1K | $520.4K | $192.7K | Added$169.4K |
| Aquatic Capital Management LLC | 12.7K | $504.4K | $186.8K | Cut−$1.24M |
| Atria Investments, Inc | 12.3K | $489.8K | $181.4K | Added$174.9K |
| DNB Asset Management AS | 10.4K | $412.9K | $152.9K | Added$94.1K |
| FOX RUN MANAGEMENT, L.L.C. | 14.9K | $411.3K | — | New |
| Virtus Investment Advisers, LLC | 10.3K | $408.6K | $147.6K | Added$157.6K |
| GABELLI & Co INVESTMENT ADVISERS, INC. | 9.4K | $373.4K | — | New |
| Bellevue Group AG | 9.03K | $358.7K | — | New |
| Rangeley Capital, LLC | 9K | $357.5K | — | New |
| AXQ CAPITAL, LP | 8.3K | $329.8K | — | New |
| Bank of New York Mellon Corp | 8.3K | $329.6K | $122.1K | Added$118.5K |
| Brooklyn Investment Group | 7.44K | $295.6K | — | New |
| Invesco Ltd. | 7.03K | $279.4K | — | New |
| Headlands Technologies LLC | 6.99K | $277.7K | — | New |
| ENVESTNET ASSET MANAGEMENT INC | 6.97K | $277K | — | New |
| BARCLAYS PLC | 6.92K | $274.9K | $16.3K | Added$247.2K |
| Allianz Asset Management GmbH | 6.9K | $274.1K | — | New |
| BBR PARTNERS, LLC | 6.55K | $260.2K | — | New |
| Mirae Asset Global Investments Co., Ltd. | 6.24K | $247.8K | $69K | Added$130.5K |
| Private Advisor Group, LLC | 6K | $238.3K | — | New |
| WELLS FARGO & COMPANY/MN | 6K | $238.3K | $49.8K | Added$153.6K |
| HighVista Strategies LLC | 5.96K | $236.9K | $87.7K | Cut−$875.8K |
| ProShare Advisors LLC | 5.35K | $212.5K | — | New |
| Empirical Asset Management, LLC | 5.08K | $201.9K | — | New |
| GAMMA Investing LLC | 3.98K | $158.1K | $53.2K | Added$67.7K |
| BNP PARIBAS FINANCIAL MARKETS | 2.48K | $98.6K | $36K | Added$37.4K |
| GF FUND MANAGEMENT CO. LTD. | 2.17K | $86K | $27.9K | Added$38.6K |
| Bayforest Capital Ltd | 1.95K | $77.3K | — | New |
| ROYAL BANK OF CANADA | 1.16K | $46K | $17K | Cut−$93K |
| ADIRONDACK TRUST CO | 925 | $36.7K | $13.6K | Added$13.6K |
| J.Safra Asset Management Corp | 397 | $15.8K | $1.46K | Added$13.3K |
| Glazer Capital, LLC | 325K | $12.9K | — | New |
| JONES FINANCIAL COMPANIES LLLP | 277 | $7.95K | — | New |
| T. Rowe Price Investment Management, Inc. | 170K | $6.75K | $22 | Added$6.71K |
| HRT FINANCIAL LP | 117K | $4.65K | $163 | Added$4.37K |
| Steward Partners Investment Advisory, LLC | 81 | $3.22K | $1.19K | Added$1.19K |
| Virtu Financial LLC | 67.8K | $2.69K | — | New |
| NBC SECURITIES, INC. | 60 | $2.38K | $883 | Added$883 |
| Tower Research Capital LLC (TRC) | 41 | $1.63K | $604 | Cut−$26.7K |
| SBI Securities Co., Ltd. | 30 | $1.19K | $368 | Added$567 |
| Aspect Partners, LLC | 30 | $1.19K | $442 | Cut−$3.69K |
| NATIONAL BANK OF CANADA /FI/ | 25 | $993 | $368 | Added$368 |
| SJS Investment Consulting Inc. | 22 | $874 | $220 | Added$498 |
| Farther Finance Advisors, LLC | 20 | $797 | $297 | Cut−$9.76K |
| Parallel Advisors, LLC | 15 | $596 | — | New |
| EverSource Wealth Advisors, LLC | 12 | $477 | $103 | Added$302 |
| SG Americas Securities, LLC | 3.08K | $122 | $45 | Cut−$6.47K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1 | $40 | $15 | Cut−$10.9K |