| Fidelity | 11.8M | $594.2M | $205.8M | Added$212.9M |
| BlackRock, Inc. | 5.52M | $278.5M | $97.6M | Added$97.6M |
| RTW INVESTMENTS, LP | 4.17M | $210.4M | $73.8M | Added$73.8M |
| Fairmount Funds Management LLC | 4.02M | $202.7M | $71M | Added$71M |
| PERCEPTIVE ADVISORS LLC | 3.78M | $190.8M | $54.3M | Added$90.3M |
| VR ADVISER, LLC | 3.69M | $185.9M | $65.2M | Added$65.2M |
| VANGUARD CAPITAL MANAGEMENT LLC | 3.06M | $154.2M | — | Held |
| Driehaus Capital Management LLC | 2.79M | $140.8M | $49.3M | Added$46.3M |
| State Street | 2.61M | $131.5M | $40M | Added$57.4M |
| Paradigm Biocapital Advisors LP | 1.96M | $98.7M | $25.9M | Added$50.7M |
| Commodore Capital LP | 1.91M | $96.5M | $33.8M | Added$18.2M |
| TCG Crossover Management, LLC | 1.9M | $95.9M | $33.6M | Added$33.6M |
| TANG CAPITAL MANAGEMENT LLC | 1.89M | $95.4M | $33.5M | Added$33.5M |
| WELLINGTON MANAGEMENT GROUP LLP | 1.82M | $92M | $27.4M | Added$41.3M |
| Capital International Investors | 1.75M | $88.1M | $30.9M | Cut−$26.3M |
| GEODE CAPITAL MANAGEMENT, LLC | 1.72M | $86.8M | $29.3M | Added$32.5M |
| JANUS HENDERSON GROUP PLC | 1.66M | $83.6M | $29.3M | Added$23.7M |
| RA CAPITAL MANAGEMENT, L.P. | 1.62M | $81.8M | $28.7M | Added$28.7M |
| Remedium Capital Partners, LLC | 1.46M | $73.5M | $73.4M | Added$73.4M |
| Affinity Asset Advisors, LLC | 1.28M | $64.5M | $22.6M | Added$17.6M |
| BANK OF AMERICA CORP /DE/ | 1.23M | $61.9M | $7.42M | Added$48.2M |
| BAKER BROS. ADVISORS LP | 1M | $50.4M | $17.7M | Added$17.7M |
| BRAIDWELL LP | 932.8K | $47.1M | $16.5M | Cut−$6.5M |
| FRANKLIN RESOURCES INC | 882.8K | $44.5M | $15.6M | Added$8.19M |
| JPMORGAN CHASE & CO | 979.3K | $44.5M | $797K | Added$42.4M |
| Caligan Partners LP | 878.1K | $44.3M | — | New |
| Siren, L.L.C. | 818.6K | $41.3M | $14.5M | Added$14.5M |
| Polar Capital Holdings Plc | 792.8K | $40M | $13.1M | Added$15.7M |
| UBS Group AG | 671.2K | $33.9M | $11.9M | Added$11.6M |
| Capital World Investors | 666.6K | $33.6M | $3.54M | Added$27.1M |
| EMERALD ADVISERS, LLC | 613.4K | $30.9M | $10.8M | Added$10.1M |
| Candriam S.C.A. | 610.3K | $30.8M | $7.52M | Added$16.8M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 585.1K | $29.5M | — | Held |
| NORTHERN TRUST CORP | 578.9K | $29.2M | $9.92M | Added$10.8M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 562.7K | $28.4M | $9.95M | Added$9.56M |
| Pictet Asset Management Holding SA | 491.6K | $24.8M | $8.69M | Cut−$5.14M |
| VANGUARD FIDUCIARY TRUST CO | 464.7K | $23.4M | — | Held |
| EMERALD MUTUAL FUND ADVISERS TRUST | 408.1K | $20.6M | $7.22M | Added$7.08M |
| SAMLYN CAPITAL, LLC | 396.7K | $20M | — | New |
| ADAR1 Capital Management, LLC | 338.3K | $17.1M | $602K | Added$15.9M |
| Blackstone Inc. | 292.8K | $14.8M | $5.18M | Cut−$1.64M |
| VICTORY CAPITAL MANAGEMENT INC | 292.1K | $14.7M | $2.58M | Added$9.95M |
| GOLDMAN SACHS GROUP INC | 269.9K | $13.6M | $4.77M | Added$4.6M |
| Woodline Partners LP | 265.9K | $13.4M | $4.7M | Added$4.7M |
| MORGAN STANLEY | 246.7K | $12.4M | $3.23M | Added$6.46M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 207.3K | $10.5M | $1.1M | Added$8.42M |
| BOOTHBAY FUND MANAGEMENT, LLC | 193K | $9.74M | — | New |
| Bank of New York Mellon Corp | 191.4K | $9.65M | $3.38M | Added$3.34M |
| SILVERARC CAPITAL MANAGEMENT, LLC | 186.6K | $9.41M | $3.3M | Added$3.26M |
| FIRST TRUST ADVISORS LP | 178.4K | $9M | — | New |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 170.4K | $8.59M | $3.01M | Added$2.99M |
| STEMPOINT CAPITAL LP | 167.6K | $8.45M | $572.4K | Added$7.39M |
| AMERIPRISE FINANCIAL INC | 159.2K | $8.03M | $676.4K | Added$6.78M |
| Nuveen, LLC | 153.9K | $7.76M | $2.67M | Added$2.82M |
| Ensign Peak Advisors, Inc | 148.5K | $7.49M | — | New |
| MILLENNIUM MANAGEMENT LLC | 146.6K | $7.4M | $1.35M | Added$4.9M |
| HighVista Strategies LLC | 146.3K | $7.38M | $2.59M | Added$1.21M |
| MARSHALL WACE, LLP | 139.3K | $7.02M | — | New |
| TD Asset Management Inc | 137.4K | $6.93M | $2.43M | Added$2.02M |
| Invesco Ltd. | 132.4K | $6.68M | $2.34M | Added$1.73M |
| DEUTSCHE BANK AG\ | 129.2K | $6.52M | $2.16M | Added$2.52M |
| ARMISTICE CAPITAL, LLC | 120.9K | $6.1M | $2.14M | Cut−$335.2K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 112.8K | $5.69M | $2.07M | Added$1.55M |
| Citadel | 108.1K | $5.45M | $1.13M | Added$3.36M |
| B Group, Inc. | 100K | $5.04M | $1.77M | Added$1.77M |
| SEVEN GRAND MANAGERS, LLC | 100K | $5.04M | $1.77M | Added$1.77M |
| F/m Investments LLC | 99.5K | $5.02M | $1.76M | Added$1.62M |
| Swiss National Bank | 96.5K | $4.87M | $1.71M | Added$1.71M |
| ExodusPoint Capital Management, LP | 87.1K | $4.39M | $669.6K | Added$3.15M |
| RHUMBLINE ADVISERS | 85.1K | $4.29M | $1.47M | Added$1.58M |
| MERCER GLOBAL ADVISORS INC /ADV | 71.1K | $3.59M | $1.26M | Added$102.9K |
| Atle Fund Management AB | 62.7K | $3.49M | — | New |
| Rockefeller Capital Management L.P. | 64K | $3.23M | $9.71K | Added$3.21M |
| ALPS ADVISORS INC | 63.9K | $3.23M | $1.13M | Added$1.14M |
| PRUDENTIAL FINANCIAL INC | 59.6K | $3M | — | New |
| FRED ALGER MANAGEMENT, LLC | 59.5K | $3M | — | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 59.2K | $2.99M | $849.3K | Added$1.41M |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 63.7K | $2.89M | $833.7K | Added$929.5K |
| Rafferty Asset Management, LLC | 56.9K | $2.87M | $944.3K | Added$1.12M |
| Balyasny Asset Management L.P. | 55.5K | $2.8M | $980.8K | Added$391.5K |
| VOYA INVESTMENT MANAGEMENT LLC | 54K | $2.72M | $482.3K | Added$1.83M |
| Susquehanna Portfolio Strategies, LLC | 53.1K | $2.68M | $938.8K | Added$938.8K |
| DIMENSIONAL FUND ADVISORS LP | 47.7K | $2.41M | $843.3K | Cut−$126.2K |
| ALLIANCEBERNSTEIN L.P. | 70.9K | $2.32M | $0 | Added$111.4K |
| BARCLAYS PLC | 45.8K | $2.31M | $809.5K | Cut−$3.67M |
| Legal & General Group Plc | 44.8K | $2.26M | $791.9K | Added$410.1K |
| MetLife Investment Management, LLC | 38.4K | $1.94M | $672K | Added$692K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 36.3K | $1.81M | $604.5K | Added$663.3K |
| VANGUARD ASSET MANAGEMENT, Ltd | 33.2K | $1.68M | — | Held |
| WELLS FARGO & COMPANY/MN | 33.2K | $1.68M | $587.1K | Cut−$1.02M |
| Vanguard Global Advisers, LLC | 31.1K | $1.57M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 29K | $1.46M | $108K | Added$1.26M |
| Cinctive Capital Management LP | 27.4K | $1.38M | $485K | Added$206.3K |
| STATE OF WISCONSIN INVESTMENT BOARD | 26.5K | $1.34M | $468.9K | Added$445K |
| PROFUND ADVISORS LLC | 26K | $1.31M | $364.1K | Added$639K |
| Waverly Advisors, LLC | 26K | $1.31M | $458.9K | Added$459.5K |
| XTX Topco Ltd | 24.4K | $1.23M | — | New |
| NEW YORK STATE COMMON RETIREMENT FUND | 22.3K | $1.12M | $338.8K | Added$495.2K |
| Ellsworth Advisors, LLC | 22K | $1.11M | — | New |
| Icahn Capital | 20.9K | $1.05M | $315.1K | Added$469.1K |
| RAYMOND JAMES FINANCIAL INC | 19.8K | $996.4K | — | New |
| Seven Fleet Capital Management LP | 19.7K | $993.2K | — | New |
| Assenagon Asset Management S.A. | 18.6K | $940.6K | $329.7K | Added$215.4K |
| BNP PARIBAS FINANCIAL MARKETS | 18.6K | $939.7K | $209.4K | Added$551.7K |
| Police & Firemen's Retirement System of New Jersey | 18.4K | $926.1K | $324.6K | Added$324.6K |
| Global Endowment Management, LP | 18.2K | $917K | $321K | Added$321K |
| KENNEDY CAPITAL MANAGEMENT LLC | 16.9K | $851.1K | — | New |
| State of New Jersey Common Pension Fund D | 16.7K | $843.4K | $295.2K | Added$296.3K |
| INTECH INVESTMENT MANAGEMENT LLC | 16.4K | $829.4K | $290.7K | Added$230.7K |
| Creative Planning | 15.5K | $781.1K | — | New |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 14K | $703.9K | $197.4K | Added$338.2K |
| China Universal Asset Management Co., Ltd. | 13.9K | $703K | $223.5K | Added$288.8K |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 13.9K | $701.4K | $159.7K | Added$405.5K |
| ProShare Advisors LLC | 13.5K | $680.8K | $238.6K | Added$157K |
| ARIZONA STATE RETIREMENT SYSTEM | 13.4K | $677.8K | $237.6K | Added$225.8K |
| Vanguard Investments Australia, Ltd. | 12.8K | $646.3K | — | Held |
| BROWN ADVISORY INC | 12.4K | $625.5K | — | New |
| CITIGROUP INC | 12K | $605.6K | $212.3K | Cut−$2.67M |
| KLP KAPITALFORVALTNING AS | 10.9K | $549.8K | $183.9K | Added$209.1K |
| Russell Investments Group, Ltd. | 9.93K | $500.9K | $98.2K | Added$319K |
| Carlyle Group Inc. | 9.62K | $485.2K | $170.2K | Added$170.2K |
| Man Group plc | 9.55K | $481.5K | — | New |
| MARTINGALE ASSET MANAGEMENT L P | 9.08K | $458K | $122.5K | Added$231K |
| SEI INVESTMENTS CO | 8.97K | $452.7K | $108.1K | Added$252.3K |
| Tower Research Capital LLC (TRC) | 8.79K | $443.4K | $7.51K | Added$429.4K |
| Bridgefront Capital, LLC | 8.65K | $436.4K | — | New |
| TUDOR INVESTMENT CORP ET AL | 8.36K | $421.9K | $147.9K | Added$90.1K |
| RWC Asset Management LLP | 8.17K | $411.9K | — | New |
| Virtus Investment Advisers, LLC | 8.11K | $409.1K | $139.9K | Added$149.8K |
| CAPSTONE INVESTMENT ADVISORS, LLC | 7.54K | $380.2K | — | New |
| E Fund Management Co., Ltd. | 7.16K | $360.9K | — | Held |
| Scientech Research LLC | 7.09K | $357.5K | — | New |
| TWO SIGMA SECURITIES, LLC | 6.85K | $345.6K | — | New |
| AlphaCentric Advisors LLC | 6.63K | $334.6K | — | New |
| XPONANCE LLC | 6.45K | $325.1K | — | New |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 6.28K | $316.8K | $111K | Added$81.8K |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 6.14K | $309.7K | $108.6K | Cut−$139.9K |
| High Net Worth Advisory Group LLC | 6K | $302.6K | — | New |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 5.86K | $295.5K | $153.4K | Cut−$17K |
| Ameritas Investment Partners, Inc. | 5.59K | $282.1K | $98.9K | Added$98.9K |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 5.2K | $262.3K | — | New |
| PSP Research LLC | 5.16K | $260.2K | $91.2K | Cut−$258.7K |
| Persistent Asset Partners Ltd | 4.8K | $242.3K | $39.7K | Added$168.7K |
| DeepCurrents Investment Group LLC | 4.74K | $239.1K | — | New |
| Quantinno Capital Management LP | 4.56K | $230.1K | — | New |
| STRS OHIO | 4.5K | $227K | — | New |
| Vanguard Personalized Indexing Management, LLC | 4.4K | $221.8K | — | New |
| PRINCIPAL FINANCIAL GROUP INC | 4.3K | $216.8K | — | New |
| Mirae Asset Global Investments Co., Ltd. | 4.1K | $206.7K | $66.7K | Added$83.1K |
| ABS Direct Equity Fund LLC | 2.8K | $193.6K | — | New |
| ROYAL BANK OF CANADA | 3.25K | $164K | $35.3K | Added$99K |
| Union Bancaire Privee, UBP SA | 3.88K | $158.8K | — | New |
| CWM, LLC | 2.1K | $106.2K | $99.3K | Added$106.1K |
| NISA INVESTMENT ADVISORS, LLC | 1.92K | $96.6K | $12.5K | Added$73.5K |
| GF FUND MANAGEMENT CO. LTD. | 1.74K | $87.9K | $26.9K | Added$38K |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.6M | $80.6K | $28.3K | Added$28.2K |
| Sterling Capital Management LLC | 1.05K | $53K | $18.6K | Added$268 |
| Patient Square Capital LP | 1K | $50.4K | $17.7K | Cut−$4.86M |
| GROUP ONE TRADING LLC | 901 | $45.4K | $7.07K | Added$32.3K |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 888 | $44.8K | $33.1K | Added$44.8K |
| Neo Ivy Capital Management | 598 | $30.2K | $10.6K | Cut−$568.1K |
| Kemnay Advisory Services Inc. | 574 | $29K | — | New |
| SUMMIT SECURITIES GROUP LLC | 562 | $28.3K | — | New |
| GAMMA Investing LLC | 523 | $26.4K | $5.83K | Added$15.6K |
| OSAIC HOLDINGS, INC. | 498 | $25.1K | $6.49K | Added$13.1K |
| Optiver Holding B.V. | 288 | $14.5K | $4.24K | Added$6.67K |
| Caitong International Asset Management Co., Ltd | 286 | $14.4K | — | New |
| Delos Wealth Advisors, LLC | 250 | $12.6K | — | New |
| QUADRANT CAPITAL GROUP LLC | 146 | $7.37K | — | New |
| Smartleaf Asset Management LLC | 157 | $7.13K | — | New |
| PNC Financial Services Group, Inc. | 123 | $6.2K | $1.52K | Added$3.39K |
| Allworth Financial LP | 117 | $5.9K | $1.02K | Added$4K |
| ROTHSCHILD INVESTMENT LLC | 99 | $4.99K | $1.45K | Added$2.31K |
| US BANCORP \DE\ | 97 | $4.89K | $176 | Added$4.56K |
| Quantbot Technologies LP | 88 | $4.44K | — | New |
| EverSource Wealth Advisors, LLC | 79 | $3.98K | $1.15K | Added$1.85K |
| Farther Finance Advisors, LLC | 74 | $3.62K | $597 | Added$2.41K |
| SIGNATUREFD, LLC | 70 | $3.53K | $1.24K | Added$1.24K |
| Larson Financial Group LLC | 36 | $1.82K | $637 | Cut−$2.9K |
| Parkside Financial Bank & Trust | 35 | $1.77K | $621 | Added$621 |
| Parallel Advisors, LLC | 32 | $1.61K | — | New |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 25.8K | $1.3K | $456 | Added$456 |
| IFP Advisors, Inc | 24 | $1.21K | $425 | Added$425 |
| Arax Advisory Partners | 18 | $908 | — | New |
| Bare Financial Services, Inc | 16 | $807 | — | New |
| SG Americas Securities, LLC | 13.4K | $676 | $237 | Cut−$89 |
| MAI Capital Management | 13 | $656 | — | New |
| Virtu Financial LLC | 8.09K | $408 | — | New |
| SBI Securities Co., Ltd. | 5 | $252 | $88 | Added$88 |
| FIFTH THIRD BANCORP | 5 | $252 | — | New |
| Keating Financial Advisory Services, Inc. | 4 | $202 | — | New |
| MassMutual Private Wealth & Trust, FSB | 3 | $151 | — | New |
| TWIN PEAKS WEALTH ADVISORS, LLC | 3 | $151 | — | New |
| Essential Partners LLC | 2 | $101 | — | New |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 1.59K | $80 | $28 | Added$28 |
| KBC Group NV | 1.37K | $69 | — | New |
| Covestor Ltd | 4 | $0 | $0 | Held |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | $0 | — | Held |