| RA CAPITAL MANAGEMENT, L.P. | 9.91M | $397.1M | −$10.4M | Cut−$10.4M |
| TPG GP A, LLC | 6.49M | $260.4M | −$6.82M | Cut−$17.1M |
| ORBIMED ADVISORS LLC | 3.53M | $141.5M | −$3.71M | Cut−$4.98M |
| Viking Global | 3.2M | $128.1M | −$3.35M | Cut−$3.35M |
| Atlas Venture Life Science Advisors, LLC | 3M | $120.1M | −$3.15M | Cut−$3.15M |
| ENAVATE SCIENCES GP, LLC | 2.48M | $99.3M | −$2.6M | Cut−$2.6M |
| JENNISON ASSOCIATES LLC | 1.45M | $58.2M | −$1.17M | Added$12.3M |
| JPMORGAN CHASE & CO | 1.47M | $53.7M | −$5.52M | Added$3.03M |
| BlackRock, Inc. | 1.3M | $52M | −$1.36M | Cut−$1.19M |
| Citadel | 1.17M | $46.8M | −$1.14M | Added$2.05M |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.03M | $41.3M | — | Held |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 970.6K | $38.9M | −$1.02M | Cut−$1.02M |
| State Street | 756.2K | $30.3M | −$728.1K | Added$1.79M |
| PERCEPTIVE ADVISORS LLC | 658.4K | $26.4M | −$691.4K | Cut−$22.1M |
| EVENTIDE ASSET MANAGEMENT, LLC | 645.5K | $25.9M | −$674.4K | Cut−$414.4K |
| Aberdeen Group plc | 564.2K | $22.6M | −$592.4K | Cut−$11.9M |
| BAKER BROS. ADVISORS LP | 400K | $16M | −$420K | Cut−$420K |
| GEODE CAPITAL MANAGEMENT, LLC | 389.9K | $15.6M | −$399.1K | Cut−$4.88K |
| Siren, L.L.C. | 300K | $12M | −$315K | Cut−$315K |
| Sio Capital Management, LLC | 294.3K | $11.8M | — | New |
| Soleus Capital Management, L.P. | 293.5K | $11.8M | −$281.9K | Added$720.3K |
| GOLDMAN SACHS GROUP INC | 263.2K | $10.6M | −$38.1K | Added$9.06M |
| Ensign Peak Advisors, Inc | 255.6K | $10.2M | −$83.9K | Added$6.96M |
| Candriam S.C.A. | 236.8K | $9.49M | — | New |
| Kalehua Capital Management LLC | 197.1K | $7.9M | −$206.9K | Cut−$206.9K |
| FRANKLIN RESOURCES INC | 175.5K | $7.04M | −$184.3K | Cut−$184.3K |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 150K | $6.01M | — | New |
| UBS Group AG | 147.6K | $5.92M | −$93.6K | Added$2.25M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 142.1K | $5.7M | — | Held |
| SUPERSTRING CAPITAL MANAGEMENT LP | 141K | $5.65M | −$148.1K | Cut−$1.78M |
| MILLENNIUM MANAGEMENT LLC | 140.6K | $5.64M | −$84.6K | Added$2.32M |
| Point72 Asset Management, L.P. | 136.5K | $5.47M | — | New |
| Alyeska Investment Group, L.P. | 136.2K | $5.46M | −$143K | Cut−$143K |
| GordonMD Global Investments LP | 136K | $5.45M | — | New |
| MORGAN STANLEY | 133K | $5.33M | −$52.4K | Added$3.28M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 120.3K | $4.82M | −$126.3K | Cut−$267.5K |
| Artia Global Partners LP | 119.7K | $4.8M | −$125.7K | Cut−$125.7K |
| NORTHERN TRUST CORP | 116.8K | $4.68M | −$117.7K | Added$69.1K |
| VANGUARD FIDUCIARY TRUST CO | 112.2K | $4.5M | — | Held |
| Rock Springs Capital Management LP | 99.4K | $3.99M | −$104.4K | Cut−$104.4K |
| Rhenman & Partners Asset Management AB | 87.5K | $3.51M | — | New |
| TD Asset Management Inc | 83K | $3.33M | −$87.1K | Cut−$1.34M |
| AMERIPRISE FINANCIAL INC | 82K | $3.29M | −$86.1K | Cut−$895.3K |
| Fidelity | 81.4K | $3.26M | −$403 | Added$3.25M |
| Driehaus Capital Management LLC | 76.6K | $3.07M | −$80.5K | Cut−$377.4K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 64.5K | $2.58M | −$82.6K | Cut−$288K |
| BANK OF AMERICA CORP /DE/ | 50.9K | $2.04M | −$45.7K | Added$247K |
| Integral Health Asset Management, LLC | 50K | $2M | — | New |
| SEVEN GRAND MANAGERS, LLC | 50K | $2M | −$52.5K | Cut−$52.5K |
| Ishara Investments LP | 49.2K | $1.97M | — | New |
| Russell Investments Group, Ltd. | 48.4K | $1.94M | −$23.1K | Added$1.04M |
| WELLINGTON MANAGEMENT GROUP LLP | 46.1K | $1.85M | −$40.3K | Added$269.7K |
| Qube Research & Technologies Ltd | 42.2K | $1.69M | — | New |
| BNP PARIBAS FINANCIAL MARKETS | 40.6K | $1.63M | −$2.38K | Added$1.53M |
| SILVERARC CAPITAL MANAGEMENT, LLC | 39.4K | $1.58M | −$41.4K | Cut−$125.4K |
| ALPS ADVISORS INC | 36.6K | $1.47M | −$38.5K | Cut−$39.3K |
| STEMPOINT CAPITAL LP | 36.5K | $1.46M | — | New |
| Bank of New York Mellon Corp | 33.8K | $1.35M | −$35.5K | Cut−$91.3K |
| POLEN CAPITAL MANAGEMENT LLC | 26.8K | $1.07M | −$28.1K | Cut−$212.5K |
| Maven Securities LTD | 25K | $1M | — | New |
| Nuveen, LLC | 23.7K | $951.5K | −$24.9K | Cut−$24.9K |
| XTX Topco Ltd | 23.6K | $944.2K | −$5.17K | Added$741.5K |
| Rafferty Asset Management, LLC | 22.1K | $887.5K | −$23.2K | Cut−$128.3K |
| BARCLAYS PLC | 18.4K | $737.1K | −$19.3K | Cut−$1.24M |
| RHUMBLINE ADVISERS | 18.3K | $734K | −$18.6K | Added$6.03K |
| CITIGROUP INC | 18.1K | $723.9K | −$5.44K | Added$510.6K |
| ALLIANCEBERNSTEIN L.P. | 16.4K | $675.1K | −$1 | Added$32.5K |
| Squarepoint Ops LLC | 15.2K | $610K | −$16K | Cut−$63K |
| Walleye Capital LLC | 15.1K | $605.2K | — | New |
| DEUTSCHE BANK AG\ | 13.2K | $531.2K | −$10.5K | Added$118.6K |
| Longaeva Partners L.P. | 12.7K | $508.9K | −$13.3K | Cut−$2.77M |
| KENNEDY CAPITAL MANAGEMENT LLC | 12.3K | $492.5K | −$7.09K | Added$214.7K |
| Vanguard Global Advisers, LLC | 11.2K | $448.6K | — | Held |
| Invesco Ltd. | 10.8K | $432.5K | −$11.3K | Cut−$4.14M |
| PROFUND ADVISORS LLC | 9.94K | $398.5K | −$9.67K | Added$19.4K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9.19K | $362.9K | −$14.8K | Cut−$4.18K |
| MetLife Investment Management, LLC | 8.56K | $343.4K | −$8.99K | Cut−$8.99K |
| China Universal Asset Management Co., Ltd. | 7.92K | $317.5K | −$8.32K | Cut−$105.1K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 7.31K | $293.1K | — | New |
| ExodusPoint Capital Management, LP | 7.19K | $288.2K | — | New |
| VARCOV Co. | 6.57K | $263.4K | — | New |
| Virtus Investment Advisers, LLC | 6.37K | $255.5K | −$6.53K | Cut−$357 |
| Quarry LP | 6.3K | $252.7K | — | New |
| Hudson Bay Capital Management LP | 6.18K | $247.8K | — | New |
| WELLS FARGO & COMPANY/MN | 5.89K | $236.3K | −$6.19K | Cut−$485.8K |
| TWO SIGMA INVESTMENTS, LP | 5.5K | $220.5K | −$5.77K | Cut−$42.8K |
| INTECH INVESTMENT MANAGEMENT LLC | 5.49K | $220.1K | −$5.76K | Cut−$92.2K |
| NEW YORK STATE COMMON RETIREMENT FUND | 5.3K | $212.5K | −$5.56K | Cut−$5.57K |
| AlphaCentric Advisors LLC | 4.82K | $193.2K | −$2.86K | Added$81.3K |
| Police & Firemen's Retirement System of New Jersey | 4.23K | $169.7K | −$4.44K | Cut−$4.44K |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 4.12K | $165K | $8.56K | Cut−$32.2K |
| STRS OHIO | 2.9K | $116.3K | — | New |
| Tower Research Capital LLC (TRC) | 2.35K | $94.3K | −$1.19K | Added$47.8K |
| Mirae Asset Global Investments Co., Ltd. | 2.33K | $93.3K | −$2.28K | Added$4.1K |
| Legal & General Group Plc | 1.43K | $57.4K | −$1.56K | Cut−$11.8K |
| Ameritas Investment Partners, Inc. | 1.3K | $52.2K | −$1.37K | Cut−$1.37K |
| GF FUND MANAGEMENT CO. LTD. | 1K | $40.2K | −$920 | Added$4.17K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 868 | $34.8K | −$911 | Cut−$5.85K |
| PRICE T ROWE ASSOCIATES INC /MD/ | 756.4K | $30.3K | −$794 | Cut−$3.88K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 371 | $14.9K | — | New |
| Steward Partners Investment Advisory, LLC | 254 | $10.2K | — | New |
| Rockefeller Capital Management L.P. | 241 | $9.66K | −$51 | Added$7.69K |
| GAMMA Investing LLC | 238 | $9.54K | −$186 | Added$2.26K |
| Farther Finance Advisors, LLC | 196 | $8.1K | $30 | Added$278 |
| Quantbot Technologies LP | 178 | $7.14K | — | New |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 116 | $4.65K | — | New |
| Sterling Capital Management LLC | 105 | $4.21K | −$111 | Cut−$111 |
| CWM, LLC | 67 | $2.69K | $2.68K | Added$2.68K |
| US BANCORP \DE\ | 51 | $2.04K | −$53 | Cut−$629 |
| Caitong International Asset Management Co., Ltd | 36 | $1.44K | — | New |
| Allworth Financial LP | 29 | $1.16K | −$29 | Added$11 |
| Hughes Financial Services, LLC | 26 | $1.04K | −$27 | Added$13 |
| ROYAL BANK OF CANADA | 30 | $1K | −$288 | Cut−$20K |
| SIGNATUREFD, LLC | 24 | $962 | — | New |
| EverSource Wealth Advisors, LLC | 23 | $922 | −$21 | Added$99 |
| PNC Financial Services Group, Inc. | 16 | $641 | −$6 | Added$435 |
| Fortitude Family Office, LLC | 15 | $601 | — | New |
| Root Financial Partners, LLC | 10 | $401 | — | New |
| Cygnus Capital Advisors, LLC | 3.8K | $152 | −$3 | Added$53 |
| MAI Capital Management | 2 | $81 | — | New |
| ROTHSCHILD INVESTMENT LLC | 1 | $40 | −$1 | Cut−$1 |
| Covestor Ltd | 3 | $0 | — | New |