| RTW INVESTMENTS, LP | 13.3M | $278.2M | $18M | Added$265M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 12.8M | $268M | $127.9M | Added$174M |
| Boxer Capital Management, LLC | 10.9M | $227.5M | $131.2M | Added$131.2M |
| TCG Crossover Management, LLC | 10.5M | $220.3M | $127M | Added$107.2M |
| Fidelity | 9.91M | $207.2M | $34.6M | Added$181.8M |
| FARALLON CAPITAL MANAGEMENT LLC | 9.1M | $190.3M | $109.7M | Added$74.6M |
| BlackRock, Inc. | 8.75M | $183M | $103M | Added$107.3M |
| Woodline Partners LP | 8M | $167.4M | $96.5M | Added$78.1M |
| Nextech Invest, Ltd. | 7.27M | $152M | $87.6M | Added$87.6M |
| TRV GP IV, LLC | 6.37M | $133.4M | $76.9M | Added$63.6M |
| Siren, L.L.C. | 5.66M | $118.3M | $68.2M | Added$46M |
| VANGUARD CAPITAL MANAGEMENT LLC | 5.16M | $108M | — | Held |
| GOLDMAN SACHS GROUP INC | 5.08M | $106.2M | $59.6M | Added$62.4M |
| State Street | 4.65M | $97.3M | $56.1M | Added$42.2M |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 4.15M | $86.8M | $35.1M | Added$61M |
| Paradigm Biocapital Advisors LP | 4.01M | $83.9M | — | New |
| Holocene Advisors, LP | 3.93M | $82.3M | — | New |
| Balyasny Asset Management L.P. | 3.83M | $80.1M | $46.1M | Added$33.3M |
| Logos Global Management LP | 3M | $62.8M | $36.2M | Added$25.5M |
| Deep Track Capital, LP | 2.75M | $57.5M | $29.6M | Added$35.8M |
| GEODE CAPITAL MANAGEMENT, LLC | 2.68M | $56M | $30.8M | Added$33.4M |
| Caligan Partners LP | 2.41M | $50.4M | $29.1M | Added$17.3M |
| Bellevue Group AG | 2.4M | $50.2M | $28.9M | Added$15.4M |
| JANUS HENDERSON GROUP PLC | 2.39M | $50.1M | $28.8M | Added$26.6M |
| Vivo Capital, LLC | 2.15M | $45.1M | $26M | Added$26M |
| MORGAN STANLEY | 1.48M | $30.9M | $17.1M | Added$18.3M |
| Cormorant Asset Management, LP | 1.43M | $29.8M | — | New |
| FRANKLIN RESOURCES INC | 1.3M | $27.1M | $15.6M | Added$14.7M |
| Candriam S.C.A. | 1.27M | $26.6M | $8.55M | Added$20.3M |
| Nantahala Capital Management, LLC | 1.25M | $26.2M | $15.1M | Cut−$5.49M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 901.5K | $18.9M | — | Held |
| NORTHERN TRUST CORP | 862.9K | $18.1M | $9.69M | Added$10.9M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 838.7K | $17.5M | $10.1M | Added$10.1M |
| PERCEPTIVE ADVISORS LLC | 808.2K | $16.9M | $6.19M | Added$12.4M |
| Seven Fleet Capital Management LP | 802.7K | $16.8M | $2.59M | Added$14.9M |
| ArrowMark Colorado Holdings LLC | 708.4K | $14.8M | $8.54M | Added$8.54M |
| UBS Group AG | 699.4K | $14.6M | $8.43M | Added$5.85M |
| VANGUARD FIDUCIARY TRUST CO | 662.9K | $13.9M | — | Held |
| Invesco Ltd. | 580.5K | $12.1M | $2.14M | Added$10.6M |
| BOOTHBAY FUND MANAGEMENT, LLC | 571.4K | $12M | $6.89M | Added$3.47M |
| Point72 Asset Management, L.P. | 533.9K | $11.2M | $6.44M | Cut−$6.32M |
| AMERIPRISE FINANCIAL INC | 506.2K | $10.6M | — | New |
| DIMENSIONAL FUND ADVISORS LP | 489.3K | $10.2M | $5.87M | Added$5.92M |
| Integral Health Asset Management, LLC | 450K | $9.41M | $2.41M | Added$7.64M |
| Soleus Capital Management, L.P. | 450K | $9.41M | $120.6K | Added$9.33M |
| ACUTA CAPITAL PARTNERS, LLC | 441.8K | $9.24M | $3.41M | Added$6.74M |
| MILLENNIUM MANAGEMENT LLC | 425.6K | $8.9M | $5.13M | Added$3.65M |
| PFM Health Sciences, LP | 406.2K | $8.5M | — | New |
| Sofinnova Investments, Inc. | 395.1K | $8.27M | — | New |
| Rock Springs Capital Management LP | 386.9K | $8.09M | $4.67M | Added$4.67M |
| Nuveen, LLC | 360.8K | $7.55M | $3.62M | Added$4.89M |
| Connor, Clark & Lunn Investment Management Ltd. | 355.2K | $7.43M | $1.56M | Added$6.28M |
| Mass General Brigham, Inc | 354.2K | $7.41M | $4.27M | Added$4.27M |
| SPHERA FUNDS MANAGEMENT LTD. | 343.6K | $7.19M | $4.14M | Added$2.36M |
| CONGRESS ASSET MANAGEMENT CO | 341.4K | $7.14M | $2.83M | Added$5.06M |
| BANK OF AMERICA CORP /DE/ | 327.1K | $6.84M | $3.95M | Added$2.61M |
| Bank of New York Mellon Corp | 318.5K | $6.66M | $3.84M | Added$3.62M |
| DV Trading LLC | 300.6K | $6.29M | — | New |
| WELLINGTON MANAGEMENT GROUP LLP | 289.2K | $6.05M | $2.82M | Added$3.98M |
| Parkman Healthcare Partners LLC | 266.1K | $5.57M | — | New |
| KVP Capital Advisors, LP | 230.3K | $4.82M | — | New |
| Cinctive Capital Management LP | 222.1K | $4.65M | — | New |
| STEMPOINT CAPITAL LP | 200.9K | $4.2M | — | New |
| TRV GP VI, LLC | 194.2K | $4.06M | $2.34M | Added$2.34M |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 207.5K | $3.99M | — | New |
| Citadel | 179.4K | $3.75M | $1.83M | Added$2.41M |
| Squarepoint Ops LLC | 178.9K | $3.74M | $2.1M | Added$2.2M |
| VOYA INVESTMENT MANAGEMENT LLC | 175.5K | $3.67M | $576.6K | Added$3.25M |
| Atle Fund Management AB | 29.9K | $3.63M | — | New |
| TWO SIGMA INVESTMENTS, LP | 173.1K | $3.62M | $1.74M | Added$2.34M |
| Informed Momentum Co LLC | 168K | $3.51M | — | New |
| Fisher Asset Management, LLC | 162.4K | $3.4M | $1.96M | Added$1.73M |
| FRED ALGER MANAGEMENT, LLC | 150.1K | $3.14M | — | New |
| RHUMBLINE ADVISERS | 126.6K | $2.65M | $1.53M | Added$1.5M |
| Schonfeld Strategic Advisors LLC | 120.7K | $2.52M | — | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 108.2K | $2.26M | $390K | Added$1.98M |
| Icahn Capital | 107.3K | $2.24M | $991.7K | Added$1.52M |
| Rafferty Asset Management, LLC | 105K | $2.2M | $1.27M | Added$188.1K |
| HighVista Strategies LLC | 104.2K | $2.18M | — | New |
| TD Asset Management Inc | 102.6K | $2.15M | — | New |
| DEUTSCHE BANK AG\ | 90K | $1.88M | $894.9K | Added$1.22M |
| Swiss National Bank | 87.8K | $1.84M | $1.06M | Added$1.06M |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 86.3K | $1.81M | $424.7K | Added$1.49M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 75.7K | $1.58M | $499.9K | Added$1.22M |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 63.2K | $1.32M | $818.7K | Added$810.5K |
| JPMORGAN CHASE & CO | 67.3K | $1.29M | $588.2K | Added$789.8K |
| MetLife Investment Management, LLC | 60.7K | $1.27M | $719.9K | Added$740.8K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 59.5K | $1.23M | $708.2K | Added$680.9K |
| Vanguard Global Advisers, LLC | 55.8K | $1.17M | — | Held |
| Creative Planning | 52.9K | $1.11M | $505.4K | Added$735.5K |
| VICTORY CAPITAL MANAGEMENT INC | 52.8K | $1.1M | $123.1K | Added$1.01M |
| Atom Investors LP | 52.8K | $1.1M | — | New |
| ADAR1 Capital Management, LLC | 50K | $1.05M | $603K | Cut−$194.6K |
| ALLIANCEBERNSTEIN L.P. | 117.6K | $1.04M | $0 | Added$98.6K |
| PROFUND ADVISORS LLC | 47.7K | $998.6K | $575.7K | Added$256.5K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 47.7K | $997.7K | $575.2K | Added$570.6K |
| SmartHarvest Portfolios, LLC | 46.4K | $970K | $556.2K | Added$561.4K |
| STATE OF WISCONSIN INVESTMENT BOARD | 45.3K | $948.7K | $353.8K | Added$688.8K |
| WELLS FARGO & COMPANY/MN | 42K | $878.1K | $506.2K | Cut−$195.7K |
| INTECH INVESTMENT MANAGEMENT LLC | 38K | $794.1K | $457.8K | Added$449.1K |
| Rockefeller Capital Management L.P. | 36.3K | $760.2K | $10.7K | Added$752.4K |
| Legal & General Group Plc | 35.4K | $740K | $426.6K | Added$390.7K |
| NEW YORK STATE COMMON RETIREMENT FUND | 33.5K | $700.3K | $296.4K | Added$482.6K |
| ALLSTATE CORP | 32K | $670.4K | — | New |
| SEI INVESTMENTS CO | 32K | $668.6K | $385.5K | Added$190.9K |
| BNP PARIBAS FINANCIAL MARKETS | 30.6K | $640.7K | $115.3K | Added$555.9K |
| Police & Firemen's Retirement System of New Jersey | 30.4K | $634.9K | $341.2K | Added$384.2K |
| VANGUARD ASSET MANAGEMENT, Ltd | 29.6K | $619.3K | — | Held |
| Virtus Investment Advisers, LLC | 29.2K | $610.1K | $343.1K | Added$358K |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 27.3K | $571.1K | $329.2K | Added$322.8K |
| EverSource Wealth Advisors, LLC | 26K | $544.5K | $309.3K | Added$317.2K |
| Harvest Investment Services, LLC | 25.4K | $530.9K | — | New |
| China Universal Asset Management Co., Ltd. | 23.9K | $500K | $264.7K | Added$305.5K |
| Vanguard Personalized Indexing Management, LLC | 23.5K | $492K | $246K | Added$311.2K |
| Persistent Asset Partners Ltd | 23.1K | $483.6K | — | New |
| ProShare Advisors LLC | 22.1K | $462.8K | $266.8K | Added$237.9K |
| BARCLAYS PLC | 21.7K | $453.3K | $261.3K | Cut−$2.81M |
| Mitsubishi UFJ Asset Management Co., Ltd. | 21.3K | $446.5K | $255.9K | Added$251.2K |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 21.1K | $440.4K | $154.1K | Added$327.2K |
| Entropy Technologies, LP | 20.7K | $432.1K | $178.4K | Added$301.1K |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 20.5K | $428.1K | — | New |
| Jain Global LLC | 20.4K | $426.1K | — | New |
| CITIGROUP INC | 19.6K | $410.7K | $236.8K | Added$89.7K |
| PRUDENTIAL FINANCIAL INC | 19.2K | $400.8K | — | New |
| Gotham Asset Management, LLC | 19.1K | $400.3K | — | New |
| Quantinno Capital Management LP | 18.4K | $385.8K | $222.4K | Added$187.9K |
| Alyeska Investment Group, L.P. | 17.2K | $359.8K | — | New |
| State of New Jersey Common Pension Fund D | 15.2K | $318.2K | — | New |
| PSP Research LLC | 14.4K | $301.2K | — | New |
| XTX Topco Ltd | 14.1K | $294.9K | $170K | Cut−$40.4K |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 14K | $292.9K | $168.8K | Added$102.4K |
| CANADA PENSION PLAN INVESTMENT BOARD | 13.9K | $290.8K | $167.6K | Cut−$155.8K |
| E Fund Management Co., Ltd. | 13.2K | $276K | — | Held |
| Russell Investments Group, Ltd. | 12.8K | $268.6K | $118.1K | Added$181.8K |
| MANGROVE PARTNERS IM, LLC | 12.6K | $262.7K | — | New |
| Tower Research Capital LLC (TRC) | 12.5K | $262.3K | $151.2K | Added$87.4K |
| SummitTX Capital, L.P. | 12.5K | $262.2K | — | New |
| Bleakley Financial Group, LLC | 12.4K | $259K | — | New |
| Vanguard Investments Australia, Ltd. | 12.2K | $256K | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 12.2K | $255.7K | $147.4K | Added$147K |
| Bridgefront Capital, LLC | 10.9K | $227.3K | $131.1K | Added$54.8K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 10.6K | $222.7K | $53.9K | Added$183.2K |
| XPONANCE LLC | 10.2K | $214.2K | — | New |
| Hudson Bay Capital Management LP | 10.2K | $212.5K | — | New |
| KLP KAPITALFORVALTNING AS | 9.7K | $202.9K | $117K | Added$117K |
| Abacus Wealth Partners, LLC | 9.56K | $200K | — | New |
| Ameritas Investment Partners, Inc. | 9.09K | $190.1K | $104.1K | Added$113.7K |
| Quantbot Technologies LP | 7.41K | $155K | — | New |
| NISA INVESTMENT ADVISORS, LLC | 7.24K | $151.5K | $21K | Added$136K |
| Mirae Asset Global Investments Co., Ltd. | 7.03K | $147K | $78.9K | Added$89K |
| State of Wyoming | 6.12K | $128K | — | New |
| CWM, LLC | 5.04K | $105.4K | $101K | Added$105.4K |
| Sterling Capital Management LLC | 3.68K | $77K | $44.4K | Added$22.7K |
| GF FUND MANAGEMENT CO. LTD. | 3.01K | $63K | $31.9K | Added$39.5K |
| ANTIPODES PARTNERS Ltd | 1.62K | $33.9K | $19.6K | Cut−$6.06K |
| TFC Financial Management, Inc. | 1.55K | $32.4K | $15.7K | Added$20.9K |
| SIMPLEX TRADING, LLC | 1.06K | $22.1K | — | New |
| Kemnay Advisory Services Inc. | 1.05K | $21.9K | — | New |
| Caitong International Asset Management Co., Ltd | 1K | $21K | $3.86K | Added$18.2K |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 904 | $18.9K | $18.9K | Added$18.9K |
| PRICE T ROWE ASSOCIATES INC /MD/ | 889.4K | $18.6K | $705 | Added$18.1K |
| Federation des caisses Desjardins du Quebec | 817 | $17.1K | — | New |
| BESSEMER GROUP INC | 708.4K | $14.8K | $8.54K | Added$8.54K |
| GAMMA Investing LLC | 606 | $12.7K | $5.75K | Added$8.45K |
| Allworth Financial LP | 563 | $11.8K | $542 | Added$11.4K |
| Advisory Services Network, LLC | 487 | $10.2K | — | New |
| T. Rowe Price Investment Management, Inc. | 440K | $9.21K | $5.31K | Added$5.25K |
| OSAIC HOLDINGS, INC. | 425 | $8.89K | $5.12K | Added$2.76K |
| Optiver Holding B.V. | 410 | $8.58K | $4.94K | Added$3.47K |
| Farther Finance Advisors, LLC | 372 | $7.89K | $4.39K | Added$4.75K |
| FEDERATED HERMES, INC. | 354 | $7.41K | $4.27K | Added$4.2K |
| ROYAL BANK OF CANADA | 350 | $7K | $3.96K | Cut−$25K |
| Larson Financial Group LLC | 250 | $5.23K | $410 | Added$4.93K |
| IFP Advisors, Inc | 233 | $4.87K | $2.81K | Added$2.81K |
| PNC Financial Services Group, Inc. | 212 | $4.44K | $2.56K | Added$2.56K |
| ALGERT GLOBAL LLC | 145.6K | $3.05K | — | New |
| Fortitude Family Office, LLC | 130 | $2.72K | — | New |
| JONES FINANCIAL COMPANIES LLLP | 122 | $2.35K | — | New |
| ROTHSCHILD INVESTMENT LLC | 86 | $1.8K | $314 | Added$1.57K |
| WPG Advisers, LLC | 78 | $1.63K | $941 | Added$223 |
| US BANCORP \DE\ | 48 | $1K | — | New |
| Clearstead Advisors, LLC | 45 | $942 | $543 | Added$543 |
| Janney Montgomery Scott LLC | 36K | $753 | $434 | Added$434 |
| Parkside Financial Bank & Trust | 35 | $733 | — | New |
| Root Financial Partners, LLC | 34 | $711 | — | New |
| Keating Financial Advisory Services, Inc. | 29 | $607 | — | New |
| SG Americas Securities, LLC | 24.3K | $507 | $265 | Added$312 |
| MassMutual Private Wealth & Trust, FSB | 19 | $397 | — | New |
| MAI Capital Management | 18 | $377 | — | New |
| Essential Partners LLC | 4 | $84 | $49 | Added$49 |
| Hughes Financial Services, LLC | 2 | $42 | — | New |
| TWIN PEAKS WEALTH ADVISORS, LLC | 2 | $42 | — | New |
| SBI Securities Co., Ltd. | 1 | $21 | $12 | Cut−$147 |
| Covestor Ltd | 10 | $0 | $0 | Held |