| ORBIMED ADVISORS LLC | 15.5M | $488.8M | $103.7M | Added$103.7M |
| RA CAPITAL MANAGEMENT, L.P. | 10.4M | $328.5M | $69.7M | Added$69.7M |
| Paradigm Biocapital Advisors LP | 7.37M | $232M | $43.7M | Added$69.7M |
| BAKER BROS. ADVISORS LP | 6.58M | $207.1M | $44M | Added$44M |
| BlackRock, Inc. | 6.47M | $203.9M | $43.3M | Added$39.4M |
| JANUS HENDERSON GROUP PLC | 5.92M | $186.3M | $30.5M | Added$73M |
| NOVO HOLDINGS A/S | 5.35M | $168.5M | $35.8M | Added$35.8M |
| Driehaus Capital Management LLC | 4.48M | $141.1M | $28M | Added$37.1M |
| Siren, L.L.C. | 4.43M | $139.6M | $29.6M | Added$27.1M |
| PERCEPTIVE ADVISORS LLC | 4.42M | $139.4M | $29.6M | Added$28.7M |
| VANGUARD CAPITAL MANAGEMENT LLC | 3.79M | $119.3M | — | Held |
| Cormorant Asset Management, LP | 3.26M | $102.7M | $21.8M | Added$21.2M |
| BRAIDWELL LP | 2.35M | $73.9M | $15.7M | Cut−$55.4M |
| MORGAN STANLEY | 2.25M | $70.7M | $15M | Cut−$1.48M |
| GEODE CAPITAL MANAGEMENT, LLC | 1.79M | $56.4M | $11.7M | Added$13.1M |
| State Street | 1.72M | $54.1M | $11.5M | Added$11.5M |
| MPM BIOIMPACT LLC | 1.66M | $52.3M | $11.1M | Added$11.2M |
| Integral Health Asset Management, LLC | 1.6M | $50.4M | $10M | Added$13.2M |
| Bellevue Group AG | 1.53M | $48.1M | $10.2M | Added$10.2M |
| Soleus Capital Management, L.P. | 1.45M | $45.7M | $6.08M | Added$23.1M |
| ALLIANCEBERNSTEIN L.P. | 1.72M | $42.7M | −$0 | Added$17M |
| BANK OF AMERICA CORP /DE/ | 1.33M | $41.8M | $8.87M | Added$5.21M |
| UBS Group AG | 1.31M | $41.3M | $8.76M | Cut−$11.2M |
| DIMENSIONAL FUND ADVISORS LP | 1.22M | $38.4M | $8.11M | Added$8.3M |
| AMERICAN CENTURY COMPANIES INC | 1.15M | $36.1M | $7.67M | Added$6.69M |
| Fidelity | 1.02M | $32M | $4.63M | Added$14.8M |
| First Light Asset Management, LLC | 1M | $31.6M | $6.7M | Cut−$7.49M |
| Aberdeen Group plc | 826.1K | $26M | $5.49M | Added$5.62M |
| Qube Research & Technologies Ltd | 825.9K | $26M | $1.98M | Added$18.7M |
| VICTORY CAPITAL MANAGEMENT INC | 789K | $24.9M | $4.99M | Added$6.33M |
| Artisan Partners Limited Partnership | 659.1K | $20.8M | $4.41M | Added$3.29M |
| MARSHALL WACE, LLP | 648.4K | $20.4M | $4.33M | Added$3.5M |
| GOLDMAN SACHS GROUP INC | 629.8K | $19.8M | $4.21M | Added$2.01M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 596.3K | $18.8M | $3.99M | Added$3.61M |
| NORTHERN TRUST CORP | 576.6K | $18.2M | $3.74M | Added$4.27M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 557.3K | $17.6M | — | Held |
| VANGUARD FIDUCIARY TRUST CO | 521.7K | $16.4M | — | Held |
| Opaleye Management Inc. | 500K | $15.8M | $3.34M | Added$3.34M |
| Candriam S.C.A. | 447.4K | $14.1M | $2.99M | Added$1.66M |
| Citadel | 429K | $13.5M | $822.9K | Added$10.5M |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 404.2K | $12.7M | $2.7M | Cut−$3.16M |
| Sofinnova Investments, Inc. | 386.5K | $12.2M | $2.58M | Added$1.31M |
| Squadron Capital Management LLC | 350K | $11M | $2.34M | Added$2.34M |
| MILLENNIUM MANAGEMENT LLC | 342.9K | $10.8M | $845.2K | Added$7.66M |
| Nuveen, LLC | 335.8K | $10.6M | $1.13M | Added$6.37M |
| Parkman Healthcare Partners LLC | 322.8K | $10.2M | $2.16M | Cut−$444K |
| STEMPOINT CAPITAL LP | 290.9K | $9.16M | $1.94M | Added$207.1K |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 283.3K | $8.92M | $1.81M | Added$2.19M |
| Sio Capital Management, LLC | 269K | $8.47M | $1.59M | Added$2.58M |
| KENNEDY CAPITAL MANAGEMENT LLC | 264.2K | $8.32M | $1.61M | Added$2.33M |
| Woodline Partners LP | 224.3K | $7.07M | $1.5M | Added$1.5M |
| DEUTSCHE BANK AG\ | 221.9K | $6.99M | $1.43M | Added$1.66M |
| PEREGRINE CAPITAL MANAGEMENT LLC | 208.7K | $6.57M | — | New |
| SEB Asset Management AB | 206.5K | $6.51M | — | Held |
| Granahan Investment Management, LLC | 200.8K | $6.33M | $1.34M | Added$562.2K |
| AMERIPRISE FINANCIAL INC | 200.7K | $6.32M | $1.34M | Added$1.3M |
| Bank of New York Mellon Corp | 192.4K | $6.06M | $1.29M | Added$1.13M |
| BARCLAYS PLC | 177.2K | $5.58M | $1.18M | Cut−$3.67M |
| NEUBERGER BERMAN GROUP LLC | 168.7K | $5.31M | $849.9K | Added$2.16M |
| Ally Bridge Group (NY) LLC | 161K | $5.07M | $1.08M | Added$232.6K |
| EVENTIDE ASSET MANAGEMENT, LLC | 149.9K | $4.72M | $1M | Cut−$9.38M |
| Freestone Grove Partners LP | 148.4K | $4.68M | — | New |
| JPMORGAN CHASE & CO | 147.6K | $4.47M | $798.1K | Added$844.6K |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 145.3K | $4.4M | $833.9K | Added$833.9K |
| Invesco Ltd. | 138.4K | $4.36M | $504.3K | Added$2.49M |
| KVP Capital Advisors, LP | 133K | $4.19M | $889.1K | Added$889.1K |
| Quantum Private Wealth, LLC | 116.6K | $3.67M | $708.8K | Added$1.04M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 114.7K | $3.61M | $655.6K | Added$1.18M |
| Moody Aldrich Partners LLC | 114.1K | $3.6M | $288.4K | Added$2.53M |
| DAFNA Capital Management LLC | 112.2K | $3.54M | $750.3K | Cut−$428.4K |
| D. E. Shaw & Co., Inc. | 104.9K | $3.3M | $701K | Cut−$6.49M |
| Swiss National Bank | 103.9K | $3.27M | $694.6K | Added$694.6K |
| Schonfeld Strategic Advisors LLC | 99.1K | $3.12M | $396.6K | Added$1.65M |
| HighVista Strategies LLC | 91.9K | $2.9M | $614.6K | Cut−$1.35M |
| ADAR1 Capital Management, LLC | 90.6K | $2.85M | $605.7K | Added$595.7K |
| NEW YORK STATE COMMON RETIREMENT FUND | 88.9K | $2.8M | $594.5K | Added$594.5K |
| ALPS ADVISORS INC | 87.3K | $2.75M | $581.1K | Added$593.6K |
| RHUMBLINE ADVISERS | 83.5K | $2.63M | $558.5K | Added$520.4K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 73.4K | $2.31M | $336.9K | Added$1.06M |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 67.4K | $2.12M | — | New |
| Artia Global Partners LP | 65.5K | $2.06M | — | New |
| J. Goldman & Co LP | 61.4K | $1.93M | — | New |
| FEDERATED HERMES, INC. | 56.8K | $1.79M | $379.6K | Cut−$248.7K |
| HighMark Wealth Management LLC | 53.2K | $1.68M | $355.5K | Added$355.5K |
| TWO SIGMA INVESTMENTS, LP | 50.8K | $1.6M | $339.9K | Added$339.9K |
| Ishara Investments LP | 49.2K | $1.55M | $328.9K | Added$110.5K |
| SEI INVESTMENTS CO | 49.1K | $1.55M | $208.9K | Added$770.6K |
| Jain Global LLC | 46.4K | $1.46M | $310.2K | Cut−$1.36M |
| SILVERARC CAPITAL MANAGEMENT, LLC | 42.6K | $1.34M | $281.1K | Added$298.9K |
| Legal & General Group Plc | 42.5K | $1.34M | $284.4K | Added$31K |
| FRANKLIN RESOURCES INC | 41.7K | $1.31M | $278.9K | Added$243.7K |
| VOYA INVESTMENT MANAGEMENT LLC | 39.2K | $1.23M | $261.7K | Added$249.5K |
| Caption Management, LLC | 38.7K | $1.22M | — | New |
| Knights of Columbus Asset Advisors LLC | 38.4K | $1.21M | $256.8K | Added$250.3K |
| MetLife Investment Management, LLC | 38.1K | $1.2M | $254.6K | Added$249.5K |
| Longaeva Partners L.P. | 36.9K | $1.16M | — | New |
| VANGUARD ASSET MANAGEMENT, Ltd | 35.7K | $1.13M | — | Held |
| JANE STREET GROUP, LLC | 35.6K | $1.12M | — | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 35.5K | $1.12M | $237K | Added$204.5K |
| STATE OF WISCONSIN INVESTMENT BOARD | 32.9K | $1.04M | $219.9K | Added$43.7K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 31.6K | $995.8K | $209.7K | Added$217.4K |
| Creative Planning | 31.3K | $984.9K | $163.6K | Added$377.8K |
| TUDOR INVESTMENT CORP ET AL | 29.9K | $941.5K | — | New |
| Vanguard Global Advisers, LLC | 29.3K | $923.8K | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 27.4K | $863.4K | $183.2K | Cut−$1.9M |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26.7K | $840.2K | $178.3K | Cut−$901.7K |
| China Universal Asset Management Co., Ltd. | 25.4K | $801.2K | $115.3K | Added$373.1K |
| WELLS FARGO & COMPANY/MN | 25.2K | $795.2K | $168.8K | Cut−$1.08M |
| BNP PARIBAS FINANCIAL MARKETS | 23.9K | $753.2K | $114.1K | Added$329.8K |
| LMR Partners LLP | 20K | $630K | $133.7K | Added$133.7K |
| RAYMOND JAMES FINANCIAL INC | 19.7K | $619.9K | $131.5K | Added$83.6K |
| GLENMEDE TRUST CO NA | 19.2K | $605.6K | — | New |
| XTX Topco Ltd | 19.1K | $601.9K | $127.7K | Cut−$778.3K |
| Police & Firemen's Retirement System of New Jersey | 18.9K | $594.2K | $126.1K | Added$126.1K |
| CITIGROUP INC | 18.5K | $583.3K | $123.8K | Cut−$4.96M |
| INTECH INVESTMENT MANAGEMENT LLC | 18.5K | $582.1K | $123.5K | Cut−$172K |
| State of New Jersey Common Pension Fund D | 18.1K | $569.9K | $120.2K | Added$123.7K |
| Odyssean, LLC | 17.9K | $562.8K | $78.6K | Added$271.2K |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 16.9K | $531.4K | $112.8K | Added$112.8K |
| Brooklyn Investment Group | 16.2K | $511K | — | New |
| ENVESTNET ASSET MANAGEMENT INC | 15.7K | $495.5K | — | New |
| AlphaCentric Advisors LLC | 15.6K | $491.9K | $98.3K | Added$127K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 14.7K | $464.3K | $75.3K | Added$184.7K |
| ProShare Advisors LLC | 14.6K | $459.2K | $97.5K | Added$37.9K |
| ARIZONA STATE RETIREMENT SYSTEM | 14.5K | $458K | $97.2K | Added$87.3K |
| Headlands Technologies LLC | 13.8K | $433.7K | — | New |
| Vanguard Investments Australia, Ltd. | 13.7K | $431.1K | — | Held |
| Verdad Advisers, LP | 13.1K | $411.1K | — | New |
| Hudson Bay Capital Management LP | 12.9K | $407.3K | — | New |
| Bridgefront Capital, LLC | 11.8K | $372K | — | New |
| Seven Fleet Capital Management LP | 11.7K | $368.6K | $13.4K | Added$319K |
| Virtus Investment Advisers, LLC | 11.5K | $363.6K | $75.3K | Added$84.1K |
| GUGGENHEIM CAPITAL LLC | 11.5K | $363K | $70.6K | Added$100.6K |
| KLP KAPITALFORVALTNING AS | 11.3K | $355.9K | $75.5K | Added$75.5K |
| PRUDENTIAL FINANCIAL INC | 10.6K | $334.1K | — | New |
| Persistent Asset Partners Ltd | 10.1K | $316.7K | $67.2K | Cut−$209.5K |
| SFMG, LLC | 10K | $315K | $66.8K | Added$66.8K |
| Elmind Capital, LP | 10K | $315K | $66.8K | Cut−$429.4K |
| Atom Investors LP | 9.94K | $313.1K | — | New |
| Connecticut Capital Management Group, LLC | 9.84K | $309.9K | $65.8K | Added$65.8K |
| AXQ CAPITAL, LP | 9.51K | $299.7K | — | New |
| FIRST TRUST ADVISORS LP | 9.13K | $287.6K | — | New |
| Lion Point Capital, LP | 9.1K | $286.6K | $60.8K | Added$60.8K |
| PROFUND ADVISORS LLC | 8.68K | $273.5K | $58K | Cut−$19.9K |
| Icahn Capital | 8.54K | $269K | $57.1K | Cut−$72.1K |
| OSAIC HOLDINGS, INC. | 8.48K | $267.2K | $2.73K | Added$257.1K |
| FOX RUN MANAGEMENT, L.L.C. | 7.98K | $241.5K | $43.6K | Cut−$65.2K |
| Pictet Asset Management Holding SA | 7.62K | $240.1K | — | New |
| Quantinno Capital Management LP | 7.45K | $234.8K | — | New |
| STRS OHIO | 6.9K | $217.3K | — | New |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 6.72K | $211.6K | — | New |
| Russell Investments Group, Ltd. | 6.57K | $207.1K | $43.4K | Added$46K |
| PSP Research LLC | 6.5K | $204.8K | — | New |
| Orion Porfolio Solutions, LLC | 6.45K | $203.1K | — | New |
| Quarry LP | 6K | $189K | $38.8K | Added$45.1K |
| ROYAL BANK OF CANADA | 5.87K | $185K | $38.9K | Cut−$68K |
| Ameritas Investment Partners, Inc. | 5.64K | $177.6K | $37.7K | Added$37.7K |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 5.6K | $176.4K | $71.8K | Added$23.7K |
| Mirae Asset Global Investments Co., Ltd. | 5.59K | $176.2K | $34.4K | Added$48.6K |
| Tower Research Capital LLC (TRC) | 5.47K | $172.4K | $10.8K | Added$132.4K |
| Caitong International Asset Management Co., Ltd | 4.28K | $134.8K | $4.75K | Added$117.1K |
| US BANCORP \DE\ | 2.97K | $93.7K | $10.5K | Added$54.8K |
| GF FUND MANAGEMENT CO. LTD. | 2.38K | $74.9K | $13.9K | Added$23.3K |
| Steward Partners Investment Advisory, LLC | 2.35K | $74.2K | $15.7K | Added$3.33K |
| GAMMA Investing LLC | 2.29K | $72.1K | $9.05K | Added$38.5K |
| SIMPLEX TRADING, LLC | 1.83K | $57.7K | $12.2K | Cut−$167.3K |
| Eleva Capital SAS | 17.5K | $55K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 1.68K | $52.8K | $7.77K | Added$24K |
| Parallel Advisors, LLC | 1.03K | $32.5K | $4.18K | Added$17K |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 972 | $30.6K | $22.9K | Added$30.6K |
| Kemnay Advisory Services Inc. | 756 | $23.8K | — | New |
| Rockefeller Capital Management L.P. | 732 | $23.1K | $1.22K | Added$18.5K |
| Farther Finance Advisors, LLC | 645 | $21.4K | $5.37K | Added$5.02K |
| SUMMIT SECURITIES GROUP LLC | 678 | $21.4K | — | New |
| Centiva Capital, LP | 539 | $17K | $3.6K | Cut−$293.2K |
| Sterling Capital Management LLC | 438 | $13.8K | $2.93K | Added$2.68K |
| SIGNATUREFD, LLC | 363 | $11.4K | $2.43K | Added$2.43K |
| CWM, LLC | 351 | $11.1K | $8.78K | Added$11.1K |
| MassMutual Private Wealth & Trust, FSB | 294 | $9.26K | $1.97K | Added$1.97K |
| Optiver Holding B.V. | 261 | $8.22K | $1.08K | Added$4.23K |
| EASTERN BANK | 223 | $7.03K | $1.49K | Added$1.49K |
| Aster Capital Management (DIFC) Ltd | 310 | $6.82K | −$428 | Added$3.05K |
| SBI Securities Co., Ltd. | 206 | $6.49K | $1.38K | Added$1.35K |
| Larson Financial Group LLC | 176 | $5.54K | $1.18K | Cut−$39 |
| EverSource Wealth Advisors, LLC | 175 | $5.51K | $1.04K | Added$1.64K |
| PNC Financial Services Group, Inc. | 172 | $5.42K | $502 | Added$3.56K |
| Fortitude Family Office, LLC | 160 | $5.04K | $1.07K | Added$1.07K |
| Smartleaf Asset Management LLC | 162 | $4.91K | $930 | Added$660 |
| Advisory Services Network, LLC | 151 | $4.77K | — | New |
| ROTHSCHILD INVESTMENT LLC | 135 | $4.25K | $903 | Added$903 |
| BFSG, LLC | 100 | $3.15K | $668 | Added$668 |
| Versant Capital Management, Inc | 95 | $2.99K | $636 | Added$636 |
| Allworth Financial LP | 84 | $2.65K | $374 | Added$1.26K |
| DekaBank Deutsche Girozentrale | 80K | $2.57K | $1.01K | Added$1.01K |
| PRICE T ROWE ASSOCIATES INC /MD/ | 69.4K | $2.19K | $383 | Added$765 |
| Parkside Financial Bank & Trust | 35 | $1.1K | $234 | Added$234 |
| FIFTH THIRD BANCORP | 33 | $1.04K | — | New |
| ALGERT GLOBAL LLC | 32.5K | $1.02K | — | New |
| Handelsbanken Fonder AB | 31.1K | $980 | $208 | Added$208 |
| Bare Financial Services, Inc | 18 | $567 | $120 | Added$120 |
| MAI Capital Management | 9 | $284 | — | New |
| QUADRANT CAPITAL GROUP LLC | 6 | $189 | — | New |
| IFP Advisors, Inc | 4 | $126 | $27 | Added$27 |
| SG Americas Securities, LLC | 3.8K | $120 | $26 | Cut−$2.08K |
| Cygnus Capital Advisors, LLC | 3.43K | $108 | $23 | Added$23 |
| GHP Investment Advisors, Inc. | 3 | $95 | — | New |
| Essential Partners LLC | 3 | $95 | $21 | Added$21 |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 2.85K | $90 | $19 | Added$19 |
| ACADIAN ASSET MANAGEMENT LLC | 2.74K | $86 | $12 | Added$44 |
| BESSEMER GROUP INC | 2.35K | $74 | $16 | Added$16 |
| Hughes Financial Services, LLC | 2 | $63 | — | New |
| KBC Group NV | 1.56K | $49 | — | New |
| Winthrop Capital Management, LLC | 1.38K | $43 | $9 | Added$9 |
| Covestor Ltd | 8 | $0 | $0 | Held |