| JANUS HENDERSON GROUP PLC | 1.82M | $29.1M | $649.2K | Added$27M |
| VR ADVISER, LLC | 1.68M | $26.8M | — | New |
| PERCEPTIVE ADVISORS LLC | 1.45M | $23.2M | $1.67M | Added$17.8M |
| Ikarian Capital, LLC | 1.02M | $16.3M | $3.68M | Added$4.48M |
| Stonepine Capital Management, LLC | 975.2K | $15.6M | $45.2K | Added$15.4M |
| Logos Global Management LP | 625K | $9.99M | — | New |
| MORGAN STANLEY | 596.6K | $9.54M | $2.27M | Added$2.27M |
| Velan Capital Investment Management LP | 583.3K | $9.33M | $316.7K | Added$8.31M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 540.1K | $8.64M | $316.7K | Added$7.62M |
| Point72 Asset Management, L.P. | 534K | $8.54M | $1.61M | Added$3.38M |
| MILLENNIUM MANAGEMENT LLC | 533.9K | $8.54M | $1.15M | Added$4.85M |
| ARMISTICE CAPITAL, LLC | 478.8K | $7.66M | — | New |
| Siren, L.L.C. | 427.1K | $6.83M | $1.62M | Added$1.62M |
| TD Asset Management Inc | 399.2K | $6.38M | — | New |
| UBS Group AG | 381.4K | $6.1M | $2.57K | Added$6.09M |
| RTW INVESTMENTS, LP | 370.2K | $5.92M | $1.41M | Added$1.31M |
| BOOTHBAY FUND MANAGEMENT, LLC | 366.8K | $5.86M | $1.34M | Added$1.57M |
| MARSHALL WACE, LLP | 352.6K | $5.64M | $1.13M | Added$2M |
| BVF INC/IL | 339.5K | $5.43M | $1.29M | Added$1.29M |
| GREAT POINT PARTNERS LLC | 327.3K | $5.23M | — | New |
| Woodline Partners LP | 323.9K | $5.18M | $545.2K | Added$3.43M |
| Fidelity | 322.6K | $5.16M | $536.2K | Added$3.44M |
| AMERIPRISE FINANCIAL INC | 279.5K | $4.47M | — | New |
| VANGUARD CAPITAL MANAGEMENT LLC | 263.4K | $4.21M | — | Held |
| Avidity Partners Management LP | 215.9K | $3.45M | — | New |
| ADAR1 Capital Management, LLC | 213.5K | $3.41M | $242K | Added$2.64M |
| Vivo Capital, LLC | 208.3K | $3.33M | $791.7K | Added$791.7K |
| BOONE CAPITAL MANAGEMENT LLC | 200K | $3.2M | — | New |
| Balyasny Asset Management L.P. | 194.6K | $3.11M | — | New |
| STEMPOINT CAPITAL LP | 188.7K | $3.02M | — | New |
| DIADEMA PARTNERS LP | 179.7K | $2.87M | $683K | Cut−$90.2K |
| Integral Health Asset Management, LLC | 167K | $2.67M | $634.6K | Added$634.6K |
| Renaissance Technologies | 152.6K | $2.44M | $477.2K | Added$909.3K |
| Citadel | 152.5K | $2.44M | $492.2K | Added$859.8K |
| SPHERA FUNDS MANAGEMENT LTD. | 136K | $2.17M | $516.9K | Cut−$142.6K |
| ExodusPoint Capital Management, LP | 120.5K | $1.93M | — | New |
| Sofinnova Investments, Inc. | 104.4K | $1.67M | — | New |
| Verdad Advisers, LP | 95.3K | $1.52M | — | New |
| GEODE CAPITAL MANAGEMENT, LLC | 69.2K | $1.11M | $212.1K | Added$427.5K |
| TWO SIGMA INVESTMENTS, LP | 68.6K | $1.1M | $127.2K | Added$688.7K |
| DIMENSIONAL FUND ADVISORS LP | 62.8K | $1M | — | New |
| Persistent Asset Partners Ltd | 58.2K | $930.3K | $221.1K | Added$134.7K |
| Vestal Point Capital, LP | 53.4K | $854.5K | $203.1K | Added$203.1K |
| Trexquant Investment LP | 50.7K | $810.9K | — | New |
| XTX Topco Ltd | 47.9K | $765.1K | — | New |
| Creek Drive Management Group LLC | 45K | $719.5K | — | New |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 44.9K | $718K | $170.6K | Added$170.6K |
| Artia Global Partners LP | 42.1K | $672.9K | $159.9K | Added$159.9K |
| JANE STREET GROUP, LLC | 33.6K | $537.7K | — | New |
| VANGUARD FIDUCIARY TRUST CO | 33.4K | $534.5K | — | Held |
| GOLDMAN SACHS GROUP INC | 31.9K | $509.3K | $85.2K | Added$236.2K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 31.3K | $501.1K | — | New |
| BNP PARIBAS FINANCIAL MARKETS | 30.6K | $490K | $58.1K | Added$303.6K |
| State Street | 29K | $463.6K | — | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 29K | $463.3K | — | New |
| Qube Research & Technologies Ltd | 28.3K | $452.3K | — | New |
| BANK OF AMERICA CORP /DE/ | 18.6K | $296.9K | $14.4K | Added$250.8K |
| BlackRock, Inc. | 17K | $271.5K | $63.5K | Added$67.7K |
| BARCLAYS PLC | 16.7K | $267K | — | New |
| Quadrature Capital Ltd | 15.5K | $247.4K | $58.8K | Cut−$4.3K |
| Verition Fund Management LLC | 13.6K | $217.3K | — | New |
| Corient Private Wealth LLC | 12.4K | $198.1K | $47.1K | Added$47.1K |
| NORTHERN TRUST CORP | 12K | $192.7K | — | New |
| LETKO, BROSSEAU & ASSOCIATES INC | 10.7K | $170.3K | $40.5K | Added$40.5K |
| JPMORGAN CHASE & CO | 9.42K | $131.9K | $1.64K | Added$121K |
| Vanguard Global Advisers, LLC | 3.3K | $52.8K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2.95M | $47.2K | — | New |
| Rockefeller Capital Management L.P. | 2.5K | $40K | $4 | Added$40K |
| Tower Research Capital LLC (TRC) | 1.1K | $17.6K | $756 | Added$15.2K |
| Caitong International Asset Management Co., Ltd | 57 | $911 | — | New |
| HRT FINANCIAL LP | 41.8K | $668 | — | New |
| ACADIAN ASSET MANAGEMENT LLC | 4.5K | $71 | — | New |
| MAI Capital Management | 1 | $16 | — | New |
| CITIGROUP INC | 1 | $16 | $4 | Added$4 |
| Titiun Yejiel | 1 | $16 | $4 | Added$4 |
| Allworth Financial LP | 1 | $16 | $3 | Added$3 |
| Physician Wealth Advisors, Inc. | 1 | $16 | $3 | Added$3 |
| JONES FINANCIAL COMPANIES LLLP | 1 | $15 | $3 | Added$3 |
| Union Bancaire Privee, UBP SA | 1 | $11 | $2 | Added$2 |
| ROYAL BANK OF CANADA | 4 | $0 | — | New |