13F

Investor

DAFNA Capital Management LLC

CIK 0001389933 · filed 2026-05-15 · SEC filing

13F book

$439.6M

Positions

83

10 new · 4 sold

Largest name

12.8%

Revolution Medicines Inc

Est. mark

$10.7M

Price effect on 73 names still held. Flow −$1.68M.
NameTickerSharesValueWeightEst. markChange
Revolution Medicines Inc580.7K$56.5M12.8%$10.2MCut$8.32M
Spdr Series Trust318.5K$40.7M9.3%$1.85MCut−$347.4K
Stereotaxis, Inc.STXS13.7M$25.2M5.7%−$6.29MHeld
Day One Biopharmaceuticals I978.5K$21M4.8%$11.9MCut$11.7M
AtriCure, Inc.ATRC597.4K$17M3.9%−$6.59MHeld
IDEAYA Biosciences, Inc.IDYA476.7K$15.9M3.6%−$595.9KCut−$1.63M
Xenon Pharmaceuticals Inc.XENE250.8K$14.6M3.3%$3.34MCut$1.68M
Cytokinetics IncCYTK217.5K$14.3M3.3%$515.5KCut−$9.24M
Compass Pathways PlcCMPS2.42M$13.4M3.0%−$1.11MAdded$7.78M
Nektar TherapeuticsNKTR165.2K$11.9M2.7%$2.23MAdded$8.71M
Ishares Tr62.1K$10.5M2.4%$4.97KCut−$1.01M
Arcus Biosciences, Inc.RCUS443.8K$9.59M2.2%−$961.9KAdded−$691.9K
Neurocrine Biosciences IncNBIX70.6K$9.3M2.1%−$712.5KHeld
Larimar Therapeutics, Inc.LRMR2.03M$9.13M2.1%$648KAdded$5.55M
Bicara Therapeutics Inc.BCAX421.7K$8.39M1.9%$800.4KAdded$3.99M
Axogen, Inc.AXGN250K$8.28M1.9%$100KCut−$7.33M
Biohaven Ltd.BHVN845.7K$7.15M1.6%−$2.39MCut−$3.63M
Tandem Diabetes Care IncTNDM355.2K$6.81M1.5%−$998.1KHeld
Denali Therapeutics Inc.DNLI318.5K$6.12M1.4%$856.8KHeld
Ascendis Pharma A/SASND4M$5.92M1.3%$456.5KHeld
Century Therapeutics, Inc.IPSC2.43M$5.5M1.3%$3.08MCut$2.72M
Dexcom IncDXCM86.3K$5.42M1.2%−$308KCut−$440.8K
Kalvista Pharmaceuticals Inc267.4K$5.38M1.2%$1.06MCut−$379.6K
Ascendis Pharma A/SASND23.2K$5.3M1.2%$359KCut−$707.2K
MBX Biosciences, Inc.MBX175.5K$5.24M1.2%−$279.3KAdded$25.2K
Inogen IncINGN845.2K$5.22M1.2%−$446.6KAdded−$334.7K
Syndax Pharmaceuticals IncSNDX217.4K$5.08M1.2%$510.8KCut−$760.3K
Alkermes plc.ALKS139.5K$4.93M1.1%$961.2KAdded$1.29M
Stoke Therapeutics, Inc.STOK130.9K$4.26M1.0%$89.3KAdded$805.6K
Biocryst Pharmaceuticals IncBCRX430.2K$4.1M0.9%$719.4KAdded$833.6K
Galapagos Nv130.2K$3.91M0.9%−$351.5KHeld
Immunovant, Inc.IMVT150.5K$3.74M0.9%−$87.3KHeld
Edgewise Therapeutics, Inc.EWTX112.2K$3.54M0.8%$750.3KCut−$428.4K
MapLight Therapeutics, Inc.MPLT171K$3.48M0.8%$397.5KAdded$951.3K
Allogene Therapeutics, Inc.ALLO1.37M$3.34M0.8%$1.47MCut$1.45M
Procept Biorobotics CorpPRCT120K$3M0.7%−$774KHeld
Align Technology IncALGN15K$2.57M0.6%$229.2KCut$73K
Proqr Thrapeutics N V1.57M$2.54M0.6%−$627KHeld
Cybin Inc.HELP498.4K$2.39M0.5%−$1.54MAdded−$1.33M
Rapport Therapeutics, Inc.RAPP75K$2.35M0.5%$71.2KHeld
Insulet CorpPODD10.9K$2.28M0.5%−$511.1KAdded$328.2K
Structure Therapeutics Inc.GPCR46.5K$2.24M0.5%−$789.9KAdded−$332.1K
Immatics N.V.IMTX225.9K$2.22M0.5%−$149.1KCut−$519.5K
Celldex Therapeutics Inc New68.5K$2.17M0.5%$312.4KHeld
Lexeo Therapeutics, Inc.LXEO377.1K$2.16M0.5%−$1.43MAdded−$1.22M
Alector, Inc.ALEC908.4K$1.95M0.4%$535.9KHeld
Viking Therapeutics, Inc.VKTX59.5K$1.94M0.4%−$157.1KHeld
Kura Oncology, Inc.KURA235.9K$1.92M0.4%−$533.1KHeld
Profound Med Corp263K$1.7M0.4%−$365.6KCut−$544.3K
Fulcrum Therapeutics, Inc.FULC205K$1.57M0.4%New
Aquestive Therapeutics, Inc.AQST368.4K$1.53M0.3%−$851KCut−$899.5K
MediWound Ltd.MDWD94.4K$1.52M0.3%−$221.9KCut−$576.4K
Orthopediatrics CorpKIDS95.7K$1.52M0.3%New
Ultragenyx Pharmaceutical In61.1K$1.28M0.3%−$32.8KAdded$912K
Engene Holdings Inc187.4K$1.28M0.3%−$363.3KAdded−$201.8K
Neurogene Inc.NGNE56.6K$1.14M0.3%−$12.3KAdded$565.5K
ARS Pharmaceuticals, Inc.SPRY139.3K$1.12M0.3%−$504.2KCut−$1.1M
CytomX Therapeutics, Inc.CTMX230K$1.08M0.2%New
Maze Therapeutics, Inc.MAZE35K$1.04M0.2%New
Mineralys Therapeutics, Inc.MLYS38.5K$1.04M0.2%−$354.1KHeld
Scynexis IncSCYX1.09M$996.6K0.2%New
Oric Pharmaceuticals, Inc.ORIC98.7K$945.5K0.2%$137.9KCut−$208.3K
Inspire Med Sys Inc18.2K$938.8K0.2%−$349.6KAdded$145.6K
PolyPid Ltd.PYPD207.9K$910.6K0.2%$8.32KHeld
TELA Bio, Inc.TELA1.44M$893.4K0.2%−$807KHeld
Zenas BioPharma, Inc.ZBIO42.5K$830.9K0.2%New
Verrica Pharmaceuticals Inc.VRCA153.7K$813.1K0.2%−$464.2KCut−$628.2K
Fate Therapeutics IncFATE550K$660K0.1%$119.6KHeld
Annexon, Inc.ANNX117.8K$652.7K0.1%$61.3KCut−$716.8K
Accuray IncARAY1.68M$652.2K0.1%−$609.1KAdded−$498.5K
Newamsterdam Pharma Company20K$640.2K0.1%New
Adicet Bio, Inc.ACET93.8K$638.9K0.1%−$151KHeld
Biontech SeBNTX7K$622.2K0.1%−$44.2KHeld
Pliant Therapeutics, Inc.PLRX487K$613.6K0.1%New
Compugen LtdCGEN257.8K$549.1K0.1%$154.7KCut$132.3K
Orchestra Biomed Hldgs Inc126.8K$539.1K0.1%$12.7KHeld
Foghorn Therapeutics Inc.FHTX111.9K$534.7K0.1%−$69.4KCut−$150.4K
iBio, Inc.IBIO193.6K$367.9K0.1%New
Bicycle Therapeutics PlcBCYC64.5K$299.2K0.1%−$157.4KHeld
Adc Therapeutics SaADCT72.1K$270.3K0.1%$15.9KCut−$1.79K
Karyopharm Therapeutics Inc.KPTI45.8K$255.1K0.1%−$82KCut−$120.3K
Autolus Therapeutics PlcAUTL179.3K$247.5K0.1%−$109.4KHeld
Neumora Therapeutics, Inc.NMRA70K$136.5K0.0%New

Positions as of Q1 2026. 13F filings arrive up to 45 days after quarter-end and omit shorts. Values are quarter-end marks, as filed. Estimated mark is the price effect on shares still held — not realized P&L or investment advice.