| Nextech Invest, Ltd. | 7.16M | $90.8M | $32.2M | Added$32.2M |
| EcoR1 Capital, LLC | 6.73M | $85.2M | $30.2M | Added$30.2M |
| BlackRock, Inc. | 5.98M | $75.8M | $26.4M | Added$27.8M |
| Viking Global | 5.82M | $73.8M | $26.2M | Added$20M |
| SR One Capital Management, LP | 4.51M | $58.5M | $20.7M | Added$20.7M |
| Pfizer Inc | 4.78M | $57.7M | $18.5M | Added$13.7M |
| ALKEON CAPITAL MANAGEMENT LLC | 4.5M | $57.1M | $20.2M | Added$20.2M |
| VR ADVISER, LLC | 4.32M | $54.7M | $19.4M | Added$8.3M |
| NEA Management Company, LLC | 4.12M | $52.2M | $18.5M | Added$18.5M |
| State Street | 3.7M | $46.9M | $16.6M | Added$12.1M |
| VANGUARD CAPITAL MANAGEMENT LLC | 3.69M | $46.7M | — | Held |
| Column Group LLC | 3.54M | $44.9M | $15.9M | Added$15.9M |
| Siren, L.L.C. | 3M | $38M | $4.52M | Added$29.7M |
| ORBIMED ADVISORS LLC | 2.69M | $34.1M | $12.1M | Added$4.34M |
| AIHC Capital Management Ltd | 2.46M | $31.2M | — | New |
| Fidelity | 2.43M | $30.8M | $10.9M | Added$10.6M |
| Citadel | 2.42M | $30.7M | $10.9M | Added$10.8M |
| First Turn Management, LLC | 2.02M | $25.6M | $9.03M | Added$9.11M |
| Vivo Capital, LLC | 1.85M | $23.4M | $8.3M | Added$6.1M |
| GEODE CAPITAL MANAGEMENT, LLC | 1.84M | $23.3M | $7.86M | Added$8.98M |
| MPM BIOIMPACT LLC | 1.8M | $22.9M | $8.08M | Added$8.14M |
| Paradigm Biocapital Advisors LP | 1.7M | $21.6M | $7.64M | Added$1.91M |
| MORGAN STANLEY | 1.68M | $21.3M | $5.36M | Added$11.6M |
| GOLDMAN SACHS GROUP INC | 1.48M | $18.7M | $6.63M | Added$2.83M |
| DIMENSIONAL FUND ADVISORS LP | 1.47M | $18.6M | $5.51M | Added$8.6M |
| FRANKLIN RESOURCES INC | 1.45M | $18.4M | $5.44M | Added$8.49M |
| Integral Health Asset Management, LLC | 1.4M | $17.7M | $5.39M | Added$7.92M |
| Woodline Partners LP | 1.25M | $15.8M | $1.11M | Added$13.8M |
| ROYCE & ASSOCIATES LP | 1.21M | $15.3M | $5.42M | Added$2.97M |
| BRAIDWELL LP | 1.13M | $14.3M | — | New |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1.1M | $13.9M | $4.94M | Added$4.8M |
| BANK OF AMERICA CORP /DE/ | 1.04M | $13.2M | $2.28M | Added$9.07M |
| Euclidean Capital LLC | 989.4K | $12.5M | $4.44M | Added$4.44M |
| ArrowMark Colorado Holdings LLC | 960.5K | $12.2M | $4.31M | Added$3.47M |
| EVENTIDE ASSET MANAGEMENT, LLC | 953.5K | $12.1M | $4.28M | Added$4.29M |
| Logos Global Management LP | 950K | $12M | $2.02M | Added$8.36M |
| Qube Research & Technologies Ltd | 859.5K | $10.9M | $3.86M | Added$1.03M |
| Defilade Capital Management, L.P. | 842.9K | $10.7M | — | New |
| NORTHERN TRUST CORP | 710.9K | $9.01M | $3.19M | Added$1.76M |
| Sofinnova Investments, Inc. | 679.6K | $8.61M | — | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 605K | $7.67M | $2.72M | Added$2.59M |
| Candriam S.C.A. | 574.1K | $7.27M | — | New |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 570.7K | $7.23M | — | Held |
| Polar Capital Holdings Plc | 539.4K | $6.83M | $2.26M | Added$2.72M |
| SPHERA FUNDS MANAGEMENT LTD. | 537.6K | $6.81M | $2.41M | Cut−$1.4M |
| Balyasny Asset Management L.P. | 523.8K | $6.64M | $2.35M | Cut−$1.14M |
| NEXTBio Capital Management LP | 523.6K | $6.63M | $2.35M | Added$1.6M |
| Connor, Clark & Lunn Investment Management Ltd. | 522.1K | $6.61M | $1.58M | Added$3.74M |
| VANGUARD FIDUCIARY TRUST CO | 507.3K | $6.43M | — | Held |
| Redmile Group, LLC | 415.7K | $5.27M | $1.87M | Added$1.6M |
| VICTORY CAPITAL MANAGEMENT INC | 405.3K | $5.13M | $1.49M | Added$2.41M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 344.3K | $4.36M | $1.55M | Cut−$128.3K |
| JPMORGAN CHASE & CO | 323.6K | $3.94M | $1.3M | Added$551.5K |
| Russell Investments Group, Ltd. | 263.1K | $3.33M | $929.6K | Added$1.64M |
| TD Asset Management Inc | 258.6K | $3.28M | $762.5K | Added$1.89M |
| Atom Investors LP | 226.8K | $2.87M | $1.02M | Added$501.7K |
| UBS Group AG | 194.7K | $2.47M | $874.2K | Cut−$3.54M |
| Bank of New York Mellon Corp | 190.5K | $2.41M | $843.8K | Added$876.1K |
| ExodusPoint Capital Management, LP | 186.1K | $2.36M | $488.7K | Added$1.47M |
| WELLINGTON MANAGEMENT GROUP LLP | 186.1K | $2.36M | $835.6K | Added$788.8K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 182.1K | $2.31M | $588.4K | Added$1.27M |
| Boxer Capital Management, LLC | 176.5K | $2.24M | — | New |
| Icahn Capital | 170.1K | $2.16M | $763.7K | Added$729.4K |
| Hennion & Walsh Asset Management, Inc. | 160.1K | $2.03M | $718.6K | Added$636.7K |
| Nuveen, LLC | 153K | $1.94M | $648.4K | Added$757.6K |
| Blue Owl Capital Holdings LP | 150K | $1.9M | $673.5K | Cut−$2.31M |
| AMERICAN CENTURY COMPANIES INC | 146.8K | $1.86M | $605.8K | Added$756.3K |
| Alyeska Investment Group, L.P. | 137.5K | $1.74M | — | New |
| Rafferty Asset Management, LLC | 115.5K | $1.46M | $518.5K | Added$13.8K |
| SUPERSTRING CAPITAL MANAGEMENT LP | 115.2K | $1.46M | $517.4K | Cut−$628.9K |
| Y-Intercept (Hong Kong) Ltd | 112K | $1.42M | $502.8K | Cut−$1.37M |
| Invesco Ltd. | 109K | $1.38M | $489.2K | Added$482.8K |
| Ishara Investments LP | 102.5K | $1.3M | $460.2K | Cut−$10.1K |
| PRUDENTIAL FINANCIAL INC | 96.1K | $1.22M | — | New |
| Abu Dhabi Investment Council Co P.J.S.C | 89.4K | $1.13M | — | Held |
| Swiss National Bank | 86.2K | $1.09M | $387K | Added$387K |
| RHUMBLINE ADVISERS | 79.1K | $1M | $348.9K | Added$366.1K |
| DAFNA Capital Management LLC | 98.7K | $945.5K | $137.9K | Cut−$208.3K |
| BOOTHBAY FUND MANAGEMENT, LLC | 62K | $785K | $278.2K | Cut−$1M |
| MOORE CAPITAL MANAGEMENT, LP | 59.6K | $754.7K | — | New |
| Tidal Investments LLC | 57.6K | $729.8K | — | New |
| TEMA ETFS LLC | 57.2K | $725.1K | $125.1K | Added$497.2K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 54.2K | $687.2K | $228K | Added$271.8K |
| JANE STREET GROUP, LLC | 53K | $672K | $238.1K | Cut−$1.32M |
| PROFUND ADVISORS LLC | 51.5K | $652.7K | $231.3K | Added$119.7K |
| DEUTSCHE BANK AG\ | 51.3K | $650.4K | $201.8K | Added$282.8K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 48.4K | $612.8K | $152.5K | Added$335.1K |
| PRELUDE CAPITAL MANAGEMENT, LLC | 46.1K | $583.7K | — | New |
| D. E. Shaw & Co., Inc. | 44.4K | $562.4K | $71.9K | Added$431.4K |
| XTX Topco Ltd | 43.3K | $548.5K | $194.4K | Cut−$355.9K |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 43.1K | $546.5K | — | New |
| SummitTX Capital, L.P. | 42.4K | $537.8K | — | New |
| ALLIANCEBERNSTEIN L.P. | 63.8K | $522K | $0 | Held |
| Vanguard Global Advisers, LLC | 39.9K | $505K | — | Held |
| WELLS FARGO & COMPANY/MN | 39.1K | $495.5K | $175.6K | Cut−$179.6K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 39.2K | $492.6K | $173K | Added$157.8K |
| STATE OF WISCONSIN INVESTMENT BOARD | 38.3K | $485.2K | $171.9K | Cut−$531.9K |
| MetLife Investment Management, LLC | 35.7K | $452.2K | $152.5K | Added$174.3K |
| LMR Partners LLP | 35.3K | $446.8K | $158.3K | Added$158.3K |
| MILLENNIUM MANAGEMENT LLC | 34K | $430.9K | $152.7K | Cut−$366.1K |
| TUDOR INVESTMENT CORP ET AL | 33.7K | $426.8K | — | New |
| Optimize Financial Inc | 32.3K | $409.6K | $145.2K | Added$85.6K |
| Campbell & CO Investment Adviser LLC | 29.8K | $377.8K | — | New |
| Graham Capital Management, L.P. | 29.4K | $372.9K | $132.2K | Cut−$294.4K |
| Legal & General Group Plc | 29.3K | $371.7K | $131.7K | Added$94.9K |
| Virtus Investment Advisers, LLC | 29.1K | $368.3K | $127.3K | Added$136.3K |
| SECTORAL ASSET MANAGEMENT INC | 23.5K | $332.7K | $134.3K | Added$148.8K |
| Quantinno Capital Management LP | 25.5K | $323.4K | $104.9K | Added$132.4K |
| VANGUARD ASSET MANAGEMENT, Ltd | 25.2K | $319.1K | — | Held |
| Trexquant Investment LP | 24K | $303.7K | — | New |
| STIFEL FINANCIAL CORP | 23.9K | $302.8K | $60.6K | Added$192.5K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 23.1K | $292.1K | — | New |
| Quarry LP | 21.8K | $276.7K | $71.8K | Added$145.8K |
| BNP PARIBAS FINANCIAL MARKETS | 21.1K | $267.4K | $94.7K | Cut−$60.8K |
| Jasper Ridge Partners, L.P. | 20.9K | $264.4K | $93.7K | Added$93.7K |
| Brevan Howard Capital Management LP | 19.7K | $249.7K | $88.5K | Cut−$482.7K |
| Police & Firemen's Retirement System of New Jersey | 19.3K | $244.9K | $70.2K | Added$117K |
| INTECH INVESTMENT MANAGEMENT LLC | 19.1K | $242.4K | $85.9K | Added$24.8K |
| NEW YORK STATE COMMON RETIREMENT FUND | 18.4K | $233.5K | $82.7K | Added$82.7K |
| China Universal Asset Management Co., Ltd. | 17.8K | $225.6K | $71.3K | Added$95.8K |
| CITIGROUP INC | 17K | $215.3K | $76.3K | Cut−$1.05M |
| Creative Planning | 16.5K | $208.6K | $66.3K | Added$87.8K |
| Palumbo Wealth Management LLC | 15.5K | $197K | $69.8K | Cut−$26.5K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 15.4K | $195.5K | $69.3K | Added$60.2K |
| State of New Jersey Common Pension Fund D | 15K | $189.8K | — | New |
| E Fund Management Co., Ltd. | 14.5K | $183.9K | — | Held |
| JANUS HENDERSON GROUP PLC | 14.4K | $182.2K | $64.4K | Added$64.4K |
| ProShare Advisors LLC | 14.1K | $178.4K | $63.2K | Added$44.3K |
| PSP Research LLC | 13K | $164.7K | — | New |
| BARCLAYS PLC | 12.4K | $157.5K | $55.8K | Cut−$5.72M |
| Hudson Bay Capital Management LP | 12.4K | $157K | — | New |
| CWM, LLC | 12.1K | $153.2K | $152.4K | Added$153.1K |
| ARIZONA STATE RETIREMENT SYSTEM | 12K | $152.5K | $54K | Added$53K |
| Susquehanna Portfolio Strategies, LLC | 11.4K | $144.1K | — | New |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 11.3K | $143.3K | $50.8K | Added$50.8K |
| VOYA INVESTMENT MANAGEMENT LLC | 11.2K | $142.2K | $49.1K | Added$52.7K |
| Vanguard Investments Australia, Ltd. | 10.7K | $135.3K | — | Held |
| KLP KAPITALFORVALTNING AS | 9.3K | $117.8K | $41.8K | Added$41.8K |
| Tower Research Capital LLC (TRC) | 8.98K | $113.8K | $1.99K | Added$110.2K |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 11.7K | $104.4K | — | New |
| PNC Financial Services Group, Inc. | 8.01K | $101.5K | $36K | Added$27.4K |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | 7.5K | $95K | $33.7K | Cut−$27.7K |
| Ameritas Investment Partners, Inc. | 5.41K | $68.6K | $20.6K | Added$31.1K |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5.39M | $68.3K | $14.8K | Added$41.3K |
| Mirae Asset Global Investments Co., Ltd. | 5.24K | $66.3K | $21.2K | Added$27.6K |
| NISA INVESTMENT ADVISORS, LLC | 3.31K | $41.9K | $10.8K | Added$22.2K |
| Federation des caisses Desjardins du Quebec | 3K | $38K | $13.5K | Added$5.29K |
| ASSETMARK, INC | 3K | $38K | $13.5K | Added$13.5K |
| GF FUND MANAGEMENT CO. LTD. | 2.18K | $27.6K | $8.59K | Added$11.9K |
| Sterling Capital Management LLC | 1.7K | $21.6K | $7.64K | Cut−$1.66K |
| Steward Partners Investment Advisory, LLC | 1.65K | $20.9K | — | New |
| SIMPLEX TRADING, LLC | 1.35K | $17.1K | $2.23K | Added$13K |
| ANTIPODES PARTNERS Ltd | 1.28K | $16.2K | $5.74K | Cut−$3.43K |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1.11K | $14.1K | $8.19K | Added$14.1K |
| Versant Capital Management, Inc | 773 | $9.79K | $3.23K | Added$3.9K |
| OSAIC HOLDINGS, INC. | 759 | $9.62K | $3.07K | Added$4.03K |
| Rockefeller Capital Management L.P. | 573 | $7.26K | — | New |
| Essential Partners LLC | 553 | $7.01K | $2.48K | Added$2.49K |
| GAMMA Investing LLC | 552 | $6.99K | $2.26K | Added$2.88K |
| LORD, ABBETT & CO. LLC | 542.6K | $6.88K | $2.44K | Added$2.26K |
| Optiver Holding B.V. | 508 | $6.44K | $1.13K | Added$4.38K |
| EverSource Wealth Advisors, LLC | 298 | $3.78K | $1.31K | Added$1.39K |
| IFP Advisors, Inc | 297 | $3.76K | $1.33K | Added$1.33K |
| Arax Advisory Partners | 215 | $2.72K | $965 | Added$384 |
| US BANCORP \DE\ | 173 | $2.19K | — | New |
| MAI Capital Management | 147 | $1.86K | — | New |
| Allworth Financial LP | 140 | $1.77K | — | New |
| ALGERT GLOBAL LLC | 136.3K | $1.73K | $182 | Added$1.4K |
| GROUP ONE TRADING LLC | 100 | $1.27K | — | New |
| JPL Wealth Management, LLC | 95 | $1.2K | — | New |
| SIGNATUREFD, LLC | 83 | $1.05K | $373 | Added$373 |
| Parallel Advisors, LLC | 83 | $1.05K | $373 | Added$373 |
| Caitong International Asset Management Co., Ltd | 77 | $976 | $346 | Added$289 |
| ROTHSCHILD INVESTMENT LLC | 77 | $976 | $202 | Added$608 |
| Larson Financial Group LLC | 36 | $456 | — | New |
| Farther Finance Advisors, LLC | 50 | $374 | −$14 | Added$210 |
| Root Financial Partners, LLC | 17 | $215 | — | New |
| SG Americas Securities, LLC | 16.1K | $204 | $72 | Cut−$132 |
| GSA CAPITAL PARTNERS LLP | 12.8K | $162 | $58 | Cut−$416 |
| CANADA LIFE ASSURANCE Co | 5.59K | $71 | $25 | Added$25 |
| ACADIAN ASSET MANAGEMENT LLC | 2.68K | $33 | — | New |
| SBI Securities Co., Ltd. | 2 | $25 | $9 | Added$9 |