| RA CAPITAL MANAGEMENT, L.P. | 17.8M | $40.1M | — | New |
| TCG Crossover Management, LLC | 17.8M | $39M | — | New |
| Versant Venture Management, LLC | 12.2M | $27.5M | — | New |
| Deep Track Capital, LP | 9.49M | $21.4M | — | New |
| Commodore Capital LP | 8.7M | $19.7M | — | New |
| VR ADVISER, LLC | 8.7M | $19.7M | — | New |
| RTW INVESTMENTS, LP | 8.7M | $19.7M | — | New |
| Point72 Asset Management, L.P. | 5.96M | $13.5M | $7.54M | Added$7.55M |
| VANGUARD CAPITAL MANAGEMENT LLC | 5.69M | $12.9M | — | Held |
| Balyasny Asset Management L.P. | 5.02M | $11.3M | — | New |
| MILLENNIUM MANAGEMENT LLC | 4.67M | $10.5M | $772.3K | Added$9.94M |
| Spruce Street Capital LP | 4.06M | $9.17M | $1.8M | Added$7.76M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3.79M | $8.56M | $2.33M | Added$6.74M |
| Woodline Partners LP | 3.04M | $6.88M | — | New |
| Seven Fleet Capital Management LP | 2.95M | $6.66M | — | New |
| Trails Edge Capital Partners, LP | 2.45M | $5.54M | — | New |
| DAFNA Capital Management LLC | 2.43M | $5.5M | $3.08M | Added$2.72M |
| TWO SIGMA INVESTMENTS, LP | 2.37M | $5.36M | $1.89M | Added$3.87M |
| BlackRock, Inc. | 1.52M | $3.45M | $761.5K | Added$2.85M |
| Rock Springs Capital Management LP | 1.3M | $2.95M | — | New |
| GEODE CAPITAL MANAGEMENT, LLC | 1.3M | $2.94M | $577.4K | Added$2.49M |
| Casdin Capital, LLC | 1.23M | $2.78M | $1.55M | Added$1.55M |
| Syncona Portfolio Ltd | 1.21M | $2.74M | $1.53M | Added$1.53M |
| Renaissance Technologies | 906.8K | $2.05M | $1.15M | Added$707.2K |
| VANGUARD FIDUCIARY TRUST CO | 693K | $1.57M | — | Held |
| MARSHALL WACE, LLP | 673.6K | $1.52M | — | New |
| State Street | 386.7K | $874K | $161.2K | Added$747.2K |
| NORTHERN TRUST CORP | 230.8K | $521.7K | $132.9K | Added$417.1K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 226.7K | $512.3K | $63.4K | Added$462.5K |
| GOLDMAN SACHS GROUP INC | 210.5K | $475.7K | — | New |
| BANK OF AMERICA CORP /DE/ | 145.1K | $327.9K | $665 | Added$327.4K |
| BARCLAYS PLC | 120.2K | $271.7K | $1 | Added$271.7K |
| Squarepoint Ops LLC | 119.5K | $270.1K | — | New |
| SUPERSTRING CAPITAL MANAGEMENT LP | 119.3K | $269.6K | $150.9K | Cut−$190.9K |
| Brevan Howard Capital Management LP | 96.6K | $218.4K | — | New |
| RAYMOND JAMES FINANCIAL INC | 91.3K | $206.4K | $115.5K | Added$115.5K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 79.4K | $179.5K | — | New |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 77.8K | $165.7K | $95.7K | Added$95.7K |
| Invesco Ltd. | 62.1K | $140.4K | — | New |
| AMERICAN CENTURY COMPANIES INC | 58.7K | $132.8K | — | New |
| DIMENSIONAL FUND ADVISORS LP | 55.2K | $122.2K | — | New |
| Cannon Global Investment Management, LLC | 49K | $110.7K | — | New |
| OMERS ADMINISTRATION Corp | 47.8K | $108K | — | New |
| Vanguard Global Advisers, LLC | 44.6K | $100.8K | — | Held |
| Tower Research Capital LLC (TRC) | 33K | $74.6K | — | New |
| HarbourVest Partners LLC | 29K | $65.6K | $36.7K | Added$36.7K |
| Parametrica Management Ltd | 27.8K | $62.9K | $35.2K | Added$35.2K |
| MORGAN STANLEY | 26.2K | $59.3K | — | New |
| PRUDENTIAL FINANCIAL INC | 25.3K | $57.2K | $32K | Cut−$2.31K |
| XTX Topco Ltd | 22.5K | $50.9K | $19.4K | Added$35.6K |
| Quadrant Private Wealth Management, LLC | 20K | $45.2K | $19.3K | Added$30K |
| UBS Group AG | 14.2K | $32.1K | $18K | Cut−$181.3K |
| Bank of New York Mellon Corp | 12.9K | $29.1K | — | New |
| SIMPLEX TRADING, LLC | 9.03K | $20.4K | $3.03K | Added$18K |
| Fidelity | 8.78K | $19.8K | $11.1K | Cut−$51.3K |
| Advisors Asset Management, Inc. | 8.31K | $18.8K | $10.5K | Added$10.5K |
| ROYAL BANK OF CANADA | 4.39K | $9K | $141 | Added$9K |
| Farther Finance Advisors, LLC | 2.5K | $5.47K | — | New |
| BNP PARIBAS FINANCIAL MARKETS | 1.42K | $3.21K | $1.79K | Added$1.77K |
| SBI Securities Co., Ltd. | 1.26K | $2.85K | $1.59K | Added$1.33K |
| NISA INVESTMENT ADVISORS, LLC | 883 | $2K | $1.12K | Added$1.12K |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 500 | $1.15K | $648 | Added$648 |
| Advisory Services Network, LLC | 407 | $920 | — | New |
| Fortitude Family Office, LLC | 294 | $664 | — | New |
| ACADIAN ASSET MANAGEMENT LLC | 278.1K | $627 | $351 | Cut−$582 |
| JPMORGAN CHASE & CO | 115 | $233 | $119 | Cut−$2.83K |
| Arax Advisory Partners | 99 | $224 | $126 | Added$126 |
| GSA CAPITAL PARTNERS LLP | 76.8K | $174 | $98 | Cut−$157 |
| WELLS FARGO & COMPANY/MN | 40 | $90 | $50 | Added$50 |
| Optiver Holding B.V. | 32 | $72 | $40 | Added$40 |
| Smartleaf Asset Management LLC | 1 | $2 | $1 | Added$1 |