| Fidelity | 4.3M | $309.6M | $3M | Added$305.3M |
| BVF INC/IL | 2.56M | $184.2M | $46.3M | Added$118.2M |
| Two Seas Capital LP | 1.96M | $141M | $22.1M | Added$109.5M |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.2M | $86.1M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 930.7K | $67M | $14M | Added$47M |
| Prosight Management, LP | 735K | $52.9M | $16.5M | Added$29.4M |
| BlackRock, Inc. | 692.6K | $49.8M | $19.2M | Added$22.5M |
| MORGAN STANLEY | 659.4K | $47.4M | $16.8M | Added$23.5M |
| ARMISTICE CAPITAL, LLC | 578K | $41.6M | $17.1M | Added$16.4M |
| Invesco Ltd. | 567.5K | $40.8M | $13.9M | Added$21M |
| Citadel | 513.5K | $36.9M | $9.19M | Added$23.9M |
| Sofinnova Investments, Inc. | 509.5K | $36.7M | $13M | Added$18.1M |
| Woodline Partners LP | 415.3K | $29.9M | $3.09M | Added$25.5M |
| MILLENNIUM MANAGEMENT LLC | 404.3K | $29.1M | $12M | Added$9.89M |
| EMERALD ADVISERS, LLC | 394.6K | $28.4M | $11.4M | Added$12.1M |
| Qube Research & Technologies Ltd | 390.7K | $28.1M | $9.61M | Added$14.4M |
| GEODE CAPITAL MANAGEMENT, LLC | 346.8K | $25M | $7.55M | Added$14.2M |
| UBS Group AG | 320.2K | $23M | $8.53M | Added$10.9M |
| GREAT POINT PARTNERS LLC | 316.5K | $22.8M | $6.25M | Added$13.9M |
| Vestal Point Capital, LP | 285K | $20.5M | — | New |
| 22NW, LP | 281.1K | $20.2M | $8.34M | Added$6.23M |
| PRIMECAP MANAGEMENT CO/CA/ | 279.1K | $20.1M | $8.28M | Added$8.24M |
| ORBIMED ADVISORS LLC | 275K | $19.8M | — | New |
| GILDER GAGNON HOWE & CO LLC | 271.8K | $19.6M | $6.18M | Added$10.7M |
| Nearwater Capital Markets, Ltd | 261.5K | $18.8M | $1.82M | Added$16.2M |
| EMERALD MUTUAL FUND ADVISERS TRUST | 256.1K | $18.4M | $7.51M | Added$7.72M |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 249.1K | $17.9M | $7.39M | Added$1.72M |
| State Street | 244.7K | $17.6M | $5.81M | Added$9.34M |
| BRAIDWELL LP | 222.7K | $16M | — | New |
| JPMORGAN CHASE & CO | 240.1K | $15.7M | $3.46M | Added$9.29M |
| Patient Square Capital LP | 210K | $15.1M | — | New |
| Bronte Capital Management Pty Ltd. | 198.3K | $14.3M | — | New |
| Quinn Opportunity Partners LLC | 179.2K | $12.9M | $2.55M | Added$9.27M |
| VANGUARD FIDUCIARY TRUST CO | 169.3K | $12.2M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 168K | $12.1M | $3.57M | Added$7M |
| DAFNA Capital Management LLC | 165.2K | $11.9M | $2.23M | Added$8.71M |
| ADAR1 Capital Management, LLC | 161.3K | $11.6M | $2.14M | Added$8.56M |
| MARSHALL WACE, LLP | 140.6K | $10.1M | $712.8K | Added$9.1M |
| AMERIPRISE FINANCIAL INC | 136.7K | $9.84M | — | New |
| GOLDMAN SACHS GROUP INC | 126.9K | $9.13M | $3.77M | Added$2.88M |
| Creek Drive Management Group LLC | 126.4K | $9.09M | $3.75M | Added$1.25M |
| Squadron Capital Management LLC | 125K | $8.99M | — | New |
| SEVEN GRAND MANAGERS, LLC | 125K | $8.99M | — | New |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 122.3K | $8.8M | $3.63M | Added$848K |
| BNP PARIBAS FINANCIAL MARKETS | 121.5K | $8.74M | $3.61M | Cut−$146.7K |
| JANE STREET GROUP, LLC | 112.7K | $8.11M | $3.34M | Cut−$1.13M |
| Squarepoint Ops LLC | 107.4K | $7.73M | $601K | Added$6.87M |
| Russell Investments Group, Ltd. | 106.2K | $7.64M | $2.54M | Added$4.02M |
| Tetragon Partners GP Ltd | 103K | $7.41M | $2.06M | Added$4.48M |
| Monashee Investment Management LLC | 100K | $7.2M | $2.79M | Added$3.22M |
| ING GROEP NV | 100K | $7.2M | $2.97M | Added$2.97M |
| Connor, Clark & Lunn Investment Management Ltd. | 98.7K | $7.1M | $2.93M | Added$2.83M |
| DEUTSCHE BANK AG\ | 91.7K | $6.6M | $2.69M | Added$2.76M |
| Moody Aldrich Partners LLC | 89.5K | $6.44M | $1.66M | Added$4.07M |
| Stonepine Capital Management, LLC | 85K | $6.12M | $2.52M | Added$2.52M |
| NORTHERN TRUST CORP | 78.6K | $5.66M | $1.66M | Added$3.28M |
| Jump Financial, LLC | 77.4K | $5.57M | $1.58M | Added$3.32M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 72.5K | $5.22M | — | Held |
| ACT CAPITAL MANAGEMENT, LLC | 70.9K | $5.1M | $1.52M | Added$2.94M |
| Voleon Capital Management LP | 65.1K | $4.68M | $1.93M | Added$1.79M |
| F/m Investments LLC | 61.1K | $4.4M | $1.72M | Added$1.94M |
| Rhenman & Partners Asset Management AB | 59K | $4.25M | — | New |
| BANK OF AMERICA CORP /DE/ | 59K | $4.24M | $774.1K | Added$3.14M |
| Aquatic Capital Management LLC | 57K | $4.1M | $1.64M | Added$1.77M |
| Trexquant Investment LP | 55.5K | $3.99M | $558.4K | Added$3.2M |
| FRED ALGER MANAGEMENT, LLC | 53.2K | $3.83M | $1.58M | Added$1.54M |
| Alyeska Investment Group, L.P. | 50K | $3.6M | — | New |
| Brevan Howard Capital Management LP | 48.5K | $3.49M | — | New |
| LMR Partners LLP | 48.3K | $3.47M | — | New |
| Swiss National Bank | 47.9K | $3.45M | $946.5K | Added$2.1M |
| Atom Investors LP | 43.2K | $3.11M | — | New |
| SummitTX Capital, L.P. | 42.6K | $3.07M | $930.2K | Added$1.74M |
| Renaissance Technologies | 41.8K | $3.01M | $1.24M | Cut−$4.3M |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 36.9K | $2.66M | $1.1M | Added$100.4K |
| Jain Global LLC | 36.2K | $2.6M | $513.3K | Added$1.87M |
| Informed Momentum Co LLC | 36.1K | $2.6M | $384.9K | Added$2.05M |
| Balyasny Asset Management L.P. | 35.9K | $2.58M | $1.06M | Cut−$9.34M |
| Susquehanna Portfolio Strategies, LLC | 34.5K | $2.48M | $476.4K | Added$1.81M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 34K | $2.45M | $480.2K | Added$1.76M |
| BARCLAYS PLC | 32.4K | $2.33M | $458.2K | Added$1.68M |
| IRIDIAN ASSET MANAGEMENT LLC/CT | 31.3K | $2.25M | $288.6K | Added$1.84M |
| Birchview Capital, LP | 31K | $2.23M | $919.8K | Added$919.8K |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 30.1K | $2.17M | $432.1K | Added$1.55M |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 28.7K | $2.06M | $430.8K | Added$1.45M |
| Headlands Technologies LLC | 28.2K | $2.03M | $838K | Added$290.2K |
| KVP Capital Advisors, LP | 26.9K | $1.94M | $798.1K | Added$798.1K |
| Y-Intercept (Hong Kong) Ltd | 26.5K | $1.91M | $322.3K | Added$1.45M |
| Erste Asset Management GmbH | 28K | $1.83M | $630.6K | Added$630.6K |
| CITIGROUP INC | 25K | $1.8M | $743.2K | Added$289.6K |
| BIT Capital GmbH | 21.1K | $1.52M | $626K | Added$626K |
| ExodusPoint Capital Management, LP | 20.5K | $1.47M | — | New |
| AWM Investment Company, Inc. | 20K | $1.44M | $593.4K | Cut−$252.2K |
| Man Group plc | 19.4K | $1.4M | — | New |
| Deuterium Capital Management, LLC | 18K | $1.3M | $534.1K | Cut−$284K |
| WINTON GROUP Ltd | 16.9K | $1.22M | $230.4K | Added$888.4K |
| Legal & General Group Plc | 16.7K | $1.2M | $368.3K | Added$673.7K |
| IMC-Chicago, LLC | 16.4K | $1.18M | — | New |
| ROYAL BANK OF CANADA | 16.2K | $1.16M | $207.9K | Added$868K |
| VANGUARD ASSET MANAGEMENT, Ltd | 15.9K | $1.15M | — | Held |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 15.8K | $1.14M | — | New |
| Steward Partners Investment Advisory, LLC | 15.5K | $1.12M | $6.32K | Added$1.11M |
| TUDOR INVESTMENT CORP ET AL | 15K | $1.08M | — | New |
| HighVista Strategies LLC | 14.6K | $1.05M | $348.6K | Added$550.5K |
| GLENMEDE TRUST CO NA | 13.9K | $997.6K | $254.9K | Added$634.4K |
| STATE OF WISCONSIN INVESTMENT BOARD | 13.7K | $983.6K | $256K | Added$618.7K |
| Point72 Asset Management, L.P. | 13.4K | $961.5K | $396.5K | Cut−$17.4M |
| Walleye Capital LLC | 12.9K | $926.6K | — | New |
| Engineers Gate Manager LP | 12.3K | $885.1K | $365K | Cut−$691.2K |
| FIFTH LANE CAPITAL, LP | 12K | $863.4K | — | New |
| SECTORAL ASSET MANAGEMENT INC | 10.9K | $820.7K | $361.9K | Added$250.5K |
| Vanguard Global Advisers, LLC | 11.3K | $809.7K | — | Held |
| Scientech Research LLC | 11K | $793.8K | — | New |
| ENVESTNET ASSET MANAGEMENT INC | 10.9K | $783K | $159.7K | Added$555.4K |
| JANUS HENDERSON GROUP PLC | 10.7K | $771.1K | $240.4K | Added$429.3K |
| OCCUDO QUANTITATIVE STRATEGIES LP | 8.95K | $760.9K | — | New |
| Hudson Bay Capital Management LP | 10.3K | $743.4K | $306.6K | Cut−$1.78M |
| Palumbo Wealth Management LLC | 10.2K | $731.9K | $301.8K | Added$109.8K |
| ALLSTATE CORP | 9.84K | $707.8K | — | New |
| State of New Jersey Common Pension Fund D | 8.29K | $596.3K | — | New |
| Schonfeld Strategic Advisors LLC | 8.06K | $580.1K | — | New |
| Diametric Capital, LP | 7.41K | $533.2K | — | New |
| CenterBook Partners LP | 7.41K | $532.9K | — | New |
| PEAK6 LLC | 7K | $503.6K | — | New |
| Catalyst Funds Management Pty Ltd | 6.7K | $482.1K | — | New |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 6.7K | $481.7K | — | New |
| ARIZONA STATE RETIREMENT SYSTEM | 6.66K | $479.3K | — | New |
| Bank of New York Mellon Corp | 6.6K | $474.7K | — | New |
| Neo Ivy Capital Management | 6.44K | $463.3K | — | New |
| Vanguard Investments Australia, Ltd. | 6.36K | $457.2K | — | Held |
| FOX RUN MANAGEMENT, L.L.C. | 6.87K | $448.3K | $157.8K | Cut−$673K |
| GROUP ONE TRADING LLC | 5.95K | $428K | $43K | Added$366.8K |
| Persistent Asset Partners Ltd | 5.82K | $418.7K | — | New |
| SIMPLEX TRADING, LLC | 5.72K | $411.7K | $169.8K | Cut−$515.8K |
| KLP KAPITALFORVALTNING AS | 5.2K | $374.1K | $103.8K | Added$226.2K |
| Gainplan LLC | 5K | $359.8K | $148.3K | Cut−$211K |
| Virtus Investment Advisers, LLC | 4.98K | $358.6K | $144.3K | Added$153K |
| Entropy Technologies, LP | 4.59K | $330.3K | — | New |
| LPL Financial LLC | 4.55K | $327.4K | — | New |
| SEI INVESTMENTS CO | 4.47K | $321.7K | $132.7K | Cut−$113.5K |
| OSAIC HOLDINGS, INC. | 4.39K | $316.1K | $130.3K | Added$88.3K |
| Seven Fleet Capital Management LP | 4.3K | $309.4K | $127.6K | Cut−$324.8K |
| XTX Topco Ltd | 4.1K | $295.2K | $121.7K | Cut−$9.04K |
| FARALLON CAPITAL MANAGEMENT LLC | 4K | $287.8K | — | New |
| China Universal Asset Management Co., Ltd. | 4K | $287.8K | — | New |
| OP Asset Management Ltd | 3.99K | $287.2K | — | New |
| GREAT LAKES ADVISORS, LLC | 3.74K | $269.2K | — | New |
| Pictet Asset Management Holding SA | 3.72K | $267.5K | — | New |
| Vanguard Personalized Indexing Management, LLC | 3.69K | $265.1K | — | New |
| Orion Porfolio Solutions, LLC | 3.54K | $254.9K | — | New |
| PROFUND ADVISORS LLC | 3.16K | $227.3K | — | New |
| VICTORY CAPITAL MANAGEMENT INC | 3.13K | $225K | — | New |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 3.1K | $222.9K | — | New |
| MANGROVE PARTNERS IM, LLC | 3.06K | $220K | — | New |
| LVW Advisors, LLC | 3.02K | $217.4K | — | New |
| RAYMOND JAMES FINANCIAL INC | 2.95K | $212.5K | — | New |
| Allspring Global Investments Holdings, LLC | 2.9K | $208.5K | — | New |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 2.83K | $203.6K | $84K | Cut−$4.7K |
| Bayforest Capital Ltd | 2.54K | $182.6K | $75.3K | Added$75.2K |
| Leonteq Securities AG | 2K | $143.9K | $59.3K | Cut−$194.3K |
| US BANCORP \DE\ | 1.92K | $137.9K | $37.4K | Added$84.6K |
| Caitong International Asset Management Co., Ltd | 1.8K | $129.4K | — | New |
| Tower Research Capital LLC (TRC) | 1.34K | $96.8K | $39.9K | Cut−$138.3K |
| Parallel Advisors, LLC | 1.05K | $75.8K | $31.2K | Added$31.2K |
| State of Wyoming | 927 | $66.7K | — | New |
| NATIXIS | 685 | $49.3K | $20.3K | Added$20.3K |
| Allworth Financial LP | 681 | $49K | $20.1K | Added$20.4K |
| RHUMBLINE ADVISERS | 600 | $43.2K | $2.97K | Added$38.9K |
| Quantbot Technologies LP | 417 | $30K | — | New |
| LORD, ABBETT & CO. LLC | 405.1K | $29.1K | — | New |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 397 | $28.6K | $12.8K | Added$28.6K |
| WELLS FARGO & COMPANY/MN | 327 | $23.5K | $5.67K | Added$15.5K |
| JONES FINANCIAL COMPANIES LLLP | 300 | $20.6K | $2.87K | Added$16K |
| MONTAG A & ASSOCIATES INC | 250 | $18K | — | New |
| KELLEHER FINANCIAL ADVISORS | 200 | $14.4K | — | New |
| Activest Wealth Management | 200 | $14.4K | $5.93K | Added$5.93K |
| Western Wealth Management, LLC | 199 | $14.3K | — | New |
| CWM, LLC | 176 | $12.7K | $12.7K | Added$12.7K |
| SBI Securities Co., Ltd. | 141 | $10.1K | $4.18K | Added$3.97K |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 127 | $9.14K | $1.16K | Added$1.16K |
| Golden State Equity Partners | 120 | $8.63K | — | New |
| EverSource Wealth Advisors, LLC | 111 | $7.99K | $3.26K | Added$3.34K |
| HRT FINANCIAL LP | 84.1K | $6.05K | $2.49K | Cut−$2.33K |
| MassMutual Private Wealth & Trust, FSB | 78 | $5.61K | $1.33K | Added$3.71K |
| BROWN BROTHERS HARRIMAN & CO | 66 | $4.75K | $1.96K | Added$1.96K |
| MTM Investment Management, LLC | 66 | $4.75K | $1.96K | Added$1.96K |
| SIGNATUREFD, LLC | 60 | $4.32K | $1.78K | Added$1.36K |
| HOLLENCREST CAPITAL MANAGEMENT | 60 | $4.32K | — | New |
| Cambridge Investment Research Advisors, Inc. | 56.1K | $4.03K | $1.59K | Added$1.76K |
| Parkside Financial Bank & Trust | 52 | $3.74K | — | New |
| Rachor Investment Advisory Services, LLC | 41 | $2.95K | $1.04K | Added$1.47K |
| ATLAS CAPITAL ADVISORS INC. | 40 | $2.88K | $1.19K | Added$1.19K |
| Boreal Capital Management LLC | 36 | $2.59K | $1.07K | Added$1.07K |
| ALGERT GLOBAL LLC | 34.8K | $2.5K | $455 | Added$1.86K |
| GSA CAPITAL PARTNERS LLP | 21.3K | $1.53K | $633 | Added$558 |
| NISA INVESTMENT ADVISORS, LLC | 20 | $1.44K | $593 | Added$593 |
| Keating Financial Advisory Services, Inc. | 18 | $1.29K | $534 | Cut−$1.62K |
| Kimelman & Baird, LLC | 13 | $936 | $386 | Added$386 |
| Medallion Wealth Advisors, LLC | 13 | $935 | $385 | Added$385 |
| AMERIFLEX GROUP, INC. | 13 | $935 | $385 | Added$385 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 11.3K | $812 | $308 | Added$373 |
| Fortitude Family Office, LLC | 7 | $504 | $208 | Cut−$384 |
| GAMMA Investing LLC | 6 | $432 | — | New |
| TWIN PEAKS WEALTH ADVISORS, LLC | 5 | $384 | — | New |
| FNY Investment Advisers, LLC | 4.75K | $341 | $141 | Added$122 |
| MAI Capital Management | 4 | $288 | — | New |
| SG Americas Securities, LLC | 3.23K | $233 | $96 | Cut−$230 |
| DANSKE BANK A/S | 2 | $144 | $59 | Added$59 |
| ACADIAN ASSET MANAGEMENT LLC | 1.99K | $141 | $57 | Cut−$2.91K |
| Smartleaf Asset Management LLC | 2 | $130 | $46 | Added$46 |
| BESSEMER GROUP INC | 1.56K | $112 | $47 | Added$46 |
| Farther Finance Advisors, LLC | 1 | $76 | $34 | Cut−$5.88K |
| LRI Investments, LLC | 1 | $72 | $30 | Added$30 |
| Root Financial Partners, LLC | 1 | $72 | — | New |
| KBC Group NV | 721 | $52 | — | New |
| Inspire Investing, LLC | 1 | $48 | — | Added$30 |
| HUNTINGTON NATIONAL BANK | 1 | $1 | $0 | Held |
| Covestor Ltd | 0 | $0 | — | Held |