| Flagship Pioneering, LLC | 12.7M | $60.6M | −$7.86M | Cut−$7.86M |
| Fidelity | 6.05M | $28.9M | −$3.35M | Cut−$237.2K |
| BVF INC/IL | 5.84M | $27.9M | −$3.29M | Cut−$706K |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 4.39M | $21M | −$2.26M | Added$1.3M |
| RAYMOND JAMES FINANCIAL INC | 2.6M | $12.4M | −$1.55M | Cut−$1.09M |
| BlackRock, Inc. | 2.36M | $11.3M | −$1.46M | Cut−$1.39M |
| Euclidean Capital LLC | 1.57M | $7.52M | −$975.7K | Cut−$975.7K |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.5M | $7.15M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 848.2K | $4.06M | −$493.1K | Cut−$239K |
| Siren, L.L.C. | 720.7K | $3.45M | −$446.8K | Cut−$446.8K |
| State Street | 679.8K | $3.25M | −$383.6K | Cut−$91.4K |
| AMERIPRISE FINANCIAL INC | 449K | $2.15M | −$278.4K | Cut−$1.14M |
| Renaissance Technologies | 406.4K | $1.94M | −$184.6K | Added$334.9K |
| Candriam S.C.A. | 313.8K | $1.5M | — | New |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 303.8K | $1.45M | −$166.9K | Cut−$1.65K |
| Birchview Capital, LP | 281.7K | $1.35M | −$174.7K | Cut−$174.7K |
| NORTHERN TRUST CORP | 275.9K | $1.32M | −$162.7K | Cut−$98.4K |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 255.9K | $1.22M | — | Held |
| VANGUARD FIDUCIARY TRUST CO | 240.6K | $1.15M | — | Held |
| Citadel | 200K | $956.1K | −$113K | Cut−$28.2K |
| Woodline Partners LP | 180.3K | $862K | −$13.3K | Added$745.8K |
| GOLDMAN SACHS GROUP INC | 136.1K | $650.6K | −$73.6K | Added$9.61K |
| Sio Capital Management, LLC | 122.9K | $587.4K | −$76.2K | Cut−$76.2K |
| PANAGORA ASSET MANAGEMENT INC | 115.1K | $550K | −$55.4K | Added$67.8K |
| DAFNA Capital Management LLC | 111.9K | $534.7K | −$69.4K | Cut−$150.4K |
| SCS Capital Management LLC | 107K | $511.4K | −$66.3K | Cut−$66.3K |
| Squarepoint Ops LLC | 103.7K | $495.9K | −$64.3K | Cut−$268.6K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 103.5K | $494.9K | −$51.1K | Added$50.1K |
| B Group, Inc. | 102K | $487.6K | — | New |
| MORGAN STANLEY | 98.5K | $470.7K | −$61.1K | Cut−$186.6K |
| Qube Research & Technologies Ltd | 81.3K | $388.5K | −$33K | Added$100.9K |
| DIADEMA PARTNERS LP | 79.9K | $382.1K | −$19K | Added$216.7K |
| Bank of New York Mellon Corp | 79.6K | $380.3K | −$48.9K | Cut−$45.8K |
| UBS Group AG | 75.8K | $362.5K | −$15.2K | Added$230.2K |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 74.6K | $356.6K | −$46.3K | Cut−$46.3K |
| STATE OF WISCONSIN INVESTMENT BOARD | 65.6K | $313.8K | −$32.9K | Added$26.8K |
| BANK OF AMERICA CORP /DE/ | 60.1K | $287.3K | −$37.3K | Cut−$111.6K |
| Nuveen, LLC | 50.4K | $240.8K | −$31.1K | Cut−$29.9K |
| Persistent Asset Partners Ltd | 46.6K | $223K | −$28.9K | Cut−$31.4K |
| RHUMBLINE ADVISERS | 39.5K | $188.8K | −$24.5K | Cut−$27.8K |
| Walleye Capital LLC | 34.4K | $164.6K | −$21.4K | Cut−$274.6K |
| Icahn Capital | 32.6K | $155.6K | −$8.4K | Added$82.5K |
| ALLIANCEBERNSTEIN L.P. | 26.7K | $144K | $0 | Held |
| Trexquant Investment LP | 30.1K | $143.9K | — | New |
| MILLENNIUM MANAGEMENT LLC | 29.6K | $141.3K | −$18.3K | Cut−$985K |
| Point72 Asset Management, L.P. | 27.6K | $132.1K | −$17.1K | Cut−$202.5K |
| DEUTSCHE BANK AG\ | 27.4K | $131.1K | −$17K | Cut−$17K |
| CANADA PENSION PLAN INVESTMENT BOARD | 25.1K | $120K | −$7.94K | Added$50.9K |
| Verdad Advisers, LP | 24.4K | $116.7K | — | New |
| BARCLAYS PLC | 19.4K | $92.9K | −$12K | Cut−$248.3K |
| Invesco Ltd. | 17.7K | $84.8K | −$6.69K | Added$26.5K |
| JPMORGAN CHASE & CO | 18.7K | $82.6K | −$16.9K | Cut−$10.4K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 16.2K | $77.6K | −$9.83K | Cut−$8.05K |
| WELLS FARGO & COMPANY/MN | 14.7K | $70.5K | −$9.14K | Cut−$138.8K |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 14.3K | $68.2K | −$8.85K | Cut−$8.85K |
| Jump Financial, LLC | 13.7K | $65.7K | −$8.52K | Cut−$64.6K |
| BNP PARIBAS FINANCIAL MARKETS | 12.8K | $61.4K | −$5.13K | Added$16.7K |
| Vanguard Global Advisers, LLC | 12.8K | $61.3K | — | Held |
| KINGSWOOD WEALTH ADVISORS, LLC | 12.5K | $59.8K | — | New |
| SPHERA FUNDS MANAGEMENT LTD. | 12.2K | $58.4K | — | New |
| PRUDENTIAL FINANCIAL INC | 12.2K | $58.3K | — | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 11.6K | $55.6K | — | New |
| Police & Firemen's Retirement System of New Jersey | 11.3K | $54.1K | −$7.02K | Cut−$7.02K |
| Fiduciary Trust Co | 10.9K | $52K | −$6.75K | Cut−$6.75K |
| DIVERSIFIED TRUST CO | 10.9K | $51.9K | — | New |
| China Universal Asset Management Co., Ltd. | 10.4K | $49.7K | −$5.71K | Cut−$68 |
| MetLife Investment Management, LLC | 9.71K | $46.4K | −$6.02K | Cut−$57K |
| STRS OHIO | 8.6K | $41.1K | −$5.33K | Cut−$5.33K |
| Evelyn Partners Asset Management Ltd | 7.1K | $33.9K | −$4.4K | Cut−$4.4K |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 5.29K | $25.3K | — | New |
| NISA INVESTMENT ADVISORS, LLC | 5.24K | $25K | −$3.25K | Cut−$3.25K |
| CITIGROUP INC | 3.42K | $16.3K | −$1.44K | Added$3.74K |
| CWM, LLC | 3.35K | $16K | $6.44K | Added$16K |
| Ameritas Investment Partners, Inc. | 3.34K | $16K | −$2.07K | Cut−$2.07K |
| Tower Research Capital LLC (TRC) | 3.29K | $15.8K | −$1.29K | Added$4.56K |
| Mirae Asset Global Investments Co., Ltd. | 3.06K | $14.6K | −$1.7K | Cut−$231 |
| Legal & General Group Plc | 2.98K | $14.2K | −$1.85K | Cut−$3.97K |
| Russell Investments Group, Ltd. | 2.9K | $13.9K | −$1.8K | Cut−$18.2K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 2.88K | $13.7K | −$232 | Added$11.7K |
| NEW YORK STATE COMMON RETIREMENT FUND | 1.87K | $8.94K | −$1.16K | Cut−$1.16K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1.8K | $8.61K | −$1.12K | Cut−$2.45K |
| GF FUND MANAGEMENT CO. LTD. | 1.26K | $6.04K | −$689 | Added$38 |
| Sunbelt Securities, Inc. | 1K | $4.78K | −$620 | Cut−$620 |
| GAMMA Investing LLC | 864 | $4.13K | −$226 | Added$2.16K |
| Sterling Capital Management LLC | 488 | $2.33K | −$302 | Cut−$2.24K |
| Optiver Holding B.V. | 294 | $1.41K | −$183 | Cut−$269 |
| NATIONAL BANK OF CANADA /FI/ | 200 | $952 | −$124 | Cut−$124 |
| TFC Financial Management, Inc. | 123 | $588 | −$77 | Cut−$77 |
| Essential Partners LLC | 112 | $535 | — | New |
| SBI Securities Co., Ltd. | 100 | $478 | −$62 | Cut−$62 |
| Allworth Financial LP | 97 | $464 | — | New |
| PNC Financial Services Group, Inc. | 93 | $445 | −$52 | Cut−$9 |
| EverSource Wealth Advisors, LLC | 82 | $392 | −$46 | Cut−$13 |
| SIMPLEX TRADING, LLC | 66 | $315 | — | New |
| ACADIAN ASSET MANAGEMENT LLC | 37.6K | $177 | −$5 | Added$136 |
| MAI Capital Management | 35 | $168 | — | New |
| ROTHSCHILD INVESTMENT LLC | 34 | $163 | — | New |
| Root Financial Partners, LLC | 28 | $134 | — | New |
| PRICE T ROWE ASSOCIATES INC /MD/ | 24.5K | $118 | −$10 | Added$29 |
| True Wealth Design, LLC | 20 | $96 | −$3 | Added$69 |
| ALGERT GLOBAL LLC | 13.9K | $67 | −$8 | Cut−$8 |
| Wealth Preservation Advisors, LLC | 13 | $62 | — | New |
| Farther Finance Advisors, LLC | 9 | $44 | — | New |
| OSAIC HOLDINGS, INC. | 5 | $24 | −$3 | Cut−$5.53K |
| ROYAL BANK OF CANADA | 24 | $0 | −$143 | Cut−$6K |