| Catalys Pacific, LLC | 7.9M | $214.1M | −$72.7M | Cut−$72.7M |
| RA CAPITAL MANAGEMENT, L.P. | 7.69M | $208.4M | −$67.4M | Cut−$57.4M |
| SAMSARA BIOCAPITAL, LLC | 5.87M | $159M | −$54M | Cut−$54M |
| Fidelity | 4.86M | $131.7M | −$44.7M | Cut−$51.8M |
| BlackRock, Inc. | 4.48M | $121.4M | −$39.8M | Cut−$35.6M |
| WELLINGTON MANAGEMENT GROUP LLP | 3.36M | $91M | −$7.22M | Added$62.5M |
| State Street | 2.94M | $79.5M | −$27M | Cut−$36M |
| Caligan Partners LP | 2.77M | $75.1M | −$25.5M | Cut−$25.5M |
| VANGUARD CAPITAL MANAGEMENT LLC | 2.45M | $66.5M | — | Held |
| Laurion Capital Management LP | 2.23M | $60.5M | −$15.8M | Cut−$1.72M |
| ORBIMED ADVISORS LLC | 2.05M | $55.6M | −$9.02M | Added$20M |
| Point72 Asset Management, L.P. | 1.91M | $51.8M | −$11.1M | Added$7.97M |
| FRANKLIN RESOURCES INC | 1.78M | $48.3M | −$16.4M | Cut−$16.6M |
| ANDERA PARTNERS | 1.59M | $43.1M | −$14.6M | Cut−$14.6M |
| SR One Capital Management, LP | 1.56M | $42.4M | −$14.4M | Cut−$14.4M |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1.54M | $41.7M | −$14.2M | Cut−$14.2M |
| Polar Capital Holdings Plc | 1.5M | $40.7M | −$12.9M | Cut−$10.2M |
| SPHERA FUNDS MANAGEMENT LTD. | 1.34M | $36.3M | −$4.13M | Added$20M |
| ALLIANCEBERNSTEIN L.P. | 976K | $35.4M | −$0 | Added$1.94M |
| GEODE CAPITAL MANAGEMENT, LLC | 1.3M | $35.3M | −$11.6M | Cut−$10.4M |
| JENNISON ASSOCIATES LLC | 1.27M | $34.3M | −$11.6M | Cut−$11.4M |
| ARMISTICE CAPITAL, LLC | 1.18M | $31.9M | −$6.22M | Added$7.32M |
| BANK OF AMERICA CORP /DE/ | 1.1M | $29.8M | −$9.08M | Cut−$6.02M |
| Pictet Asset Management Holding SA | 1.03M | $28M | −$7.85M | Cut−$2.93M |
| BOOTHBAY FUND MANAGEMENT, LLC | 1M | $27.1M | −$9.13M | Cut−$8.87M |
| Qube Research & Technologies Ltd | 914.7K | $24.8M | −$4.57M | Added$6.76M |
| Nantahala Capital Management, LLC | 895.5K | $24.3M | −$1.04M | Added$20.1M |
| D. E. Shaw & Co., Inc. | 887.2K | $24M | −$8.16M | Cut−$17.7M |
| AMERICAN CENTURY COMPANIES INC | 884.1K | $24M | −$8.13M | Cut−$9M |
| MORGAN STANLEY | 849.2K | $23M | −$5.88M | Cut−$203.3K |
| Candriam S.C.A. | 801.9K | $21.7M | −$6.24M | Cut−$2.9M |
| GOLDMAN SACHS GROUP INC | 785K | $21.3M | −$7.22M | Cut−$31.4M |
| Affinity Asset Advisors, LLC | 750K | $20.3M | −$6.72M | Cut−$6.17M |
| Integral Health Asset Management, LLC | 750K | $20.3M | −$6.9M | Cut−$6.9M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 706.7K | $19.1M | — | Held |
| Troluce Capital Advisors LLC | 655K | $17.7M | — | New |
| Citadel | 600K | $16.3M | −$3.68M | Added$1.74M |
| STEMPOINT CAPITAL LP | 533.4K | $14.4M | −$2.67M | Added$3.92M |
| MILLENNIUM MANAGEMENT LLC | 525.3K | $14.2M | −$723.3K | Added$11.4M |
| Davern Capital Partners, LP | 447.2K | $12.1M | −$1.94M | Added$4.47M |
| 22NW, LP | 444.3K | $12M | −$3.3M | Cut−$966.9K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 443.9K | $12M | −$4.08M | Cut−$4.72M |
| NORTHERN TRUST CORP | 442.9K | $12M | −$2.76M | Added$1.12M |
| Rock Springs Capital Management LP | 439.8K | $11.9M | −$3.93M | Cut−$3.6M |
| Catalio Capital Management, LP | 439K | $11.9M | −$3.05M | Cut−$149.2K |
| Capital World Investors | 398.2K | $10.8M | — | New |
| Renaissance Technologies | 382.8K | $10.4M | −$2.96M | Cut−$1.32M |
| Parkman Healthcare Partners LLC | 380.1K | $10.3M | −$3.5M | Cut−$4.59M |
| VANGUARD FIDUCIARY TRUST CO | 375.3K | $10.2M | — | Held |
| Pale Fire Capital SE | 365.6K | $9.9M | −$95.3K | Added$9.53M |
| TimesSquare Capital Management, LLC | 338.8K | $9.18M | −$3.12M | Cut−$4.62M |
| TWO SIGMA INVESTMENTS, LP | 311.5K | $8.44M | −$2.87M | Cut−$13.7M |
| Rhenman & Partners Asset Management AB | 263.1K | $7.13M | −$1.31M | Added$1.95M |
| AMERIPRISE FINANCIAL INC | 221.3K | $6M | −$425.5K | Added$4.32M |
| VOYA INVESTMENT MANAGEMENT LLC | 216.1K | $5.85M | −$1.04M | Added$1.76M |
| Russell Investments Group, Ltd. | 203.5K | $5.51M | −$1.61M | Cut−$850.9K |
| FINDELL CAPITAL MANAGEMENT LLC | 202K | $5.47M | −$460K | Added$3.66M |
| Schonfeld Strategic Advisors LLC | 177.6K | $4.81M | −$458.4K | Added$3M |
| Buckley Capital Advisors, LLC | 173.1K | $4.69M | −$1.59M | Cut−$1.64M |
| TUDOR INVESTMENT CORP ET AL | 155.7K | $4.22M | −$359.2K | Added$2.8M |
| ADAR1 Capital Management, LLC | 154.7K | $4.19M | −$1.25M | Cut−$753.4K |
| BURKEHILL GLOBAL MANAGEMENT, LP | 150K | $4.06M | −$1.38M | Cut−$1.38M |
| Icahn Capital | 149.1K | $4.04M | −$573.2K | Added$1.78M |
| MARK ASSET MANAGEMENT LP | 144.9K | $3.92M | — | New |
| PFM Health Sciences, LP | 142.7K | $3.87M | −$438.3K | Added$2.14M |
| Artia Global Partners LP | 137.8K | $3.73M | −$1.27M | Cut−$1.27M |
| DIMENSIONAL FUND ADVISORS LP | 137.4K | $3.72M | −$1.27M | Cut−$1.28M |
| Y-Intercept (Hong Kong) Ltd | 132.1K | $3.58M | −$288.5K | Added$2.44M |
| Bank of New York Mellon Corp | 130K | $3.52M | −$1.2M | Cut−$1.26M |
| Swedbank AB | 122.1K | $3.31M | −$1.12M | Cut−$4.73M |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 130.6K | $3.07M | −$1.57M | Cut−$1.57M |
| Ensign Peak Advisors, Inc | 112.2K | $3.04M | −$1.03M | Cut−$1.03M |
| Nuveen, LLC | 112K | $3.03M | −$1.03M | Cut−$1.43M |
| Squarepoint Ops LLC | 105.5K | $2.86M | −$970.5K | Cut−$6.1M |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 105K | $2.84M | −$965.6K | Cut−$21.1M |
| CAPITAL FUND MANAGEMENT S.A. | 102.2K | $2.77M | — | New |
| UBS Group AG | 98K | $2.66M | −$901.9K | Cut−$4.65M |
| Verition Fund Management LLC | 95.1K | $2.58M | −$771.3K | Cut−$465.7K |
| Rafferty Asset Management, LLC | 94.4K | $2.56M | −$868.1K | Cut−$2.09M |
| J. Goldman & Co LP | 94.1K | $2.55M | −$435.1K | Added$833.1K |
| Brevan Howard Capital Management LP | 90.9K | $2.46M | −$790.2K | Cut−$2.52M |
| Swiss National Bank | 90.1K | $2.44M | −$828.9K | Cut−$828.9K |
| CenterBook Partners LP | 89.3K | $2.42M | −$239.2K | Added$1.48M |
| Ishara Investments LP | 82K | $2.22M | — | New |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 79.5K | $2.15M | −$698.3K | Cut−$599.6K |
| Susquehanna Portfolio Strategies, LLC | 78.1K | $2.12M | −$718.4K | Cut−$718.4K |
| Hennion & Walsh Asset Management, Inc. | 70.2K | $1.9M | −$638.1K | Cut−$615.7K |
| Seven Fleet Capital Management LP | 69.6K | $1.88M | −$386.6K | Added$359.6K |
| XTX Topco Ltd | 68.4K | $1.85M | −$629.3K | Cut−$820.6K |
| ALPS ADVISORS INC | 64.4K | $1.75M | −$592.7K | Cut−$613.3K |
| STATE OF WISCONSIN INVESTMENT BOARD | 64.1K | $1.74M | −$459.5K | Cut−$74.9K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 61.3K | $1.66M | −$398.8K | Added$86.6K |
| PRUDENTIAL FINANCIAL INC | 59.6K | $1.61M | −$547.9K | Cut−$1.62M |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 59.2K | $1.6M | −$545K | Cut−$2.45M |
| Greenland Capital Management LP | 57.5K | $1.56M | −$529K | Cut−$946.3K |
| RHUMBLINE ADVISERS | 57.4K | $1.56M | −$499.4K | Cut−$413.8K |
| Trexquant Investment LP | 57.2K | $1.55M | −$526.2K | Cut−$2.54M |
| CANADA PENSION PLAN INVESTMENT BOARD | 51.4K | $1.39M | −$272.3K | Added$318.2K |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 46.8K | $1.27M | −$3.86K | Added$1.26M |
| HighVista Strategies LLC | 46.8K | $1.27M | −$430.4K | Cut−$3.25M |
| JPMORGAN CHASE & CO | 51.9K | $1.22M | −$596.6K | Cut−$473.4K |
| Invesco Ltd. | 42.3K | $1.15M | −$268.1K | Added$88.7K |
| PROFUND ADVISORS LLC | 42K | $1.14M | −$386.3K | Cut−$569.2K |
| DEUTSCHE BANK AG\ | 40.1K | $1.09M | −$342.7K | Cut−$264.9K |
| Erste Asset Management GmbH | 45K | $1.06M | −$599.4K | Cut−$599.4K |
| DAFNA Capital Management LLC | 38.5K | $1.04M | −$354.1K | Cut−$354.1K |
| Legal & General Group Plc | 38.5K | $1.04M | −$354.6K | Cut−$553K |
| BARCLAYS PLC | 33.9K | $917.7K | −$311.7K | Cut−$7.19M |
| VICTORY CAPITAL MANAGEMENT INC | 33.1K | $897.8K | −$302.5K | Cut−$295.5K |
| SECTORAL ASSET MANAGEMENT INC | 31.6K | $895.1K | −$252.3K | Cut−$252.5K |
| Vanguard Global Advisers, LLC | 30.5K | $825.5K | — | Held |
| Bellevue Group AG | 29.4K | $795.7K | −$182.4K | Added$76.3K |
| VANGUARD ASSET MANAGEMENT, Ltd | 29.3K | $792.5K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 29.2K | $766.7K | −$286.5K | Cut−$286.4K |
| MetLife Investment Management, LLC | 26.8K | $726.7K | −$239.2K | Cut−$217K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 26.4K | $715.5K | −$148.9K | Added$128.3K |
| DIADEMA PARTNERS LP | 26.3K | $713.7K | −$230K | Cut−$193.5K |
| WELLS FARGO & COMPANY/MN | 26.1K | $706.5K | −$239.9K | Cut−$1.35M |
| RAYMOND JAMES FINANCIAL INC | 24.7K | $668.5K | −$227K | Cut−$237.8K |
| Creative Planning | 24.3K | $658.3K | −$194.1K | Cut−$107.5K |
| Allianz Asset Management GmbH | 21.9K | $593.3K | −$201.5K | Cut−$502.7K |
| Blue Owl Capital Holdings LP | 200K | $590K | −$2.2M | Cut−$1.8M |
| Quantinno Capital Management LP | 20.5K | $556.5K | −$167.8K | Cut−$105.6K |
| NOMURA HOLDINGS INC | 20K | $541.8K | — | New |
| JANUS HENDERSON GROUP PLC | 19.8K | $537.3K | −$182.6K | Cut−$43.5M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 19.7K | $533.4K | −$110.4K | Added$98K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 19.6K | $532.1K | −$159.6K | Cut−$97.5K |
| SIMPLEX TRADING, LLC | 19.6K | $529.9K | −$44.2K | Added$355.7K |
| Magnetar Financial LLC | 18.5K | $502.5K | — | New |
| Eleva Capital SAS | 17.1K | $462.7K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 16.7K | $452.8K | −$153.8K | Cut−$5.82M |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 15.8K | $427.2K | −$145.1K | Cut−$4.77M |
| State of New Jersey Common Pension Fund D | 15.6K | $422.7K | −$143.4K | Cut−$142.8K |
| Persistent Asset Partners Ltd | 15.4K | $417.2K | −$68.2K | Added$148.1K |
| NEW YORK STATE COMMON RETIREMENT FUND | 15.4K | $416.2K | −$115.6K | Cut−$39.7K |
| CITIGROUP INC | 15.1K | $408.7K | −$138.8K | Cut−$256K |
| China Universal Asset Management Co., Ltd. | 14K | $380.5K | −$118.6K | Cut−$87.5K |
| Police & Firemen's Retirement System of New Jersey | 12.7K | $343.6K | −$116.7K | Cut−$116.7K |
| ARIZONA STATE RETIREMENT SYSTEM | 12.5K | $339.8K | −$115.4K | Cut−$132K |
| MAI Capital Management | 12.2K | $331.5K | −$221 | Added$330.6K |
| E Fund Management Co., Ltd. | 11.9K | $321.3K | — | Held |
| SEI INVESTMENTS CO | 11.7K | $316.7K | −$80.8K | Cut−$1.89K |
| INTECH INVESTMENT MANAGEMENT LLC | 11.3K | $305K | −$103.6K | Cut−$301.9K |
| Velan Capital Investment Management LP | 11K | $298K | −$101.2K | Cut−$5.18M |
| FOX RUN MANAGEMENT, L.L.C. | 12.7K | $297.9K | −$161.9K | Cut−$229.3K |
| Vanguard Investments Australia, Ltd. | 10.8K | $291.6K | — | Held |
| CreativeOne Wealth, LLC | 10.8K | $291.2K | −$98.9K | Cut−$98.9K |
| Lion Point Capital, LP | 10.5K | $284.4K | −$96.6K | Cut−$96.6K |
| ProShare Advisors LLC | 10.5K | $283.3K | −$96.2K | Cut−$153.6K |
| KLP KAPITALFORVALTNING AS | 10.4K | $281.7K | −$88.3K | Cut−$66.6K |
| Entropy Technologies, LP | 10.2K | $275.8K | −$93.7K | Cut−$311.2K |
| Man Group plc | 10.1K | $274.7K | — | New |
| Quarry LP | 10K | $270.9K | — | New |
| VARCOV Co. | 9.76K | $264.4K | — | New |
| CAPSTONE INVESTMENT ADVISORS, LLC | 9.68K | $262.1K | — | New |
| KINGSWOOD WEALTH ADVISORS, LLC | 9.6K | $260.1K | −$65.1K | Added$3.35K |
| MARSHALL WACE, LLP | 8.99K | $243.5K | −$82.7K | Cut−$8.8M |
| Tower Research Capital LLC (TRC) | 7.92K | $214.6K | −$4.78K | Added$195.8K |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 7.67K | $207.8K | −$69.6K | Cut−$66.6K |
| Virtus Investment Advisers, LLC | 7.39K | $200.2K | −$66.3K | Cut−$61.4K |
| CWM, LLC | 6.05K | $163.9K | $137.9K | Added$163.7K |
| Mirae Asset Global Investments Co., Ltd. | 4.13K | $111.8K | −$35.4K | Cut−$27.7K |
| Ameritas Investment Partners, Inc. | 3.8K | $102.9K | −$34.9K | Cut−$34.9K |
| NISA INVESTMENT ADVISORS, LLC | 2.36K | $63.9K | −$17.9K | Cut−$6.82K |
| PNC Financial Services Group, Inc. | 2.23K | $60.5K | −$20.6K | Cut−$20.6K |
| GF FUND MANAGEMENT CO. LTD. | 1.78K | $48.1K | −$14.3K | Cut−$8.29K |
| Smartleaf Asset Management LLC | 1.64K | $38.5K | −$12K | Added$2.93K |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.34M | $36.4K | −$12.2K | Cut−$11.7K |
| OSAIC HOLDINGS, INC. | 1.16K | $31.4K | −$10.6K | Cut−$10.5K |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 837 | $22.7K | — | New |
| FIFTH THIRD BANCORP | 784 | $21.2K | — | New |
| Rockefeller Capital Management L.P. | 555 | $15K | −$1.23K | Added$10.2K |
| Versant Capital Management, Inc | 513 | $13.9K | −$4.72K | Cut−$4.72K |
| GAMMA Investing LLC | 474 | $12.8K | −$4.15K | Cut−$3.53K |
| Pinnacle Wealth Planning Services, Inc. | 355 | $9.62K | −$3.27K | Cut−$3.27K |
| Allworth Financial LP | 354 | $9.59K | −$2.02K | Added$1.64K |
| MassMutual Private Wealth & Trust, FSB | 319 | $8.64K | −$2.93K | Cut−$2.94K |
| Sterling Capital Management LLC | 306 | $8.29K | −$2.82K | Cut−$2.81K |
| US BANCORP \DE\ | 302 | $8.18K | −$745 | Added$5.24K |
| LORD, ABBETT & CO. LLC | 300.9K | $8.15K | −$2.77K | Cut−$3.19K |
| ALGERT GLOBAL LLC | 260.3K | $7.05K | −$437 | Added$5.33K |
| J.Safra Asset Management Corp | 250 | $6.77K | −$745 | Added$3.83K |
| FIL Ltd | 229 | $6.2K | — | New |
| Keating Financial Advisory Services, Inc. | 226 | $6.12K | — | New |
| SG Americas Securities, LLC | 225.8K | $6.12K | −$2.08K | Cut−$2.26K |
| SMA Capital LLC | 208 | $5.63K | — | New |
| EverSource Wealth Advisors, LLC | 196 | $5.31K | −$1.42K | Cut−$279 |
| ROYAL BANK OF CANADA | 152 | $4K | −$1.57K | Cut−$52K |
| SBI Securities Co., Ltd. | 117 | $3.17K | −$1.07K | Cut−$1.04K |
| HRT FINANCIAL LP | 95.9K | $2.6K | −$802 | Cut−$567 |
| ROTHSCHILD INVESTMENT LLC | 92 | $2.49K | −$506 | Added$496 |
| Optiver Holding B.V. | 80 | $2.17K | −$386 | Added$643 |
| True Wealth Design, LLC | 76 | $2.06K | −$700 | Cut−$700 |
| Kilter Group LLC | 69 | $1.87K | — | New |
| Arax Advisory Partners | 69 | $1.87K | −$635 | Cut−$2.09K |
| Advisory Services Network, LLC | 41 | $1.11K | — | New |
| Farther Finance Advisors, LLC | 37 | $977 | −$346 | Cut−$293 |
| Parkside Financial Bank & Trust | 35 | $948 | −$323 | Cut−$323 |
| Private Wealth Management Group, LLC | 28 | $759 | −$258 | Cut−$258 |
| Parallel Advisors, LLC | 22 | $596 | −$202 | Cut−$202 |
| Handelsbanken Fonder AB | 14.1K | $382 | −$130 | Cut−$130 |
| SJS Investment Consulting Inc. | 12 | $326 | — | New |
| Clearstead Advisors, LLC | 11 | $298 | −$102 | Cut−$102 |
| Larson Financial Group LLC | 6 | $163 | −$55 | Cut−$5.43K |
| QUADRANT CAPITAL GROUP LLC | 5 | $136 | −$46 | Cut−$155 |
| Stone House Investment Management, LLC | 4 | $108 | — | New |
| JPL Wealth Management, LLC | 3 | $82 | — | New |
| Hughes Financial Services, LLC | 2 | $54 | — | New |
| KBC Group NV | 1.23K | $33 | — | New |
| IFP Advisors, Inc | 1 | $27 | −$9 | Cut−$263 |
| Essential Partners LLC | 1 | $27 | −$9 | Cut−$9 |
| Covestor Ltd | 567 | $15 | −$4 | Cut−$2 |
| FNY Investment Advisers, LLC | 500 | $13 | — | New |
| Avion Wealth | 21 | $0 | $0 | Held |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | $0 | — | Held |