| SUVRETTA CAPITAL MANAGEMENT, LLC | 6.56M | $50.3M | −$23.9M | Cut−$23.9M |
| RA CAPITAL MANAGEMENT, L.P. | 6.05M | $46.4M | −$22M | Cut−$22M |
| BlackRock, Inc. | 5.39M | $41.3M | −$15.5M | Cut−$6.88M |
| TCG Crossover Management, LLC | 5.25M | $40.3M | −$19.1M | Cut−$19.1M |
| BRAIDWELL LP | 3.13M | $24M | −$11.1M | Cut−$10.6M |
| Nantahala Capital Management, LLC | 3.05M | $23.4M | −$11.1M | Cut−$25.2M |
| VANGUARD CAPITAL MANAGEMENT LLC | 2.69M | $20.7M | — | Held |
| Siren, L.L.C. | 2.35M | $18M | −$7.1M | Cut−$4.03M |
| First Turn Management, LLC | 2.26M | $17.3M | −$6.89M | Cut−$4.1M |
| Aberdeen Group plc | 2.21M | $17M | −$4.56M | Added$2.78M |
| Point72 Asset Management, L.P. | 2.07M | $15.9M | −$7.55M | Cut−$11.2M |
| GSK plc | 1.79M | $13.7M | −$6.5M | Cut−$6.5M |
| Balyasny Asset Management L.P. | 1.78M | $13.7M | −$3.53M | Added$2.68M |
| Jones Hill Capital LP | 1.77M | $13.6M | — | Held |
| D. E. Shaw & Co., Inc. | 1.62M | $12.5M | −$5.91M | Cut−$9.19M |
| State Street | 1.55M | $11.9M | −$3.66M | Added$516.9K |
| GEODE CAPITAL MANAGEMENT, LLC | 1.49M | $11.4M | −$4.03M | Cut−$1.11M |
| Alyeska Investment Group, L.P. | 1.33M | $10.2M | — | New |
| Citadel | 1.29M | $9.91M | −$4.39M | Cut−$3.74M |
| Assenagon Asset Management S.A. | 1.19M | $9.16M | — | New |
| DIMENSIONAL FUND ADVISORS LP | 1.13M | $8.66M | −$3.83M | Cut−$3.22M |
| Vestal Point Capital, LP | 1.1M | $8.44M | −$3.46M | Cut−$2.31M |
| Ikarian Capital, LLC | 1.05M | $8.05M | −$3.82M | Cut−$7.51M |
| Qube Research & Technologies Ltd | 974.7K | $7.48M | −$1.43M | Added$3.04M |
| Connor, Clark & Lunn Investment Management Ltd. | 736.7K | $5.65M | −$2.12M | Cut−$936.3K |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 599.4K | $4.6M | — | Held |
| GOLDMAN SACHS GROUP INC | 571.9K | $4.39M | −$1.18M | Added$723.5K |
| Icahn Capital | 543.2K | $4.17M | −$56.4K | Added$3.99M |
| NORTHERN TRUST CORP | 473K | $3.63M | −$1.72M | Cut−$2.62M |
| Trexquant Investment LP | 453.5K | $3.48M | −$1.29M | Cut−$542.7K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 426.9K | $3.27M | −$1.42M | Cut−$1.12M |
| SILVERARC CAPITAL MANAGEMENT, LLC | 419.9K | $3.22M | −$1.44M | Cut−$1.24M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 400K | $3.07M | −$1.46M | Cut−$16.2M |
| Jump Financial, LLC | 369.8K | $2.84M | −$335.6K | Added$1.79M |
| MILLENNIUM MANAGEMENT LLC | 356.5K | $2.73M | −$198.1K | Added$2.12M |
| VANGUARD FIDUCIARY TRUST CO | 329.9K | $2.53M | — | Held |
| UBS Group AG | 315.2K | $2.42M | −$374.8K | Added$1.25M |
| JANE STREET GROUP, LLC | 310.4K | $2.38M | −$1.13M | Cut−$3.2M |
| BOOTHBAY FUND MANAGEMENT, LLC | 304K | $2.33M | −$1.11M | Cut−$3.52M |
| PANAGORA ASSET MANAGEMENT INC | 243.6K | $1.87M | — | New |
| DAFNA Capital Management LLC | 205K | $1.57M | — | New |
| Squarepoint Ops LLC | 175.9K | $1.35M | −$239.7K | Added$604.7K |
| MORGAN STANLEY | 173.3K | $1.33M | −$602.9K | Cut−$543.7K |
| AMERICAN CENTURY COMPANIES INC | 156.2K | $1.2M | −$568.7K | Cut−$584.9K |
| STATE OF WISCONSIN INVESTMENT BOARD | 154.4K | $1.18M | −$314.9K | Added$206.2K |
| Y-Intercept (Hong Kong) Ltd | 153.3K | $1.18M | −$242.8K | Added$421.6K |
| Bank of New York Mellon Corp | 149.9K | $1.15M | −$425.5K | Cut−$172.2K |
| TWO SIGMA INVESTMENTS, LP | 139K | $1.07M | — | New |
| Fiduciary Trust Co | 136.6K | $1.05M | −$497.1K | Cut−$497.1K |
| ADAR1 Capital Management, LLC | 130.6K | $1M | −$475.2K | Cut−$13.2M |
| Nuveen, LLC | 129.6K | $994.2K | −$408.4K | Cut−$274.8K |
| BANK OF AMERICA CORP /DE/ | 126.6K | $970.7K | −$460.7K | Cut−$1.64M |
| Engineers Gate Manager LP | 126.1K | $967.3K | — | New |
| WELLINGTON MANAGEMENT GROUP LLP | 118.6K | $909.7K | −$431.7K | Cut−$746.4K |
| Simplify Asset Management Inc. | 116K | $889.7K | −$422.2K | Cut−$916.2K |
| Invesco Ltd. | 111.1K | $852.3K | −$404.5K | Cut−$3.87M |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 101.3K | $777.2K | −$320.1K | Cut−$217.2K |
| BARCLAYS PLC | 88.5K | $678.5K | −$322K | Cut−$820.6K |
| Russell Investments Group, Ltd. | 79.2K | $607.1K | −$13K | Added$566.7K |
| XTX Topco Ltd | 71.6K | $549.2K | −$188.6K | Cut−$36.7K |
| RBF Capital, LLC | 70K | $536.9K | −$254.8K | Cut−$373.6K |
| Atom Investors LP | 69.2K | $530.4K | −$220.6K | Cut−$154.9K |
| RHUMBLINE ADVISERS | 66.2K | $507.6K | −$202.8K | Cut−$122.6K |
| Creative Planning | 64.1K | $491.6K | −$80.5K | Added$241.6K |
| Fidelity | 61K | $468.2K | −$28K | Added$381.2K |
| HSBC HOLDINGS PLC | 58.6K | $441.5K | −$172.2K | Cut−$56.4K |
| FRANKLIN RESOURCES INC | 54.7K | $419.3K | −$161.1K | Cut−$81.2K |
| GROUP ONE TRADING LLC | 53.8K | $412.3K | −$126.5K | Added$19.3K |
| ALLIANCEBERNSTEIN L.P. | 34.6K | $391K | −$0 | Added$218.3K |
| BURKEHILL GLOBAL MANAGEMENT, LP | 50K | $383.5K | −$182K | Cut−$182K |
| STRS OHIO | 49.3K | $378.1K | −$179.5K | Cut−$179.5K |
| DEUTSCHE BANK AG\ | 48.8K | $374.5K | −$177.7K | Cut−$2.87M |
| Man Group plc | 46.1K | $353.7K | −$55.5K | Added$181.2K |
| EntryPoint Capital, LLC | 45.2K | $347.1K | −$54.9K | Added$176.5K |
| Graham Capital Management, L.P. | 42.7K | $327.8K | −$155.6K | Cut−$220.3K |
| Marex Group plc | 42K | $322.1K | — | New |
| SIMPLEX TRADING, LLC | 41.9K | $321.7K | −$29.2K | Added$231K |
| COMMONWEALTH EQUITY SERVICES, LLC | 40.3K | $309K | −$145.6K | Cut−$143.4K |
| BIT Capital GmbH | 40K | $306.8K | — | New |
| Matisse Capital | 39.6K | $304.1K | −$49K | Added$151.9K |
| Brevan Howard Capital Management LP | 39.4K | $302.5K | −$148.7K | Cut−$256.9K |
| Vanguard Global Advisers, LLC | 38.5K | $295.4K | — | Held |
| Seven Fleet Capital Management LP | 38.1K | $292.2K | — | New |
| MetLife Investment Management, LLC | 33.2K | $254.4K | −$82.7K | Cut−$2.53K |
| Woodline Partners LP | 30.8K | $236.2K | −$112.1K | Cut−$112.1K |
| COUNTRY TRUST BANK | 30K | $230.4K | −$109.3K | Cut−$109.3K |
| LMR Partners LLP | 30K | $230.1K | −$109.2K | Cut−$109.2K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 28.1K | $215.4K | −$72.9K | Cut−$11.1K |
| Pale Fire Capital SE | 26.1K | $200.2K | — | New |
| Quantinno Capital Management LP | 25.7K | $196.9K | −$93.4K | Cut−$134.1K |
| JPMORGAN CHASE & CO | 29.8K | $196K | −$98.3K | Cut−$39.1K |
| CITIGROUP INC | 23.4K | $179.7K | −$85.3K | Cut−$579.2K |
| Mariner, LLC | 23.3K | $178.4K | — | New |
| ExodusPoint Capital Management, LP | 23.2K | $177.7K | — | New |
| WELLS FARGO & COMPANY/MN | 22.6K | $173K | −$82.1K | Cut−$1.71M |
| AXQ CAPITAL, LP | 22K | $169.1K | −$80.2K | Cut−$187.7K |
| Virtus Investment Advisers, LLC | 21K | $160.9K | −$74.5K | Cut−$70.6K |
| Susquehanna Portfolio Strategies, LLC | 19.3K | $148.2K | — | New |
| Police & Firemen's Retirement System of New Jersey | 18.6K | $142.4K | −$46.7K | Cut−$2.88K |
| CANADA PENSION PLAN INVESTMENT BOARD | 18.4K | $141.1K | — | New |
| Legal & General Group Plc | 17.7K | $135.8K | −$59.6K | Cut−$49.4K |
| Westshore Wealth, LLC | 17K | $130.4K | — | New |
| DRW Securities, LLC | 16.4K | $125.9K | — | New |
| Vanguard Personalized Indexing Management, LLC | 16.1K | $123.8K | −$47.9K | Cut−$25K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16.1K | $123.5K | −$46.9K | Cut−$22.2K |
| PROFUND ADVISORS LLC | 15.5K | $118.9K | — | New |
| BNP PARIBAS FINANCIAL MARKETS | 14.1K | $108.5K | −$38.3K | Cut−$10.5K |
| Renaissance Technologies | 13.6K | $104.3K | −$49.5K | Cut−$92.5K |
| INTECH INVESTMENT MANAGEMENT LLC | 13.2K | $101.6K | −$48.2K | Cut−$121.8K |
| NEW YORK STATE COMMON RETIREMENT FUND | 13.1K | $100.5K | −$47.7K | Cut−$552.4K |
| CWM, LLC | 12.1K | $92.8K | $2.85K | Added$92.8K |
| China Universal Asset Management Co., Ltd. | 11.8K | $90.7K | −$32.1K | Cut−$9.09K |
| BAILARD, INC. | 11.8K | $90.4K | −$42.9K | Cut−$42.9K |
| ProShare Advisors LLC | 11.7K | $89.4K | −$37.3K | Cut−$26.6K |
| MERCER GLOBAL ADVISORS INC /ADV | 10.9K | $83.3K | — | New |
| Entropy Technologies, LP | 10.8K | $83K | −$39.4K | Cut−$52.7K |
| VOYA INVESTMENT MANAGEMENT LLC | 10K | $76.9K | — | New |
| ASSETMARK, INC | 7.53K | $57.7K | −$27.4K | Cut−$34.8K |
| SUMMIT SECURITIES GROUP LLC | 6.97K | $53.5K | — | New |
| Tower Research Capital LLC (TRC) | 6.57K | $50.4K | −$5.91K | Added$32K |
| Ameritas Investment Partners, Inc. | 4.9K | $37.6K | −$13.1K | Cut−$3.13K |
| Mirae Asset Global Investments Co., Ltd. | 3.47K | $26.6K | −$9.57K | Cut−$3.1K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3.26K | $25K | −$9.65K | Cut−$4.96K |
| NISA INVESTMENT ADVISORS, LLC | 3.16K | $24.2K | −$11.5K | Cut−$16.5K |
| ROYAL BANK OF CANADA | 2.85K | $21K | −$11.6K | Cut−$26K |
| Farther Finance Advisors, LLC | 2.39K | $17.9K | −$8.39K | Cut−$6.89K |
| MAI Capital Management | 1.87K | $14.3K | −$37 | Added$14.2K |
| Sterling Capital Management LLC | 1.85K | $14.2K | −$6.73K | Cut−$12.2K |
| State of Wyoming | 1.81K | $13.9K | — | New |
| GF FUND MANAGEMENT CO. LTD. | 1.2K | $9.23K | −$3.87K | Cut−$2.78K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1.18K | $9.07K | — | New |
| Rockefeller Capital Management L.P. | 1.12K | $8.58K | −$815 | Added$6.05K |
| IFP Advisors, Inc | 988 | $7.58K | −$3.6K | Cut−$3.6K |
| PNC Financial Services Group, Inc. | 885 | $6.79K | −$3.22K | Cut−$9.52K |
| Allworth Financial LP | 863 | $6.62K | — | New |
| Versant Capital Management, Inc | 858 | $6.58K | −$3.12K | Cut−$13.8K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 773 | $5.93K | −$2.58K | Cut−$2.09K |
| ACADIAN ASSET MANAGEMENT LLC | 727.3K | $5.57K | −$2.65K | Cut−$2.75K |
| MassMutual Private Wealth & Trust, FSB | 581 | $4.46K | — | New |
| Optiver Holding B.V. | 530 | $4.07K | −$1.17K | Added$423 |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 472 | $3.62K | −$1.72K | Cut−$1.72K |
| NATIONAL BANK OF CANADA /FI/ | 422 | $3.23K | −$1.53K | Cut−$1.77K |
| EverSource Wealth Advisors, LLC | 409 | $3.14K | −$753 | Added$796 |
| Larson Financial Group LLC | 407 | $3.12K | — | New |
| FEDERATED HERMES, INC. | 328 | $2.52K | −$1.19K | Cut−$1.19K |
| ROTHSCHILD INVESTMENT LLC | 295 | $2.26K | −$29 | Added$2.17K |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 295 | $2.26K | −$274 | Cut−$5.61K |
| BESSEMER GROUP INC | 287K | $2.2K | −$1.04K | Cut−$1.04K |
| Physician Wealth Advisors, Inc. | 283 | $2.17K | −$1.03K | Cut−$1.03K |
| OSAIC HOLDINGS, INC. | 271 | $2.08K | −$327 | Added$1.06K |
| Caitong International Asset Management Co., Ltd | 262 | $2.01K | −$149 | Added$1.55K |
| Rialto Wealth Management, LLC | 159 | $1.22K | −$579 | Cut−$579 |
| GSA CAPITAL PARTNERS LLP | 136.7K | $1.05K | −$363 | Cut−$80 |
| Arax Advisory Partners | 111 | $852 | −$404 | Cut−$1.2K |
| Altshuler Shaham Ltd | 100 | $767 | −$364 | Cut−$364 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 80.2K | $615 | −$233 | Cut−$107 |
| SJS Investment Consulting Inc. | 76 | $583 | −$11 | Added$549 |
| True Wealth Design, LLC | 49 | $376 | −$58 | Added$195 |
| TWIN PEAKS WEALTH ADVISORS, LLC | 38 | $291 | — | New |
| ALGERT GLOBAL LLC | 33K | $253 | — | New |
| US BANCORP \DE\ | 26 | $199 | — | New |
| JPL Wealth Management, LLC | 17 | $131 | — | New |
| Root Financial Partners, LLC | 14 | $107 | — | New |
| SG Americas Securities, LLC | 12.1K | $93 | −$43 | Cut−$40 |
| SBI Securities Co., Ltd. | 4 | $31 | −$14 | Cut−$14 |
| Keating Financial Advisory Services, Inc. | 3 | $23 | −$11 | Cut−$248 |
| Hughes Financial Services, LLC | 1 | $8 | — | New |
| Essential Partners LLC | 1 | $8 | −$3 | Cut−$3 |