| Fidelity | 8.4M | $405M | −$179.4M | Cut−$200.9M |
| WELLINGTON MANAGEMENT GROUP LLP | 7.26M | $349.9M | −$152.1M | Cut−$145.4M |
| Avoro Capital Advisors LLC | 6.56M | $316M | −$140M | Cut−$140M |
| JANUS HENDERSON GROUP PLC | 5.35M | $258.3M | −$108.5M | Cut−$95.7M |
| Deep Track Capital, LP | 4.28M | $206.3M | −$87.8M | Cut−$79.7M |
| BVF INC/IL | 3.46M | $166.7M | −$73.9M | Cut−$75.2M |
| MORGAN STANLEY | 2.31M | $111.1M | −$44.6M | Cut−$34.1M |
| PRINCIPAL FINANCIAL GROUP INC | 1.75M | $84.5M | −$27.4M | Cut−$4.79M |
| Driehaus Capital Management LLC | 1.58M | $76M | −$33.7M | Cut−$38.2M |
| ORBIMED ADVISORS LLC | 1.48M | $71.1M | −$24.8M | Cut−$9.69M |
| AMERICAN CENTURY COMPANIES INC | 1.44M | $69.3M | −$10.8M | Added$34.1M |
| BAKER BROS. ADVISORS LP | 1.43M | $69M | −$30.6M | Cut−$30.6M |
| Siren, L.L.C. | 1.33M | $64M | −$23M | Cut−$11M |
| Casdin Capital, LLC | 1.18M | $56.6M | −$25.1M | Cut−$25.1M |
| CAPITOLIS LIQUID GLOBAL MARKETS LLC | 1.15M | $55.5M | — | Held |
| ALLIANCEBERNSTEIN L.P. | 638.8K | $44.4M | −$0 | Cut−$14.6M |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 768K | $37M | −$16.4M | Cut−$16.4M |
| Pacific Heights Asset Management LLC | 750K | $36.1M | −$14.9M | Cut−$12.5M |
| Rock Springs Capital Management LP | 640.2K | $30.9M | −$13.7M | Cut−$21.2M |
| Paradigm Biocapital Advisors LP | 545.3K | $26.3M | — | New |
| FRANKLIN RESOURCES INC | 531.6K | $25.6M | −$11.3M | Cut−$34.9M |
| Logos Global Management LP | 500K | $24.1M | −$10.7M | Cut−$17.6M |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 467.8K | $22.5M | −$9.99M | Cut−$9.99M |
| BlackRock, Inc. | 442K | $21.3M | −$9.18M | Cut−$8.61M |
| Aberdeen Group plc | 391.8K | $18.9M | −$5.65M | Added$463.6K |
| DEUTSCHE BANK AG\ | 331.9K | $16M | −$7.09M | Cut−$42.5M |
| NATIONAL BANK OF CANADA /FI/ | 305.4K | $14.7M | −$5.67M | Cut−$3.74M |
| Balyasny Asset Management L.P. | 304.9K | $14.7M | −$4.62M | Cut−$338.8K |
| GOLDMAN SACHS GROUP INC | 260.5K | $12.6M | −$4.79M | Cut−$3.04M |
| Catalio Capital Management, LP | 255.4K | $12.3M | −$5.4M | Cut−$5.28M |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 255K | $12.3M | −$5.34M | Cut−$5.1M |
| SEB Asset Management AB | 245K | $11.8M | — | Held |
| Pentwater Capital Management LP | 245K | $11.8M | — | New |
| Parkman Healthcare Partners LLC | 232.1K | $11.2M | −$1.17M | Added$7.36M |
| BANK OF AMERICA CORP /DE/ | 227.1K | $10.9M | −$676.3K | Added$8.74M |
| AMERIPRISE FINANCIAL INC | 219.5K | $10.6M | −$4.69M | Cut−$9.28M |
| UBS Group AG | 212.9K | $10.3M | −$4.32M | Cut−$3.82M |
| Sio Capital Management, LLC | 209.1K | $10.1M | −$4.3M | Cut−$3.94M |
| D. E. Shaw & Co., Inc. | 204.8K | $9.87M | −$184.1K | Added$9.27M |
| TD Asset Management Inc | 204.8K | $9.87M | −$3.73M | Cut−$2.28M |
| STEMPOINT CAPITAL LP | 200.3K | $9.65M | −$4.28M | Cut−$14.8M |
| JPMORGAN CHASE & CO | 212.8K | $9.35M | −$331.8K | Added$8.45M |
| Woodline Partners LP | 190.8K | $9.2M | −$2.65M | Added$579.6K |
| ArrowMark Colorado Holdings LLC | 188.2K | $9.07M | −$4.02M | Cut−$9.79M |
| TWO SIGMA INVESTMENTS, LP | 181.4K | $8.74M | −$2.04M | Added$2.1M |
| Cormorant Asset Management, LP | 175K | $8.44M | — | New |
| MILLENNIUM MANAGEMENT LLC | 168.9K | $8.14M | −$3.26M | Cut−$2.47M |
| Schonfeld Strategic Advisors LLC | 165.4K | $7.97M | −$186.3K | Added$7.37M |
| Holocene Advisors, LP | 159K | $7.66M | — | New |
| TCG Crossover Management, LLC | 140.4K | $6.77M | −$3M | Cut−$57.3M |
| Eversept Partners, LP | 138K | $6.65M | −$2.72M | Cut−$2.22M |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 134K | $6.46M | −$1.76M | Added$712K |
| NEXTBio Capital Management LP | 133.2K | $6.42M | −$2.02M | Cut−$146.4K |
| HSG Holding Ltd | 266.1K | $6.2M | −$18.2M | Cut−$18.2M |
| Rhenman & Partners Asset Management AB | 128.1K | $6.17M | −$2.73M | Cut−$4.09M |
| B Group, Inc. | 127.5K | $6.15M | −$1.92M | Cut−$114K |
| Davern Capital Partners, LP | 126.5K | $6.1M | — | New |
| PFM Health Sciences, LP | 126.4K | $6.09M | −$1.46M | Added$1.35M |
| HighVista Strategies LLC | 123.9K | $5.97M | −$2.65M | Cut−$7.45M |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 114.8K | $5.53M | −$1.89M | Cut−$999.1K |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 109.6K | $5.28M | −$1.77M | Cut−$491.7K |
| Trexquant Investment LP | 107.9K | $5.2M | −$1.92M | Cut−$1.06M |
| Jump Financial, LLC | 107.9K | $5.2M | — | New |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 118.2K | $5.19M | — | New |
| Jones Hill Capital LP | 100.6K | $4.85M | — | Held |
| Birchview Capital, LP | 100K | $4.82M | −$1.92M | Cut−$1.44M |
| PEREGRINE CAPITAL MANAGEMENT LLC | 97.1K | $4.68M | −$1.8M | Cut−$1.18M |
| Soleus Capital Management, L.P. | 80K | $3.86M | −$1.71M | Cut−$2.4M |
| TUDOR INVESTMENT CORP ET AL | 75.3K | $3.63M | −$748.4K | Added$1.19M |
| Boxer Capital Management, LLC | 75K | $3.62M | −$1.6M | Cut−$1.6M |
| Qube Research & Technologies Ltd | 73.6K | $3.55M | — | New |
| DIADEMA PARTNERS LP | 72.2K | $3.48M | — | New |
| MARSHALL WACE, LLP | 69.1K | $3.33M | −$1.48M | Cut−$8.39M |
| GEODE CAPITAL MANAGEMENT, LLC | 67.9K | $3.27M | −$1.18M | Cut−$564.6K |
| PLATINUM INVESTMENT MANAGEMENT LTD | 66.9K | $3.22M | −$1.43M | Cut−$2.89M |
| Jefferies Financial Group Inc. | 62.6K | $3.02M | −$1.34M | Cut−$4.15M |
| Susquehanna Portfolio Strategies, LLC | 60.5K | $2.92M | −$1.29M | Cut−$1.82M |
| BURKEHILL GLOBAL MANAGEMENT, LP | 60K | $2.89M | −$1.28M | Cut−$1.28M |
| ALPS ADVISORS INC | 57.7K | $2.78M | −$1.06M | Cut−$678.9K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 55.8K | $2.69M | −$192.1K | Added$2.07M |
| Renaissance Technologies | 55.8K | $2.69M | −$1.19M | Cut−$5.32M |
| SPHERA FUNDS MANAGEMENT LTD. | 50.8K | $2.45M | −$875.3K | Cut−$403K |
| Buckland Partners Management Co LLC | 50K | $2.41M | −$1.07M | Cut−$1.07M |
| SEVEN GRAND MANAGERS, LLC | 50K | $2.41M | −$1.07M | Cut−$1.07M |
| Monashee Investment Management LLC | 50K | $2.41M | −$1.07M | Cut−$13.2M |
| BANQUE PICTET & CIE SA | 49.4K | $2.38M | −$1.05M | Cut−$1.79M |
| State Street | 47.6K | $2.29M | −$1.02M | Cut−$1.06M |
| Pier Capital, LLC | 47.6K | $2.29M | −$1.02M | Cut−$1.1M |
| DAFNA Capital Management LLC | 46.5K | $2.24M | −$789.9K | Cut−$332.1K |
| Brevan Howard Capital Management LP | 47.3K | $2.2M | −$1.06M | Cut−$3.76M |
| ANTIPODES PARTNERS Ltd | 45.4K | $2.19M | −$994.8K | Cut−$1.06M |
| RAYMOND JAMES FINANCIAL INC | 45.1K | $2.18M | −$947.7K | Cut−$911.5K |
| OSAIC HOLDINGS, INC. | 44.4K | $2.14M | −$948.3K | Cut−$1.98M |
| VOYA INVESTMENT MANAGEMENT LLC | 44.4K | $2.14M | −$948.2K | Cut−$1.71M |
| BANK OF MONTREAL /CAN/ | 40K | $1.93M | −$782.9K | Cut−$1.76M |
| Headlands Technologies LLC | 37.2K | $1.79M | −$793.3K | Cut−$1.25M |
| FLAX POND CAPITAL, LLC | 36K | $1.74M | −$768.6K | Cut−$1.65M |
| PSquared Asset Management AG | 35K | $1.69M | — | New |
| Mariner, LLC | 34.5K | $1.66M | −$736.1K | Cut−$1.41M |
| Private Capital Advisors, Inc. | 34.4K | $1.66M | −$156.9K | Added$1.15M |
| TrueMark Investments, LLC | 34.4K | $1.66M | −$723.6K | Cut−$700.3K |
| NOMURA ASSET MANAGEMENT CO LTD | 32.8K | $1.58M | −$622.4K | Cut−$447K |
| CAPITAL FUND MANAGEMENT S.A. | 32.4K | $1.56M | — | New |
| XTX Topco Ltd | 30.9K | $1.49M | −$409.8K | Added$155.5K |
| Avidity Partners Management LP | 30K | $1.45M | — | New |
| Verition Fund Management LLC | 28.1K | $1.35M | −$599.4K | Cut−$4.08M |
| DCF Advisers, LLC | 27.5K | $1.33M | −$587.1K | Cut−$761K |
| EXCHANGE TRADED CONCEPTS, LLC | 25.4K | $1.22M | −$541.8K | Cut−$583.8K |
| Squarepoint Ops LLC | 22.6K | $1.09M | — | New |
| Walleye Capital LLC | 21.4K | $1.03M | −$43 | Added$1.03M |
| CenterBook Partners LP | 21.2K | $1.02M | — | New |
| CITIGROUP INC | 20.5K | $987.8K | −$156.6K | Added$477.7K |
| BARCLAYS PLC | 19.2K | $924.9K | −$167.2K | Added$380.1K |
| Persistent Asset Partners Ltd | 18.3K | $880.3K | −$52K | Added$710.9K |
| Aquatic Capital Management LLC | 14.8K | $714K | — | New |
| SECTORAL ASSET MANAGEMENT INC | 14.1K | $710.8K | −$270K | Cut−$949.5K |
| SEI INVESTMENTS CO | 14K | $674.3K | −$298.7K | Cut−$362.2K |
| MML INVESTORS SERVICES, LLC | 13.9K | $669.4K | −$167.1K | Added$125.1K |
| China Universal Asset Management Co., Ltd. | 13.8K | $666.3K | −$232.5K | Cut−$90.9K |
| WEXFORD CAPITAL LP | 13.7K | $660.8K | −$292.7K | Cut−$371K |
| BRANDYWINE MANAGERS, LLC | 13.4K | $643.8K | −$285.2K | Cut−$285.2K |
| ENVESTNET ASSET MANAGEMENT INC | 11.4K | $548.4K | −$242.9K | Cut−$256.3K |
| STIFEL FINANCIAL CORP | 11.3K | $546.7K | −$103.1K | Added$210.8K |
| Verdad Advisers, LP | 11.3K | $546.3K | — | New |
| BNP PARIBAS FINANCIAL MARKETS | 10.9K | $524.4K | −$186.7K | Cut−$83.9K |
| Russell Investments Group, Ltd. | 10.7K | $515.8K | −$228.5K | Cut−$1.31M |
| Quinn Opportunity Partners LLC | 10K | $482K | −$213.5K | Cut−$1.26M |
| HighTower Advisors, LLC | 9.62K | $463.7K | −$199K | Cut−$184.5K |
| LPL Financial LLC | 9.26K | $446.3K | −$173.1K | Cut−$117.6K |
| Gilbert & Cook, Inc. | 9.19K | $443.1K | −$121.3K | Added$47.9K |
| SmartHarvest Portfolios, LLC | 9.06K | $436.5K | −$193.3K | Cut−$193.3K |
| Seven Fleet Capital Management LP | 9K | $433.8K | — | New |
| Cinctive Capital Management LP | 8.71K | $420K | — | New |
| Allianz Asset Management GmbH | 8.6K | $414.5K | −$183.6K | Cut−$420.1K |
| DNB Asset Management AS | 8.19K | $394.7K | −$174.8K | Cut−$484.4K |
| AXQ CAPITAL, LP | 7.92K | $381.6K | — | New |
| WELLS FARGO & COMPANY/MN | 7.82K | $376.8K | −$120.9K | Cut−$17.1K |
| Cetera Investment Advisers | 7.72K | $372.1K | −$140.8K | Cut−$86.6K |
| MISSION WEALTH MANAGEMENT, LP | 7.58K | $365.5K | −$161.9K | Cut−$301K |
| Vestmark Advisory Solutions, Inc. | 7.53K | $363.1K | −$160.9K | Cut−$160.9K |
| Independent Advisor Alliance | 7.44K | $358.8K | −$97K | Added$42.8K |
| Parallel Advisors, LLC | 7.35K | $354.4K | −$157K | Cut−$157K |
| Scientech Research LLC | 6.96K | $335.4K | — | New |
| Bellevue Group AG | 6.8K | $327.9K | −$145.2K | Cut−$9.77M |
| Mirae Asset Global Investments Co., Ltd. | 6.41K | $309K | −$112.5K | Cut−$57.3K |
| PEAK6 LLC | 6.05K | $291.9K | −$129.3K | Cut−$261.4K |
| Advisory Services Network, LLC | 5.88K | $283.4K | — | New |
| Jain Global LLC | 5.77K | $278.2K | −$123.2K | Cut−$6.68M |
| Concurrent Investment Advisors, LLC | 5K | $241K | −$106.7K | Cut−$106.8K |
| Quadcap Wealth Management, LLC | 4.73K | $227.9K | $3.73K | Cut−$126.8K |
| Tidal Investments LLC | 4.64K | $223.8K | — | New |
| Invesco Ltd. | 4.58K | $220.8K | −$68.3K | Cut−$1.76K |
| E. Ohman J:or Asset Management AB | 4.52K | $217.8K | −$96.5K | Cut−$96.5K |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 4.19K | $202K | — | New |
| Virtus Investment Advisers, LLC | 4.07K | $195.9K | −$84.7K | Cut−$80K |
| PNC Financial Services Group, Inc. | 2.85K | $137.6K | −$60.9K | Cut−$135.5K |
| ASSETMARK, INC | 2.54K | $122.6K | −$44.7K | Cut−$23.1K |
| Rockefeller Capital Management L.P. | 2.22K | $107K | −$15.6K | Added$56.2K |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2M | $96.4K | −$35.7K | Cut−$19.8K |
| GF FUND MANAGEMENT CO. LTD. | 1.5K | $72.3K | −$28K | Cut−$18.9K |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | 1.5K | $72.3K | — | New |
| Steward Partners Investment Advisory, LLC | 1.4K | $67.5K | −$29.9K | Cut−$109.2K |
| GAMMA Investing LLC | 999 | $48.2K | −$19.9K | Cut−$16.5K |
| Farther Finance Advisors, LLC | 931 | $46.7K | −$13.4K | Cut−$1.28K |
| ROYAL BANK OF CANADA | 722 | $35K | −$15.2K | Cut−$674K |
| Tower Research Capital LLC (TRC) | 646 | $31.1K | −$876 | Added$28.3K |
| Sterling Capital Management LLC | 590 | $28.4K | — | New |
| EverSource Wealth Advisors, LLC | 558 | $26.9K | −$11.9K | Cut−$13.3K |
| Blue Owl Capital Holdings LP | 100K | $25K | — | New |
| State of Wyoming | 433 | $20.9K | −$9.24K | Cut−$101.6K |
| WOLFF WIESE MAGANA LLC | 400 | $19.3K | −$8.54K | Cut−$8.54K |
| Caitong International Asset Management Co., Ltd | 376 | $18.1K | — | New |
| North Star Investment Management Corp. | 330 | $15.9K | −$7.05K | Cut−$7.05K |
| JONES FINANCIAL COMPANIES LLLP | 341 | $15.7K | −$8.06K | Cut−$57.1K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 212 | $10.2K | — | New |
| SOA Wealth Advisors, LLC. | 200 | $9.64K | −$4.27K | Cut−$14.7K |
| Dynamic Wealth Strategies, LLC | 150 | $7.23K | −$3.2K | Cut−$3.2K |
| CWM, LLC | 125 | $6.03K | $6.02K | Added$5.99K |
| FARMERS & MERCHANTS INVESTMENTS INC | 100 | $4.82K | — | New |
| Key Financial Inc | 100 | $4.82K | — | New |
| SHP Wealth Management | 100 | $4.82K | −$2.13K | Cut−$2.13K |
| SIGNATUREFD, LLC | 100 | $4.82K | −$2.14K | Cut−$457.7K |
| Rakuten Securities, Inc. | 60 | $2.89K | — | New |
| Transamerica Financial Advisors, LLC | 22 | $1.06K | — | New |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 17.3K | $834 | −$369 | Cut−$369 |
| Smartleaf Asset Management LLC | 17 | $747 | — | New |
| GSA CAPITAL PARTNERS LLP | 13.8K | $666 | — | New |
| Ancora Advisors LLC | 10 | $482 | −$213 | Cut−$213 |
| US BANCORP \DE\ | 10 | $482 | — | New |
| Allworth Financial LP | 9 | $434 | −$192 | Cut−$192 |
| Cullen/Frost Bankers, Inc. | 8 | $386 | −$170 | Cut−$170 |
| Janney Montgomery Scott LLC | 6.82K | $329 | — | New |
| Larson Financial Group LLC | 5 | $241 | −$107 | Cut−$107 |
| SG Americas Securities, LLC | 2.65K | $128 | −$56 | Cut−$578 |
| HUNTINGTON NATIONAL BANK | 2 | $96 | −$43 | Cut−$43 |
| IMA Advisory Services, Inc. | 2 | $96 | — | New |
| Penserra Capital Management LLC | 1.74K | $83 | — | New |
| Capital Analysts, LLC | 18 | $1 | $0 | Held |