13F

Stock

Karyopharm Therapeutics Inc.

KPTI · held by 78 managers

Reported value

$87.8M

Holders

78

+22 new · −15 exited

Holders’ est. mark

−$8.04M

Price effect on 52 books still in the name

Largest holder

$10.9M

Commodore Capital LP

Notable conviction

Share of each notable manager’s 13F book.

Holder count by quarter

Who holds it

Notable only
InvestorSharesValueEst. markChange
Commodore Capital LP1.95M$10.9MNew
RA CAPITAL MANAGEMENT, L.P.1.92M$10.7MNew
ADAGE CAPITAL PARTNERS GP, L.L.C.1.81M$10.1M−$754.2KAdded$6.96M
GOLDMAN SACHS GROUP INC947.6K$5.28MNew
Catalio Capital Management, LP897.7K$5M−$255.9KAdded$3.95M
VANGUARD CAPITAL MANAGEMENT LLC739.7K$4.12MHeld
Ikarian Capital, LLC733.4K$4.09M−$974.8KAdded$77.3K
Affinity Asset Advisors, LLC500K$2.79M−$895KCut−$3.76M
Avidity Partners Management LP463.7K$2.58M−$240.9KAdded$1.59M
Soleus Capital Management, L.P.440K$2.45M−$787.6KCut−$787.6K
MILLENNIUM MANAGEMENT LLC420.6K$2.34MNew
Boxer Capital Management, LLC302.5K$1.69M−$452KCut−$173.5K
Davidson Kempner Capital Management LP300K$1.67M−$537KCut−$610.7K
ACORN CAPITAL ADVISORS, LLC287.8K$1.6MNew
Eversept Partners, LP276.2K$1.54MNew
Jump Financial, LLC262.1K$1.46M−$96.3KAdded$1.06M
Trexquant Investment LP257.9K$1.44M−$74.7KAdded$1.13M
BlackRock, Inc.244.9K$1.36M−$438.4KCut−$457.9K
BOOTHBAY FUND MANAGEMENT, LLC213.8K$1.19M−$258.9KAdded$126.5K
Brevan Howard Capital Management LP212.4K$1.18MNew
GEODE CAPITAL MANAGEMENT, LLC206.1K$1.15M−$335.6KCut−$233K
UBS Group AG194K$1.08M−$158.3KAdded$429.6K
GROUP ONE TRADING LLC191.5K$1.07M−$183.3KAdded$313K
XTX Topco Ltd164.4K$915.9K−$21.3KAdded$828.3K
TWO SIGMA INVESTMENTS, LP151.2K$842.4K−$266.3KCut−$252.8K
ADAR1 Capital Management, LLC136.7K$761.6K−$89.5KAdded$393.6K
MARSHALL WACE, LLP128.5K$715.5K−$229.9KCut−$229.9K
VANGUARD FIDUCIARY TRUST CO114.9K$640.2KHeld
Engineers Gate Manager LP112.4K$626.2KNew
JANE STREET GROUP, LLC105.9K$589.9K−$63.6KAdded$328.3K
Renaissance Technologies105.4K$587.2K−$107.2KAdded$146.2K
Birchview Capital, LP84K$467.6KNew
State Street80.7K$449.7K−$105.5KAdded$15.9K
Connor, Clark & Lunn Investment Management Ltd.79.1K$440.5K−$102.4KAdded$19.4K
BRIDGEWAY CAPITAL MANAGEMENT, LLC71.9K$400.3K−$117.9KCut−$84.5K
Balyasny Asset Management L.P.70.7K$394.1KNew
SILVERBACK ASSET MANAGEMENT LLC65K$362.1K−$71.6KAdded$67.7K
ROYAL BANK OF CANADA60.4K$336K−$104.3KCut−$91K
Tetragon Partners GP Ltd53K$295.1KNew
DAFNA Capital Management LLC45.8K$255.1K−$82KCut−$120.3K
NORTHERN TRUST CORP38.6K$214.8K−$52KAdded$1.15K
Zimmer Partners, LP37.5K$208.9KNew
Centiva Capital, LP30.2K$168.3KNew
China Universal Asset Management Co., Ltd.30K$167.1KNew
Baird Financial Group, Inc.29.8K$165.9K−$50.1KCut−$40.1K
Susquehanna Portfolio Strategies, LLC25K$139.4KNew
SUSQUEHANNA INTERNATIONAL GROUP, LLP24.1K$134.4K−$43.2KCut−$952.6K
BANK OF AMERICA CORP /DE/19.5K$108.5K−$34.9KCut−$245.5K
OMERS ADMINISTRATION Corp19.4K$108.1KNew
MORGAN STANLEY18.6K$103.4K−$15.9KAdded$38.2K
Invesco Ltd.16.7K$93.2KNew
Velan Capital Investment Management LP15K$83.5KNew
CHARLES SCHWAB INVESTMENT MANAGEMENT INC13.4K$74.8KNew
HSBC HOLDINGS PLC11.5K$65.6KNew
Bank of New York Mellon Corp11.4K$63.5K−$19.8KCut−$18.1K
Vanguard Global Advisers, LLC8.21K$45.7KHeld
BARCLAYS PLC7.42K$41.4K−$7.35KAdded$11.1K
CITIGROUP INC4.94K$27.5K−$1Added$27.5K
TD Waterhouse Canada Inc.3.2K$18.6K−$4.93KCut−$4.93K
T. Rowe Price Investment Management, Inc.1.54M$8.59K−$2.67KCut−$2.39K
Rockefeller Capital Management L.P.733$4.08K−$1.31KCut−$1.31K
Fidelity665$3.7K−$1.19KCut−$1.29K
JPMORGAN CHASE & CO471$2.5K−$971Cut−$10.3K
OSAIC HOLDINGS, INC.402$2.24K−$505Added$163
HARBOUR INVESTMENTS, INC.285$1.59K−$153Added$961
ACADIAN ASSET MANAGEMENT LLC249K$1.38K−$6Added$1.35K
Quent Capital, LLC235$1.31K−$421Cut−$421
MB, LEVIS & ASSOCIATES, LLC100$557−$179Cut−$179
C WorldWide Group Holding A/S100K$557−$179Cut−$179
BNP PARIBAS FINANCIAL MARKETS84$468−$147Cut−$136
HRT FINANCIAL LP70K$389New
SBI Securities Co., Ltd.67$373−$120Cut−$172
Activest Wealth Management66$368−$118Cut−$118
Allworth Financial LP26$145−$47Cut−$47
Advisory Services Network, LLC12$67New
PRICE T ROWE ASSOCIATES INC /MD/10.9K$61−$20Cut−$20
West Branch Capital LLC3$17−$6Cut−$6
PlanVest Financial, Inc1$6Held

Who left

Positions as of Q1 2026. 13F filings arrive up to 45 days after quarter-end and omit shorts. Values are quarter-end marks, as filed. Estimated mark is the price effect on shares still held — not realized P&L or investment advice.