| RTW INVESTMENTS, LP | 5.62M | $183.1M | $4.55M | Added$7.04M |
| BlackRock, Inc. | 5.39M | $175.4M | $4.27M | Added$9.91M |
| Fidelity | 5.38M | $175.3M | $4.41M | Cut−$2.48M |
| Lynx1 Capital Management LP | 4.76M | $155.1M | $3.91M | Cut−$16.4M |
| Redmile Group, LLC | 4.16M | $135.6M | $3.31M | Added$7.54M |
| MORGAN STANLEY | 3.42M | $111.5M | $2.81M | Cut−$1.09M |
| BAKER BROS. ADVISORS LP | 3.34M | $108.6M | $2.74M | Added$2.74M |
| TORONTO DOMINION BANK | 3.17M | $103.3M | $2.6M | Added$2.6M |
| WELLINGTON MANAGEMENT GROUP LLP | 3.1M | $100.8M | $603.4K | Added$77.4M |
| BVF INC/IL | 2.55M | $82.9M | $1.86M | Added$11M |
| VANGUARD CAPITAL MANAGEMENT LLC | 2.36M | $76.7M | — | Held |
| State Street | 2.28M | $74.1M | $1.87M | Cut−$5.16M |
| Siren, L.L.C. | 2M | $65M | $1.64M | Cut−$6.36M |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1.82M | $59.4M | $1.5M | Added$1.5M |
| JANUS HENDERSON GROUP PLC | 1.61M | $52.5M | $1.16M | Added$6.42M |
| GEODE CAPITAL MANAGEMENT, LLC | 1.32M | $43.1M | $956.8K | Added$6.04M |
| Polar Capital Holdings Plc | 1.13M | $36.9M | $928.7K | Cut−$3.41M |
| DIMENSIONAL FUND ADVISORS LP | 989.9K | $32.2M | $674.8K | Added$5.97M |
| Assenagon Asset Management S.A. | 907K | $29.5M | $743.8K | Cut−$9.44M |
| GOLDMAN SACHS GROUP INC | 830.7K | $27M | $681.2K | Cut−$9.22M |
| MPM BIOIMPACT LLC | 767K | $25M | $629K | Added$525.8K |
| Opaleye Management Inc. | 700K | $22.8M | $569.9K | Added$732.7K |
| Troluce Capital Advisors LLC | 652.8K | $21.3M | — | New |
| BAILLIE GIFFORD & CO | 575.2K | $18.7M | $202.5K | Added$10.9M |
| BANK OF AMERICA CORP /DE/ | 543.1K | $17.7M | $169.1K | Added$11.1M |
| Candriam S.C.A. | 502K | $16.3M | $365.7K | Added$2.17M |
| TANG CAPITAL MANAGEMENT LLC | 500K | $16.3M | $410K | Added$410K |
| MILLENNIUM MANAGEMENT LLC | 472.1K | $15.4M | — | New |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 462.7K | $15.1M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 437.2K | $14.2M | $336.9K | Added$1.19M |
| Erste Asset Management GmbH | 446K | $14.2M | −$17.2K | Added$1.57M |
| NORTHERN TRUST CORP | 431.6K | $14.1M | $330.6K | Added$1.26M |
| VANGUARD FIDUCIARY TRUST CO | 356.9K | $11.6M | — | Held |
| Parkman Healthcare Partners LLC | 336.5K | $11M | $275.9K | Cut−$2.7M |
| Granahan Investment Management, LLC | 335.6K | $10.9M | $156.9K | Added$4.85M |
| Artisan Partners Limited Partnership | 315.5K | $10.3M | — | New |
| JPMORGAN CHASE & CO | 265.5K | $8.43M | $7.96K | Cut−$387.4K |
| Birchview Capital, LP | 210K | $6.84M | $172.2K | Cut−$1.41M |
| FIRST TRUST ADVISORS LP | 163.5K | $5.32M | $133.4K | Added$158.8K |
| UBS Group AG | 158.3K | $5.15M | $129.8K | Cut−$232.3K |
| Invesco Ltd. | 150K | $4.89M | $123K | Cut−$3.35M |
| Bank of New York Mellon Corp | 143.4K | $4.67M | $115.5K | Added$200.3K |
| FRANKLIN RESOURCES INC | 142.8K | $4.65M | $108.4K | Added$452.6K |
| DAFNA Capital Management LLC | 130.9K | $4.26M | $89.3K | Added$805.6K |
| Citadel | 123K | $4.01M | $13K | Added$3.5M |
| Susquehanna Portfolio Strategies, LLC | 119.2K | $3.88M | $97.8K | Cut−$128.3K |
| GILDER GAGNON HOWE & CO LLC | 112.6K | $3.67M | $92.4K | Cut−$219.4K |
| Nuveen, LLC | 108.6K | $3.54M | $85.5K | Added$227.3K |
| EcoR1 Capital, LLC | 100K | $3.26M | — | New |
| Palo Alto Investors LP | 84.6K | $2.76M | $59.1K | Added$469.6K |
| HUSSMAN STRATEGIC ADVISORS, INC. | 84K | $2.74M | $51.7K | Added$735.4K |
| Rhenman & Partners Asset Management AB | 83K | $2.7M | $68.1K | Cut−$4.15M |
| Swiss National Bank | 79.1K | $2.58M | $62.1K | Added$172.8K |
| Quantedge Capital Pte Ltd | 78.6K | $2.56M | $64.5K | Cut−$208.5K |
| TD Asset Management Inc | 74.4K | $2.42M | — | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 69.2K | $2.25M | $11.1K | Added$1.82M |
| RHUMBLINE ADVISERS | 67.3K | $2.19M | $51.2K | Added$210.8K |
| JANE STREET GROUP, LLC | 64.3K | $2.1M | $52.8K | Cut−$34.9K |
| PRINCIPAL FINANCIAL GROUP INC | 63.9K | $2.08M | $52.4K | Cut−$149.1K |
| Harvest Investment Services, LLC | 62.8K | $2.05M | $31.4K | Added$828.9K |
| HighVista Strategies LLC | 62.6K | $2.04M | $51.3K | Cut−$1.63M |
| Rafferty Asset Management, LLC | 59.9K | $1.95M | $49.1K | Cut−$912.4K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 58.2K | $1.89M | $46.9K | Added$78.6K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 57.3K | $1.87M | $37.7K | Added$404.7K |
| BNP PARIBAS FINANCIAL MARKETS | 56.1K | $1.83M | $3.49K | Added$1.69M |
| Informed Momentum Co LLC | 52K | $1.69M | $42.6K | Cut−$2.05M |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 51.6K | $1.68M | $30.4K | Added$501.9K |
| Woodline Partners LP | 50.1K | $1.63M | $41.1K | Added$41.1K |
| Privium Fund Management B.V. | 50K | $1.63M | $41K | Cut−$117.7K |
| D. E. Shaw & Co., Inc. | 50K | $1.63M | $40.9K | Added$43.2K |
| Schonfeld Strategic Advisors LLC | 49.3K | $1.61M | $40.4K | Cut−$397.8K |
| Creative Planning | 48.1K | $1.57M | $34.2K | Added$242.5K |
| STATE OF WISCONSIN INVESTMENT BOARD | 47.9K | $1.56M | $12.2K | Added$1.09M |
| BOOTHBAY FUND MANAGEMENT, LLC | 47.3K | $1.54M | — | New |
| ALPS ADVISORS INC | 46.5K | $1.51M | $38.1K | Cut−$596.8K |
| Icahn Capital | 46.5K | $1.51M | $24.2K | Added$577.4K |
| OMERS ADMINISTRATION Corp | 41.5K | $1.35M | — | New |
| PLATINUM INVESTMENT MANAGEMENT LTD | 40.8K | $1.33M | $33.5K | Added$33.5K |
| ALLIANCEBERNSTEIN L.P. | 41.8K | $1.33M | $0 | Added$38.1K |
| DEUTSCHE BANK AG\ | 40.6K | $1.32M | $27.4K | Added$261.5K |
| Moran Wealth Management, LLC | 40.6K | $1.32M | — | New |
| NEW YORK STATE COMMON RETIREMENT FUND | 39.2K | $1.27M | $12.3K | Added$797.8K |
| LPL Financial LLC | 36K | $1.17M | $6.05K | Added$939.4K |
| Caption Management, LLC | 35.2K | $1.15M | — | New |
| VICTORY CAPITAL MANAGEMENT INC | 33.9K | $1.1M | $27.8K | Cut−$202.3K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 33.9K | $1.1M | $23K | Added$67.1K |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 34.1K | $1.08M | — | New |
| Legal & General Group Plc | 32K | $1.04M | $26.3K | Cut−$110.8K |
| Blackstone Inc. | 30.6K | $995.7K | — | New |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 30.5K | $992.4K | $7.92K | Added$700.6K |
| PROFUND ADVISORS LLC | 27K | $878.6K | $22.1K | Cut−$181.1K |
| NOMURA HOLDINGS INC | 26.9K | $875.6K | $22.1K | Cut−$532.2K |
| Vanguard Global Advisers, LLC | 26.6K | $867.4K | — | Held |
| CANADA PENSION PLAN INVESTMENT BOARD | 26.2K | $853.1K | $21.5K | Cut−$264.2K |
| MetLife Investment Management, LLC | 26.1K | $850K | $20.8K | Added$46.4K |
| VANGUARD ASSET MANAGEMENT, Ltd | 25.1K | $817.7K | — | Held |
| Cresset Asset Management, LLC | 24.5K | $797.5K | $20.1K | Cut−$38K |
| Balyasny Asset Management L.P. | 23.9K | $777.5K | $7.66K | Added$481K |
| AMERICAN CENTURY COMPANIES INC | 23.4K | $761.8K | $19.2K | Cut−$2.89M |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 22.6K | $737.3K | $15.7K | Added$131.1K |
| HSBC HOLDINGS PLC | 20.5K | $686K | — | New |
| Allspring Global Investments Holdings, LLC | 21K | $683.3K | $34.8K | Cut−$72.6K |
| WELLS FARGO & COMPANY/MN | 19.9K | $646.9K | $16.3K | Cut−$926.9K |
| AMERIPRISE FINANCIAL INC | 18.1K | $589.8K | $14.9K | Cut−$79.2K |
| Jefferies Financial Group Inc. | 16.3K | $530.7K | — | New |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 16.2K | $527.7K | — | New |
| China Universal Asset Management Co., Ltd. | 15.1K | $492.8K | $10.6K | Added$83.2K |
| Campbell & CO Investment Adviser LLC | 15K | $490K | $10.7K | Added$77.5K |
| INTECH INVESTMENT MANAGEMENT LLC | 14.5K | $471.9K | $11.9K | Cut−$120.1K |
| CIM, LLC | 14.2K | $463.3K | — | New |
| State of New Jersey Common Pension Fund D | 13.7K | $444.9K | — | New |
| State of Wyoming | 13.3K | $431.8K | $911 | Added$396.6K |
| CITIGROUP INC | 12.7K | $414.4K | $10.4K | Cut−$17.4K |
| Police & Firemen's Retirement System of New Jersey | 12.5K | $408.1K | $10.3K | Added$10.3K |
| CAPSTONE INVESTMENT ADVISORS, LLC | 12.2K | $398.2K | — | New |
| PSP Research LLC | 12K | $390.7K | $9.84K | Cut−$136.8K |
| ARIZONA STATE RETIREMENT SYSTEM | 11K | $357.6K | $8.97K | Added$10.5K |
| Dorsey & Whitney Trust CO LLC | 10.8K | $352.1K | $8.87K | Added$8.87K |
| OSAIC HOLDINGS, INC. | 10.3K | $335.8K | $8.41K | Added$10.1K |
| Quadrature Capital Ltd | 10.3K | $335.1K | — | New |
| Vanguard Investments Australia, Ltd. | 10.2K | $331.7K | — | Held |
| BARCLAYS PLC | 10.1K | $329.5K | $8.3K | Cut−$4.46M |
| SEI INVESTMENTS CO | 9.99K | $325.4K | $8.19K | Cut−$202.5K |
| Quantinno Capital Management LP | 9.77K | $318.2K | $8.01K | Cut−$33.7K |
| ProShare Advisors LLC | 9.65K | $314.3K | $7.92K | Cut−$25.9K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 9.58K | $312K | $7.49K | Added$22.2K |
| AVIVA PLC | 9.27K | $301.9K | $7.6K | Cut−$201.8K |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 9.09K | $295.9K | — | New |
| FARALLON CAPITAL MANAGEMENT LLC | 9K | $293K | $7.38K | Added$7.38K |
| KLP KAPITALFORVALTNING AS | 8.8K | $286.5K | $6.72K | Added$26.3K |
| Tidal Investments LLC | 8.54K | $278.1K | $6.85K | Added$12.9K |
| TEMA ETFS LLC | 8.54K | $278.1K | — | New |
| Virtus Investment Advisers, LLC | 8.42K | $274.1K | $6.74K | Added$13.4K |
| VOYA INVESTMENT MANAGEMENT LLC | 8.21K | $267.2K | $6.36K | Added$20.8K |
| XTX Topco Ltd | 8.05K | $262.2K | — | New |
| PRUDENTIAL FINANCIAL INC | 7.64K | $248.8K | — | New |
| Pictet Asset Management Holding SA | 7.58K | $246.8K | — | New |
| E Fund Management Co., Ltd. | 7.53K | $245.2K | — | Held |
| STRS OHIO | 7K | $227.9K | $5.74K | Added$5.74K |
| Generali Investments, Management Co LLC | 6.91K | $225.1K | $2.03K | Added$146.6K |
| Swiss Life Asset Management Ltd | 6.54K | $213.1K | $5.37K | Cut−$2.7K |
| Caitong International Asset Management Co., Ltd | 5.66K | $184.4K | — | New |
| Tower Research Capital LLC (TRC) | 4.43K | $144.1K | $517 | Added$124.1K |
| Ameritas Investment Partners, Inc. | 4.01K | $130.5K | $3.07K | Added$11.6K |
| Russell Investments Group, Ltd. | 3.62K | $117.9K | $2.97K | Added$3.13K |
| HARBOUR INVESTMENTS, INC. | 3.35K | $109.1K | $972 | Added$71.5K |
| Mirae Asset Global Investments Co., Ltd. | 2.98K | $97K | $2.28K | Added$8.89K |
| NISA INVESTMENT ADVISORS, LLC | 2.84K | $92.4K | $2K | Added$15.1K |
| JONES FINANCIAL COMPANIES LLLP | 2.12K | $69.6K | $2.35K | Cut−$11.9K |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.93M | $63K | $305 | Added$51.2K |
| EverSource Wealth Advisors, LLC | 1.84K | $59.8K | $509 | Added$40.1K |
| Western Wealth Management, LLC | 1.7K | $55.4K | — | New |
| Versant Capital Management, Inc | 1.59K | $51.8K | $1.31K | Added$1.31K |
| GF FUND MANAGEMENT CO. LTD. | 1.28K | $41.8K | $918 | Added$6.19K |
| GAMMA Investing LLC | 840 | $27.4K | $680 | Added$1.01K |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 648 | $21.1K | $15.5K | Added$21.1K |
| CWM, LLC | 619 | $20.2K | $18.4K | Added$20.1K |
| Stone House Investment Management, LLC | 500 | $16.3K | $410 | Added$410 |
| Rockefeller Capital Management L.P. | 481 | $15.7K | $80 | Added$12.6K |
| Kemnay Advisory Services Inc. | 471 | $15.3K | — | New |
| ROYAL BANK OF CANADA | 458 | $15K | $326 | Cut−$37K |
| Wilmington Savings Fund Society, FSB | 400 | $13K | $328 | Added$328 |
| Sterling Capital Management LLC | 318 | $10.4K | $244 | Added$895 |
| J.Safra Asset Management Corp | 299 | $9.73K | $79 | Added$6.66K |
| ROTHSCHILD INVESTMENT LLC | 291 | $9.47K | $238 | Added$175 |
| US BANCORP \DE\ | 265 | $8.63K | $200 | Added$884 |
| T. Rowe Price Investment Management, Inc. | 250.9K | $8.17K | — | New |
| Prestige Wealth Management Group LLC | 200 | $6.51K | $164 | Added$164 |
| Smartleaf Asset Management LLC | 155 | $4.92K | −$8 | Cut−$8 |
| Owl Creek Wealth Partners LLC | 150 | $4.88K | — | Held |
| LRI Investments, LLC | 146 | $4.75K | — | New |
| Financial Life Planners | 144 | $4.69K | — | New |
| SIMPLEX TRADING, LLC | 130 | $4.23K | $106 | Cut−$449K |
| Larson Financial Group LLC | 117 | $3.81K | $76 | Added$890 |
| SIGNATUREFD, LLC | 110 | $3.58K | $69 | Added$948 |
| PNC Financial Services Group, Inc. | 44 | $1.43K | $36 | Added$36 |
| Farther Finance Advisors, LLC | 40 | $1.28K | $5 | Added$709 |
| Rachor Investment Advisory Services, LLC | 37 | $1.21K | $30 | Cut−$65 |
| SG Americas Securities, LLC | 34K | $1.11K | $21 | Added$287 |
| Root Financial Partners, LLC | 23 | $749 | $6 | Added$527 |
| CANADA LIFE ASSURANCE Co | 18.8K | $613 | $12 | Added$144 |
| Parallel Advisors, LLC | 13 | $423 | $10 | Added$10 |
| Allworth Financial LP | 12 | $391 | $5 | Added$168 |
| Virtu Financial LLC | 11K | $360 | — | New |
| HARBOR CAPITAL ADVISORS, INC. | 10.9K | $354 | — | New |
| Vestcor Inc | 10.2K | $331 | $8 | Added$8 |
| ACADIAN ASSET MANAGEMENT LLC | 8.76K | $284 | $7 | Cut−$163 |
| SBI Securities Co., Ltd. | 5 | $163 | $4 | Added$4 |
| IFP Advisors, Inc | 5 | $163 | $4 | Added$4 |
| True Wealth Design, LLC | 4 | $131 | $4 | Added$4 |
| TWIN PEAKS WEALTH ADVISORS, LLC | 3 | $98 | — | New |
| MAI Capital Management | 3 | $98 | — | New |
| Cygnus Capital Advisors, LLC | 1.5K | $49 | $1 | Cut−$46 |
| KBC Group NV | 1.1K | $36 | — | New |
| Keating Financial Advisory Services, Inc. | 1 | $33 | — | New |
| VALLEY NATIONAL ADVISERS INC | 750 | $24 | $1 | Added$1 |
| Covestor Ltd | 4 | $0 | — | New |