| Frazier Life Sciences Management, L.P. | 4.57M | $136.3M | −$52.9M | Cut−$52.9M |
| TRV GP IV, LLC | 4.47M | $133.5M | −$51.8M | Cut−$51.8M |
| ARCH Venture Management, LLC | 4.12M | $123M | −$47.7M | Cut−$47.7M |
| Deep Track Capital, LP | 3.48M | $103.8M | −$40.3M | Cut−$72.1M |
| JANUS HENDERSON GROUP PLC | 2.86M | $85.3M | −$33.2M | Cut−$44.9M |
| Paradigm Biocapital Advisors LP | 2.74M | $81.9M | — | New |
| BlackRock, Inc. | 2.57M | $76.7M | −$26.5M | Cut−$18M |
| a16z Capital Management, L.L.C. | 1.7M | $50.8M | −$19.7M | Cut−$19.7M |
| VR ADVISER, LLC | 1.6M | $47.8M | −$17.9M | Cut−$16.3M |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.44M | $42.9M | — | Held |
| Alphabet Inc. | 1.39M | $41.4M | −$16.1M | Cut−$16.1M |
| Logos Global Management LP | 1.24M | $36.9M | −$11M | Cut−$2.49M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.18M | $35.2M | — | New |
| General Catalyst Group Management, LLC | 1.04M | $30.9M | −$12M | Cut−$12M |
| TRV GP V, LLC | 950.8K | $28.4M | −$11M | Cut−$11M |
| Fidelity | 864.2K | $25.8M | −$8.44M | Cut−$4.39M |
| Citadel | 775.7K | $23.2M | −$5.19M | Added$4.59M |
| ArrowMark Colorado Holdings LLC | 767.4K | $22.9M | −$8.89M | Cut−$8.89M |
| Casdin Capital, LLC | 758.9K | $22.7M | −$8.79M | Cut−$8.79M |
| Cormorant Asset Management, LP | 750K | $22.4M | — | New |
| Woodline Partners LP | 650.2K | $19.4M | −$7.53M | Cut−$23.5M |
| State Street | 636.7K | $19M | −$6.17M | Cut−$3.08M |
| Driehaus Capital Management LLC | 636.2K | $19M | −$4.38M | Added$3.33M |
| Caligan Partners LP | 615K | $18.4M | −$6.37M | Cut−$4.44M |
| GEODE CAPITAL MANAGEMENT, LLC | 600K | $17.9M | −$6.11M | Cut−$3.94M |
| Balyasny Asset Management L.P. | 461.2K | $13.8M | −$2.31M | Added$5.51M |
| Ikarian Capital, LLC | 379K | $11.3M | −$4.39M | Cut−$15.4M |
| FARALLON CAPITAL MANAGEMENT LLC | 373K | $11.1M | — | New |
| HHLR ADVISORS, LTD. | 366K | $10.9M | −$4.24M | Cut−$8.03M |
| MARSHALL WACE, LLP | 310.6K | $9.27M | −$3.6M | Cut−$25.8M |
| BOOTHBAY FUND MANAGEMENT, LLC | 284.5K | $8.49M | −$3.29M | Cut−$8.47M |
| WASHINGTON UNIVERSITY | 280.8K | $8.38M | −$3.25M | Cut−$3.25M |
| GOLDMAN SACHS GROUP INC | 279.7K | $8.35M | −$1.33M | Added$3.61M |
| Candriam S.C.A. | 278.2K | $8.3M | — | New |
| Squadron Capital Management LLC | 257.5K | $7.69M | −$2.98M | Cut−$12.6M |
| Mass General Brigham, Inc | 240K | $7.16M | −$2.78M | Cut−$2.78M |
| Freestone Grove Partners LP | 235K | $7.01M | −$1.38M | Added$2.09M |
| SPHERA FUNDS MANAGEMENT LTD. | 227.3K | $6.79M | −$831.9K | Added$3.81M |
| Aberdeen Group plc | 226.2K | $6.75M | — | New |
| NORTHERN TRUST CORP | 211.4K | $6.31M | −$2.04M | Cut−$992.7K |
| MORGAN STANLEY | 204.8K | $6.11M | −$2.37M | Cut−$4.58M |
| Spruce Street Capital LP | 200K | $5.97M | — | New |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 195.5K | $5.84M | — | Held |
| BANK OF AMERICA CORP /DE/ | 195.1K | $5.82M | −$212.9K | Added$5.06M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 186.4K | $5.57M | −$2.04M | Cut−$1.73M |
| Ensign Peak Advisors, Inc | 185.8K | $5.55M | −$2.15M | Cut−$2.15M |
| Foresite Capital Management IV, LLC | 156.9K | $4.68M | −$1.82M | Cut−$17M |
| VANGUARD FIDUCIARY TRUST CO | 151K | $4.51M | — | Held |
| Holocene Advisors, LP | 136.2K | $4.06M | — | New |
| Qube Research & Technologies Ltd | 134.9K | $4.03M | — | New |
| Atika Capital Management LLC | 111.5K | $3.33M | — | New |
| AMERIPRISE FINANCIAL INC | 107.5K | $3.21M | −$1.12M | Cut−$797.3K |
| Alyeska Investment Group, L.P. | 100K | $2.98M | −$1.16M | Cut−$5.14M |
| Integral Health Asset Management, LLC | 100K | $2.98M | −$1.16M | Cut−$1.16M |
| HighVista Strategies LLC | 99.8K | $2.98M | −$1.16M | Cut−$4.08M |
| UBS Group AG | 93.9K | $2.8M | −$332.3K | Added$1.61M |
| ALLIANCEBERNSTEIN L.P. | 64.8K | $2.68M | −$0 | Added$1.31M |
| Exome Asset Management LLC | 88.5K | $2.64M | — | New |
| Invesco Ltd. | 86.4K | $2.58M | −$1M | Cut−$2.97M |
| SummitTX Capital, L.P. | 83.8K | $2.5M | −$805.5K | Cut−$381.9K |
| Bank of New York Mellon Corp | 74.3K | $2.22M | −$699.8K | Cut−$287K |
| RAYMOND JAMES FINANCIAL INC | 69.4K | $2.07M | −$784.2K | Cut−$734.7K |
| Nuveen, LLC | 63.4K | $1.89M | −$663K | Cut−$480.9K |
| WELLINGTON MANAGEMENT GROUP LLP | 60.6K | $1.81M | −$701.6K | Cut−$727.2K |
| OSAIC HOLDINGS, INC. | 59.9K | $1.79M | −$692K | Cut−$686.6K |
| FRANKLIN RESOURCES INC | 59.6K | $1.78M | −$639.6K | Cut−$508K |
| JPMORGAN CHASE & CO | 58.4K | $1.7M | −$248.5K | Added$866.6K |
| ADAR1 Capital Management, LLC | 50.1K | $1.5M | −$580.1K | Cut−$5.94M |
| D. E. Shaw & Co., Inc. | 45.6K | $1.36M | −$390.2K | Cut−$33.7K |
| Propel Bio Management, LLC | 43.8K | $1.31M | — | New |
| ALPS ADVISORS INC | 39.2K | $1.17M | — | New |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 37.2K | $1.08M | — | New |
| DAFNA Capital Management LLC | 35K | $1.04M | — | New |
| Aquatic Capital Management LLC | 35K | $1.04M | — | New |
| Russell Investments Group, Ltd. | 32.5K | $970.9K | −$261.1K | Added$36.9K |
| Parkman Healthcare Partners LLC | 31.8K | $950.5K | −$368.8K | Cut−$7.72M |
| RHUMBLINE ADVISERS | 31.5K | $940.7K | −$274.8K | Cut−$42.5K |
| TWINBEECH CAPITAL LP | 31K | $925K | — | New |
| Seven Fleet Capital Management LP | 30.7K | $916.6K | — | New |
| MILLENNIUM MANAGEMENT LLC | 29.9K | $892.3K | −$346.1K | Cut−$5.51M |
| Walleye Capital LLC | 27.9K | $834.2K | — | New |
| Icahn Capital | 27.9K | $834.2K | −$317.7K | Cut−$302.6K |
| XTX Topco Ltd | 26.9K | $801.6K | −$311K | Cut−$566.5K |
| Foresite Capital Management V, LLC | 25.9K | $773.3K | −$300K | Cut−$2.8M |
| FIRST TRUST ADVISORS LP | 25.5K | $760.7K | — | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 25.3K | $755.2K | — | New |
| Blackstone Inc. | 25K | $746K | — | New |
| Y-Intercept (Hong Kong) Ltd | 21.7K | $648.6K | — | New |
| DEUTSCHE BANK AG\ | 20.3K | $604.9K | −$179.7K | Cut−$38.2K |
| ACUTA CAPITAL PARTNERS, LLC | 19.3K | $577.1K | −$223.9K | Cut−$251.4K |
| Verition Fund Management LLC | 19.1K | $571.1K | −$221.6K | Cut−$361.5K |
| PRELUDE CAPITAL MANAGEMENT, LLC | 18.1K | $541.1K | — | New |
| Caitong International Asset Management Co., Ltd | 17.8K | $530.8K | −$40.5K | Added$385.8K |
| GILDER GAGNON HOWE & CO LLC | 17.5K | $522K | −$202.5K | Cut−$442.6K |
| TWO SIGMA INVESTMENTS, LP | 15.8K | $473K | −$83.9K | Added$172.8K |
| Renaissance Technologies | 15.8K | $471.6K | −$183K | Cut−$651.1K |
| Vanguard Global Advisers, LLC | 15.2K | $453.8K | — | Held |
| Engineers Gate Manager LP | 15.1K | $451K | — | New |
| DIADEMA PARTNERS LP | 15K | $447.8K | — | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 14.6K | $434.9K | −$79.9K | Added$149.2K |
| MetLife Investment Management, LLC | 14.5K | $434.1K | −$136.7K | Cut−$54.8K |
| Squarepoint Ops LLC | 13.6K | $406.3K | — | New |
| Ground Swell Capital, LLC | 13.6K | $406.2K | — | New |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 12.4K | $370.6K | −$143.8K | Cut−$925.9K |
| China Universal Asset Management Co., Ltd. | 12K | $358.1K | −$132.5K | Cut−$116K |
| WELLS FARGO & COMPANY/MN | 10.4K | $309.5K | −$120.1K | Cut−$685.1K |
| Falcon Wealth Planning | 9.64K | $287.7K | −$111.6K | Cut−$127.8K |
| AMERICAN CENTURY COMPANIES INC | 9.63K | $287.6K | −$111.6K | Cut−$603.5K |
| INTECH INVESTMENT MANAGEMENT LLC | 9.52K | $284.3K | −$74.6K | Added$17.3K |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 9.42K | $281.2K | −$31.7K | Cut−$353.3K |
| BARCLAYS PLC | 9.26K | $276.5K | −$107.3K | Cut−$1.36M |
| CAPSTONE INVESTMENT ADVISORS, LLC | 9.14K | $272.8K | — | New |
| IFP Advisors, Inc | 8.99K | $268.3K | −$40.7K | Added$122.7K |
| Persistent Asset Partners Ltd | 8.77K | $261.7K | −$76.5K | Cut−$11.9K |
| CITIGROUP INC | 8.56K | $255.6K | −$99.2K | Cut−$210.6K |
| NEW YORK STATE COMMON RETIREMENT FUND | 8.2K | $244.8K | −$77.6K | Cut−$32.8K |
| Hudson Bay Capital Management LP | 8.15K | $243.3K | — | New |
| Voleon Capital Management LP | 7.29K | $217.5K | — | New |
| Police & Firemen's Retirement System of New Jersey | 7.1K | $212K | −$69K | Cut−$35K |
| AXQ CAPITAL, LP | 7.09K | $211.8K | — | New |
| Virtus Investment Advisers, LLC | 7.02K | $209.4K | −$79.3K | Cut−$74.2K |
| MANGROVE PARTNERS IM, LLC | 6.75K | $201.4K | — | New |
| BNP PARIBAS FINANCIAL MARKETS | 6.47K | $193.3K | −$63.4K | Cut−$33.5K |
| STRS OHIO | 6.3K | $188.1K | −$73K | Cut−$276K |
| Legal & General Group Plc | 5.79K | $172.8K | −$62.3K | Cut−$50.1K |
| Caption Management, LLC | 5K | $149.3K | — | New |
| Tower Research Capital LLC (TRC) | 2.78K | $82.9K | −$15.6K | Added$27K |
| Mirae Asset Global Investments Co., Ltd. | 2.51K | $74.9K | −$27.1K | Cut−$21.9K |
| Ameritas Investment Partners, Inc. | 2.17K | $64.6K | −$18.9K | Cut−$2.99K |
| CWM, LLC | 2.14K | $64K | $63.9K | Added$63.9K |
| ROYAL BANK OF CANADA | 2.03K | $61K | −$7.58K | Added$34K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1.44K | $42.8K | −$15.3K | Cut−$11.9K |
| NISA INVESTMENT ADVISORS, LLC | 1.4K | $41.9K | −$2.36K | Added$33.5K |
| SIMPLEX TRADING, LLC | 1.21K | $36.1K | — | New |
| FEDERATED HERMES, INC. | 1.1K | $32.7K | — | New |
| GF FUND MANAGEMENT CO. LTD. | 1.08K | $32.2K | −$10.9K | Cut−$6.87K |
| Sterling Capital Management LLC | 829 | $24.7K | −$9.6K | Cut−$23.4K |
| BESSEMER GROUP INC | 481.8K | $14.4K | −$5.58K | Cut−$5.58K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 427 | $12.7K | −$1.15K | Added$8.64K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 361 | $10.8K | — | New |
| GAMMA Investing LLC | 352 | $10.5K | −$1.99K | Added$3.38K |
| Farther Finance Advisors, LLC | 359 | $10.4K | −$4.44K | Cut−$4.44K |
| Kemnay Advisory Services Inc. | 306 | $9.13K | — | New |
| EverSource Wealth Advisors, LLC | 203 | $6.06K | −$1.73K | Cut−$113 |
| SIGNATUREFD, LLC | 169 | $5.04K | −$162 | Added$4.46K |
| SMA Capital LLC | 134 | $4K | — | New |
| PRICE T ROWE ASSOCIATES INC /MD/ | 122.7K | $3.66K | −$1.34K | Cut−$1.13K |
| Torren Management, LLC | 112 | $3.34K | −$1.3K | Cut−$1.3K |
| JONES FINANCIAL COMPANIES LLLP | 90 | $2.73K | −$995 | Cut−$995 |
| PNC Financial Services Group, Inc. | 58 | $1.73K | −$672 | Cut−$672 |
| Cornerstone Financial Management LLC | 28 | $836 | −$324 | Cut−$324 |
| ROTHSCHILD INVESTMENT LLC | 20 | $597 | −$115 | Added$183 |
| Allworth Financial LP | 14 | $418 | −$59 | Added$210 |
| Sunbelt Securities, Inc. | 12 | $358 | −$139 | Cut−$139 |
| US BANCORP \DE\ | 9 | $269 | −$104 | Cut−$1.43K |
| Essential Partners LLC | 7 | $209 | −$81 | Cut−$81 |
| Larson Financial Group LLC | 6 | $179 | — | New |
| SBI Securities Co., Ltd. | 6 | $179 | −$70 | Cut−$2.6K |
| MAI Capital Management | 5 | $150 | — | New |
| True Wealth Design, LLC | 5 | $150 | −$58 | Cut−$58 |
| QUADRANT CAPITAL GROUP LLC | 4 | $120 | — | New |
| Rachor Investment Advisory Services, LLC | 3 | $90 | −$35 | Cut−$159 |
| Stone House Investment Management, LLC | 2 | $60 | — | New |
| Hughes Financial Services, LLC | 1 | $30 | — | New |
| Covestor Ltd | 3 | $0 | — | New |