| Frazier Life Sciences Management, L.P. | 6.65M | $198.6M | −$11.2M | Cut−$11.2M |
| ORBIMED ADVISORS LLC | 3.64M | $108.6M | −$6.15M | Cut−$15.5M |
| NEA Management Company, LLC | 3.61M | $107.9M | −$6.11M | Cut−$6.11M |
| WELLINGTON MANAGEMENT GROUP LLP | 3.19M | $95.3M | −$5.39M | Cut−$10.4M |
| BlackRock, Inc. | 2.94M | $87.8M | −$4.93M | Cut−$4.29M |
| Fidelity | 2.94M | $87.7M | −$26.6K | Added$87.2M |
| Deep Track Capital, LP | 2.76M | $82.3M | −$4.66M | Cut−$20.2M |
| NVP ASSOCIATES, LLC | 2.14M | $63.8M | −$3.61M | Cut−$3.61M |
| Polar Capital Holdings Plc | 1.62M | $48.4M | — | New |
| BRAIDWELL LP | 1.49M | $44.6M | −$1.72M | Added$12.4M |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.48M | $44.1M | — | Held |
| Aaron Wealth Advisors LLC | 1.17M | $34.9M | −$118.3K | Added$32.7M |
| Cormorant Asset Management, LP | 1.12M | $33.4M | −$1.89M | Cut−$1.89M |
| Driehaus Capital Management LLC | 1.02M | $30.4M | −$1.72M | Cut−$14M |
| Kynam Capital Management, LP | 934.8K | $27.9M | −$1.58M | Cut−$1.58M |
| Citadel | 932.8K | $27.8M | −$1.37M | Added$2.3M |
| Woodline Partners LP | 900.1K | $26.9M | −$1.52M | Cut−$4.68M |
| EVENTIDE ASSET MANAGEMENT, LLC | 890K | $26.6M | −$1.5M | Cut−$1.5M |
| Caligan Partners LP | 848.6K | $25.3M | — | New |
| Parkman Healthcare Partners LLC | 800K | $23.9M | −$1.35M | Cut−$4.05M |
| State Street | 787.2K | $23.5M | −$1.14M | Added$2.28M |
| EcoR1 Capital, LLC | 777K | $23.2M | −$1.31M | Cut−$43.8M |
| GEODE CAPITAL MANAGEMENT, LLC | 670.4K | $20M | −$1.1M | Cut−$470.8K |
| TCG Crossover Management, LLC | 650K | $19.4M | −$1.1M | Cut−$1.1M |
| MILLENNIUM MANAGEMENT LLC | 564.4K | $16.8M | −$780.9K | Added$2.27M |
| STEMPOINT CAPITAL LP | 499.5K | $14.9M | −$132.8K | Added$12.4M |
| GOLDMAN SACHS GROUP INC | 457.9K | $13.7M | −$561K | Added$3.2M |
| UBS Group AG | 346.9K | $10.4M | −$475.2K | Added$1.49M |
| Candriam S.C.A. | 294.4K | $8.79M | — | New |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 293.3K | $8.75M | — | Held |
| D. E. Shaw & Co., Inc. | 288.9K | $8.62M | −$488.2K | Cut−$12.6M |
| Rock Springs Capital Management LP | 288K | $8.6M | −$477.6K | Cut−$318.1K |
| Opaleye Management Inc. | 260K | $7.76M | −$439.4K | Cut−$439.4K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 214.9K | $6.42M | −$363.2K | Cut−$592.6K |
| Elmind Capital, LP | 211K | $6.3M | −$356.6K | Cut−$356.6K |
| NORTHERN TRUST CORP | 210.6K | $6.29M | −$322.6K | Added$265.3K |
| BOOTHBAY FUND MANAGEMENT, LLC | 208K | $6.21M | — | New |
| Soleus Capital Management, L.P. | 178.9K | $5.34M | −$302.3K | Cut−$7.56M |
| DAFNA Capital Management LLC | 175.5K | $5.24M | −$279.3K | Added$25.2K |
| VANGUARD FIDUCIARY TRUST CO | 170.2K | $5.08M | — | Held |
| Goelzer Investment Management, Inc. | 164.2K | $4.9M | −$277.4K | Cut−$2.09M |
| Affinity Asset Advisors, LLC | 150K | $4.48M | −$253.5K | Cut−$3.41M |
| Tetragon Partners GP Ltd | 145.5K | $4.34M | −$242.2K | Cut−$178K |
| JPMORGAN CHASE & CO | 147.1K | $3.96M | −$67.7K | Added$3.5M |
| Schonfeld Strategic Advisors LLC | 123.8K | $3.7M | −$209.2K | Cut−$1.58M |
| KVP Capital Advisors, LP | 121.5K | $3.63M | −$205.4K | Cut−$205.4K |
| TD Asset Management Inc | 116K | $3.46M | −$171.5K | Added$262.8K |
| TWO SIGMA INVESTMENTS, LP | 115.1K | $3.43M | −$194.5K | Cut−$935.5K |
| BURKEHILL GLOBAL MANAGEMENT, LP | 100K | $2.98M | −$169K | Cut−$169K |
| Squarepoint Ops LLC | 97.2K | $2.9M | −$78.9K | Added$1.43M |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 90.6K | $2.71M | −$78.7K | Added$550.7K |
| Nuveen, LLC | 81.8K | $2.44M | −$127.7K | Added$58.2K |
| Bank of New York Mellon Corp | 80.2K | $2.39M | −$127.2K | Added$20.9K |
| PFM Health Sciences, LP | 71.9K | $2.15M | −$121.5K | Cut−$355.4K |
| VICTORY CAPITAL MANAGEMENT INC | 71K | $2.12M | — | New |
| MARSHALL WACE, LLP | 62.7K | $1.87M | — | New |
| XTX Topco Ltd | 53.2K | $1.59M | −$34K | Added$953.1K |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 57.3K | $1.54M | −$228.1K | Cut−$735.3K |
| DIMENSIONAL FUND ADVISORS LP | 46.8K | $1.4M | — | New |
| Swiss National Bank | 44.4K | $1.33M | — | New |
| PLATINUM INVESTMENT MANAGEMENT LTD | 43.6K | $1.3M | −$73.7K | Cut−$73.7K |
| ALPS ADVISORS INC | 36.5K | $1.09M | −$61.8K | Cut−$71.9K |
| Creative Planning | 36K | $1.07M | −$56.9K | Added$12.4K |
| EXCHANGE TRADED CONCEPTS, LLC | 34.3K | $1.02M | — | New |
| RHUMBLINE ADVISERS | 33.9K | $1.01M | −$56.5K | Cut−$43K |
| ALLIANCEBERNSTEIN L.P. | 30.5K | $962K | $0 | Added$82K |
| MORGAN STANLEY | 31.6K | $942.1K | −$53.3K | Cut−$919.6K |
| BANK OF AMERICA CORP /DE/ | 28.8K | $858.2K | −$48.6K | Cut−$337K |
| ExodusPoint Capital Management, LP | 28.1K | $838.4K | −$47.5K | Cut−$959.5K |
| Invesco Ltd. | 27.5K | $821.6K | −$35.8K | Added$152.9K |
| Icahn Capital | 27.4K | $817.5K | −$46.3K | Cut−$173.1K |
| DEUTSCHE BANK AG\ | 22.9K | $685.1K | −$33.8K | Added$53.4K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 22.8K | $679.5K | −$2.96K | Added$624.2K |
| Swiss Life Asset Management Ltd | 12.1K | $657.2K | — | New |
| Cerity Partners LLC | 21.2K | $631.7K | −$35.8K | Cut−$40.8K |
| Legal & General Group Plc | 19.4K | $577.8K | −$4.29K | Added$497.8K |
| STATE OF WISCONSIN INVESTMENT BOARD | 19.3K | $575K | — | New |
| Koa Wealth Management, LLC | 17.9K | $534.7K | −$30.3K | Cut−$46K |
| Engineers Gate Manager LP | 17.4K | $518.8K | — | New |
| Qube Research & Technologies Ltd | 17.2K | $513K | −$29K | Cut−$219.1K |
| Vanguard Global Advisers, LLC | 16K | $478.4K | — | Held |
| MetLife Investment Management, LLC | 16K | $478.1K | −$27.1K | Cut−$27.1K |
| VANGUARD ASSET MANAGEMENT, Ltd | 14.8K | $440.3K | — | Held |
| Optimize Financial Inc | 14.5K | $433.1K | — | New |
| CITIGROUP INC | 13.5K | $402.9K | −$22.8K | Cut−$114K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13.3K | $397.8K | −$22.4K | Cut−$20.4K |
| Jump Financial, LLC | 12.7K | $379.1K | — | New |
| BARCLAYS PLC | 11.8K | $353.4K | −$20K | Cut−$1.31M |
| HighVista Strategies LLC | 11.5K | $342.4K | — | New |
| CANADA PENSION PLAN INVESTMENT BOARD | 10.9K | $325.4K | −$18.4K | Cut−$40.5K |
| WELLS FARGO & COMPANY/MN | 10.8K | $321.2K | −$18.2K | Cut−$685.9K |
| BNP PARIBAS FINANCIAL MARKETS | 10.4K | $310K | −$11.5K | Added$96K |
| JANUS HENDERSON GROUP PLC | 10.3K | $308.2K | — | New |
| Verition Fund Management LLC | 10.2K | $305.1K | −$17.3K | Cut−$1.51M |
| Aquatic Capital Management LLC | 10.2K | $303.1K | — | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 9.49K | $283.2K | −$16K | Cut−$2.13M |
| Virtus Investment Advisers, LLC | 9.13K | $272.6K | −$15.1K | Cut−$8.46K |
| NEW YORK STATE COMMON RETIREMENT FUND | 9K | $268.6K | −$7.27K | Added$133K |
| ACT CAPITAL MANAGEMENT, LLC | 9K | $268.6K | — | New |
| SEI INVESTMENTS CO | 8.99K | $268.3K | −$12.9K | Added$26.8K |
| Tidal Investments LLC | 8.88K | $265K | — | New |
| TEMA ETFS LLC | 8.88K | $265K | — | New |
| AMERICAN CENTURY COMPANIES INC | 8.73K | $260.5K | −$14.7K | Cut−$125.5K |
| PROFUND ADVISORS LLC | 8.39K | $250.4K | −$14.2K | Cut−$40.2K |
| China Universal Asset Management Co., Ltd. | 7.97K | $237.8K | −$13.5K | Cut−$245.3K |
| Orion Porfolio Solutions, LLC | 7.95K | $237.3K | — | New |
| State of New Jersey Common Pension Fund D | 7.67K | $229K | — | New |
| Police & Firemen's Retirement System of New Jersey | 7.52K | $224.5K | −$12.7K | Cut−$12.7K |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 7.5K | $223.9K | −$12.7K | Cut−$91.5K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 7.24K | $216.1K | −$169 | Added$212.9K |
| INTECH INVESTMENT MANAGEMENT LLC | 6.84K | $204.3K | −$11.6K | Cut−$12K |
| GROUP ONE TRADING LLC | 6.25K | $186.6K | −$10.6K | Cut−$110.8K |
| Vanguard Investments Australia, Ltd. | 6.1K | $182.2K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 5.6K | $167.2K | $45.1K | Cut−$58.6K |
| KLP KAPITALFORVALTNING AS | 4.9K | $146.3K | — | New |
| Russell Investments Group, Ltd. | 3.86K | $115.1K | −$4.83K | Added$25K |
| Rockefeller Capital Management L.P. | 3.22K | $96.2K | −$5.07K | Added$1.62K |
| Mirae Asset Global Investments Co., Ltd. | 2.34K | $69.9K | −$3.69K | Added$1.09K |
| Ameritas Investment Partners, Inc. | 2.31K | $69K | −$3.91K | Cut−$3.91K |
| CWM, LLC | 1.77K | $52.9K | $52.8K | Added$52.8K |
| STRS OHIO | 1.6K | $47.8K | −$1.18K | Added$25.7K |
| NISA INVESTMENT ADVISORS, LLC | 1.59K | $47.5K | −$2.69K | Cut−$2.69K |
| Tower Research Capital LLC (TRC) | 1.41K | $42.1K | −$2.38K | Cut−$65.6K |
| SIMPLEX TRADING, LLC | 1.31K | $39K | −$2.21K | Cut−$242.5K |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.03M | $30.7K | −$1.42K | Added$4.21K |
| GF FUND MANAGEMENT CO. LTD. | 1.01K | $30.1K | −$1.49K | Added$2.3K |
| Sterling Capital Management LLC | 949 | $28.3K | −$1.6K | Cut−$23.4K |
| ROYAL BANK OF CANADA | 751 | $22K | −$2.02K | Cut−$27K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 470 | $14K | — | New |
| GAMMA Investing LLC | 299 | $8.93K | −$505 | Cut−$505 |
| US BANCORP \DE\ | 284 | $8.48K | −$480 | Cut−$1.36K |
| OSAIC HOLDINGS, INC. | 269 | $8.03K | −$455 | Cut−$2.44M |
| PNC Financial Services Group, Inc. | 207 | $6.18K | −$333 | Cut−$5 |
| SIGNATUREFD, LLC | 179 | $5.34K | −$303 | Cut−$303 |
| FIL Ltd | 178 | $5.31K | — | New |
| Physician Wealth Advisors, Inc. | 109 | $3.25K | −$184 | Cut−$184 |
| JONES FINANCIAL COMPANIES LLLP | 80 | $2.28K | −$243 | Cut−$243 |
| Allworth Financial LP | 70 | $2.09K | −$88 | Added$449 |
| Parallel Advisors, LLC | 61 | $1.82K | −$103 | Cut−$103 |
| Larson Financial Group LLC | 49 | $1.46K | — | New |
| ALGERT GLOBAL LLC | 36K | $1.07K | — | New |
| Cornerstone Financial Management LLC | 34 | $1.01K | −$57 | Cut−$57 |
| EverSource Wealth Advisors, LLC | 25 | $746 | −$43 | Cut−$43 |
| ROTHSCHILD INVESTMENT LLC | 24 | $716 | −$41 | Cut−$41 |
| Versant Capital Management, Inc | 24 | $716 | — | New |
| Fortitude Family Office, LLC | 19 | $567 | — | New |
| Keating Financial Advisory Services, Inc. | 16 | $478 | — | New |
| Essential Partners LLC | 15 | $448 | −$25 | Cut−$25 |
| Farther Finance Advisors, LLC | 9 | $291 | $8 | Cut−$24 |
| ACADIAN ASSET MANAGEMENT LLC | 8.82K | $262 | −$16 | Cut−$1.27K |
| MAI Capital Management | 7 | $209 | — | New |
| SG Americas Securities, LLC | 3.39K | $101 | −$6 | Cut−$49 |
| True Wealth Design, LLC | 2 | $60 | −$4 | Cut−$4 |
| Cygnus Capital Advisors, LLC | 1.8K | $54 | −$3 | Cut−$3 |
| IFP Advisors, Inc | 1 | $30 | −$2 | Cut−$2 |
| KBC Group NV | 810 | $24 | — | New |
| Covestor Ltd | 3 | $0 | — | New |