| Fidelity | 9.08M | $177.6M | −$129.1M | Cut−$102.2M |
| SR One Capital Management, LP | 5.04M | $98.5M | −$84.4M | Cut−$84.4M |
| NEA Management Company, LLC | 4.02M | $78.7M | −$59M | Cut−$49.3M |
| ENAVATE SCIENCES GP, LLC | 3.92M | $76.6M | −$65.7M | Cut−$65.7M |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 65M | $67.3M | — | New |
| FEDERATED HERMES, INC. | 3.13M | $61.1M | −$45.5M | Cut−$37.5M |
| Polar Capital Holdings Plc | 2.55M | $49.8M | −$17.7M | Added$11.4M |
| Capital International Investors | 2.43M | $47.6M | — | New |
| Fairmount Funds Management LLC | 2.36M | $46.1M | −$37M | Cut−$34.1M |
| BlackRock, Inc. | 2.04M | $39.8M | −$29.6M | Cut−$24.3M |
| NVP ASSOCIATES, LLC | 1.84M | $35.9M | −$30.8M | Cut−$30.8M |
| ALLIANCEBERNSTEIN L.P. | 897.3K | $32.6M | −$0 | Added$31.9M |
| Context Capital Management, LLC | 29.1M | $30.1M | — | New |
| State Street | 1.47M | $28.8M | −$7.35M | Added$12.8M |
| WELLINGTON MANAGEMENT GROUP LLP | 1.25M | $24.4M | −$14.3M | Cut−$6.7M |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.25M | $24.3M | — | Held |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1.14M | $22.2M | — | New |
| HIGHBRIDGE CAPITAL MANAGEMENT LLC | 20M | $19.8M | — | New |
| EcoR1 Capital, LLC | 789.5K | $15.4M | −$13.2M | Cut−$13.2M |
| Woodline Partners LP | 3.09M | $14.1M | — | New |
| BRAIDWELL LP | 13M | $13.5M | — | New |
| Balyasny Asset Management L.P. | 667.1K | $13M | −$3.24M | Added$6.03M |
| ArrowMark Colorado Holdings LLC | 658.9K | $12.9M | −$11M | Cut−$14.4M |
| GEODE CAPITAL MANAGEMENT, LLC | 655.8K | $12.8M | −$9.86M | Cut−$8.55M |
| Pivotal bioVenture Partners Investment Advisor LLC | 592K | $11.6M | −$9.92M | Cut−$9.92M |
| MILLENNIUM MANAGEMENT LLC | 1.68M | $10.6M | −$1.48M | Added$8.77M |
| GREAT POINT PARTNERS LLC | 524.1K | $10.2M | — | New |
| Jefferies Financial Group Inc. | 5.77M | $10.1M | — | New |
| Rock Springs Capital Management LP | 502.1K | $9.82M | −$8.41M | Cut−$8.41M |
| MARSHALL WACE, LLP | 501.9K | $9.81M | −$119K | Added$9.55M |
| Citadel | 8.07M | $9.6M | −$859K | Added$8.71M |
| JANE STREET GROUP, LLC | 9.5M | $9.52M | — | New |
| NEXTBio Capital Management LP | 426.7K | $8.34M | −$5.4M | Cut−$3.35M |
| Linden Advisors LP | 7.5M | $7.79M | — | New |
| BANK OF AMERICA CORP /DE/ | 388.3K | $7.59M | −$790.4K | Added$5.88M |
| GOLDMAN SACHS GROUP INC | 381.5K | $7.46M | −$2.19M | Added$2.71M |
| UBS Group AG | 367.4K | $7.18M | −$1.16M | Added$4.66M |
| Sio Capital Management, LLC | 331.7K | $6.49M | — | New |
| Monashee Investment Management LLC | 3.3M | $6.14M | — | New |
| TWO SIGMA INVESTMENTS, LP | 275.1K | $5.38M | −$253.1K | Added$4.83M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 251.4K | $4.92M | — | Held |
| JENNISON ASSOCIATES LLC | 250K | $4.89M | — | New |
| Maven Securities LTD | 1.65M | $4.49M | — | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 224.4K | $4.39M | −$3.57M | Cut−$3.35M |
| SPHERA FUNDS MANAGEMENT LTD. | 214.3K | $4.19M | — | New |
| Vestal Point Capital, LP | 200K | $3.91M | — | New |
| NORTHERN TRUST CORP | 194.6K | $3.81M | −$2.6M | Cut−$1.84M |
| CAPSTONE INVESTMENT ADVISORS, LLC | 3.5M | $3.62M | — | New |
| VANGUARD FIDUCIARY TRUST CO | 179.4K | $3.51M | — | Held |
| SEB Asset Management AB | 163.9K | $3.2M | — | Held |
| D. E. Shaw & Co., Inc. | 3M | $3.12M | — | New |
| Graham Capital Management, L.P. | 2.5M | $2.6M | — | New |
| Calamos Advisors LLC | 2.5M | $2.59M | — | New |
| Walleye Capital LLC | 125.2K | $2.45M | — | New |
| Invesco Ltd. | 113.5K | $2.22M | −$1.9M | Cut−$4.61M |
| Atom Investors LP | 107K | $2.09M | — | New |
| SEVEN GRAND MANAGERS, LLC | 100K | $1.96M | — | New |
| MORGAN STANLEY | 93.4K | $1.83M | −$1.57M | Cut−$2.83M |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 85K | $1.66M | −$229.2K | Added$1.17M |
| Exome Asset Management LLC | 80.7K | $1.58M | — | New |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 77.5K | $1.51M | −$1.3M | Cut−$3.33M |
| Birchview Capital, LP | 70K | $1.37M | — | New |
| Nuveen, LLC | 67.8K | $1.32M | −$852.2K | Cut−$521.5K |
| Bank of New York Mellon Corp | 60.9K | $1.19M | −$868.2K | Cut−$691K |
| Jump Financial, LLC | 60K | $1.17M | — | New |
| Icahn Capital | 51K | $996.5K | −$854.3K | Cut−$1.84M |
| Rafferty Asset Management, LLC | 48.2K | $941.7K | — | New |
| ALPS ADVISORS INC | 43.7K | $854.2K | −$732.3K | Cut−$746.2K |
| Squarepoint Ops LLC | 42.9K | $838.2K | −$260.5K | Added$273.9K |
| DAFNA Capital Management LLC | 42.5K | $830.9K | — | New |
| BURKEHILL GLOBAL MANAGEMENT, LP | 40K | $782K | — | New |
| J. Goldman & Co LP | 36.8K | $719.4K | — | New |
| Swiss National Bank | 31.6K | $617.8K | −$529.6K | Cut−$529.6K |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 33.7K | $614.1K | −$618.5K | Cut−$1.24M |
| Voleon Capital Management LP | 29.6K | $578.9K | −$170.7K | Added$209K |
| BARCLAYS PLC | 29.6K | $578.9K | −$496.3K | Cut−$669.4K |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 27.5K | $538.3K | — | New |
| RHUMBLINE ADVISERS | 26.8K | $524.2K | −$367.8K | Cut−$272.7K |
| ARISTEIA CAPITAL, L.L.C. | 500K | $517.5K | — | New |
| JPMORGAN CHASE & CO | 25.1K | $457.6K | −$392.9K | Cut−$331.3K |
| PROFUND ADVISORS LLC | 21.4K | $418.7K | — | New |
| Quantinno Capital Management LP | 21.1K | $413K | — | New |
| Vanguard Global Advisers, LLC | 20.8K | $407.4K | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 20.8K | $406.9K | −$171.3K | Added$35.8K |
| XTX Topco Ltd | 19.3K | $377.5K | −$204.2K | Cut−$64.8K |
| DEUTSCHE BANK AG\ | 19.3K | $376.6K | −$214.2K | Cut−$87.4K |
| Aquatic Capital Management LLC | 18.6K | $364.4K | — | New |
| ALLSTATE CORP | 18.2K | $356.3K | — | New |
| Schonfeld Strategic Advisors LLC | 17.6K | $344.8K | −$153K | Added$13.4K |
| Corient Private Wealth LLC | 16.8K | $329.3K | — | New |
| PRELUDE CAPITAL MANAGEMENT, LLC | 16.6K | $325.4K | — | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 15.8K | $309.3K | −$263.1K | Cut−$260.8K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 15.5K | $303.5K | −$140.8K | Cut−$1.53K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 14.4K | $276.8K | −$149.9K | Cut−$42K |
| China Universal Asset Management Co., Ltd. | 13.5K | $264.4K | −$223.1K | Cut−$219K |
| Scientech Research LLC | 13K | $253.2K | — | New |
| MetLife Investment Management, LLC | 12.9K | $252.4K | −$169.3K | Cut−$114.4K |
| Creative Planning | 12.7K | $247.5K | −$205.7K | Cut−$198.2K |
| FOX RUN MANAGEMENT, L.L.C. | 13.3K | $243K | — | New |
| SEI INVESTMENTS CO | 12.4K | $242.1K | — | New |
| VANGUARD ASSET MANAGEMENT, Ltd | 10.6K | $208.1K | — | Held |
| Legal & General Group Plc | 10.4K | $203.9K | −$174.8K | Cut−$269.1K |
| BNP PARIBAS FINANCIAL MARKETS | 10K | $195.5K | −$119.6K | Cut−$63.7K |
| CITIGROUP INC | 9.89K | $193.3K | −$39.4K | Added$107.9K |
| WELLS FARGO & COMPANY/MN | 8.88K | $173.7K | −$148.9K | Cut−$594.3K |
| Tower Research Capital LLC (TRC) | 7.24K | $141.4K | −$13.3K | Added$112.6K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 6.78K | $132.5K | — | New |
| Virtus Investment Advisers, LLC | 6.72K | $131.3K | −$109.8K | Cut−$106.7K |
| Police & Firemen's Retirement System of New Jersey | 6.36K | $124.4K | −$75.4K | Cut−$39K |
| NEW YORK STATE COMMON RETIREMENT FUND | 6.2K | $121.2K | −$103.9K | Cut−$103.9K |
| PNC Financial Services Group, Inc. | 4.77K | $93.2K | −$79.9K | Cut−$118.3K |
| Vanguard Investments Australia, Ltd. | 4.2K | $82.1K | — | Held |
| KLP KAPITALFORVALTNING AS | 3.4K | $66.5K | −$57K | Cut−$57K |
| Mirae Asset Global Investments Co., Ltd. | 2.8K | $54.7K | −$43.7K | Cut−$40K |
| STRS OHIO | 2.8K | $54.7K | −$46.9K | Cut−$46.9K |
| Russell Investments Group, Ltd. | 2.72K | $53.2K | −$22.5K | Added$4.37K |
| NISA INVESTMENT ADVISORS, LLC | 2.42K | $47.2K | −$1.93K | Added$43K |
| Ameritas Investment Partners, Inc. | 1.92K | $37.6K | −$22.9K | Cut−$12.1K |
| CWM, LLC | 1.47K | $28.8K | $28.7K | Added$28.7K |
| HARBOUR INVESTMENTS, INC. | 1.37K | $26.8K | — | New |
| GF FUND MANAGEMENT CO. LTD. | 1.21K | $23.6K | −$17.7K | Cut−$14.7K |
| US BANCORP \DE\ | 994 | $19.4K | −$14.8K | Cut−$12.7K |
| Sterling Capital Management LLC | 779 | $15.2K | −$13.1K | Cut−$24.2K |
| OSAIC HOLDINGS, INC. | 677 | $13.2K | −$50 | Added$13.1K |
| SIGNATUREFD, LLC | 370 | $7.23K | −$6.2K | Cut−$6.89K |
| PRICE T ROWE ASSOCIATES INC /MD/ | 357.3K | $6.99K | −$5.99K | Cut−$6.42K |
| GROUP ONE TRADING LLC | 300 | $5.87K | — | New |
| Larson Financial Group LLC | 293 | $5.73K | −$319 | Added$5.04K |
| J.Safra Asset Management Corp | 270 | $5.28K | −$1.54K | Added$1.94K |
| Quantbot Technologies LP | 256 | $5K | — | New |
| GAMMA Investing LLC | 245 | $4.79K | −$3K | Cut−$1.71K |
| iA Global Asset Management Inc. | 215.8K | $4.22K | — | New |
| FIFTH THIRD BANCORP | 107 | $2.09K | — | New |
| EverSource Wealth Advisors, LLC | 98 | $1.92K | −$1.22K | Cut−$736 |
| Torren Management, LLC | 95 | $1.86K | −$1.59K | Cut−$1.59K |
| Physician Wealth Advisors, Inc. | 92 | $1.8K | −$1.12K | Cut−$634 |
| Caitong International Asset Management Co., Ltd | 60 | $1.17K | — | New |
| Allworth Financial LP | 26 | $509 | −$435 | Cut−$1.2K |
| Cornerstone Financial Management LLC | 26 | $508 | −$436 | Cut−$436 |
| HRT FINANCIAL LP | 25.7K | $503 | — | New |
| ROTHSCHILD INVESTMENT LLC | 21 | $411 | −$16 | Added$375 |
| SBI Securities Co., Ltd. | 20 | $391 | — | New |
| Bare Financial Services, Inc | 14 | $274 | — | New |
| MAI Capital Management | 12 | $235 | −$118 | Cut−$20 |
| Sunbelt Securities, Inc. | 11 | $215 | −$184 | Cut−$184 |
| Ameritas Advisory Services, LLC | 6 | $117 | — | New |
| Stone House Investment Management, LLC | 5 | $98 | — | New |
| True Wealth Design, LLC | 3 | $59 | −$50 | Cut−$50 |
| Essential Partners LLC | 2 | $39 | −$34 | Cut−$70 |
| Covestor Ltd | 6 | $0 | — | New |