| Nextech Invest, Ltd. | 7.16M | $58.6M | — | Held |
| EcoR1 Capital, LLC | 6.73M | $55M | — | Held |
| Viking Global | 6.57M | $53.8M | — | Held |
| BlackRock, Inc. | 5.88M | $48.1M | — | Held |
| VR ADVISER, LLC | 5.68M | $46.4M | — | Held |
| Pfizer Inc | 5.38M | $44M | — | Held |
| SR One Capital Management, LP | 4.51M | $37.8M | — | Held |
| Vanguard | 4.54M | $37.2M | — | Held |
| ALKEON CAPITAL MANAGEMENT LLC | 4.5M | $36.8M | — | Held |
| State Street | 4.26M | $34.8M | — | Held |
| NEA Management Company, LLC | 4.12M | $33.7M | — | Held |
| ORBIMED ADVISORS LLC | 3.64M | $29.8M | — | Held |
| Column Group LLC | 3.54M | $29M | — | Held |
| Point72 Asset Management, L.P. | 2.92M | $23.9M | — | Held |
| Fidelity | 2.48M | $20.3M | — | Held |
| Citadel | 2.43M | $19.9M | — | Held |
| Paradigm Biocapital Advisors LP | 2.4M | $19.6M | — | Held |
| Vivo Capital, LLC | 2.12M | $17.3M | — | Held |
| First Turn Management, LLC | 2.01M | $16.4M | — | Held |
| GOLDMAN SACHS GROUP INC | 1.94M | $15.9M | — | Held |
| MPM BIOIMPACT LLC | 1.8M | $14.7M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 1.75M | $14.3M | — | Held |
| ROYCE & ASSOCIATES LP | 1.51M | $12.3M | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 1.23M | $10M | — | Held |
| FRANKLIN RESOURCES INC | 1.21M | $9.92M | — | Held |
| Qube Research & Technologies Ltd | 1.21M | $9.86M | — | Held |
| Integral Health Asset Management, LLC | 1.2M | $9.82M | — | Held |
| MORGAN STANLEY | 1.19M | $9.77M | −$2.85M | Added$821.2K |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1.12M | $9.13M | — | Held |
| ArrowMark Colorado Holdings LLC | 1.06M | $8.7M | — | Held |
| Siren, L.L.C. | 1.01M | $8.24M | — | Held |
| SPHERA FUNDS MANAGEMENT LTD. | 1M | $8.22M | — | Held |
| Euclidean Capital LLC | 989.4K | $8.09M | — | Held |
| EVENTIDE ASSET MANAGEMENT, LLC | 952.4K | $7.79M | — | Held |
| Balyasny Asset Management L.P. | 950.2K | $7.77M | — | Held |
| NORTHERN TRUST CORP | 885.5K | $7.24M | — | Held |
| UBS Group AG | 734.9K | $6.01M | — | Held |
| BARCLAYS PLC | 718.5K | $5.88M | −$703.2K | Added$3.67M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 621.1K | $5.08M | — | Held |
| NEXTBio Capital Management LP | 615.7K | $5.04M | — | Held |
| Renaissance Technologies | 572.7K | $4.68M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 549K | $4.49M | — | Held |
| Blue Owl Capital Holdings LP | 515K | $4.21M | — | Held |
| BANK OF AMERICA CORP /DE/ | 507.5K | $4.15M | −$395.2K | Added$2.91M |
| Polar Capital Holdings Plc | 502.4K | $4.11M | — | Held |
| Logos Global Management LP | 450K | $3.68M | — | Held |
| Redmile Group, LLC | 448.1K | $3.67M | — | Held |
| JPMORGAN CHASE & CO | 414.8K | $3.39M | — | Held |
| Connor, Clark & Lunn Investment Management Ltd. | 350.9K | $2.87M | — | Held |
| Y-Intercept (Hong Kong) Ltd | 341.4K | $2.79M | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 332.8K | $2.72M | — | Held |
| Atom Investors LP | 290K | $2.37M | — | Held |
| Kalehua Capital Management LLC | 267.1K | $2.18M | — | Held |
| SUPERSTRING CAPITAL MANAGEMENT LP | 255.4K | $2.09M | — | Held |
| Woodline Partners LP | 246.5K | $2.02M | — | Held |
| JANE STREET GROUP, LLC | 244K | $2M | — | Held |
| Squarepoint Ops LLC | 229.4K | $1.88M | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 218.6K | $1.79M | — | Held |
| Russell Investments Group, Ltd. | 207K | $1.69M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 191.8K | $1.57M | — | Held |
| Bank of New York Mellon Corp | 187.9K | $1.54M | — | Held |
| Rafferty Asset Management, LLC | 177.2K | $1.45M | — | Held |
| Icahn Capital | 174.3K | $1.43M | — | Held |
| Hennion & Walsh Asset Management, Inc. | 170.1K | $1.39M | — | Held |
| TD Asset Management Inc | 169.8K | $1.39M | — | Held |
| Ishara Investments LP | 160K | $1.31M | — | Held |
| CITIGROUP INC | 154.1K | $1.26M | — | Held |
| Nuveen, LLC | 144.4K | $1.18M | — | Held |
| DAFNA Capital Management LLC | 141K | $1.15M | — | Held |
| AMERICAN CENTURY COMPANIES INC | 134.9K | $1.1M | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 128.6K | $1.04M | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 124.3K | $1.02M | — | Held |
| XTX Topco Ltd | 110.6K | $904.4K | — | Held |
| Invesco Ltd. | 109.7K | $897.7K | — | Held |
| ExodusPoint Capital Management, LP | 108.8K | $890.3K | — | Held |
| MILLENNIUM MANAGEMENT LLC | 97.4K | $797K | — | Held |
| Brevan Howard Capital Management LP | 89.5K | $732.4K | — | Held |
| Swiss National Bank | 86.2K | $705.1K | — | Held |
| WELLS FARGO & COMPANY/MN | 82.5K | $675.1K | — | Held |
| Graham Capital Management, L.P. | 81.6K | $667.3K | — | Held |
| RHUMBLINE ADVISERS | 77.7K | $635.6K | — | Held |
| PROFUND ADVISORS LLC | 65.2K | $533K | — | Held |
| ALLIANCEBERNSTEIN L.P. | 63.8K | $522K | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 50.8K | $415.4K | — | Held |
| DEUTSCHE BANK AG\ | 44.9K | $367.6K | — | Held |
| AlphaQuest LLC | 44.4K | $363.1K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 41.1K | $334.8K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 40.1K | $328.1K | — | Held |
| Optimize Financial Inc | 39.6K | $324K | — | Held |
| LMR Partners LLP | 35.3K | $288.5K | — | Held |
| MetLife Investment Management, LLC | 34K | $277.9K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 34K | $277.8K | — | Held |
| Legal & General Group Plc | 33.8K | $276.8K | — | Held |
| VARCOV Co. | 32K | $262.1K | — | Held |
| Virtus Investment Advisers, LLC | 28.4K | $232K | — | Held |
| NEOS Investment Management LLC | 28.3K | $231.2K | — | Held |
| TEMA ETFS LLC | 27.9K | $227.8K | — | Held |
| Palumbo Wealth Management LLC | 27.3K | $223.5K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 26.6K | $217.6K | — | Held |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 25.5K | $208.7K | — | Held |
| Freestone Grove Partners LP | 24.2K | $198K | — | Held |
| Quantinno Capital Management LP | 23.4K | $191.1K | — | Held |
| Entropy Technologies, LP | 22.8K | $186.5K | — | Held |
| SECTORAL ASSET MANAGEMENT INC | 22.5K | $183.9K | — | Held |
| Jasper Ridge Partners, L.P. | 20.9K | $170.7K | — | Held |
| OXFORD ASSET MANAGEMENT LLP | 19.6K | $160.6K | — | New |
| DRW Securities, LLC | 19.2K | $157K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 18.4K | $150.7K | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 16.5K | $135.3K | — | Held |
| ProShare Advisors LLC | 16.4K | $134.1K | — | Held |
| D. E. Shaw & Co., Inc. | 16K | $131.1K | — | Held |
| Quarry LP | 16K | $130.9K | — | Held |
| China Universal Asset Management Co., Ltd. | 15.9K | $129.8K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 15.6K | $128K | — | Held |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | 15K | $122.7K | — | Held |
| Creative Planning | 14.8K | $120.9K | — | Held |
| JANUS HENDERSON GROUP PLC | 14.4K | $117.9K | — | Held |
| Schonfeld Strategic Advisors LLC | 14.3K | $117.4K | — | Held |
| STIFEL FINANCIAL CORP | 13.5K | $110.3K | — | Held |
| Corient Private Wealth LLC | 12.5K | $102.3K | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 12.2K | $99.5K | — | Held |
| Scientech Research LLC | 11.5K | $94.3K | — | Held |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 11.3K | $92.5K | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 10.9K | $89.4K | — | Held |
| AXQ CAPITAL, LP | 10.4K | $84.8K | — | Held |
| Engineers Gate Manager LP | 10.3K | $84.5K | — | Held |
| Bellevue Group AG | 9.71K | $79.4K | — | Held |
| KLP KAPITALFORVALTNING AS | 9.3K | $76.1K | — | Held |
| PNC Financial Services Group, Inc. | 9.06K | $74.1K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 4.73K | $38.7K | — | Held |
| Ameritas Investment Partners, Inc. | 4.58K | $37.5K | — | Held |
| Federation des caisses Desjardins du Quebec | 4K | $32.7K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3.3M | $27K | — | Held |
| ASSETMARK, INC | 3K | $24.5K | — | Held |
| Sterling Capital Management LLC | 2.84K | $23.2K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 2.41K | $19.7K | — | Held |
| ANTIPODES PARTNERS Ltd | 2.4K | $19.6K | — | Held |
| ROYAL BANK OF CANADA | 2.34K | $18K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.91K | $15.6K | — | Held |
| Inspire Investing, LLC | 753 | $6.16K | — | Held |
| Versant Capital Management, Inc | 720 | $5.89K | — | Held |
| OSAIC HOLDINGS, INC. | 683 | $5.59K | — | Held |
| LORD, ABBETT & CO. LLC | 564.3K | $4.62K | — | Held |
| Essential Partners LLC | 552 | $4.51K | −$2.11K | Cut−$2.11K |
| GAMMA Investing LLC | 503 | $4.12K | — | Held |
| SIMPLEX TRADING, LLC | 496 | $4.06K | — | Held |
| Tower Research Capital LLC (TRC) | 443 | $3.62K | — | Held |
| IFP Advisors, Inc | 297 | $2.43K | −$1.14K | Cut−$1.14K |
| EverSource Wealth Advisors, LLC | 292 | $2.39K | — | Held |
| Arax Advisory Partners | 286 | $2.34K | — | Held |
| Optiver Holding B.V. | 252 | $2.06K | — | Held |
| Caitong International Asset Management Co., Ltd | 84 | $687 | — | Held |
| SIGNATUREFD, LLC | 83 | $679 | — | Held |
| Parallel Advisors, LLC | 83 | $679 | — | Held |
| GSA CAPITAL PARTNERS LLP | 70.6K | $578 | — | Held |
| ROTHSCHILD INVESTMENT LLC | 45 | $368 | — | Held |
| SG Americas Securities, LLC | 41K | $336 | — | Held |
| ALGERT GLOBAL LLC | 40.5K | $331 | — | Held |
| Farther Finance Advisors, LLC | 20 | $164 | — | Held |
| CWM, LLC | 12K | $98 | — | Held |
| CANADA LIFE ASSURANCE Co | 5.59K | $46 | — | Held |
| AMALGAMATED BANK | 2.08K | $17 | — | Held |
| SBI Securities Co., Ltd. | 2 | $16 | — | Held |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 647 | $5 | — | Held |
| Daiwa Securities Group Inc. | 249 | $2 | — | Held |