| Fidelity | 5.59M | $357.2M | −$84.3M | Cut−$75.6M |
| RA CAPITAL MANAGEMENT, L.P. | 2.45M | $156.7M | −$30.6M | Cut−$257.5K |
| BlackRock, Inc. | 2.27M | $145.4M | −$35.2M | Cut−$35.3M |
| WELLINGTON MANAGEMENT GROUP LLP | 1.74M | $111M | −$23.5M | Cut−$9.61M |
| State Street | 1.7M | $108.6M | −$18.4M | Added$14.2M |
| Atlas Venture Life Science Advisors, LLC | 1.51M | $96.8M | −$23.4M | Cut−$23.4M |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.38M | $87.9M | — | Held |
| Frazier Life Sciences Management, L.P. | 1.35M | $86.6M | −$19.5M | Cut−$13.4M |
| TCG Crossover Management, LLC | 1.34M | $85.8M | — | New |
| JPMORGAN CHASE & CO | 1.37M | $83.4M | −$25.6M | Cut−$42.2M |
| BVF INC/IL | 1.27M | $81.4M | −$10.1M | Added$29.7M |
| ORBIMED ADVISORS LLC | 1.07M | $68.3M | −$16.5M | Cut−$16.5M |
| Siren, L.L.C. | 988.4K | $63.2M | −$15.3M | Cut−$15.3M |
| Woodline Partners LP | 958.3K | $61.3M | −$14.8M | Cut−$14.8M |
| GEODE CAPITAL MANAGEMENT, LLC | 744.2K | $47.6M | −$10.6M | Cut−$6.81M |
| Vestal Point Capital, LP | 700K | $44.8M | −$10.8M | Cut−$13.6M |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 657K | $42M | −$7.91M | Added$1.42M |
| GOLDMAN SACHS GROUP INC | 639.8K | $40.9M | −$9.9M | Cut−$19M |
| JENNISON ASSOCIATES LLC | 610.4K | $39M | −$8.23M | Cut−$3.22M |
| Logos Global Management LP | 560K | $35.8M | −$7.89M | Cut−$4.69M |
| Assenagon Asset Management S.A. | 546.2K | $34.9M | −$5.54M | Added$6.51M |
| ARMISTICE CAPITAL, LLC | 536K | $34.3M | −$7.73M | Cut−$5.38M |
| Bellevue Group AG | 459.3K | $29.4M | — | New |
| Saturn V Capital Management LP | 449.9K | $28.8M | −$4.62M | Added$5.07M |
| Opaleye Management Inc. | 421K | $26.9M | −$3.09M | Added$11M |
| Palo Alto Investors LP | 401.7K | $25.7M | −$4.91M | Added$476.7K |
| EVENTIDE ASSET MANAGEMENT, LLC | 395.6K | $25.3M | −$6.12M | Cut−$6.11M |
| DIMENSIONAL FUND ADVISORS LP | 394.4K | $25.2M | −$3.46M | Added$7.47M |
| Pictet Asset Management Holding SA | 387K | $24.7M | −$5.99M | Cut−$6.57M |
| Aberdeen Group plc | 375.6K | $24M | −$3.63M | Added$5.41M |
| Foresite Capital Management V, LLC | 374.1K | $23.9M | −$4.63M | Added$168.9K |
| BAKER BROS. ADVISORS LP | 349.7K | $22.4M | −$5.21M | Cut−$4.41M |
| LOOMIS SAYLES & CO L P | 317.2K | $20.3M | −$4.37M | Cut−$2.14M |
| Checkpoint Capital L.P. | 286.7K | $18.3M | −$4.43M | Cut−$17.6M |
| Octagon Capital Advisors LP | 270K | $17.3M | — | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 251.2K | $16.1M | −$3.82M | Cut−$3.56M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 247.3K | $15.8M | — | Held |
| NORTHERN TRUST CORP | 247.2K | $15.8M | −$3.53M | Cut−$2.31M |
| VANGUARD FIDUCIARY TRUST CO | 217.4K | $13.9M | — | Held |
| Bank of New York Mellon Corp | 205K | $13.1M | −$1.05M | Added$7.73M |
| SILVERARC CAPITAL MANAGEMENT, LLC | 196K | $12.5M | — | New |
| Ensign Peak Advisors, Inc | 191.5K | $12.2M | −$2.74M | Cut−$1.82M |
| Integral Health Asset Management, LLC | 170K | $10.9M | — | New |
| BANK OF AMERICA CORP /DE/ | 166.8K | $10.7M | −$2.1M | Cut−$135.1K |
| Bain Capital Life Sciences Investors, LLC | 141.2K | $9.03M | — | New |
| BNP PARIBAS FINANCIAL MARKETS | 127.7K | $8.17M | −$1.89M | Cut−$1.53M |
| Alyeska Investment Group, L.P. | 125K | $7.99M | −$773.5K | Added$4.02M |
| Catalio Capital Management, LP | 123K | $7.86M | −$1.71M | Cut−$905.8K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 110.9K | $7.09M | −$1.72M | Cut−$1.99M |
| KENNEDY CAPITAL MANAGEMENT LLC | 108.3K | $6.92M | −$144.2K | Added$6.18M |
| UBS Group AG | 98.6K | $6.31M | −$1.53M | Cut−$2.91M |
| Citadel | 97.9K | $6.26M | −$1.51M | Cut−$1.71M |
| DNB Asset Management AS | 96.8K | $6.19M | −$1.3M | Cut−$504.2K |
| MORGAN STANLEY | 94.3K | $6.03M | −$1.16M | Added$85.3K |
| MILLENNIUM MANAGEMENT LLC | 83.3K | $5.32M | −$1.29M | Cut−$9.35M |
| Jump Financial, LLC | 81.8K | $5.23M | — | New |
| Sofinnova Investments, Inc. | 78.3K | $5.01M | −$1.21M | Cut−$3.81M |
| Freestone Grove Partners LP | 68.7K | $4.39M | — | New |
| Sio Capital Management, LLC | 65.2K | $4.17M | −$890.9K | Cut−$403.8K |
| Casdin Capital, LLC | 65K | $4.16M | — | New |
| KVP Capital Advisors, LP | 58.3K | $3.72M | −$901.1K | Cut−$901.1K |
| MOORE CAPITAL MANAGEMENT, LP | 57.8K | $3.7M | — | New |
| Rafferty Asset Management, LLC | 53.9K | $3.44M | −$558.4K | Added$578.2K |
| SPHERA FUNDS MANAGEMENT LTD. | 53.5K | $3.42M | — | New |
| NEXTBio Capital Management LP | 52.7K | $3.37M | −$661.8K | Cut−$30.2K |
| Nuveen, LLC | 51.4K | $3.29M | −$749.8K | Cut−$563.8K |
| BURKEHILL GLOBAL MANAGEMENT, LP | 50K | $3.2M | −$773.5K | Cut−$773.5K |
| Atle Fund Management AB | 107.3K | $3.19M | −$2.38M | Cut−$620.4K |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 51K | $3.1M | −$807.2K | Cut−$755.1K |
| Swiss National Bank | 48K | $3.07M | −$742.6K | Cut−$742.6K |
| AMERIPRISE FINANCIAL INC | 45.8K | $2.93M | −$709.1K | Cut−$3.66M |
| RAYMOND JAMES FINANCIAL INC | 44.7K | $2.73M | −$712K | Cut−$3.45M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 39.9K | $2.55M | $2.55M | Added$2.55M |
| LAZARD ASSET MANAGEMENT LLC | 39.4K | $2.52M | −$609.5K | Cut−$2.09M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 38K | $2.43M | −$422.3K | Added$262.1K |
| SEVEN GRAND MANAGERS, LLC | 35K | $2.24M | −$541.5K | Cut−$541.5K |
| XTX Topco Ltd | 34.4K | $2.2M | −$357.3K | Added$366.8K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 34.4K | $2.2M | −$359.8K | Added$351.6K |
| BARCLAYS PLC | 33.3K | $2.13M | −$514.6K | Cut−$5.78M |
| RHUMBLINE ADVISERS | 33.1K | $2.11M | −$461.5K | Cut−$255.3K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 32.5K | $2.08M | −$442K | Cut−$1.99M |
| Brevan Howard Capital Management LP | 32.4K | $2.04M | −$494.2K | Cut−$1.85M |
| Renaissance Technologies | 31.8K | $2.03M | −$492.3K | Cut−$2.95M |
| Squarepoint Ops LLC | 31.7K | $2.03M | −$243.7K | Added$776.4K |
| ALPS ADVISORS INC | 31.1K | $1.99M | −$479.6K | Cut−$476K |
| TUDOR INVESTMENT CORP ET AL | 31K | $1.98M | −$479.6K | Cut−$3.27M |
| Invesco Ltd. | 30.6K | $1.96M | −$474K | Cut−$2.89M |
| ALLIANCEBERNSTEIN L.P. | 24.5K | $1.95M | $0 | Held |
| TD Asset Management Inc | 30.5K | $1.95M | −$471.5K | Cut−$3.58M |
| RTW INVESTMENTS, LP | 30K | $1.92M | −$464.1K | Cut−$464.1K |
| VICTORY CAPITAL MANAGEMENT INC | 29.2K | $1.87M | −$452K | Cut−$4.19M |
| BANK OF MONTREAL /CAN/ | 28.8K | $1.84M | −$384.1K | Cut−$131.7K |
| Nantahala Capital Management, LLC | 25.7K | $1.64M | −$396.9K | Cut−$8.91M |
| PNC Financial Services Group, Inc. | 25.3K | $1.62M | −$389.8K | Cut−$384K |
| DEUTSCHE BANK AG\ | 24.4K | $1.56M | −$317.5K | Cut−$69.5K |
| PROFUND ADVISORS LLC | 24K | $1.53M | −$208.5K | Added$462.5K |
| BOOTHBAY FUND MANAGEMENT, LLC | 21.4K | $1.37M | — | New |
| Legal & General Group Plc | 19.4K | $1.24M | −$299.8K | Cut−$639.3K |
| Zimmer Partners, LP | 16.7K | $1.07M | −$258.3K | Cut−$1.12M |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 16.7K | $1.06M | −$216.7K | Cut−$27.8K |
| VANGUARD ASSET MANAGEMENT, Ltd | 16.1K | $1.03M | — | Held |
| SEI INVESTMENTS CO | 15.5K | $991.7K | — | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 15.4K | $985.1K | −$144K | Added$245.8K |
| MetLife Investment Management, LLC | 15.1K | $963.3K | −$214K | Cut−$135.1K |
| WELLS FARGO & COMPANY/MN | 14.7K | $939.2K | −$227.3K | Cut−$1.7M |
| Headlands Technologies LLC | 14.6K | $934.2K | — | New |
| STATE OF WISCONSIN INVESTMENT BOARD | 14.3K | $913.6K | −$221K | Cut−$444.8K |
| Icahn Capital | 14.2K | $905.1K | −$216.7K | Cut−$207.2K |
| SummitTX Capital, L.P. | 13.8K | $883.7K | — | New |
| Vanguard Global Advisers, LLC | 12.5K | $800.3K | — | Held |
| Atom Investors LP | 12.2K | $777.6K | — | New |
| JANUS HENDERSON GROUP PLC | 11.6K | $739.5K | −$178.5K | Cut−$178.5K |
| Man Group plc | 10K | $639.8K | — | New |
| Ghisallo Capital Management LLC | 10K | $639.4K | −$154.7K | Cut−$154.7K |
| Engineers Gate Manager LP | 9.27K | $592.7K | −$84.5K | Added$159.1K |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 8.7K | $556.5K | −$134.7K | Cut−$134.7K |
| NEW YORK STATE COMMON RETIREMENT FUND | 8.58K | $548.3K | −$132.7K | Cut−$562.2K |
| China Universal Asset Management Co., Ltd. | 8.37K | $535.3K | −$119.9K | Cut−$80.2K |
| State of New Jersey Common Pension Fund D | 8.32K | $531.8K | −$128.5K | Cut−$127.8K |
| Lion Point Capital, LP | 8.1K | $517.9K | −$125.3K | Cut−$125.3K |
| PSP Research LLC | 8K | $511.5K | — | New |
| CITIGROUP INC | 7.74K | $495K | −$119.8K | Cut−$2.38M |
| Police & Firemen's Retirement System of New Jersey | 7.47K | $477.9K | −$103.9K | Cut−$55.4K |
| E Fund Management Co., Ltd. | 6.77K | $433K | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 6.68K | $427.4K | −$103.4K | Cut−$112.5K |
| INCEPTIONR LLC | 6.49K | $414.9K | — | New |
| EntryPoint Capital, LLC | 6.37K | $407.4K | — | New |
| CAPSTONE INVESTMENT ADVISORS, LLC | 6.26K | $400.6K | — | New |
| Tower Research Capital LLC (TRC) | 6.02K | $384.7K | −$12K | Added$323.1K |
| STRS OHIO | 6K | $383.6K | −$92.8K | Cut−$92.8K |
| Vanguard Investments Australia, Ltd. | 5.96K | $381K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 5.87K | $375.2K | −$90.8K | Cut−$411.8K |
| ProShare Advisors LLC | 5.69K | $363.7K | −$88K | Cut−$130.8K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 5.64K | $360.6K | −$46.2K | Added$123.3K |
| KLP KAPITALFORVALTNING AS | 5.2K | $332.5K | −$80.4K | Cut−$80.4K |
| Eleva Capital SAS | 5.12K | $327.1K | — | Held |
| Entropy Technologies, LP | 4.79K | $306.1K | −$67.4K | Cut−$39.8K |
| VOYA INVESTMENT MANAGEMENT LLC | 4.42K | $282.6K | −$68.4K | Cut−$764.5K |
| PRUDENTIAL FINANCIAL INC | 4.26K | $272.7K | — | New |
| Fiduciary Trust Co | 4.05K | $259K | −$62.7K | Cut−$62.7K |
| AlphaCentric Advisors LLC | 3.97K | $254K | −$58.1K | Cut−$44.3K |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 3.95K | $252.7K | −$86.2K | Cut−$304.2K |
| Creative Planning | 3.77K | $241K | −$58.3K | Cut−$65.8K |
| Bayforest Capital Ltd | 3.56K | $227.9K | — | New |
| Seven Fleet Capital Management LP | 3.23K | $206.6K | — | New |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 3.14K | $201K | −$48.6K | Cut−$86K |
| Virtus Investment Advisers, LLC | 2.97K | $189.7K | −$44.8K | Cut−$40.3K |
| Russell Investments Group, Ltd. | 2.63K | $168.4K | −$40.8K | Cut−$1.71M |
| Ameritas Investment Partners, Inc. | 2.25K | $143.7K | −$31.9K | Cut−$19.8K |
| Mirae Asset Global Investments Co., Ltd. | 1.99K | $127.2K | −$28.4K | Cut−$18.4K |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.55M | $99.1K | −$24K | Cut−$35.8K |
| JONES FINANCIAL COMPANIES LLLP | 1.63K | $97.8K | — | New |
| US BANCORP \DE\ | 1.19K | $75.8K | −$18.2K | Cut−$17.6K |
| CWM, LLC | 1.03K | $66.2K | $66K | Added$66.1K |
| Caitong International Asset Management Co., Ltd | 1K | $64K | −$3.59K | Added$45.6K |
| GF FUND MANAGEMENT CO. LTD. | 848 | $54.2K | −$11.5K | Cut−$4.7K |
| Aquatic Capital Management LLC | 693 | $44.3K | — | New |
| Allworth Financial LP | 599 | $38.3K | −$108 | Added$37.7K |
| Steward Partners Investment Advisory, LLC | 528 | $33.8K | −$8.17K | Cut−$8.17K |
| ANTIPODES PARTNERS Ltd | 476 | $30.4K | −$6.48K | Cut−$2.84K |
| SUMMIT SECURITIES GROUP LLC | 287 | $18.4K | — | New |
| OSAIC HOLDINGS, INC. | 275 | $17.6K | −$4.22K | Cut−$4.09K |
| GAMMA Investing LLC | 268 | $17.1K | −$4.15K | Cut−$7K |
| Kemnay Advisory Services Inc. | 246 | $15.7K | −$1.07K | Added$10.3K |
| NISA INVESTMENT ADVISORS, LLC | 240 | $15.3K | −$3.71K | Cut−$3.71K |
| J.Safra Asset Management Corp | 194 | $12.4K | −$975 | Added$7.4K |
| Sterling Capital Management LLC | 178 | $11.4K | −$2.52K | Cut−$1.56K |
| Larson Financial Group LLC | 123 | $7.87K | −$1.73K | Cut−$1.03K |
| Smartleaf Asset Management LLC | 92 | $5.59K | −$1.18K | Cut−$21 |
| Optiver Holding B.V. | 82 | $5.24K | −$1.08K | Cut−$316 |
| EverSource Wealth Advisors, LLC | 71 | $4.54K | −$1.04K | Cut−$780 |
| iA Global Asset Management Inc. | 66.2K | $4.24K | −$1.02K | Cut−$1.04K |
| Farther Finance Advisors, LLC | 44 | $2.85K | −$644 | Cut−$1.36K |
| ROTHSCHILD INVESTMENT LLC | 41 | $2.62K | −$618 | Cut−$554 |
| Aster Capital Management (DIFC) Ltd | 52 | $2.58K | — | New |
| ROYAL BANK OF CANADA | 24 | $2K | $85 | Cut−$62K |
| FIRST HORIZON CORP | 30 | $1.92K | −$433 | Cut−$305 |
| FIFTH THIRD BANCORP | 29 | $1.86K | — | New |
| ALGERT GLOBAL LLC | 22.7K | $1.45K | — | New |
| Parkside Financial Bank & Trust | 20 | $1.28K | −$309 | Cut−$309 |
| Versant Capital Management, Inc | 19 | $1.22K | −$294 | Cut−$294 |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 19K | $1.21K | −$250 | Cut−$69 |
| JPL Wealth Management, LLC | 17 | $1.09K | — | New |
| Geneos Wealth Management Inc. | 13 | $831 | — | New |
| ASSETMARK, INC | 12 | $767 | −$186 | Cut−$186 |
| SG Americas Securities, LLC | 11.2K | $718 | −$173 | Cut−$959 |
| Cornerstone Financial Management LLC | 11 | $703 | −$171 | Cut−$171 |
| GROUP ONE TRADING LLC | 11 | $703 | — | New |
| Bare Financial Services, Inc | 9 | $575 | −$140 | Cut−$140 |
| CAPITAL & PLANNING, LLC | 6 | $384 | — | New |
| Essential Partners LLC | 4 | $256 | −$62 | Cut−$62 |
| Root Financial Partners, LLC | 4 | $256 | — | New |
| Virtu Financial LLC | 3.79K | $242 | — | New |
| IFP Advisors, Inc | 3 | $192 | −$46 | Cut−$46 |
| MAI Capital Management | 3 | $192 | — | New |
| Keating Financial Advisory Services, Inc. | 3 | $192 | — | New |
| KBC Group NV | 1.01K | $65 | −$15 | Cut−$15 |
| TWIN PEAKS WEALTH ADVISORS, LLC | 1 | $64 | — | New |
| Hughes Financial Services, LLC | 1 | $64 | −$15 | Cut−$15 |
| SBI Securities Co., Ltd. | 1 | $64 | −$15 | Cut−$15 |
| True Wealth Design, LLC | 1 | $64 | −$16 | Cut−$16 |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 730 | $47 | −$11 | Cut−$11 |
| Covestor Ltd | 2 | $0 | $0 | Held |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | $0 | — | Held |