| Fidelity | 5.45M | $432.8M | — | Held |
| BlackRock, Inc. | 2.27M | $180.7M | — | Held |
| RA CAPITAL MANAGEMENT, L.P. | 1.98M | $156.9M | — | Held |
| Vanguard | 1.77M | $140.4M | — | Held |
| JPMORGAN CHASE & CO | 1.58M | $125.6M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 1.52M | $120.6M | — | Held |
| Atlas Venture Life Science Advisors, LLC | 1.51M | $120.2M | — | Held |
| Frazier Life Sciences Management, L.P. | 1.26M | $100.1M | — | Held |
| State Street | 1.19M | $94.3M | — | Held |
| ORBIMED ADVISORS LLC | 1.07M | $84.8M | — | Held |
| Siren, L.L.C. | 988.4K | $78.5M | — | Held |
| Woodline Partners LP | 957.8K | $76.1M | — | Held |
| GOLDMAN SACHS GROUP INC | 754.2K | $59.9M | — | Held |
| Vestal Point Capital, LP | 735K | $58.4M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 685K | $54.4M | — | Held |
| BVF INC/IL | 650K | $51.6M | — | Held |
| JENNISON ASSOCIATES LLC | 532.1K | $42.3M | — | Held |
| First Light Asset Management, LLC | 523.2K | $41.5M | — | Held |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 511.2K | $40.6M | — | Held |
| Logos Global Management LP | 510K | $40.5M | — | Held |
| ARMISTICE CAPITAL, LLC | 499.4K | $39.7M | — | Held |
| Checkpoint Capital L.P. | 453K | $36M | — | Held |
| PERCEPTIVE ADVISORS LLC | 450.7K | $35.8M | — | Held |
| EVENTIDE ASSET MANAGEMENT, LLC | 395.4K | $31.4M | — | Held |
| Pictet Asset Management Holding SA | 394.4K | $31.3M | — | Held |
| Assenagon Asset Management S.A. | 357.8K | $28.4M | — | Held |
| BAKER BROS. ADVISORS LP | 337.1K | $26.8M | — | Held |
| Palo Alto Investors LP | 317.5K | $25.2M | — | Held |
| Foresite Capital Management V, LLC | 299.1K | $23.7M | — | Held |
| Saturn V Capital Management LP | 298.4K | $23.7M | — | Held |
| LOOMIS SAYLES & CO L P | 282.4K | $22.4M | — | Held |
| GREAT POINT PARTNERS LLC | 250K | $19.9M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 247K | $19.6M | — | Held |
| Aberdeen Group plc | 234.4K | $18.6M | — | Held |
| NORTHERN TRUST CORP | 228.1K | $18.1M | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 223.6K | $17.7M | — | Held |
| Balyasny Asset Management L.P. | 221.8K | $17.6M | — | Held |
| Opaleye Management Inc. | 200K | $15.9M | — | Held |
| TimesSquare Capital Management, LLC | 187.8K | $14.9M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 184.8K | $14.7M | — | Held |
| Ensign Peak Advisors, Inc | 177.1K | $14.1M | — | Held |
| First Turn Management, LLC | 153.2K | $12.2M | — | Held |
| BANK OF AMERICA CORP /DE/ | 136K | $10.8M | $1.81M | Added$147.6K |
| Nantahala Capital Management, LLC | 132.8K | $10.5M | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 122.2K | $9.7M | — | Held |
| UBS Group AG | 116.1K | $9.22M | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 114.4K | $9.08M | — | Held |
| Sofinnova Investments, Inc. | 111K | $8.82M | — | Held |
| Catalio Capital Management, LP | 110.4K | $8.77M | — | Held |
| Citadel | 100.4K | $7.97M | — | Held |
| BARCLAYS PLC | 99.6K | $7.91M | $1.33M | Added$826.2K |
| DNB Asset Management AS | 84.3K | $6.69M | — | Held |
| AMERIPRISE FINANCIAL INC | 83K | $6.59M | — | Held |
| RAYMOND JAMES FINANCIAL INC | 80.3K | $6.18M | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 76.3K | $6.06M | — | Held |
| MORGAN STANLEY | 74.8K | $5.94M | $747.5K | Added$2.24M |
| Patient Square Capital LP | 74K | $5.88M | — | Held |
| TD Asset Management Inc | 69.6K | $5.53M | — | Held |
| Bank of New York Mellon Corp | 67.7K | $5.38M | — | Held |
| TUDOR INVESTMENT CORP ET AL | 66.1K | $5.25M | — | New |
| Verition Fund Management LLC | 63.5K | $5.05M | — | Held |
| Renaissance Technologies | 62.8K | $4.99M | — | Held |
| Invesco Ltd. | 61.1K | $4.85M | — | Held |
| KVP Capital Advisors, LP | 58.3K | $4.63M | — | Held |
| ExodusPoint Capital Management, LP | 58.2K | $4.62M | — | Held |
| LAZARD ASSET MANAGEMENT LLC | 58.1K | $4.61M | — | Held |
| Sio Capital Management, LLC | 57.6K | $4.57M | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 52.5K | $4.07M | — | Held |
| Alyeska Investment Group, L.P. | 50K | $3.97M | — | Held |
| BURKEHILL GLOBAL MANAGEMENT, LP | 50K | $3.97M | — | Held |
| Brevan Howard Capital Management LP | 49.7K | $3.89M | — | Held |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 50.1K | $3.85M | — | Held |
| Nuveen, LLC | 48.5K | $3.85M | — | Held |
| Nicholas Investment Partners, LP | 48.1K | $3.82M | — | Held |
| Swiss National Bank | 48K | $3.81M | — | Held |
| Atle Fund Management AB | 48K | $3.81M | — | Held |
| Exome Asset Management LLC | 46.7K | $3.71M | — | Held |
| NEXTBio Capital Management LP | 42.8K | $3.4M | — | Held |
| CITIGROUP INC | 36.2K | $2.87M | — | Held |
| Rafferty Asset Management, LLC | 36.1K | $2.87M | — | Held |
| SEVEN GRAND MANAGERS, LLC | 35K | $2.78M | — | Held |
| WELLS FARGO & COMPANY/MN | 33.3K | $2.64M | — | Held |
| ALPS ADVISORS INC | 31K | $2.46M | — | Held |
| AMERICAN CENTURY COMPANIES INC | 30.3K | $2.41M | — | Held |
| RTW INVESTMENTS, LP | 30K | $2.38M | — | Held |
| RHUMBLINE ADVISERS | 29.8K | $2.37M | — | Held |
| Zimmer Partners, LP | 27.5K | $2.18M | — | Held |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 27.3K | $2.17M | — | Held |
| Eagle Health Investments LP | 27.1K | $2.15M | — | Held |
| PNC Financial Services Group, Inc. | 25.2K | $2M | — | Held |
| BANK OF MONTREAL /CAN/ | 24.8K | $1.97M | — | Held |
| ALLIANCEBERNSTEIN L.P. | 24.5K | $1.95M | — | Held |
| Russell Investments Group, Ltd. | 23.7K | $1.88M | — | Held |
| Legal & General Group Plc | 23.7K | $1.88M | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 23.3K | $1.85M | — | Held |
| XTX Topco Ltd | 23.1K | $1.83M | — | Held |
| DEUTSCHE BANK AG\ | 20.5K | $1.63M | — | Held |
| Campbell & CO Investment Adviser LLC | 17.4K | $1.38M | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 17.1K | $1.36M | — | Held |
| Squarepoint Ops LLC | 15.8K | $1.25M | — | Held |
| Icahn Capital | 14K | $1.11M | — | Held |
| PRELUDE CAPITAL MANAGEMENT, LLC | 14K | $1.11M | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 14K | $1.11M | — | Held |
| MetLife Investment Management, LLC | 13.8K | $1.1M | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13.7K | $1.08M | — | Held |
| PROFUND ADVISORS LLC | 13.5K | $1.07M | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 13.2K | $1.05M | — | Held |
| FRED ALGER MANAGEMENT, LLC | 12.3K | $974.1K | — | Held |
| JANUS HENDERSON GROUP PLC | 11.6K | $918K | — | Held |
| Y-Intercept (Hong Kong) Ltd | 11.4K | $902K | — | Held |
| PFM Health Sciences, LP | 11K | $873.7K | — | Held |
| Ghisallo Capital Management LLC | 10K | $794.1K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 9.91K | $787K | — | Held |
| KENNEDY CAPITAL MANAGEMENT LLC | 9.32K | $740.4K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 9.31K | $739.2K | — | Held |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 8.7K | $691.2K | — | Held |
| State of New Jersey Common Pension Fund D | 8.31K | $659.6K | — | Held |
| Legato Capital Management LLC | 8.25K | $655K | — | Held |
| Lion Point Capital, LP | 8.1K | $643.2K | — | Held |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 7.77K | $616.8K | — | Held |
| China Universal Asset Management Co., Ltd. | 7.75K | $615.5K | — | Held |
| Jain Global LLC | 7.32K | $581.2K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 6.49K | $556.9K | — | Held |
| FORA Capital, LLC | 6.74K | $543.9K | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 6.8K | $539.8K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 6.72K | $533.3K | — | Held |
| ProShare Advisors LLC | 6.23K | $494.5K | — | Held |
| STRS OHIO | 6K | $476.5K | — | Held |
| Engineers Gate Manager LP | 5.46K | $433.6K | — | Held |
| VARCOV Co. | 5.33K | $423K | — | Held |
| KLP KAPITALFORVALTNING AS | 5.2K | $412.9K | — | Held |
| MARSHALL WACE, LLP | 4.64K | $368.6K | — | Held |
| Abel Hall, LLC | 4.44K | $352.8K | — | Held |
| Entropy Technologies, LP | 4.36K | $346K | — | Held |
| Fiduciary Trust Co | 4.05K | $321.7K | — | Held |
| Creative Planning | 3.86K | $306.8K | — | Held |
| AlphaCentric Advisors LLC | 3.76K | $298.3K | — | Held |
| Susquehanna Portfolio Strategies, LLC | 3.73K | $296.4K | — | Held |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 3.61K | $287K | — | Held |
| Allianz Asset Management GmbH | 3K | $238.2K | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2.99K | $237.3K | — | Held |
| Virtus Investment Advisers, LLC | 2.9K | $230.1K | — | Held |
| SAXON INTERESTS, INC. | 2.58K | $204.6K | — | Held |
| Ameritas Investment Partners, Inc. | 2.06K | $163.5K | — | Held |
| Avanza Fonder AB | 1.9K | $151.1K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 1.83K | $145.6K | — | Held |
| Persistent Asset Partners Ltd | 1.78K | $141.3K | — | New |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.7M | $134.8K | — | Held |
| US BANCORP \DE\ | 1.18K | $93.4K | — | Held |
| ROYAL BANK OF CANADA | 802 | $64K | — | Held |
| Tower Research Capital LLC (TRC) | 776 | $61.6K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 742 | $58.9K | — | Held |
| Steward Partners Investment Advisory, LLC | 528 | $41.9K | — | Held |
| ANTIPODES PARTNERS Ltd | 419 | $33.3K | — | Held |
| AlphaQuest LLC | 366 | $29.1K | — | Held |
| GAMMA Investing LLC | 304 | $24.1K | — | Held |
| OSAIC HOLDINGS, INC. | 273 | $21.7K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 240 | $19.1K | — | Held |
| Caitong International Asset Management Co., Ltd | 232 | $18.4K | — | Held |
| Sterling Capital Management LLC | 163 | $12.9K | — | Held |
| Larson Financial Group LLC | 112 | $8.89K | — | Held |
| Smartleaf Asset Management LLC | 73 | $5.61K | — | Held |
| Optiver Holding B.V. | 70 | $5.56K | — | Held |
| Kemnay Advisory Services Inc. | 69 | $5.48K | — | Held |
| EverSource Wealth Advisors, LLC | 67 | $5.32K | — | Held |
| iA Global Asset Management Inc. | 66.4K | $5.28K | — | Held |
| J.Safra Asset Management Corp | 63 | $5K | — | Held |
| Farther Finance Advisors, LLC | 53 | $4.21K | — | Held |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 40.2K | $3.19K | — | Held |
| ROTHSCHILD INVESTMENT LLC | 40 | $3.18K | — | Held |
| FIRST HORIZON CORP | 28 | $2.22K | — | Held |
| SG Americas Securities, LLC | 21.1K | $1.68K | — | Held |
| Parkside Financial Bank & Trust | 20 | $1.59K | — | Held |
| COMERICA BANK | 19 | $1.54K | — | Held |
| Versant Capital Management, Inc | 19 | $1.51K | — | Held |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 16.2K | $1.28K | — | Held |
| ASSETMARK, INC | 12 | $953 | — | Held |
| Cornerstone Financial Management LLC | 11 | $874 | — | Held |
| Bare Financial Services, Inc | 9 | $715 | — | Held |
| Allworth Financial LP | 7 | $556 | $80 | Added$159 |
| Essential Partners LLC | 4 | $318 | $54 | Added$54 |
| GSA CAPITAL PARTNERS LLP | 3.29K | $261 | — | Held |
| Global Retirement Partners, LLC | 3 | $238 | — | Held |
| IFP Advisors, Inc | 3 | $238 | $40 | Added$40 |
| Arax Advisory Partners | 2 | $159 | — | Held |
| CWM, LLC | 1.03K | $82 | — | Held |
| True Wealth Design, LLC | 1 | $80 | — | Held |
| KBC Group NV | 1.01K | $80 | — | New |
| SBI Securities Co., Ltd. | 1 | $79 | — | Held |
| Hughes Financial Services, LLC | 1 | $79 | — | Held |
| AMALGAMATED BANK | 784 | $62 | — | Held |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 730 | $58 | — | Held |
| Cygnus Capital Advisors, LLC | 502 | $40 | — | Held |
| Daiwa Securities Group Inc. | 113 | $9 | — | Held |
| Covestor Ltd | 2 | $0 | — | Held |
| BESSEMER GROUP INC | 2 | $0 | — | Held |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | $0 | — | Held |