| SUVRETTA CAPITAL MANAGEMENT, LLC | 2.84M | $32.5M | — | Held |
| JANUS HENDERSON GROUP PLC | 2.45M | $27.9M | — | Held |
| RA CAPITAL MANAGEMENT, L.P. | 2.18M | $24.9M | — | Held |
| JOHNSON & JOHNSON | 1.98M | $22.6M | −$633.3K | Cut−$633.3K |
| FRANKLIN RESOURCES INC | 1.88M | $21.5M | — | Held |
| Balyasny Asset Management L.P. | 1.84M | $21.1M | — | Held |
| PERCEPTIVE ADVISORS LLC | 1.46M | $16.7M | — | Held |
| BAKER BROS. ADVISORS LP | 1.42M | $16.2M | — | Held |
| Vanguard | 1.27M | $14.5M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 830.7K | $9.49M | — | Held |
| Commodore Capital LP | 816.3K | $9.33M | — | Held |
| Fidelity | 814.9K | $9.31M | — | Held |
| SECTORAL ASSET MANAGEMENT INC | 800.8K | $9.15M | — | Held |
| GREAT POINT PARTNERS LLC | 800K | $9.14M | — | Held |
| Point72 Asset Management, L.P. | 759.2K | $8.68M | — | Held |
| HHLR ADVISORS, LTD. | 669.3K | $7.65M | — | Held |
| RED TREE MANAGEMENT, LLC | 638.2K | $7.29M | — | Held |
| Versant Venture Management, LLC | 542.6K | $6.2M | — | Held |
| BlackRock, Inc. | 536.2K | $6.13M | — | Held |
| Boxer Capital Management, LLC | 494K | $5.65M | — | New |
| Longaeva Partners L.P. | 470K | $5.37M | — | Held |
| SILVERARC CAPITAL MANAGEMENT, LLC | 307.5K | $3.52M | — | Held |
| Ikarian Capital, LLC | 282.9K | $3.23M | — | Held |
| ADAR1 Capital Management, LLC | 279K | $3.19M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 265.8K | $3.04M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 213.9K | $2.45M | — | Held |
| AMERIPRISE FINANCIAL INC | 209.6K | $2.4M | — | Held |
| UBS Group AG | 199.4K | $2.28M | — | Held |
| MARSHALL WACE, LLP | 180.8K | $2.07M | — | Held |
| SPHERA FUNDS MANAGEMENT LTD. | 173.5K | $1.98M | — | Held |
| Casdin Capital, LLC | 148.3K | $1.7M | — | Held |
| Eversept Partners, LP | 137.5K | $1.57M | — | Held |
| Monashee Investment Management LLC | 137.4K | $1.57M | — | Held |
| MORGAN STANLEY | 124.3K | $1.42M | −$29.8K | Added$327.9K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 110.1K | $1.26M | — | Held |
| GOLDMAN SACHS GROUP INC | 105.6K | $1.21M | — | Held |
| 683 Capital Management, LLC | 91.4K | $1.05M | — | Held |
| State Street | 84.4K | $965K | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 72.5K | $828.6K | — | Held |
| SAMSARA BIOCAPITAL, LLC | 72.2K | $825.8K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 64.2K | $734.1K | — | Held |
| BARCLAYS PLC | 59.5K | $680.2K | −$2.07K | Added$604.1K |
| Trexquant Investment LP | 59K | $674.7K | — | Held |
| Renaissance Technologies | 57.1K | $652.7K | — | Held |
| NORTHERN TRUST CORP | 53.9K | $615.8K | — | Held |
| ExodusPoint Capital Management, LP | 51K | $583.3K | — | Held |
| Strategies Wealth Advisors, LLC | 50K | $571.5K | — | Held |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 49.3K | $563.3K | — | Held |
| Qube Research & Technologies Ltd | 43.1K | $492.4K | — | Held |
| TWO SIGMA INVESTMENTS, LP | 37.9K | $433.4K | — | Held |
| OMERS ADMINISTRATION Corp | 34.9K | $398.9K | — | Held |
| JANE STREET GROUP, LLC | 27.9K | $319.4K | — | Held |
| INDEPENDENT FINANCIAL GROUP, LLC | 27K | $308.9K | −$8.65K | Cut−$8.65K |
| Hudson Bay Capital Management LP | 25.9K | $296.5K | — | New |
| Quadrature Capital Ltd | 23.4K | $267.2K | — | Held |
| Schonfeld Strategic Advisors LLC | 22.7K | $259.1K | — | Held |
| RBF Capital, LLC | 20K | $228.6K | — | Held |
| AMERICAN CENTURY COMPANIES INC | 19.5K | $223.1K | — | Held |
| Brevan Howard Capital Management LP | 19.4K | $222K | — | Held |
| Graham Capital Management, L.P. | 17.1K | $195.2K | — | Held |
| OCCUDO QUANTITATIVE STRATEGIES LP | 15K | $171.9K | — | Held |
| Persistent Asset Partners Ltd | 13.9K | $158.3K | — | New |
| CITIGROUP INC | 12.3K | $140.9K | — | Held |
| BANK OF AMERICA CORP /DE/ | 9.27K | $105.9K | −$2.32K | Added$20.9K |
| China Universal Asset Management Co., Ltd. | 3.76K | $43K | — | Held |
| ROYAL BANK OF CANADA | 3.34K | $38K | — | Held |
| Federation des caisses Desjardins du Quebec | 2.56K | $29.3K | — | Held |
| JPMORGAN CHASE & CO | 1.79K | $20.5K | — | Held |
| Torren Management, LLC | 1.56K | $17.9K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 1.12K | $12.8K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 454 | $5.19K | — | Held |
| Fortitude Family Office, LLC | 445 | $5.09K | — | Held |
| Banque Transatlantique SA | 220 | $2.51K | — | Held |
| Tower Research Capital LLC (TRC) | 124 | $1.42K | — | Held |
| Optiver Holding B.V. | 104 | $1.19K | — | Held |
| GROUP ONE TRADING LLC | 103 | $1.18K | — | Held |
| ACADIAN ASSET MANAGEMENT LLC | 64.7K | $735 | — | Held |
| Cornerstone Financial Management LLC | 64 | $732 | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 11.3K | $130 | — | Held |
| CWM, LLC | 1.18K | $13 | — | Held |