| Fidelity | 7.7M | $279.7M | — | Held |
| SR One Capital Management, LP | 5.04M | $182.9M | — | Held |
| ENAVATE SCIENCES GP, LLC | 3.92M | $142.3M | — | Held |
| NEA Management Company, LLC | 3.52M | $127.9M | — | Held |
| FEDERATED HERMES, INC. | 2.72M | $98.6M | — | Held |
| Fairmount Funds Management LLC | 2.21M | $80.2M | — | Held |
| NVP ASSOCIATES, LLC | 1.84M | $66.8M | — | Held |
| BlackRock, Inc. | 1.77M | $64.2M | — | Held |
| Vanguard | 1.45M | $52.8M | — | Held |
| NOVO HOLDINGS A/S | 1.45M | $52.6M | — | Held |
| Polar Capital Holdings Plc | 1.06M | $38.4M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 855.3K | $31.1M | — | Held |
| Vivo Capital, LLC | 853.5K | $31M | — | Held |
| EcoR1 Capital, LLC | 789.5K | $28.7M | — | Held |
| ArrowMark Colorado Holdings LLC | 751.2K | $27.3M | — | Held |
| Pivotal bioVenture Partners Investment Advisor LLC | 592K | $21.5M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 588.4K | $21.4M | — | Held |
| Rock Springs Capital Management LP | 502.1K | $18.2M | — | Held |
| State Street | 438.3K | $15.9M | — | Held |
| NEXTBio Capital Management LP | 322K | $11.7M | — | Held |
| Point72 Asset Management, L.P. | 368.4K | $9.21M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 213.2K | $7.74M | — | Held |
| Balyasny Asset Management L.P. | 193.2K | $7.01M | — | Held |
| Invesco Ltd. | 188K | $6.83M | — | Held |
| Skandinaviska Enskilda Banken AB (publ) | 163.9K | $5.95M | — | Held |
| NORTHERN TRUST CORP | 155.4K | $5.64M | — | Held |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 133.4K | $4.85M | — | Held |
| GOLDMAN SACHS GROUP INC | 130.7K | $4.75M | — | Held |
| MORGAN STANLEY | 128.3K | $4.66M | $1.25M | Added$2.69M |
| Eversept Partners, LP | 121K | $4.39M | — | Held |
| SUPERSTRING CAPITAL MANAGEMENT LP | 83.4K | $3.03M | — | Held |
| Icahn Capital | 78.2K | $2.84M | — | Held |
| UBS Group AG | 69.5K | $2.52M | — | Held |
| Bank of New York Mellon Corp | 51.8K | $1.88M | — | Held |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 50.6K | $1.85M | — | Held |
| Nuveen, LLC | 50.9K | $1.85M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 49.2K | $1.78M | — | Held |
| BANK OF AMERICA CORP /DE/ | 47.2K | $1.71M | $209K | Added$1.38M |
| ALPS ADVISORS INC | 44.1K | $1.6M | — | Held |
| BARCLAYS PLC | 34.4K | $1.25M | $322.8K | Added$740.4K |
| Swiss National Bank | 31.6K | $1.15M | — | Held |
| Citadel | 24.5K | $888.1K | — | Held |
| RHUMBLINE ADVISERS | 21.9K | $796.9K | — | Held |
| JPMORGAN CHASE & CO | 21.7K | $788.9K | — | Held |
| WELLS FARGO & COMPANY/MN | 21.2K | $768K | — | Held |
| ALLIANCEBERNSTEIN L.P. | 18.4K | $666.3K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 15.7K | $570.1K | — | Held |
| Squarepoint Ops LLC | 15.5K | $564.3K | — | Held |
| TWO SIGMA INVESTMENTS, LP | 15.1K | $548.3K | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 14.7K | $534.7K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 13.7K | $496.6K | — | Held |
| China Universal Asset Management Co., Ltd. | 13.3K | $483.4K | — | Held |
| Legal & General Group Plc | 13K | $473K | — | Held |
| DEUTSCHE BANK AG\ | 12.8K | $464.1K | — | Held |
| Creative Planning | 12.3K | $445.6K | — | Held |
| XTX Topco Ltd | 12.2K | $442.4K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 14.4K | $431.7K | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 10.2K | $371.1K | — | Held |
| Voleon Capital Management LP | 10.2K | $369.9K | — | Held |
| MetLife Investment Management, LLC | 10.1K | $366.7K | — | Held |
| Schonfeld Strategic Advisors LLC | 9.13K | $331.4K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 8.86K | $321.8K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 8.78K | $318.8K | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 8.4K | $305K | — | Held |
| JANUS HENDERSON GROUP PLC | 7.9K | $286.6K | — | Held |
| Mariner, LLC | 7.68K | $278.7K | — | Held |
| VARCOV Co. | 7.33K | $266.3K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 7.14K | $259.2K | — | Held |
| MARSHALL WACE, LLP | 7.1K | $257.8K | — | Held |
| Virtus Investment Advisers, LLC | 6.55K | $238K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 6.26K | $227.2K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 6.2K | $225.1K | — | Held |
| Brevan Howard Capital Management LP | 6.17K | $224.1K | — | Held |
| PNC Financial Services Group, Inc. | 5.82K | $211.5K | — | Held |
| ProShare Advisors LLC | 5.82K | $211.3K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 4.5K | $163.4K | — | Held |
| KLP KAPITALFORVALTNING AS | 3.4K | $123.5K | — | Held |
| STRS OHIO | 2.8K | $101.7K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 2.61K | $94.7K | — | Held |
| CITIGROUP INC | 2.35K | $85.4K | — | Held |
| SIMPLEX TRADING, LLC | 1.97K | $71.7K | — | Held |
| Ameritas Investment Partners, Inc. | 1.37K | $49.7K | — | Held |
| Russell Investments Group, Ltd. | 1.34K | $48.8K | — | Held |
| Sterling Capital Management LLC | 1.09K | $39.5K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.05K | $38.3K | — | Held |
| US BANCORP \DE\ | 884 | $32.1K | — | Held |
| Tower Research Capital LLC (TRC) | 795 | $28.9K | — | Held |
| ROYAL BANK OF CANADA | 544 | $20K | — | Held |
| SIGNATUREFD, LLC | 389 | $14.1K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 369.2K | $13.4K | — | Held |
| GAMMA Investing LLC | 179 | $6.5K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 115 | $4.18K | — | Held |
| Torren Management, LLC | 95 | $3.45K | — | Held |
| J.Safra Asset Management Corp | 92 | $3.34K | — | Held |
| Farther Finance Advisors, LLC | 86 | $3.12K | — | Held |
| EverSource Wealth Advisors, LLC | 73 | $2.65K | — | Held |
| Physician Wealth Advisors, Inc. | 67 | $2.43K | — | Held |
| Allworth Financial LP | 47 | $1.71K | — | New |
| Aster Capital Management (DIFC) Ltd | 42 | $1.52K | — | Held |
| Cornerstone Financial Management LLC | 26 | $944 | — | Held |
| Larson Financial Group LLC | 19 | $690 | — | Held |
| IFP Advisors, Inc | 12 | $436 | — | New |
| Sunbelt Securities, Inc. | 11 | $399 | — | Held |
| Global Retirement Partners, LLC | 11 | $399 | — | Held |
| GSA CAPITAL PARTNERS LLP | 8.96K | $325 | — | Held |
| SJS Investment Consulting Inc. | 7 | $255 | — | Held |
| MAI Capital Management | 7 | $255 | — | Held |
| SageView Advisory Group, LLC | 4 | $146 | — | Held |
| Arax Advisory Partners | 4 | $145 | — | Held |
| OSAIC HOLDINGS, INC. | 3 | $109 | — | Held |
| True Wealth Design, LLC | 3 | $109 | — | Held |
| Essential Partners LLC | 3 | $109 | $29 | Added$65 |
| CWM, LLC | 2.18K | $79 | — | Held |
| Clearstead Advisors, LLC | 1 | $37 | — | Held |
| ROTHSCHILD INVESTMENT LLC | 1 | $36 | — | Held |
| Keating Financial Advisory Services, Inc. | 1 | $36 | — | Held |
| AMALGAMATED BANK | 593 | $22 | — | Held |
| Daiwa Securities Group Inc. | 179 | $6 | — | Held |