| SB INVESTMENT ADVISERS (UK) LTD | 27.9M | $277.7M | $41.6M | Added$41.6M |
| Commodore Capital LP | 17M | $169.2M | $25.3M | Added$25.3M |
| Casdin Capital, LLC | 14.4M | $143.5M | $19.4M | Added$33.5M |
| BlackRock, Inc. | 13M | $129.1M | $19.3M | Added$17.2M |
| PERCEPTIVE ADVISORS LLC | 9.75M | $97M | $2.84M | Added$80.9M |
| Bellevue Group AG | 7.8M | $77.6M | $11.6M | Added$6.96M |
| VANGUARD CAPITAL MANAGEMENT LLC | 7.39M | $73.5M | — | Held |
| State Street | 6.23M | $62M | $9.29M | Added$7.66M |
| Nextech Invest, Ltd. | 5.53M | $55M | $7.01M | Added$15.2M |
| TCG Crossover Management, LLC | 4.27M | $42.5M | $4.8M | Added$15.3M |
| Fidelity | 3.7M | $36.8M | $241.7K | Added$35.4M |
| GEODE CAPITAL MANAGEMENT, LLC | 3.51M | $34.9M | $5.08M | Added$6.09M |
| Balyasny Asset Management L.P. | 3.04M | $30.2M | $3.13M | Added$12.5M |
| Spruce Street Capital LP | 2.98M | $29.7M | $4.45M | Added$4.45M |
| DIMENSIONAL FUND ADVISORS LP | 2.94M | $29.2M | $3.69M | Added$8.27M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2.59M | $25.8M | $745K | Added$21.5M |
| GOLDMAN SACHS GROUP INC | 2.54M | $25.3M | $2.77M | Added$9.56M |
| MPM BIOIMPACT LLC | 2.36M | $23.5M | $3.33M | Added$4.59M |
| BANK OF AMERICA CORP /DE/ | 1.94M | $19.3M | $1.55M | Added$10.5M |
| EcoR1 Capital, LLC | 1.9M | $19M | — | New |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1.86M | $18.5M | — | Held |
| NORTHERN TRUST CORP | 1.68M | $16.7M | $1.7M | Added$7.04M |
| Alphabet Inc. | 1.56M | $15.6M | $2.33M | Added$2.29M |
| MORGAN STANLEY | 1.43M | $14.2M | $2.13M | Cut−$2.83M |
| Kynam Capital Management, LP | 1.42M | $14.2M | $2.12M | Added$2.12M |
| TWO SIGMA INVESTMENTS, LP | 1.37M | $13.6M | $2.04M | Added$423.2K |
| Icahn Capital | 1.29M | $12.8M | $1.73M | Added$3M |
| BAKER BROS. ADVISORS LP | 1.16M | $11.5M | $1.73M | Added$1.73M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1.11M | $11.1M | $1.66M | Added$1.45M |
| Foresite Capital Management IV, LLC | 1M | $9.95M | $1.49M | Added$1.49M |
| MARSHALL WACE, LLP | 941.8K | $9.37M | — | New |
| Kalehua Capital Management LLC | 901.5K | $8.97M | $1.34M | Added$1.34M |
| VANGUARD FIDUCIARY TRUST CO | 900.5K | $8.96M | — | Held |
| Connor, Clark & Lunn Investment Management Ltd. | 837K | $8.33M | $580.4K | Added$5.03M |
| PANAGORA ASSET MANAGEMENT INC | 818K | $8.14M | — | New |
| Logos Global Management LP | 750K | $7.46M | — | New |
| Woodline Partners LP | 679.3K | $6.76M | $1.01M | Added$1.01M |
| Renaissance Technologies | 673.6K | $6.7M | $965.4K | Added$1.22M |
| Squadron Capital Management LLC | 672.5K | $6.69M | — | New |
| Invesco Ltd. | 669.9K | $6.67M | $998.1K | Cut−$656.7K |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 668.3K | $6.65M | — | New |
| Qube Research & Technologies Ltd | 619.7K | $6.17M | — | New |
| CONGRESS ASSET MANAGEMENT CO | 618.9K | $6.16M | $617.1K | Added$2.65M |
| JPMORGAN CHASE & CO | 647.5K | $6.05M | $379.1K | Added$2.45M |
| ArrowMark Colorado Holdings LLC | 541.1K | $5.38M | $806.3K | Added$806.3K |
| Elmind Capital, LP | 536.9K | $5.34M | $800.1K | Added$800K |
| UBS Group AG | 527.6K | $5.25M | $441.1K | Added$2.75M |
| Longaeva Partners L.P. | 470.5K | $4.68M | — | New |
| AMERICAN CENTURY COMPANIES INC | 440.2K | $4.38M | $644.4K | Added$721K |
| JANE STREET GROUP, LLC | 423.5K | $4.21M | $113.9K | Added$3.57M |
| HighVista Strategies LLC | 421.9K | $4.2M | $628.6K | Cut−$413.7K |
| SPHERA FUNDS MANAGEMENT LTD. | 408.4K | $4.06M | — | New |
| Affinity Asset Advisors, LLC | 400K | $3.98M | — | New |
| Bank of New York Mellon Corp | 382.9K | $3.81M | $564.3K | Added$606.2K |
| Rhenman & Partners Asset Management AB | 360K | $3.58M | $536.4K | Cut−$309.6K |
| AMERIPRISE FINANCIAL INC | 356.9K | $3.55M | — | New |
| MILLENNIUM MANAGEMENT LLC | 347.7K | $3.46M | $518.1K | Cut−$4.13M |
| RAYMOND JAMES FINANCIAL INC | 346.3K | $3.45M | $386.5K | Added$1.25M |
| Susquehanna Portfolio Strategies, LLC | 339.1K | $3.37M | $505.2K | Added$505.2K |
| Hudson Bay Capital Management LP | 311.3K | $3.1M | $463.9K | Cut−$722K |
| Nuveen, LLC | 302.2K | $3.01M | $447.7K | Added$464.9K |
| Exome Asset Management LLC | 278.3K | $2.77M | — | New |
| Eversept Partners, LP | 270.7K | $2.69M | $403.4K | Cut−$1.44M |
| Seven Fleet Capital Management LP | 257.7K | $2.56M | $108.8K | Added$1.95M |
| Swiss National Bank | 238K | $2.37M | $354.6K | Added$354.6K |
| RHUMBLINE ADVISERS | 216.9K | $2.16M | $321.5K | Added$333.3K |
| VOYA INVESTMENT MANAGEMENT LLC | 216.1K | $2.15M | $36.6K | Added$1.94M |
| TD Asset Management Inc | 214.2K | $2.13M | $271.2K | Added$591.4K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 210.5K | $2.09M | $312.7K | Added$318.8K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 209.7K | $2.09M | $279.2K | Added$599.8K |
| IEQ CAPITAL, LLC | 205.3K | $2.04M | $241.8K | Added$669.9K |
| XTX Topco Ltd | 188.9K | $1.88M | $234.5K | Added$548.3K |
| OSAIC HOLDINGS, INC. | 186.1K | $1.85M | $277.3K | Added$275.1K |
| Tetragon Partners GP Ltd | 181.5K | $1.81M | — | New |
| Squarepoint Ops LLC | 180.3K | $1.79M | $140.4K | Added$996.9K |
| Raiffeisen Bank International AG | 190K | $1.78M | $190K | Cut−$311K |
| Citadel | 176.3K | $1.75M | $170.1K | Added$788.2K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 174.1K | $1.73M | $175.3K | Added$736.7K |
| STATE OF WISCONSIN INVESTMENT BOARD | 162.2K | $1.61M | $150.7K | Added$758.4K |
| TEMA ETFS LLC | 154.1K | $1.53M | $166.2K | Added$589.5K |
| Tidal Investments LLC | 154.1K | $1.53M | — | New |
| Rafferty Asset Management, LLC | 150.6K | $1.5M | $224.4K | Cut−$140.5K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 147.2K | $1.46M | $219.3K | Cut−$421.8K |
| ALPS ADVISORS INC | 145.5K | $1.45M | $212.1K | Added$243.6K |
| Sanctuary Advisors, LLC | 143.8K | $1.43M | $211.9K | Added$227.7K |
| Engineers Gate Manager LP | 141.5K | $1.41M | $116.8K | Added$744.5K |
| DEUTSCHE BANK AG\ | 129.6K | $1.29M | $184.8K | Added$240.7K |
| ALLIANCEBERNSTEIN L.P. | 145.3K | $1.23M | $0 | Held |
| Man Group plc | 112.8K | $1.12M | $129.7K | Added$386.5K |
| WELLS FARGO & COMPANY/MN | 110K | $1.09M | $163.8K | Cut−$241.7K |
| Creative Planning | 101.3K | $1.01M | $127.9K | Added$282.3K |
| ICONIQ Capital, LLC | 94.7K | $942.2K | $141.1K | Added$141.1K |
| Trexquant Investment LP | 94.2K | $937.8K | $140.4K | Cut−$3.06M |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | 94.2K | $937K | $140.3K | Added$49.1K |
| VANGUARD ASSET MANAGEMENT, Ltd | 82.3K | $818.9K | — | Held |
| Legal & General Group Plc | 82.1K | $816.5K | $122.3K | Cut−$107.4K |
| VICTORY CAPITAL MANAGEMENT INC | 80K | $795.9K | $22.4K | Added$668.9K |
| MetLife Investment Management, LLC | 79K | $786.3K | $115.5K | Added$130.3K |
| Allspring Global Investments Holdings, LLC | 72.7K | $783.4K | $169.5K | Added$248K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 76.7K | $756.4K | $109.1K | Added$108.9K |
| Vanguard Global Advisers, LLC | 75.1K | $747K | — | Held |
| Schonfeld Strategic Advisors LLC | 71.9K | $715.2K | $92.2K | Added$191.9K |
| CWM, LLC | 70K | $696.1K | $672.1K | Added$695.5K |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 55.4K | $694.5K | $208.2K | Added$305.3K |
| PROFUND ADVISORS LLC | 68.2K | $678.3K | $101.6K | Added$64.2K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 66.7K | $664.1K | $85.3K | Added$179.9K |
| JANUS HENDERSON GROUP PLC | 65.6K | $652.1K | $54.2K | Added$339.6K |
| J. Goldman & Co LP | 63.6K | $633.2K | $18.7K | Added$527K |
| PRELUDE CAPITAL MANAGEMENT, LLC | 61.9K | $615.9K | — | New |
| WELLINGTON MANAGEMENT GROUP LLP | 59.5K | $592.1K | — | New |
| BANK OF MONTREAL /CAN/ | 52.9K | $526.8K | $78.9K | Added$49.2K |
| FRANKLIN RESOURCES INC | 48.9K | $486.7K | $72.9K | Added$72.9K |
| Aquatic Capital Management LLC | 48.1K | $478.8K | — | New |
| Headlands Technologies LLC | 47.6K | $473.9K | — | New |
| NEW YORK STATE COMMON RETIREMENT FUND | 45.8K | $455.7K | $68.2K | Added$68.2K |
| BARCLAYS PLC | 45.3K | $450.4K | $67.4K | Cut−$3.05M |
| Intellectus Partners, LLC | 42.2K | $420.1K | $62.9K | Added$48.5K |
| State of New Jersey Common Pension Fund D | 41.5K | $412.6K | — | New |
| LPL Financial LLC | 40.5K | $402.6K | $50.9K | Added$113.7K |
| BNP PARIBAS FINANCIAL MARKETS | 39.5K | $392.7K | $29.8K | Added$223.5K |
| BRANDYWINE MANAGERS, LLC | 38.4K | $382.4K | $57.3K | Added$57.3K |
| Police & Firemen's Retirement System of New Jersey | 37K | $368.2K | $55.1K | Added$55.1K |
| CAPTRUST FINANCIAL ADVISORS | 36.8K | $365.8K | $53K | Added$64.9K |
| Cresset Asset Management, LLC | 36.5K | $363.1K | $54.4K | Added$49.4K |
| SEI INVESTMENTS CO | 36.1K | $359.5K | $38.2K | Added$142.7K |
| Mariner, LLC | 36.1K | $358.4K | — | New |
| Valeo Financial Advisors, LLC | 35.7K | $355.4K | — | New |
| Virtus Investment Advisers, LLC | 34K | $337.9K | $49.4K | Added$57.6K |
| Gotham Asset Management, LLC | 33.6K | $334.4K | — | New |
| ARIZONA STATE RETIREMENT SYSTEM | 33.3K | $331.6K | $49.7K | Added$47.9K |
| Brooklyn Investment Group | 32.6K | $324.1K | $41.8K | Added$95.9K |
| China Universal Asset Management Co., Ltd. | 31.7K | $315.6K | $42.1K | Added$76.6K |
| INTECH INVESTMENT MANAGEMENT LLC | 31.6K | $314.6K | $47.1K | Cut−$135.5K |
| Vanguard Personalized Indexing Management, LLC | 31.6K | $314.2K | $41.1K | Added$80.9K |
| Vanguard Investments Australia, Ltd. | 30.1K | $299.7K | — | Held |
| CITIGROUP INC | 29.8K | $296.1K | $44.3K | Added$34.4K |
| OP Asset Management Ltd | 29.2K | $290.7K | — | New |
| Pallas Capital Advisors LLC | 28.6K | $284.3K | $37.4K | Added$71.8K |
| ProShare Advisors LLC | 28.4K | $282.7K | $42.3K | Added$181 |
| Fiduciary Trust Co | 28K | $278.3K | $41.7K | Added$41.7K |
| KLP KAPITALFORVALTNING AS | 27.2K | $270.6K | $36.8K | Added$61.7K |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 25.8K | $256.8K | $38.5K | Added$38.5K |
| NOMURA HOLDINGS INC | 25K | $248.8K | — | New |
| Cerity Partners LLC | 24.2K | $240.7K | $31.4K | Added$62.7K |
| OXFORD ASSET MANAGEMENT LLP | 22.5K | $224.1K | — | New |
| Aigen Investment Management, LP | 22.1K | $219.6K | — | New |
| Erste Asset Management GmbH | 23.1K | $216K | $21.7K | Added$21.7K |
| Amundi | 21.4K | $212.7K | — | New |
| PRUDENTIAL FINANCIAL INC | 21.4K | $212.4K | — | New |
| Quantinno Capital Management LP | 21.2K | $210.8K | $25.7K | Added$64.7K |
| Quadrature Capital Ltd | 21.1K | $210.2K | — | New |
| Merit Financial Group, LLC | 21K | $208.9K | $30.5K | Added$35.6K |
| Pictet Asset Management Holding SA | 19.6K | $194.9K | $22.4K | Added$67.6K |
| E Fund Management Co., Ltd. | 18.9K | $188.4K | — | Held |
| Abel Hall, LLC | 18.2K | $181.5K | $19.3K | Added$71.6K |
| Callan Family Office, LLC | 17.9K | $178K | $26.7K | Added$4.31K |
| Y-Intercept (Hong Kong) Ltd | 17.5K | $174.3K | — | New |
| Russell Investments Group, Ltd. | 16.8K | $167.6K | $18.6K | Added$62.1K |
| MERCER GLOBAL ADVISORS INC /ADV | 16.4K | $163.4K | $19.1K | Added$54.8K |
| Persistent Asset Partners Ltd | 16.4K | $162.8K | — | New |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 15.9K | $157.9K | $23.6K | Added$10.1K |
| DNB Asset Management AS | 15.8K | $157.3K | — | New |
| MIRABELLA FINANCIAL SERVICES LLP | 15.1K | $150.5K | — | New |
| AssuredPartners Investment Advisors, LLC | 12.1K | $150.2K | $48.1K | Added$13.8K |
| FOX RUN MANAGEMENT, L.L.C. | 15.3K | $142.9K | $13.6K | Cut−$366.4K |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 13.9K | $138K | — | New |
| XPONANCE LLC | 12.9K | $127.9K | $16.4K | Added$34.8K |
| GABELLI FUNDS LLC | 12K | $119.4K | — | New |
| QUADRANT CAPITAL GROUP LLC | 11.8K | $117.3K | $17.6K | Added$17.6K |
| Focus Partners Advisor Solutions, LLC | 11.6K | $115.1K | $15.3K | Added$24.9K |
| Duncan Williams Asset Management, LLC | 11.4K | $113.8K | $16.7K | Added$13.9K |
| Ameritas Investment Partners, Inc. | 11.2K | $111.2K | $16.7K | Added$16.7K |
| 49 WEALTH MANAGEMENT, LLC | 11K | $109.7K | $16.4K | Added$13.3K |
| Plante Moran Financial Advisors, LLC | 10.8K | $107.8K | $13.1K | Added$33.7K |
| Focus Partners Wealth | 10.8K | $107K | $16K | Cut−$39.6K |
| HighTower Advisors, LLC | 10.7K | $106.8K | — | New |
| Tower Research Capital LLC (TRC) | 10.7K | $106.7K | $1.01K | Added$100.9K |
| EP Wealth Advisors, LLC | 10.4K | $103.8K | $15.5K | Cut−$1.95K |
| NEUBERGER BERMAN GROUP LLC | 10K | $100K | — | New |
| PORTLAND INVESTMENT COUNSEL INC. | 10K | $99.5K | $14.9K | Added$14.9K |
| Mirae Asset Global Investments Co., Ltd. | 9.32K | $92.8K | $12.5K | Added$21.5K |
| Steward Partners Investment Advisory, LLC | 8.1K | $80.6K | $12.1K | Added$5.3K |
| GROUP ONE TRADING LLC | 6.64K | $66K | $9.89K | Cut−$178.9K |
| Essential Partners LLC | 5.36K | $53.3K | $7.97K | Added$8.09K |
| US BANCORP \DE\ | 5.23K | $52.1K | $7.65K | Added$8.65K |
| Sterling Capital Management LLC | 4.67K | $46.4K | $6.95K | Cut−$22.2K |
| Farther Finance Advisors, LLC | 4.3K | $46.3K | $9.56K | Added$11.3K |
| PNC Financial Services Group, Inc. | 4.49K | $44.7K | $6.69K | Added$5.74K |
| Smartleaf Asset Management LLC | 4.42K | $41.3K | $4.41K | Added$4.32K |
| NISA INVESTMENT ADVISORS, LLC | 3.88K | $38.6K | $3.09K | Added$21.1K |
| GF FUND MANAGEMENT CO. LTD. | 3.88K | $38.6K | $5.07K | Added$9.75K |
| SIGNATUREFD, LLC | 3.12K | $31.1K | $4.65K | Added$4.66K |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 2.99K | $29.7K | $7.8K | Cut−$322.4K |
| EverSource Wealth Advisors, LLC | 2.88K | $28.6K | $3.3K | Added$9.91K |
| Caitong International Asset Management Co., Ltd | 2.79K | $27.8K | $4.16K | Cut−$87.6K |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 2.45K | $24.4K | $17.6K | Added$24.4K |
| Rockefeller Capital Management L.P. | 2.26K | $22.5K | $676 | Added$18.7K |
| HAGER INVESTMENT MANAGEMENT SERVICES, LLC | 2.18K | $21.7K | $3.24K | Added$3.25K |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.92M | $19.2K | $2.45K | Added$5.23K |
| Allworth Financial LP | 1.73K | $17.2K | $1.99K | Added$5.92K |
| Advisory Services Network, LLC | 1.7K | $16.9K | — | New |
| SBI Securities Co., Ltd. | 1.46K | $14.6K | $2.17K | Added$2.27K |
| Kemnay Advisory Services Inc. | 1.45K | $14.4K | — | New |
| Parallel Advisors, LLC | 1.24K | $12.3K | $1.77K | Added$2.25K |
| GAMMA Investing LLC | 1.17K | $11.6K | $527 | Added$8.61K |
| Quantbot Technologies LP | 1.05K | $10.5K | — | New |
| WEBSTER BANK, N. A. | 1K | $9.95K | $1.49K | Added$1.49K |
| MAI Capital Management | 743 | $7.39K | $269 | Added$5.86K |
| UMB Bank, n.a. | 735 | $7.31K | $1.1K | Added$1.09K |
| Red Tortoise LLC | 698 | $6.95K | $1.04K | Added$1.04K |
| Keating Financial Advisory Services, Inc. | 679 | $6.76K | $1.01K | Added$1.01K |
| FIFTH THIRD BANCORP | 664 | $6.61K | — | New |
| IFP Advisors, Inc | 576 | $5.73K | $858 | Added$858 |
| ROTHSCHILD INVESTMENT LLC | 540 | $5.37K | $699 | Added$1.41K |
| Versant Capital Management, Inc | 493 | $4.91K | $734 | Added$734 |
| BESSEMER GROUP INC | 457.9K | $4.56K | $682 | Added$682 |
| Fortitude Family Office, LLC | 405 | $4.03K | $449 | Added$1.48K |
| JONES FINANCIAL COMPANIES LLLP | 350 | $3.36K | $175 | Added$2.06K |
| ACADIAN ASSET MANAGEMENT LLC | 290.4K | $2.89K | $430 | Cut−$976 |
| True Wealth Design, LLC | 278 | $2.77K | $415 | Added$415 |
| Arax Advisory Partners | 227 | $2.26K | $28 | Added$2.1K |
| SG Americas Securities, LLC | 197.5K | $1.97K | $294 | Added$96 |
| Cornerstone Financial Management LLC | 162 | $1.61K | $241 | Added$241 |
| Parkside Financial Bank & Trust | 129 | $1.28K | $192 | Added$192 |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 93 | $1K | $215 | Added$215 |
| ROYAL BANK OF CANADA | 146 | $1K | −$259 | Cut−$34K |
| Your Advocates Ltd., LLP | 100 | $995 | $149 | Added$149 |
| Root Financial Partners, LLC | 93 | $925 | — | New |
| Hughes Financial Services, LLC | 87 | $866 | $130 | Cut−$978 |
| DekaBank Deutsche Girozentrale | 60K | $591 | $59 | Added$59 |
| Sunbelt Securities, Inc. | 52 | $517 | $77 | Added$77 |
| ALGERT GLOBAL LLC | 48.5K | $483 | $73 | Cut−$756 |
| Clearstead Advisors, LLC | 23 | $225 | $32 | Cut−$60 |
| Transamerica Financial Advisors, LLC | 13 | $129 | $19 | Added$19 |
| CANADA LIFE ASSURANCE Co | 8.62K | $86 | $13 | Added$13 |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 5.89K | $59 | $9 | Added$9 |
| FNY Investment Advisers, LLC | 5K | $49 | $7 | Added$7 |
| KBC Group NV | 3.45K | $34 | — | New |
| JPL Wealth Management, LLC | 3 | $30 | — | New |
| Avion Wealth | 136 | $1 | $0 | Held |
| Covestor Ltd | 17 | $0 | $0 | Held |