| Fidelity | 7.17M | $224.3M | $6.76M | Added$8.54M |
| TRV GP V, LLC | 7.14M | $223.3M | $6.78M | Added$6.78M |
| ARCH Venture Management, LLC | 3.73M | $116.7M | $3.54M | Added$3.54M |
| Capital International Investors | 3.1M | $96.9M | $2.94M | Cut−$6.3M |
| Cormorant Asset Management, LP | 2.96M | $92.5M | $2.81M | Added$685.8K |
| GOLDMAN SACHS GROUP INC | 2.94M | $92.1M | $2.8M | Added$986K |
| BlackRock, Inc. | 2.51M | $78.4M | $2.31M | Added$4.63M |
| Sofinnova Investments, Inc. | 1.9M | $59.6M | $1.81M | Added$1.81M |
| JOHNSON & JOHNSON | 1.78M | $55.8M | $1.7M | Added$1.7M |
| Polar Capital Holdings Plc | 1.64M | $51.4M | $954.5K | Added$20.9M |
| BAKER BROS. ADVISORS LP | 1.55M | $48.4M | $1.47M | Added$1.47M |
| Vestal Point Capital, LP | 1.44M | $44.9M | $1.05M | Added$11.3M |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.33M | $41.5M | — | Held |
| TRV GP VI, LLC | 969.2K | $30.3M | $920.8K | Added$920.8K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 918.9K | $28.8M | $872.9K | Cut−$143.6K |
| State Street | 759.6K | $23.8M | $679.1K | Added$2.08M |
| GEODE CAPITAL MANAGEMENT, LLC | 721.6K | $22.6M | $660.3K | Added$1.5M |
| ALLIANCEBERNSTEIN L.P. | 727.8K | $22.1M | $0 | Cut−$1.84M |
| PERCEPTIVE ADVISORS LLC | 673.9K | $21.1M | $640.2K | Added$640.2K |
| Siren, L.L.C. | 641.5K | $20.1M | $609.4K | Cut−$1.42M |
| Capital World Investors | 536.6K | $16.8M | — | New |
| Sio Capital Management, LLC | 366.8K | $11.5M | $176K | Added$5.86M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 320.9K | $10M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 319.6K | $10M | $191.7K | Added$3.88M |
| KENNEDY CAPITAL MANAGEMENT LLC | 257.4K | $8.06M | $169.8K | Added$2.63M |
| BURKEHILL GLOBAL MANAGEMENT, LP | 250K | $7.82M | $237.5K | Added$237.5K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 239.9K | $7.51M | $227.9K | Added$92.2K |
| NORTHERN TRUST CORP | 238K | $7.45M | $209.8K | Added$747.2K |
| DIMENSIONAL FUND ADVISORS LP | 224.5K | $7.02M | $79.3K | Added$4.49M |
| Ensign Peak Advisors, Inc | 194.2K | $6.08M | $184.5K | Added$184.5K |
| VANGUARD FIDUCIARY TRUST CO | 189.3K | $5.92M | — | Held |
| Candriam S.C.A. | 185.9K | $5.82M | — | New |
| D. E. Shaw & Co., Inc. | 175.4K | $5.49M | $166.7K | Cut−$2.01M |
| Invesco Ltd. | 171.8K | $5.37M | $163.2K | Cut−$2.73M |
| MORGAN STANLEY | 166K | $5.19M | $157.7K | Cut−$1.19M |
| UBS Group AG | 151.8K | $4.75M | $144.2K | Cut−$2.12M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 150K | $4.69M | $142.5K | Added$142.5K |
| Artia Global Partners LP | 138.5K | $4.33M | $131.6K | Added$131.6K |
| Freestone Grove Partners LP | 127.8K | $4M | — | New |
| PRUDENTIAL FINANCIAL INC | 114.8K | $3.59M | $109.1K | Cut−$4.14M |
| Swedbank AB | 113.2K | $3.54M | $107.5K | Added$107.5K |
| BANK OF AMERICA CORP /DE/ | 110.8K | $3.47M | $32.8K | Added$2.42M |
| TD Asset Management Inc | 99.1K | $3.1M | $94.1K | Cut−$394.7K |
| CITIGROUP INC | 78.8K | $2.47M | $53.7K | Added$751.9K |
| WELLINGTON MANAGEMENT GROUP LLP | 78.2K | $2.45M | $53.6K | Added$734.9K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 75.4K | $2.36M | $51.9K | Cut−$49.1K |
| DAFNA Capital Management LLC | 75K | $2.35M | $71.2K | Added$71.3K |
| VOYA INVESTMENT MANAGEMENT LLC | 72.9K | $2.28M | $62.8K | Added$275.6K |
| Bank of New York Mellon Corp | 72.3K | $2.26M | $68.7K | Added$15.2K |
| Nuveen, LLC | 71.5K | $2.24M | $67.4K | Added$85K |
| Swiss National Bank | 56.5K | $1.77M | $51.9K | Added$111.3K |
| AMERICAN CENTURY COMPANIES INC | 56.3K | $1.76M | $44.5K | Added$340K |
| XTX Topco Ltd | 47.9K | $1.5M | $12.4K | Added$1.1M |
| ALPS ADVISORS INC | 38.9K | $1.22M | $37K | Added$29.9K |
| BNP PARIBAS FINANCIAL MARKETS | 36K | $1.12M | $11.7K | Added$750.1K |
| Y-Intercept (Hong Kong) Ltd | 35.8K | $1.12M | — | New |
| RHUMBLINE ADVISERS | 34.5K | $1.08M | $29.2K | Added$148.3K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 33.4K | $1.05M | $25.4K | Added$236.1K |
| Russell Investments Group, Ltd. | 32.9K | $1.03M | $2.17K | Added$960.8K |
| SEI INVESTMENTS CO | 30.8K | $964.3K | $17.4K | Added$410.1K |
| TWO SIGMA INVESTMENTS, LP | 28.1K | $879.3K | $26.7K | Cut−$656.4K |
| SECTORAL ASSET MANAGEMENT INC | 25.4K | $835K | $63.7K | Cut−$346K |
| Icahn Capital | 25.5K | $798.2K | $19.8K | Added$164.8K |
| DEUTSCHE BANK AG\ | 24.2K | $756.2K | $20.5K | Added$102.9K |
| STATE OF WISCONSIN INVESTMENT BOARD | 23.9K | $748.3K | $7.88K | Added$496.5K |
| Susquehanna Portfolio Strategies, LLC | 22.8K | $712.9K | $6.68K | Added$499.6K |
| Trexquant Investment LP | 21K | $656.6K | $19.9K | Cut−$1.25M |
| VANGUARD ASSET MANAGEMENT, Ltd | 18.5K | $579.9K | — | Held |
| Vanguard Global Advisers, LLC | 17.2K | $539.4K | — | Held |
| Legal & General Group Plc | 17.2K | $536.7K | $16.3K | Cut−$142.4K |
| MetLife Investment Management, LLC | 16K | $500.5K | $15.2K | Added$15.2K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 15.7K | $490.4K | $9.7K | Added$180.7K |
| Creative Planning | 15.5K | $485.6K | $11.6K | Added$115.1K |
| VARCOV Co. | 15.5K | $484.1K | — | New |
| Optimize Financial Inc | 14.7K | $458.6K | — | New |
| AMERIPRISE FINANCIAL INC | 14.6K | $456.4K | $13.9K | Added$7.51K |
| JPMORGAN CHASE & CO | 15.8K | $438.8K | −$40.1K | Cut−$20.2K |
| PSP Research LLC | 14K | $438.1K | $13.3K | Cut−$93.1K |
| JANUS HENDERSON GROUP PLC | 13.8K | $432.8K | $14.1K | Added$14.1K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13.6K | $426.1K | $12.6K | Added$24.1K |
| Allianz Asset Management GmbH | 13.2K | $413K | $12.5K | Added$12.5K |
| China Universal Asset Management Co., Ltd. | 12.1K | $377.3K | $10.2K | Added$50.7K |
| Walleye Capital LLC | 11.1K | $348.8K | — | New |
| WELLS FARGO & COMPANY/MN | 11.1K | $347.8K | $10.6K | Cut−$626.4K |
| NEW YORK STATE COMMON RETIREMENT FUND | 11K | $344.2K | $6.93K | Added$122.7K |
| Soleus Capital Management, L.P. | 10K | $312.9K | — | New |
| CATALYST PRIVATE WEALTH, LLC | 10K | $312.9K | $9.5K | Added$9.5K |
| State of New Jersey Common Pension Fund D | 9.77K | $305.8K | — | New |
| Renaissance Technologies | 9.7K | $303.5K | $9.21K | Cut−$3.3M |
| BARCLAYS PLC | 9.61K | $300.7K | $9.13K | Cut−$1.29M |
| CLEAR WAVE WEALTH MANAGEMENT LLC | 9.5K | $297.3K | — | Held |
| STIFEL FINANCIAL CORP | 9.02K | $282.3K | $6.48K | Added$75.3K |
| Virtus Investment Advisers, LLC | 9.01K | $281.8K | $8.35K | Added$15.2K |
| ARIZONA STATE RETIREMENT SYSTEM | 7.85K | $245.8K | $7.34K | Added$11.3K |
| Verition Fund Management LLC | 7.53K | $235.6K | — | New |
| Police & Firemen's Retirement System of New Jersey | 7.47K | $233.8K | $7.1K | Added$7.1K |
| Vanguard Investments Australia, Ltd. | 7.26K | $227.1K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 7.04K | $220.1K | $6.68K | Cut−$23.4K |
| Allspring Global Investments Holdings, LLC | 6.87K | $214.9K | — | New |
| MANGROVE PARTNERS IM, LLC | 6.75K | $211.3K | — | New |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 6.61K | $206.9K | — | New |
| Quantbot Technologies LP | 6.49K | $203.2K | — | New |
| AlphaCentric Advisors LLC | 6.44K | $201.4K | $5.73K | Added$18.5K |
| ProShare Advisors LLC | 6.39K | $200.1K | $6.08K | Cut−$21.7K |
| KLP KAPITALFORVALTNING AS | 5.9K | $184.6K | $5.6K | Added$5.61K |
| Tower Research Capital LLC (TRC) | 3.79K | $118.7K | $409 | Added$105.6K |
| Mirae Asset Global Investments Co., Ltd. | 2.49K | $77.8K | $2.2K | Added$7.52K |
| Ameritas Investment Partners, Inc. | 2.31K | $72.3K | $2.19K | Added$2.19K |
| STRS OHIO | 2.1K | $65.7K | $1.99K | Added$2K |
| CWM, LLC | 1.48K | $46.2K | $45.9K | Added$46.1K |
| NISA INVESTMENT ADVISORS, LLC | 1.35K | $42.3K | $1.28K | Added$1.28K |
| Tidemark, LLC | 1.09K | $34K | $1.03K | Added$1.03K |
| GF FUND MANAGEMENT CO. LTD. | 1.07K | $33.5K | $888 | Added$5.11K |
| Sterling Capital Management LLC | 975 | $30.5K | $926 | Cut−$19.3K |
| PRICE T ROWE ASSOCIATES INC /MD/ | 866.5K | $27.1K | $823 | Added$363 |
| T. Rowe Price Investment Management, Inc. | 620.6K | $19.4K | $588 | Added$637 |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 582 | $18.2K | $13.1K | Added$18.2K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 513 | $16.1K | — | New |
| GAMMA Investing LLC | 378 | $11.8K | $326 | Added$1.45K |
| SIMPLEX TRADING, LLC | 344 | $10.8K | $26 | Added$9.94K |
| ROYAL BANK OF CANADA | 225 | $7K | $250 | Cut−$26K |
| SIGNATUREFD, LLC | 205 | $6.41K | $194 | Cut−$413 |
| Optiver Holding B.V. | 204 | $6.38K | $69 | Added$4.2K |
| Caitong International Asset Management Co., Ltd | 197 | $6.16K | — | New |
| MassMutual Private Wealth & Trust, FSB | 163 | $5.1K | $152 | Added$215 |
| EverSource Wealth Advisors, LLC | 147 | $4.6K | $108 | Added$1.11K |
| FEDERATED HERMES, INC. | 143 | $4.47K | $52 | Added$2.81K |
| OSAIC HOLDINGS, INC. | 116 | $3.63K | $9 | Added$3.36K |
| Larson Financial Group LLC | 102 | $3.19K | $79 | Added$674 |
| SBI Securities Co., Ltd. | 63 | $1.97K | $60 | Added$60 |
| QUADRANT CAPITAL GROUP LLC | 57 | $1.78K | $54 | Added$54 |
| Cornerstone Financial Management LLC | 49 | $1.53K | $46 | Added$46 |
| PNC Financial Services Group, Inc. | 48 | $1.5K | $45 | Added$76 |
| True Wealth Design, LLC | 44 | $1.38K | $42 | Added$42 |
| Essential Partners LLC | 40 | $1.25K | $38 | Added$38 |
| Versant Capital Management, Inc | 27 | $845 | — | New |
| ROTHSCHILD INVESTMENT LLC | 20 | $626 | — | New |
| ACADIAN ASSET MANAGEMENT LLC | 11.8K | $367 | $10 | Cut−$973 |
| Sunbelt Securities, Inc. | 11 | $344 | $10 | Added$10 |
| GSA CAPITAL PARTNERS LLP | 9.93K | $311 | $10 | Cut−$75 |
| MAI Capital Management | 6 | $188 | — | New |
| US BANCORP \DE\ | 5 | $156 | — | New |
| Allworth Financial LP | 4 | $126 | — | New |
| SG Americas Securities, LLC | 3.78K | $118 | $4 | Cut−$175 |
| IFP Advisors, Inc | 3 | $94 | $3 | Added$3 |
| KBC Group NV | 962 | $30 | — | New |
| Covestor Ltd | 5 | $0 | — | New |