| TRV GP V, LLC | 7.14M | $216.5M | — | Held |
| Fidelity | 7.11M | $215.8M | — | Held |
| ARCH Venture Management, LLC | 3.73M | $113.1M | — | Held |
| Capital International Investors | 3.4M | $103.2M | — | Held |
| Cormorant Asset Management, LP | 3.03M | $91.9M | — | Held |
| GOLDMAN SACHS GROUP INC | 3M | $91.1M | — | Held |
| BlackRock, Inc. | 2.43M | $73.8M | — | Held |
| Sofinnova Investments, Inc. | 1.9M | $57.8M | — | Held |
| Vanguard | 1.82M | $55.2M | — | Held |
| JOHNSON & JOHNSON | 1.78M | $54.1M | $1.14M | Added$1.14M |
| BAKER BROS. ADVISORS LP | 1.55M | $46.9M | — | Held |
| Vestal Point Capital, LP | 1.11M | $33.7M | — | Held |
| Polar Capital Holdings Plc | 1M | $30.5M | — | Held |
| TRV GP VI, LLC | 969.2K | $29.4M | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 952.4K | $28.9M | — | Held |
| ALLIANCEBERNSTEIN L.P. | 788.4K | $23.9M | — | Held |
| State Street | 714.8K | $21.7M | — | Held |
| Siren, L.L.C. | 708.5K | $21.5M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 694.7K | $21.1M | — | Held |
| PERCEPTIVE ADVISORS LLC | 673.9K | $20.4M | — | Held |
| Invesco Ltd. | 267.1K | $8.1M | — | Held |
| PRUDENTIAL FINANCIAL INC | 255K | $7.74M | — | Held |
| BURKEHILL GLOBAL MANAGEMENT, LP | 250K | $7.58M | — | Held |
| D. E. Shaw & Co., Inc. | 247.3K | $7.5M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 244.4K | $7.41M | — | Held |
| UBS Group AG | 226.4K | $6.87M | — | Held |
| NORTHERN TRUST CORP | 220.8K | $6.7M | — | Held |
| MORGAN STANLEY | 210.3K | $6.38M | $134.6K | Cut−$1.77M |
| MILLENNIUM MANAGEMENT LLC | 201.8K | $6.12M | — | Held |
| Ensign Peak Advisors, Inc | 194.2K | $5.89M | — | Held |
| Sio Capital Management, LLC | 185.3K | $5.62M | — | Held |
| KENNEDY CAPITAL MANAGEMENT LLC | 178.7K | $5.42M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 150K | $4.55M | — | Held |
| Artia Global Partners LP | 138.5K | $4.2M | — | Held |
| Renaissance Technologies | 118.8K | $3.6M | — | Held |
| TD Asset Management Inc | 115.2K | $3.49M | — | Held |
| Swedbank AB | 113.2K | $3.43M | — | Held |
| Informed Momentum Co LLC | 85.6K | $2.6M | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 83.5K | $2.53M | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 78.7K | $2.41M | — | Held |
| DAFNA Capital Management LLC | 75K | $2.28M | — | Held |
| Bank of New York Mellon Corp | 74.1K | $2.25M | — | Held |
| Nuveen, LLC | 70.9K | $2.15M | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 66.1K | $2.01M | — | Held |
| Trexquant Investment LP | 63K | $1.91M | — | Held |
| Eversept Partners, LP | 59.2K | $1.8M | — | Held |
| CITIGROUP INC | 56.5K | $1.71M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 56.5K | $1.71M | — | Held |
| Swiss National Bank | 54.6K | $1.66M | — | Held |
| BARCLAYS PLC | 52.5K | $1.59M | $17.1K | Added$798.9K |
| TWO SIGMA INVESTMENTS, LP | 50.6K | $1.54M | — | Held |
| AMERICAN CENTURY COMPANIES INC | 46.8K | $1.42M | — | Held |
| ALPS ADVISORS INC | 39.1K | $1.19M | — | Held |
| SECTORAL ASSET MANAGEMENT INC | 38.9K | $1.18M | — | Held |
| ExodusPoint Capital Management, LP | 34.7K | $1.05M | — | Held |
| BANK OF AMERICA CORP /DE/ | 34.6K | $1.05M | $22.1K | Cut−$676.1K |
| WELLS FARGO & COMPANY/MN | 32.1K | $974.2K | — | Held |
| RHUMBLINE ADVISERS | 30.7K | $932.2K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 26.7K | $809.8K | — | Held |
| Legal & General Group Plc | 22.4K | $679.1K | — | Held |
| DEUTSCHE BANK AG\ | 21.5K | $653.4K | — | Held |
| DARK FOREST CAPITAL MANAGEMENT LP | 21.1K | $639.4K | — | Held |
| Icahn Capital | 20.9K | $633.4K | — | Held |
| SEI INVESTMENTS CO | 18.3K | $554.3K | — | Held |
| PSP Research LLC | 17.5K | $531.1K | — | Held |
| Brevan Howard Capital Management LP | 16.8K | $509.2K | — | Held |
| MetLife Investment Management, LLC | 16K | $485.3K | — | Held |
| JPMORGAN CHASE & CO | 15.1K | $459K | — | Held |
| AMERIPRISE FINANCIAL INC | 14.8K | $448.9K | — | Held |
| JANUS HENDERSON GROUP PLC | 13.8K | $418.7K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13.2K | $402K | — | Held |
| Allianz Asset Management GmbH | 13.2K | $400.5K | — | Held |
| XTX Topco Ltd | 13.1K | $396.3K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 12.4K | $374.8K | — | Held |
| Creative Planning | 12.2K | $370.5K | — | Held |
| China Universal Asset Management Co., Ltd. | 10.8K | $326.6K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 10.2K | $309.7K | — | Held |
| CATALYST PRIVATE WEALTH, LLC | 10K | $303.4K | — | Held |
| SILVERARC CAPITAL MANAGEMENT, LLC | 9.66K | $293.1K | — | Held |
| CANADA PENSION PLAN INVESTMENT BOARD | 9.1K | $276.1K | — | Held |
| PROFUND ADVISORS LLC | 8.88K | $269.4K | — | Held |
| Quadrature Capital Ltd | 8.84K | $268.1K | — | Held |
| Virtus Investment Advisers, LLC | 8.79K | $266.7K | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 8.3K | $251.7K | — | Held |
| Citadel | 8.1K | $245.7K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 8.03K | $243.5K | — | Held |
| Squarepoint Ops LLC | 7.86K | $238.4K | — | Held |
| Rafferty Asset Management, LLC | 7.8K | $236.7K | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 7.73K | $234.4K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 7.47K | $226.7K | — | Held |
| ProShare Advisors LLC | 7.31K | $221.7K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 7.3K | $221.5K | — | Held |
| Susquehanna Portfolio Strategies, LLC | 7.03K | $213.3K | — | Held |
| STIFEL FINANCIAL CORP | 6.82K | $207K | — | Held |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 6.59K | $200.1K | — | Held |
| AlphaCentric Advisors LLC | 6.03K | $182.9K | — | Held |
| Sandia Investment Management LP | 6K | $182K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 6.69K | $179.8K | — | Held |
| KLP KAPITALFORVALTNING AS | 5.9K | $179K | — | Held |
| AlphaQuest LLC | 3.75K | $113.9K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 2.32K | $70.3K | — | Held |
| Ameritas Investment Partners, Inc. | 2.31K | $70.1K | — | Held |
| Russell Investments Group, Ltd. | 2.28K | $69.2K | — | Held |
| STRS OHIO | 2.1K | $63.7K | — | Held |
| Sterling Capital Management LLC | 1.64K | $49.8K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 1.35K | $41K | — | Held |
| MEEDER ASSET MANAGEMENT INC | 1.21K | $36.7K | — | Held |
| Tidemark, LLC | 1.09K | $33K | — | Held |
| ROYAL BANK OF CANADA | 1.1K | $33K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 935 | $28.4K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 881.6K | $26.7K | — | Held |
| T. Rowe Price Investment Management, Inc. | 619K | $18.8K | — | Held |
| Arax Advisory Partners | 500 | $15.2K | — | Held |
| Tower Research Capital LLC (TRC) | 430 | $13K | — | Held |
| GAMMA Investing LLC | 342 | $10.4K | — | Held |
| Aster Capital Management (DIFC) Ltd | 300 | $9.1K | — | Held |
| SIGNATUREFD, LLC | 225 | $6.83K | — | Held |
| MassMutual Private Wealth & Trust, FSB | 161 | $4.88K | — | Held |
| EverSource Wealth Advisors, LLC | 115 | $3.49K | — | Held |
| Larson Financial Group LLC | 83 | $2.52K | — | Held |
| Optiver Holding B.V. | 72 | $2.18K | — | Held |
| SBI Securities Co., Ltd. | 63 | $1.91K | — | Held |
| QUADRANT CAPITAL GROUP LLC | 57 | $1.73K | — | Held |
| FEDERATED HERMES, INC. | 55 | $1.67K | — | Held |
| Cornerstone Financial Management LLC | 49 | $1.49K | — | Held |
| PNC Financial Services Group, Inc. | 47 | $1.43K | — | Held |
| ACADIAN ASSET MANAGEMENT LLC | 44.3K | $1.34K | — | Held |
| True Wealth Design, LLC | 44 | $1.33K | — | Held |
| Essential Partners LLC | 40 | $1.21K | $26 | Added$26 |
| Global Retirement Partners, LLC | 40 | $1.21K | — | Held |
| SIMPLEX TRADING, LLC | 27 | $819 | — | Held |
| SageView Advisory Group, LLC | 16 | $486 | — | Held |
| Bare Financial Services, Inc | 16 | $485 | — | Held |
| GSA CAPITAL PARTNERS LLP | 12.7K | $386 | — | Held |
| Sunbelt Securities, Inc. | 11 | $334 | — | Held |
| SG Americas Securities, LLC | 9.67K | $293 | — | Held |
| OSAIC HOLDINGS, INC. | 9 | $273 | — | Held |
| IFP Advisors, Inc | 3 | $91 | $2 | Added$2 |
| CWM, LLC | 1.47K | $45 | — | Held |
| Farther Finance Advisors, LLC | 1 | $30 | — | Held |
| AMALGAMATED BANK | 894 | $27 | — | Held |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 420 | $13 | — | Held |
| Cygnus Capital Advisors, LLC | 341 | $10 | — | Held |
| Daiwa Securities Group Inc. | 121 | $4 | — | Held |