| Bain Capital Life Sciences Investors, LLC | 8.51M | $212.7M | — | Held |
| Paradigm Biocapital Advisors LP | 7.54M | $188.6M | — | Held |
| JANUS HENDERSON GROUP PLC | 6.71M | $167.9M | — | Held |
| BlackRock, Inc. | 5.56M | $139.1M | — | Held |
| BVF INC/IL | 5.3M | $132.4M | — | Held |
| Fidelity | 5.02M | $125.6M | — | Held |
| Vanguard | 3.56M | $89M | — | Held |
| Siren, L.L.C. | 3.3M | $82.5M | — | Held |
| Logos Global Management LP | 3.21M | $80.2M | — | Held |
| Cormorant Asset Management, LP | 2.75M | $68.8M | — | Held |
| RA CAPITAL MANAGEMENT, L.P. | 2.6M | $65M | — | Held |
| FRANKLIN RESOURCES INC | 2.48M | $61.9M | — | Held |
| LIGHTSPEED MANAGEMENT COMPANY, L.L.C. | 1.93M | $48.3M | — | Held |
| State Street | 1.88M | $47.1M | — | Held |
| Vestal Point Capital, LP | 1.65M | $41.3M | — | Held |
| Woodline Partners LP | 1.48M | $37M | — | Held |
| Polar Capital Holdings Plc | 1.38M | $34.5M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 1.26M | $31.4M | — | Held |
| Defilade Capital Management, L.P. | 1.23M | $30.9M | — | Held |
| Citadel | 1.2M | $30M | — | Held |
| SAMLYN CAPITAL, LLC | 1.07M | $26.7M | — | Held |
| JENNISON ASSOCIATES LLC | 964K | $24.1M | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 958.6K | $24M | — | Held |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 953.6K | $23.8M | — | Held |
| GOLDMAN SACHS GROUP INC | 817.9K | $20.4M | — | Held |
| Ikarian Capital, LLC | 758.7K | $19M | — | Held |
| Candriam S.C.A. | 679.5K | $17M | — | Held |
| Vivo Capital, LLC | 671.8K | $16.8M | — | Held |
| MORGAN STANLEY | 665.8K | $16.6M | $10.1M | Added$1.41M |
| First Turn Management, LLC | 617.7K | $15.4M | — | Held |
| EVENTIDE ASSET MANAGEMENT, LLC | 569K | $14.2M | — | Held |
| Holocene Advisors, LP | 506K | $12.7M | — | Held |
| Pictet Asset Management Holding SA | 502.6K | $12.6M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 498.5K | $12.5M | — | Held |
| Hennion & Walsh Asset Management, Inc. | 447K | $11.2M | — | Held |
| NORTHERN TRUST CORP | 445.3K | $11.1M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 407.1K | $10.2M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 393.7K | $9.84M | — | Held |
| MARSHALL WACE, LLP | 360.4K | $9.01M | — | Held |
| Squarepoint Ops LLC | 328.7K | $8.22M | — | Held |
| Point72 Asset Management, L.P. | 307.9K | $7.7M | — | Held |
| UBS Group AG | 293.6K | $7.34M | — | Held |
| Skandinaviska Enskilda Banken AB (publ) | 281.7K | $7.04M | — | Held |
| Birchview Capital, LP | 269K | $6.72M | — | Held |
| JPMORGAN CHASE & CO | 268.5K | $6.71M | — | Held |
| Catalio Capital Management, LP | 267.1K | $6.68M | — | Held |
| HighVista Strategies LLC | 241.5K | $6.04M | — | Held |
| BANK OF AMERICA CORP /DE/ | 238.9K | $5.97M | $3.63M | Cut−$1.88M |
| Nuveen, LLC | 229.5K | $5.74M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 221K | $5.52M | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 219.1K | $5.48M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 210K | $5.25M | — | Held |
| SILVERARC CAPITAL MANAGEMENT, LLC | 206.3K | $5.16M | — | Held |
| AMERIPRISE FINANCIAL INC | 204.6K | $5.12M | — | Held |
| Bank of New York Mellon Corp | 176.2K | $4.41M | — | Held |
| Balyasny Asset Management L.P. | 167.3K | $4.18M | — | Held |
| PERCEPTIVE ADVISORS LLC | 165.7K | $4.14M | — | Held |
| Invesco Ltd. | 155.7K | $3.89M | — | Held |
| ExodusPoint Capital Management, LP | 150.7K | $3.77M | — | Held |
| CITIGROUP INC | 147.4K | $3.68M | — | Held |
| Pier Capital, LLC | 140.1K | $3.5M | — | Held |
| TD Asset Management Inc | 136.4K | $3.41M | — | Held |
| BARCLAYS PLC | 133.1K | $3.33M | $1.59M | Added$2.3M |
| BURKEHILL GLOBAL MANAGEMENT, LP | 125K | $3.13M | — | Held |
| Susquehanna Portfolio Strategies, LLC | 121.3K | $3.03M | — | Held |
| Schonfeld Strategic Advisors LLC | 114K | $2.85M | — | Held |
| Brevan Howard Capital Management LP | 108K | $2.7M | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 102.3K | $2.56M | — | Held |
| Jump Financial, LLC | 100.3K | $2.51M | — | Held |
| Rock Springs Capital Management LP | 98.2K | $2.46M | — | Held |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 94.9K | $2.37M | — | Held |
| AMERICAN CENTURY COMPANIES INC | 93.9K | $2.35M | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 86.1K | $2.15M | — | Held |
| WELLS FARGO & COMPANY/MN | 84.1K | $2.1M | — | Held |
| ADAR1 Capital Management, LLC | 81.4K | $2.03M | — | Held |
| Icahn Capital | 81.2K | $2.03M | — | Held |
| RHUMBLINE ADVISERS | 74.4K | $1.86M | — | Held |
| Soleus Capital Management, L.P. | 69.9K | $1.75M | — | Held |
| Harvest Investment Services, LLC | 68.7K | $1.72M | — | Held |
| Nicholas Investment Partners, LP | 64.8K | $1.62M | — | Held |
| Creative Planning | 64.7K | $1.62M | — | Held |
| ALPS ADVISORS INC | 64.6K | $1.61M | — | Held |
| FRED ALGER MANAGEMENT, LLC | 64.5K | $1.61M | — | Held |
| DEUTSCHE BANK AG\ | 63.1K | $1.58M | — | Held |
| ALLIANCEBERNSTEIN L.P. | 62.6K | $1.57M | — | Held |
| Quantinno Capital Management LP | 61.3K | $1.53M | — | Held |
| LPL Financial LLC | 56.2K | $1.4M | — | Held |
| Swedbank AB | 55.1K | $1.38M | — | Held |
| ACT CAPITAL MANAGEMENT, LLC | 53.5K | $1.34M | — | Held |
| PORTLAND INVESTMENT COUNSEL INC. | 50K | $1.25M | — | Held |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 50K | $1.25M | — | Held |
| Trexquant Investment LP | 49.8K | $1.24M | — | Held |
| NEOS Investment Management LLC | 45.2K | $1.13M | — | Held |
| Rafferty Asset Management, LLC | 45K | $1.13M | — | Held |
| TEMA ETFS LLC | 44.5K | $1.11M | — | Held |
| RAYMOND JAMES FINANCIAL INC | 40.6K | $1.02M | — | Held |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 40.5K | $1.01M | — | Held |
| Y-Intercept (Hong Kong) Ltd | 37.2K | $930K | — | Held |
| Campbell & CO Investment Adviser LLC | 35.6K | $888.9K | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 34.9K | $873.5K | — | Held |
| MetLife Investment Management, LLC | 33.5K | $837.5K | — | Held |
| Verition Fund Management LLC | 33.4K | $834.5K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30.3K | $756.9K | — | Held |
| Jain Global LLC | 30.2K | $754K | — | Held |
| Ishara Investments LP | 30K | $750K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 28.2K | $705.9K | — | Held |
| PDT Partners, LLC | 27.4K | $684.2K | — | Held |
| Engineers Gate Manager LP | 26.2K | $655.2K | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 26K | $649.8K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 25.2K | $630K | — | Held |
| Renaissance Technologies | 25.1K | $626.7K | — | Held |
| Empire Financial Management Company, LLC | 25K | $625K | — | Held |
| AXQ CAPITAL, LP | 21.3K | $533.1K | — | Held |
| Shay Capital LLC | 21K | $525K | — | Held |
| Legal & General Group Plc | 20.5K | $512.3K | — | Held |
| Huntleigh Advisors, Inc. | 20.1K | $503.3K | — | Held |
| PSP Research LLC | 19.1K | $476.6K | — | Held |
| Scientech Research LLC | 17.5K | $436.9K | — | Held |
| PROFUND ADVISORS LLC | 17.4K | $434.5K | — | Held |
| Entropy Technologies, LP | 17.3K | $432.6K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 16.6K | $416K | — | Held |
| Aquatic Capital Management LLC | 15.3K | $382.9K | — | Held |
| Inscription Capital, LLC | 15.3K | $381.8K | — | Held |
| POLEN CAPITAL MANAGEMENT LLC | 15.2K | $380.1K | — | Held |
| ProShare Advisors LLC | 14.4K | $359.2K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 38.1K | $334.3K | — | Held |
| China Universal Asset Management Co., Ltd. | 13K | $325.4K | — | Held |
| Legato Capital Management LLC | 11.6K | $288.9K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 11.2K | $280.6K | — | Held |
| Cetera Investment Advisers | 10.5K | $262.5K | — | Held |
| STRS OHIO | 10.5K | $262.5K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 10.4K | $259.1K | — | Held |
| Blueshift Asset Management, LLC | 10.2K | $255.9K | — | Held |
| Wealthspire Advisors, LLC | 10.2K | $254.3K | — | Held |
| EP Wealth Advisors, LLC | 10K | $250.2K | — | Held |
| CONWAY CAPITAL MANAGEMENT, INC. | 10K | $250K | — | Held |
| D. E. Shaw & Co., Inc. | 9.95K | $248.8K | — | Held |
| Tower Research Capital LLC (TRC) | 9.94K | $248.4K | — | Held |
| OPPENHEIMER & CO INC | 9.5K | $237.5K | — | Held |
| Persistent Asset Partners Ltd | 9.07K | $226.7K | — | New |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 8.88K | $222K | — | Held |
| SEI INVESTMENTS CO | 8.26K | $206.5K | — | Held |
| Virtus Investment Advisers, LLC | 8.05K | $201.2K | — | Held |
| Quantbot Technologies LP | 8.05K | $201.2K | — | Held |
| ROYAL BANK OF CANADA | 6.7K | $167K | — | Held |
| SIMPLEX TRADING, LLC | 5.32K | $133K | — | Held |
| Ameritas Investment Partners, Inc. | 4.97K | $124.4K | — | Held |
| Russell Investments Group, Ltd. | 4.74K | $118.4K | — | Held |
| State of Wyoming | 4.68K | $116.9K | — | Held |
| Bellevue Group AG | 3.9K | $97.5K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 3.82K | $95.5K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 3.76K | $94.1K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3.67K | $91.7K | — | Held |
| FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A. | 3.5K | $87.5K | — | Held |
| Sterling Capital Management LLC | 3.44K | $86K | — | Held |
| Quarry LP | 3K | $75K | — | Held |
| Jefferies Financial Group Inc. | 3K | $75K | — | Held |
| Federation des caisses Desjardins du Quebec | 2K | $50K | — | Held |
| Torren Management, LLC | 1.76K | $44K | — | Held |
| AlphaQuest LLC | 1.69K | $42.3K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.55K | $38.6K | — | Held |
| EverSource Wealth Advisors, LLC | 1.25K | $31.1K | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 1.19K | $29.8K | — | Held |
| Versant Capital Management, Inc | 1.18K | $29.4K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.1M | $27.4K | — | Held |
| Truvestments Capital LLC | 838 | $20.9K | — | Held |
| GAMMA Investing LLC | 723 | $18.1K | — | Held |
| WOLFF WIESE MAGANA LLC | 600 | $15K | — | Held |
| Arax Advisory Partners | 564 | $14.1K | — | Held |
| PNC Financial Services Group, Inc. | 551 | $13.8K | — | Held |
| US BANCORP \DE\ | 538 | $13.4K | — | Held |
| OSAIC HOLDINGS, INC. | 474 | $11.8K | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 412 | $10.3K | — | Held |
| Physician Wealth Advisors, Inc. | 391 | $9.78K | — | Held |
| Allworth Financial LP | 372 | $9.3K | — | New |
| Steward Partners Investment Advisory, LLC | 360 | $9K | — | Held |
| Optiver Holding B.V. | 339 | $8.47K | — | Held |
| ROTHSCHILD INVESTMENT LLC | 227 | $5.67K | — | Held |
| Farther Finance Advisors, LLC | 180 | $4.5K | — | Held |
| Rockefeller Capital Management L.P. | 150 | $3.75K | — | Held |
| Parkside Financial Bank & Trust | 135 | $3.38K | — | Held |
| Greenline Wealth Management LLC | 111 | $2.77K | — | Held |
| SG Americas Securities, LLC | 69.4K | $1.74K | — | Held |
| True Wealth Design, LLC | 61 | $1.52K | — | Held |
| SBI Securities Co., Ltd. | 61 | $1.52K | — | Held |
| Atlantic Edge Private Wealth Management, LLC | 50 | $1.25K | — | Held |
| Clearstead Advisors, LLC | 43 | $1.07K | — | Held |
| Virtu Financial LLC | 42.4K | $1.06K | — | Held |
| HRT FINANCIAL LP | 40.3K | $1.01K | — | Held |
| Hurley Capital, LLC | 29 | $725 | — | Held |
| ACADIAN ASSET MANAGEMENT LLC | 19.1K | $477 | — | Held |
| CWM, LLC | 6.28K | $157 | — | Held |
| IFP Advisors, Inc | 6 | $150 | $91 | Added$91 |
| AMALGAMATED BANK | 1.87K | $47 | — | Held |
| Hughes Financial Services, LLC | 1 | $25 | — | Held |
| HUNTINGTON NATIONAL BANK | 1 | $25 | — | Held |
| Activest Wealth Management | 1 | $13 | — | Held |
| Daiwa Securities Group Inc. | 224 | $6 | — | Held |
| HAZLETT, BURT & WATSON, INC. | 50 | $1 | — | Held |
| Covestor Ltd | 16 | $0 | — | Held |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | $0 | — | Held |