| BVF INC/IL | 1.56M | $65.9M | — | Held |
| Vanguard | 1.03M | $43.4M | — | Held |
| Two Seas Capital LP | 745.2K | $31.5M | — | Held |
| BlackRock, Inc. | 645.6K | $27.3M | — | Held |
| ARMISTICE CAPITAL, LLC | 596K | $25.2M | — | Held |
| MORGAN STANLEY | 566.4K | $23.9M | −$8.28M | Cut−$28.9M |
| Prosight Management, LP | 554.6K | $23.4M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 473K | $20M | — | Held |
| Invesco Ltd. | 468.2K | $19.8M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 454.1K | $19.2M | — | Held |
| Sofinnova Investments, Inc. | 438.6K | $18.5M | — | Held |
| Point72 Asset Management, L.P. | 433.4K | $18.3M | — | Held |
| EMERALD ADVISERS, LLC | 384.3K | $16.2M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 383.3K | $16.2M | — | Held |
| 22NW, LP | 331.1K | $14M | — | Held |
| Qube Research & Technologies Ltd | 323.9K | $13.7M | — | Held |
| Citadel | 309.8K | $13.1M | — | Held |
| TWO SIGMA ADVISERS, LP | 308.4K | $13M | — | Held |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 295.7K | $12.5M | — | Held |
| UBS Group AG | 287.6K | $12.2M | — | Held |
| Balyasny Asset Management L.P. | 282K | $11.9M | — | Held |
| PRIMECAP MANAGEMENT CO/CA/ | 280.1K | $11.8M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 254.4K | $10.8M | — | Held |
| EMERALD MUTUAL FUND ADVISERS TRUST | 253.1K | $10.7M | — | Held |
| JANE STREET GROUP, LLC | 218.3K | $9.23M | — | Held |
| GREAT POINT PARTNERS LLC | 210.7K | $8.91M | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 210.3K | $8.89M | — | Held |
| GILDER GAGNON HOWE & CO LLC | 208.3K | $8.81M | — | Held |
| State Street | 195.7K | $8.27M | — | Held |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 188.1K | $7.95M | — | Held |
| Creek Drive Management Group LLC | 185.5K | $7.84M | — | Held |
| STEMPOINT CAPITAL LP | 178.3K | $7.54M | — | Held |
| Renaissance Technologies | 172.9K | $7.31M | — | Held |
| JPMORGAN CHASE & CO | 150.8K | $6.38M | — | Held |
| GOLDMAN SACHS GROUP INC | 147.8K | $6.25M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 120.4K | $5.09M | — | Held |
| Nantahala Capital Management, LLC | 112.9K | $4.78M | — | Held |
| Jefferies Financial Group Inc. | 111.9K | $4.73M | — | Held |
| Woodline Partners LP | 104K | $4.4M | — | Held |
| Connor, Clark & Lunn Investment Management Ltd. | 101.2K | $4.28M | — | Held |
| Fidelity | 101.1K | $4.28M | — | Held |
| ING GROEP NV | 100K | $4.23M | — | Held |
| Monashee Investment Management LLC | 94.1K | $3.98M | — | Held |
| DEUTSCHE BANK AG\ | 90.7K | $3.84M | — | Held |
| Quinn Opportunity Partners LLC | 85.9K | $3.63M | — | Held |
| Russell Investments Group, Ltd. | 85.7K | $3.62M | — | Held |
| Stonepine Capital Management, LLC | 85K | $3.59M | — | Held |
| Propel Bio Management, LLC | 82.8K | $3.5M | — | Held |
| DAFNA Capital Management LLC | 75K | $3.17M | — | Held |
| ADAR1 Capital Management, LLC | 72K | $3.05M | — | Held |
| Tetragon Partners GP Ltd | 69.3K | $2.93M | — | Held |
| Voleon Capital Management LP | 68.3K | $2.89M | — | Held |
| Nearwater Capital Markets, Ltd | 61.5K | $2.6M | — | Held |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 60.4K | $2.56M | — | Held |
| Hudson Bay Capital Management LP | 59.7K | $2.52M | −$872.7K | Cut−$3.6M |
| F/m Investments LLC | 58.1K | $2.46M | — | Held |
| NORTHERN TRUST CORP | 56.1K | $2.37M | — | Held |
| Moody Aldrich Partners LLC | 56K | $2.37M | — | Held |
| Aquatic Capital Management LLC | 55.2K | $2.34M | — | Held |
| FRED ALGER MANAGEMENT, LLC | 54K | $2.28M | — | Held |
| Jump Financial, LLC | 53.2K | $2.25M | — | Held |
| ACT CAPITAL MANAGEMENT, LLC | 51.2K | $2.16M | — | Held |
| NORGES BANK | 50K | $2.11M | — | New |
| DARK FOREST CAPITAL MANAGEMENT LP | 42.3K | $1.79M | — | Held |
| Headlands Technologies LLC | 41.2K | $1.74M | — | Held |
| AWM Investment Company, Inc. | 40K | $1.69M | — | Held |
| Deuterium Capital Management, LLC | 37.3K | $1.58M | — | Held |
| Engineers Gate Manager LP | 37.3K | $1.58M | — | Held |
| CITIGROUP INC | 35.8K | $1.51M | — | Held |
| Caption Management, LLC | 35K | $1.48M | — | Held |
| Swiss National Bank | 31.9K | $1.35M | — | Held |
| SummitTX Capital, L.P. | 31.4K | $1.33M | — | Held |
| Birchview Capital, LP | 31K | $1.31M | — | Held |
| Erste Asset Management GmbH | 28K | $1.2M | — | Held |
| Simplify Asset Management Inc. | 28K | $1.18M | — | Held |
| KVP Capital Advisors, LP | 26.9K | $1.14M | — | Held |
| FOX RUN MANAGEMENT, L.L.C. | 26.5K | $1.12M | — | Held |
| BANK OF AMERICA CORP /DE/ | 26.1K | $1.1M | −$381.5K | Cut−$1.63M |
| MARSHALL WACE, LLP | 24K | $1.02M | — | Held |
| SIMPLEX TRADING, LLC | 21.9K | $927.5K | — | Held |
| BIT Capital GmbH | 21.1K | $892.1K | — | Held |
| Squarepoint Ops LLC | 20.3K | $856.5K | — | Held |
| Ishara Investments LP | 20K | $845.6K | — | Held |
| Trexquant Investment LP | 18.8K | $795.8K | — | Held |
| J. Goldman & Co LP | 18.4K | $775.9K | — | Held |
| Jain Global LLC | 17.3K | $731.4K | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 16.2K | $684.3K | — | Held |
| Susquehanna Portfolio Strategies, LLC | 16.1K | $678.9K | — | Held |
| Knott David M Jr | 15.5K | $655.3K | — | Held |
| BARCLAYS PLC | 15.4K | $653K | −$225.8K | Cut−$296.1K |
| Seven Fleet Capital Management LP | 15K | $634.2K | — | Held |
| Palumbo Wealth Management LLC | 14.7K | $622.1K | — | Held |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 14.6K | $615.8K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14.5K | $613.9K | — | Held |
| Gainplan LLC | 13.5K | $570.8K | — | Held |
| SECTORAL ASSET MANAGEMENT INC | 13.5K | $570.1K | — | Held |
| CIBC WORLD MARKET INC. | 13.3K | $561.6K | — | Held |
| Informed Momentum Co LLC | 13K | $548.5K | — | Held |
| Legal & General Group Plc | 12.4K | $524.8K | — | Held |
| HighVista Strategies LLC | 11.7K | $496.7K | — | Held |
| Y-Intercept (Hong Kong) Ltd | 10.9K | $459.2K | — | Held |
| SEI INVESTMENTS CO | 10.3K | $435.1K | — | Held |
| IRIDIAN ASSET MANAGEMENT LLC/CT | 9.73K | $411.3K | — | Held |
| HB Wealth Management, LLC | 9.24K | $390.8K | — | Held |
| Sigma Planning Corp | 9K | $380.5K | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 8.63K | $364.8K | — | Held |
| GLENMEDE TRUST CO NA | 8.59K | $363.2K | — | Held |
| JANUS HENDERSON GROUP PLC | 8.1K | $341.8K | — | Held |
| Leonteq Securities AG | 8K | $338.2K | — | New |
| WINTON GROUP Ltd | 7.76K | $328.3K | — | Held |
| OMERS ADMINISTRATION Corp | 7.2K | $304.4K | — | Held |
| XTX Topco Ltd | 7.2K | $304.2K | — | Held |
| Verition Fund Management LLC | 7.04K | $297.4K | — | Held |
| ROYAL BANK OF CANADA | 7K | $296K | — | Held |
| Tower Research Capital LLC (TRC) | 5.56K | $235.1K | — | Held |
| FORA Capital, LLC | 5.76K | $232.5K | — | Held |
| 49 WEALTH MANAGEMENT, LLC | 5.43K | $229.6K | — | Held |
| OSAIC HOLDINGS, INC. | 5.39K | $227.8K | — | Held |
| ENVESTNET ASSET MANAGEMENT INC | 5.38K | $227.6K | — | Held |
| OPAL CAPITAL LLC | 5.95K | $220.5K | — | Held |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 4.93K | $208.3K | — | Held |
| Virtus Investment Advisers, LLC | 4.86K | $205.6K | — | Held |
| KLP KAPITALFORVALTNING AS | 3.5K | $148K | — | Held |
| Bayforest Capital Ltd | 2.54K | $107.4K | — | Held |
| FLAGSHIP HARBOR ADVISORS, LLC | 2.18K | $92.1K | — | New |
| Quarry LP | 2K | $84.6K | — | Held |
| GROUP ONE TRADING LLC | 1.45K | $61.2K | — | Held |
| US BANCORP \DE\ | 1.26K | $53.3K | — | Held |
| Parallel Advisors, LLC | 1.05K | $44.5K | — | Held |
| NATIXIS | 685 | $29K | — | Held |
| Allworth Financial LP | 676 | $28.6K | −$9.88K | Cut−$9.88K |
| CANADA PENSION PLAN INVESTMENT BOARD | 400 | $16.9K | — | Held |
| Steward Partners Investment Advisory, LLC | 213 | $9.01K | — | Held |
| Activest Wealth Management | 200 | $8.46K | — | Held |
| Founders Capital Management | 200 | $8.46K | — | Held |
| HRT FINANCIAL LP | 198.1K | $8.38K | — | Held |
| WELLS FARGO & COMPANY/MN | 191 | $8.08K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 127 | $7.98K | — | Held |
| SBI Securities Co., Ltd. | 146 | $6.17K | — | Held |
| Farther Finance Advisors, LLC | 141 | $5.96K | — | Held |
| EverSource Wealth Advisors, LLC | 110 | $4.65K | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 109 | $4.61K | — | Held |
| CIBC Private Wealth Group LLC | 100 | $4.23K | — | Held |
| RHUMBLINE ADVISERS | 100 | $4.23K | — | Held |
| EFG International AG | 75 | $3.17K | — | Held |
| ACADIAN ASSET MANAGEMENT LLC | 72.2K | $3.05K | — | Held |
| SIGNATUREFD, LLC | 70 | $2.96K | — | Held |
| Keating Financial Advisory Services, Inc. | 69 | $2.92K | — | Held |
| MTM Investment Management, LLC | 66 | $2.79K | — | Held |
| BROWN BROTHERS HARRIMAN & CO | 66 | $2.79K | — | Held |
| SJS Investment Consulting Inc. | 58 | $2.45K | — | Held |
| Cambridge Investment Research Advisors, Inc. | 53.7K | $2.27K | — | Held |
| MassMutual Private Wealth & Trust, FSB | 45 | $1.9K | — | Held |
| ATLAS CAPITAL ADVISORS INC. | 40 | $1.69K | — | Held |
| Nova Wealth Management, Inc. | 40 | $1.69K | — | Held |
| Boreal Capital Management LLC | 36 | $1.52K | −$526 | Cut−$526 |
| Rachor Investment Advisory Services, LLC | 35 | $1.48K | — | Held |
| Global Retirement Partners, LLC | 27 | $1.14K | — | Held |
| GSA CAPITAL PARTNERS LLP | 23.1K | $977 | — | Held |
| Fortitude Family Office, LLC | 21 | $888 | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 20 | $846 | — | Held |
| ORG Partners LLC | 20 | $845 | — | Held |
| ALGERT GLOBAL LLC | 15.3K | $647 | — | Held |
| Virtu Financial LLC | 13.8K | $584 | — | Held |
| AMERIFLEX GROUP, INC. | 13 | $550 | — | Held |
| Medallion Wealth Advisors, LLC | 13 | $550 | −$190 | Cut−$190 |
| Kimelman & Baird, LLC | 13 | $550 | — | Held |
| SG Americas Securities, LLC | 11K | $463 | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10.4K | $439 | — | Held |
| Arlington Trust Co LLC | 6 | $254 | — | Held |
| FNY Investment Advisers, LLC | 5.2K | $219 | −$38 | Added$71 |
| Arax Advisory Partners | 2 | $85 | — | Held |
| DANSKE BANK A/S | 2 | $85 | $33 | Added$33 |
| Smartleaf Asset Management LLC | 2 | $84 | — | Held |
| BESSEMER GROUP INC | 1.58K | $66 | — | Held |
| LRI Investments, LLC | 1 | $42 | — | Held |
| Inspire Investing, LLC | 0 | $18 | — | Held |
| CWM, LLC | 205 | $9 | — | Held |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 178 | $8 | — | Held |
| HUNTINGTON NATIONAL BANK | 1 | $1 | — | Held |
| AMALGAMATED BANK | 1 | $0 | — | Held |
| Covestor Ltd | 0 | $0 | — | Held |