| SAMSARA BIOCAPITAL, LLC | 1.72M | $34.6M | −$755.5K | Cut−$755.5K |
| Redmile Group, LLC | 1.46M | $29.4M | −$642.2K | Cut−$642.2K |
| Casdin Capital, LLC | 1.42M | $28.6M | −$570K | Added$1.95M |
| RTW INVESTMENTS, LP | 1.36M | $27.5M | −$599.5K | Cut−$599.5K |
| EcoR1 Capital, LLC | 1.27M | $25.6M | −$559.4K | Cut−$559.4K |
| BlackRock, Inc. | 1.01M | $20.3M | −$416.1K | Added$783.2K |
| BAKER BROS. ADVISORS LP | 991.7K | $20M | −$436.3K | Cut−$436.3K |
| Trails Edge Capital Partners, LP | 782.8K | $15.8M | −$344.4K | Cut−$390K |
| Balyasny Asset Management L.P. | 718.4K | $14.5M | −$267.8K | Added$1.95M |
| TORONTO DOMINION BANK | 681.3K | $13.7M | −$299.8K | Cut−$299.8K |
| JENNISON ASSOCIATES LLC | 527.7K | $10.6M | −$232.2K | Cut−$343.5K |
| ArrowMark Colorado Holdings LLC | 524.8K | $10.6M | −$230.9K | Cut−$1.32M |
| VANGUARD CAPITAL MANAGEMENT LLC | 514.7K | $10.4M | — | Held |
| GREAT POINT PARTNERS LLC | 500K | $10.1M | −$154K | Added$2.87M |
| Citadel | 387K | $7.8M | −$160.3K | Added$299.4K |
| Fidelity | 382.6K | $7.71M | −$57.3K | Added$5.03M |
| State Street | 313K | $6.31M | −$135.4K | Cut−$30.4K |
| MORGAN STANLEY | 285.2K | $5.75M | −$125.5K | Cut−$1.9M |
| GEODE CAPITAL MANAGEMENT, LLC | 279K | $5.63M | −$109.6K | Added$481.3K |
| MILLENNIUM MANAGEMENT LLC | 204.8K | $4.13M | −$31.4K | Added$2.66M |
| UBS Group AG | 185.7K | $3.74M | −$67.8K | Added$568.4K |
| BLAIR WILLIAM & CO/IL | 168.2K | $3.39M | −$72K | Added$20K |
| GOLDMAN SACHS GROUP INC | 107.7K | $2.17M | −$47.4K | Cut−$1.17M |
| DEUTSCHE BANK AG\ | 106.3K | $2.14M | −$37.7K | Added$379.3K |
| Rock Springs Capital Management LP | 104.3K | $2.1M | −$45.9K | Cut−$45.9K |
| NORTHERN TRUST CORP | 97.6K | $1.97M | −$37.6K | Added$205.5K |
| Woodline Partners LP | 83.8K | $1.69M | −$36.9K | Cut−$36.9K |
| VANGUARD FIDUCIARY TRUST CO | 69.7K | $1.41M | — | Held |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 65.1K | $1.31M | — | Held |
| JPMORGAN CHASE & CO | 64.9K | $1.25M | −$6.97K | Added$1.14M |
| DAFNA Capital Management LLC | 56.6K | $1.14M | −$12.3K | Added$565.5K |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 52.3K | $1.01M | −$147K | Cut−$147K |
| Renaissance Technologies | 43.4K | $874.9K | −$6.16K | Added$586.5K |
| Raiffeisen Bank International AG | 43K | $829.9K | −$118K | Cut−$98.7K |
| Driehaus Capital Management LLC | 32.8K | $660.5K | −$14.4K | Cut−$14.4K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 30.1K | $606K | −$13.2K | Cut−$11.2K |
| XTX Topco Ltd | 27.4K | $553K | — | New |
| Bank of New York Mellon Corp | 26K | $525K | −$10.2K | Added$49.3K |
| Nuveen, LLC | 25.2K | $508.2K | −$9.28K | Added$73.7K |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 18.8K | $378.6K | −$4.74K | Added$156.5K |
| AMERICAN CENTURY COMPANIES INC | 18.5K | $373.8K | −$7.73K | Added$12K |
| Mariner, LLC | 16.7K | $336.4K | — | New |
| RHUMBLINE ADVISERS | 13.9K | $280.1K | −$5.89K | Added$4.37K |
| TWO SIGMA INVESTMENTS, LP | 13.9K | $280K | −$5.28K | Added$33K |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 13.8K | $278.1K | −$179K | Cut−$203.5K |
| Virtus Investment Advisers, LLC | 13K | $262.7K | −$5.6K | Added$795 |
| Brevan Howard Capital Management LP | 12.8K | $257.1K | — | New |
| NOMURA HOLDINGS INC | 12.7K | $256.5K | — | New |
| ALPS ADVISORS INC | 12.6K | $254.1K | −$5.55K | Cut−$7.92K |
| DIMENSIONAL FUND ADVISORS LP | 11.4K | $230.1K | −$5.02K | Cut−$4.92K |
| BANK OF AMERICA CORP /DE/ | 10.9K | $219K | −$4.78K | Cut−$641.2K |
| ALLIANCEBERNSTEIN L.P. | 10.6K | $217.7K | $0 | Held |
| Icahn Capital | 10.3K | $207.9K | — | New |
| Mitsubishi UFJ Asset Management Co., Ltd. | 7.99K | $161.2K | −$0 | Cut−$3.99K |
| MetLife Investment Management, LLC | 5.93K | $119.6K | −$2.61K | Cut−$2.61K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 5.31K | $107K | −$2.02K | Added$12.4K |
| PNC Financial Services Group, Inc. | 5.05K | $101.7K | −$2.22K | Cut−$3.81K |
| Vanguard Global Advisers, LLC | 4.85K | $97.9K | — | Held |
| WELLS FARGO & COMPANY/MN | 4.27K | $86K | −$1.88K | Cut−$141.3K |
| NEW YORK STATE COMMON RETIREMENT FUND | 4.2K | $84.7K | −$1.85K | Cut−$1.85K |
| Police & Firemen's Retirement System of New Jersey | 3.85K | $77.5K | −$886 | Added$36.1K |
| BARCLAYS PLC | 2.75K | $55.5K | −$1.21K | Cut−$261.3K |
| China Universal Asset Management Co., Ltd. | 2.75K | $55.4K | −$1.11K | Added$3.43K |
| BNP PARIBAS FINANCIAL MARKETS | 2.69K | $54.3K | −$1.07K | Added$4.38K |
| Russell Investments Group, Ltd. | 1.61K | $32.4K | −$377 | Added$14.8K |
| Tower Research Capital LLC (TRC) | 1.28K | $25.8K | −$542 | Added$385 |
| CWM, LLC | 1.03K | $20.8K | $3.1K | Added$20.8K |
| Ameritas Investment Partners, Inc. | 1.01K | $20.3K | −$444 | Cut−$444 |
| CITIGROUP INC | 930 | $18.7K | −$332 | Added$3.22K |
| Legal & General Group Plc | 898 | $18.1K | −$395 | Cut−$395 |
| Mirae Asset Global Investments Co., Ltd. | 808 | $16.3K | −$332 | Added$777 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 604 | $12.2K | −$266 | Cut−$307 |
| GAMMA Investing LLC | 535 | $10.8K | −$179 | Added$2.38K |
| Sterling Capital Management LLC | 374 | $7.54K | −$164 | Cut−$4.14K |
| GF FUND MANAGEMENT CO. LTD. | 340 | $6.85K | −$133 | Added$633 |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 292 | $5.89K | — | New |
| Farther Finance Advisors, LLC | 170 | $3.68K | — | New |
| SBI Securities Co., Ltd. | 125 | $2.52K | −$11 | Added$2K |
| ROYAL BANK OF CANADA | 112 | $2K | −$344 | Cut−$7K |
| Parallel Advisors, LLC | 96 | $1.94K | — | New |
| SIMPLEX TRADING, LLC | 89 | $1.79K | −$27 | Added$517 |
| Optiver Holding B.V. | 67 | $1.35K | −$27 | Added$94 |
| NISA INVESTMENT ADVISORS, LLC | 63 | $1.27K | −$20 | Added$343 |
| Truvestments Capital LLC | 46 | $927 | −$21 | Cut−$21 |
| ROTHSCHILD INVESTMENT LLC | 45 | $907 | −$18 | Added$83 |
| EverSource Wealth Advisors, LLC | 44 | $888 | −$19 | Cut−$19 |
| US BANCORP \DE\ | 30 | $605 | −$13 | Cut−$2.75K |
| Allworth Financial LP | 30 | $605 | — | New |
| Investors Portfolio Services LLC | 15 | $477 | — | New |
| Essential Partners LLC | 20 | $403 | — | New |
| Arax Advisory Partners | 14 | $282 | −$1 | Added$241 |
| MAI Capital Management | 11 | $222 | — | New |
| NATIONAL BANK OF CANADA /FI/ | 8 | $161 | −$3 | Cut−$3 |
| Sunbelt Securities, Inc. | 2 | $40 | — | New |
| Larson Financial Group LLC | 1 | $20 | — | New |
| IFP Advisors, Inc | 1 | $20 | — | New |