| SAMSARA BIOCAPITAL, LLC | 1.72M | $35.4M | — | Held |
| Redmile Group, LLC | 1.46M | $30.1M | — | Held |
| RTW INVESTMENTS, LP | 1.36M | $28.1M | — | Held |
| Casdin Capital, LLC | 1.3M | $26.7M | — | Held |
| EcoR1 Capital, LLC | 1.27M | $26.2M | — | Held |
| BAKER BROS. ADVISORS LP | 991.7K | $20.4M | — | Held |
| BlackRock, Inc. | 945.6K | $19.5M | — | Held |
| Trails Edge Capital Partners, LP | 785K | $16.2M | — | Held |
| TORONTO DOMINION BANK | 681.3K | $14M | — | Held |
| Vanguard | 656.6K | $13.5M | — | Held |
| Balyasny Asset Management L.P. | 608.6K | $12.5M | — | Held |
| ArrowMark Colorado Holdings LLC | 577.5K | $11.9M | — | Held |
| JENNISON ASSOCIATES LLC | 533.1K | $11M | — | Held |
| MORGAN STANLEY | 371.2K | $7.65M | $1.21M | Added$253.6K |
| Citadel | 364.2K | $7.5M | — | Held |
| GREAT POINT PARTNERS LLC | 350K | $7.21M | — | Held |
| State Street | 307.8K | $6.34M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 249.7K | $5.14M | — | Held |
| Logos Global Management LP | 195K | $4.02M | — | Held |
| BLAIR WILLIAM & CO/IL | 163.7K | $3.37M | — | Held |
| GOLDMAN SACHS GROUP INC | 162K | $3.34M | — | Held |
| UBS Group AG | 154.1K | $3.17M | — | Held |
| Fidelity | 130.3K | $2.68M | — | Held |
| Rock Springs Capital Management LP | 104.3K | $2.15M | — | Held |
| DEUTSCHE BANK AG\ | 85.6K | $1.76M | — | Held |
| NORTHERN TRUST CORP | 85.6K | $1.76M | — | Held |
| Woodline Partners LP | 83.8K | $1.73M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 71.3K | $1.47M | — | Held |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 52.3K | $1.16M | — | Held |
| Raiffeisen Bank International AG | 42K | $928.6K | — | Held |
| Trexquant Investment LP | 43.3K | $892.5K | — | Held |
| BANK OF AMERICA CORP /DE/ | 41.8K | $860.2K | $132.6K | Added$157.5K |
| D. E. Shaw & Co., Inc. | 40.3K | $831.1K | — | Held |
| Walleye Capital LLC | 36.1K | $743.7K | — | Held |
| Driehaus Capital Management LLC | 32.8K | $675K | — | Held |
| Squarepoint Ops LLC | 32.5K | $669.3K | — | Held |
| ADAR1 Capital Management, LLC | 30.6K | $631K | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 30K | $617.2K | — | Held |
| ExodusPoint Capital Management, LP | 29.1K | $599.9K | — | Held |
| DAFNA Capital Management LLC | 28K | $576.3K | — | Held |
| Schonfeld Strategic Advisors LLC | 27.9K | $574.6K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 14.5K | $481.5K | — | Held |
| Bank of New York Mellon Corp | 23.1K | $475.7K | — | Held |
| Nuveen, LLC | 21.1K | $434.5K | — | Held |
| AMERICAN CENTURY COMPANIES INC | 17.6K | $361.7K | — | Held |
| BARCLAYS PLC | 15.4K | $316.7K | $48.8K | Added$58K |
| JANE STREET GROUP, LLC | 15.1K | $311.2K | — | Held |
| Renaissance Technologies | 14K | $288.4K | — | Held |
| RHUMBLINE ADVISERS | 13.4K | $275.7K | — | Held |
| ALPS ADVISORS INC | 12.7K | $262.1K | — | Held |
| Virtus Investment Advisers, LLC | 12.7K | $261.9K | — | Held |
| TWO SIGMA INVESTMENTS, LP | 12K | $247K | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 11.4K | $235K | — | Held |
| WELLS FARGO & COMPANY/MN | 11K | $227.4K | — | Held |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 10.8K | $222.1K | — | Held |
| ALLIANCEBERNSTEIN L.P. | 10.6K | $217.7K | — | Held |
| Mitsubishi UFJ Asset Management Co., Ltd. | 8.19K | $165.2K | — | Held |
| AlphaQuest LLC | 7.21K | $148.6K | — | Held |
| MetLife Investment Management, LLC | 5.93K | $122.2K | — | Held |
| JPMORGAN CHASE & CO | 5.36K | $110.5K | — | Held |
| PNC Financial Services Group, Inc. | 5.12K | $105.6K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4.59K | $94.6K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 4.2K | $86.5K | — | Held |
| China Universal Asset Management Co., Ltd. | 2.52K | $52K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 2.42K | $49.9K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 2.01K | $41.5K | — | Held |
| Tower Research Capital LLC (TRC) | 1.23K | $25.4K | — | Held |
| Ameritas Investment Partners, Inc. | 1.01K | $20.8K | — | Held |
| Leonteq Securities AG | 1K | $20.6K | $3.27K | Added$3.27K |
| Legal & General Group Plc | 898 | $18.5K | — | Held |
| Russell Investments Group, Ltd. | 856 | $17.6K | — | Held |
| CITIGROUP INC | 754 | $15.5K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 753 | $15.5K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 606 | $12.5K | — | Held |
| Sterling Capital Management LLC | 567 | $11.7K | — | Held |
| ROYAL BANK OF CANADA | 430 | $9K | — | Held |
| GAMMA Investing LLC | 408 | $8.4K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 302 | $6.22K | — | Held |
| US BANCORP \DE\ | 163 | $3.36K | — | Held |
| SIMPLEX TRADING, LLC | 62 | $1.28K | — | Held |
| Optiver Holding B.V. | 61 | $1.26K | — | Held |
| Truvestments Capital LLC | 46 | $948 | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 45 | $927 | — | Held |
| SageView Advisory Group, LLC | 45 | $927 | — | Held |
| EverSource Wealth Advisors, LLC | 44 | $907 | — | Held |
| ROTHSCHILD INVESTMENT LLC | 40 | $824 | — | Held |
| Versant Capital Management, Inc | 33 | $680 | — | Held |
| SBI Securities Co., Ltd. | 25 | $515 | — | Held |
| NATIONAL BANK OF CANADA /FI/ | 8 | $164 | — | Held |
| Daiwa Securities Group Inc. | 3.23K | $66 | — | Held |
| Arax Advisory Partners | 2 | $41 | — | Held |
| AMALGAMATED BANK | 309 | $6 | — | Held |
| CWM, LLC | 154 | $3 | — | Held |