| Catalys Pacific, LLC | 7.9M | $286.8M | — | Held |
| RA CAPITAL MANAGEMENT, L.P. | 7.32M | $265.8M | — | Held |
| SAMSARA BIOCAPITAL, LLC | 5.87M | $213.1M | — | Held |
| Fidelity | 5.06M | $183.5M | — | Held |
| BlackRock, Inc. | 4.33M | $157.1M | — | Held |
| Vanguard | 3.35M | $121.7M | — | Held |
| State Street | 3.18M | $115.6M | — | Held |
| Caligan Partners LP | 2.77M | $100.6M | — | Held |
| FRANKLIN RESOURCES INC | 1.79M | $64.9M | — | Held |
| Laurion Capital Management LP | 1.71M | $62.2M | — | Held |
| Holocene Advisors, LP | 1.6M | $58.1M | — | Held |
| ANDERA PARTNERS | 1.59M | $57.8M | — | Held |
| SR One Capital Management, LP | 1.56M | $56.8M | — | Held |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1.54M | $55.8M | — | Held |
| GOLDMAN SACHS GROUP INC | 1.45M | $52.7M | — | Held |
| Polar Capital Holdings Plc | 1.4M | $50.8M | — | Held |
| SAMLYN CAPITAL, LLC | 1.3M | $47.4M | — | Held |
| JENNISON ASSOCIATES LLC | 1.26M | $45.7M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 1.26M | $45.6M | — | Held |
| JANUS HENDERSON GROUP PLC | 1.21M | $44M | — | Held |
| Point72 Asset Management, L.P. | 1.21M | $43.8M | — | Held |
| Capital International Investors | 1.16M | $42.2M | — | Held |
| D. E. Shaw & Co., Inc. | 1.15M | $41.8M | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 992.1K | $36M | — | Held |
| BANK OF AMERICA CORP /DE/ | 987.3K | $35.8M | −$1.25M | Added$6.7M |
| ORBIMED ADVISORS LLC | 980.4K | $35.6M | — | Held |
| ALLIANCEBERNSTEIN L.P. | 922.5K | $33.5M | — | Held |
| AMERICAN CENTURY COMPANIES INC | 908.1K | $33M | — | Held |
| Pictet Asset Management Holding SA | 852.9K | $31M | — | Held |
| FARALLON CAPITAL MANAGEMENT LLC | 823.3K | $29.9M | −$1.34M | Cut−$33.6M |
| WELLINGTON MANAGEMENT GROUP LLP | 784.3K | $28.5M | — | Held |
| Integral Health Asset Management, LLC | 750K | $27.2M | — | Held |
| Affinity Asset Advisors, LLC | 730K | $26.5M | — | Held |
| Siren, L.L.C. | 700K | $25.4M | — | Held |
| Candriam S.C.A. | 678.4K | $24.6M | — | Held |
| ARMISTICE CAPITAL, LLC | 676K | $24.5M | — | Held |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 659.1K | $23.9M | — | Held |
| MORGAN STANLEY | 639.5K | $23.2M | −$1.04M | Cut−$29M |
| TWO SIGMA INVESTMENTS, LP | 610.4K | $22.2M | — | Held |
| Qube Research & Technologies Ltd | 496.5K | $18M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 461.3K | $16.7M | — | Held |
| SPHERA FUNDS MANAGEMENT LTD. | 449K | $16.3M | — | Held |
| Rock Springs Capital Management LP | 427.6K | $15.5M | — | Held |
| Parkman Healthcare Partners LLC | 410.2K | $14.9M | — | Held |
| Citadel | 399.9K | $14.5M | — | Held |
| TimesSquare Capital Management, LLC | 380.1K | $13.8M | — | Held |
| 22NW, LP | 358.3K | $13M | — | Held |
| TWO SIGMA ADVISERS, LP | 353.7K | $12.8M | — | Held |
| Catalio Capital Management, LP | 331.8K | $12M | — | Held |
| Renaissance Technologies | 322.1K | $11.7M | — | Held |
| NORTHERN TRUST CORP | 299.9K | $10.9M | — | Held |
| STEMPOINT CAPITAL LP | 290K | $10.5M | — | Held |
| Iron Triangle Partners LP | 257.1K | $9.33M | — | Held |
| MARSHALL WACE, LLP | 249.1K | $9.04M | — | Held |
| Squarepoint Ops LLC | 246.8K | $8.96M | — | Held |
| BARCLAYS PLC | 223.3K | $8.1M | −$364K | Cut−$16.7M |
| Swedbank AB | 221.4K | $8.03M | — | Held |
| Davern Capital Partners, LP | 210.6K | $7.64M | — | Held |
| UBS Group AG | 201.3K | $7.3M | — | Held |
| Ikarian Capital, LLC | 200K | $7.26M | — | Held |
| Russell Investments Group, Ltd. | 175.4K | $6.36M | — | Held |
| Buckley Capital Advisors, LLC | 174.3K | $6.33M | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 172.9K | $6.28M | — | Held |
| Velan Capital Investment Management LP | 151K | $5.48M | — | Held |
| BURKEHILL GLOBAL MANAGEMENT, LP | 150K | $5.44M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 143.2K | $5.2M | — | Held |
| Rhenman & Partners Asset Management AB | 142.6K | $5.17M | — | Held |
| Artia Global Partners LP | 137.8K | $5M | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 137.6K | $4.99M | — | Held |
| Brevan Howard Capital Management LP | 139.3K | $4.98M | — | Held |
| ADAR1 Capital Management, LLC | 136.2K | $4.94M | — | Held |
| Bank of New York Mellon Corp | 131.8K | $4.78M | — | Held |
| Rafferty Asset Management, LLC | 127.9K | $4.64M | — | Held |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 130.6K | $4.64M | — | Held |
| HighVista Strategies LLC | 124.5K | $4.52M | — | Held |
| Nuveen, LLC | 122.9K | $4.46M | — | Held |
| Simplify Asset Management Inc. | 114.2K | $4.14M | — | Held |
| Nantahala Capital Management, LLC | 113.3K | $4.11M | — | Held |
| Trexquant Investment LP | 112.8K | $4.09M | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 112.7K | $4.09M | — | Held |
| Ensign Peak Advisors, Inc | 112.2K | $4.07M | — | Held |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 111.8K | $4.06M | — | New |
| Informed Momentum Co LLC | 96.1K | $3.49M | — | Held |
| SILVERARC CAPITAL MANAGEMENT, LLC | 95K | $3.45M | — | Held |
| Swiss National Bank | 90.1K | $3.27M | — | Held |
| PRUDENTIAL FINANCIAL INC | 89.1K | $3.23M | — | Held |
| Verition Fund Management LLC | 83.8K | $3.04M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 78.6K | $2.85M | — | Held |
| Susquehanna Portfolio Strategies, LLC | 78.1K | $2.83M | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 75.9K | $2.75M | — | Held |
| XTX Topco Ltd | 73.7K | $2.67M | — | Held |
| Hennion & Walsh Asset Management, Inc. | 69.4K | $2.52M | — | Held |
| Greenland Capital Management LP | 69K | $2.5M | — | Held |
| Blue Owl Capital Holdings LP | 65.9K | $2.39M | — | Held |
| ALPS ADVISORS INC | 65K | $2.36M | — | Held |
| WINTON GROUP Ltd | 64.8K | $2.35M | — | Held |
| Icahn Capital | 62.3K | $2.26M | — | Held |
| MOORE CAPITAL MANAGEMENT, LP | 60K | $2.18M | — | Held |
| Zimmer Partners, LP | 57.5K | $2.09M | — | Held |
| WELLS FARGO & COMPANY/MN | 56.8K | $2.06M | — | Held |
| RHUMBLINE ADVISERS | 54.3K | $1.97M | — | Held |
| FINDELL CAPITAL MANAGEMENT LLC | 50K | $1.81M | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 49.9K | $1.81M | — | Held |
| Schonfeld Strategic Advisors LLC | 49.8K | $1.81M | — | Held |
| PFM Health Sciences, LP | 47.6K | $1.73M | — | Held |
| J. Goldman & Co LP | 47.3K | $1.72M | — | Held |
| PROFUND ADVISORS LLC | 47K | $1.71M | — | Held |
| JPMORGAN CHASE & CO | 46.7K | $1.69M | — | Held |
| AMERIPRISE FINANCIAL INC | 46.2K | $1.68M | — | Held |
| Erste Asset Management GmbH | 45K | $1.66M | — | Held |
| Legal & General Group Plc | 43.9K | $1.59M | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 43.3K | $1.57M | — | Held |
| Seven Fleet Capital Management LP | 42K | $1.53M | — | Held |
| TUDOR INVESTMENT CORP ET AL | 39K | $1.42M | — | New |
| DAFNA Capital Management LLC | 38.5K | $1.4M | — | Held |
| DEUTSCHE BANK AG\ | 37.2K | $1.35M | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 32.9K | $1.19M | — | Held |
| SECTORAL ASSET MANAGEMENT INC | 31.6K | $1.15M | — | Held |
| Y-Intercept (Hong Kong) Ltd | 31.4K | $1.14M | — | Held |
| Allianz Asset Management GmbH | 30.2K | $1.1M | — | Held |
| CANADA PENSION PLAN INVESTMENT BOARD | 29.6K | $1.07M | — | Held |
| Invesco Ltd. | 29.1K | $1.06M | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 29.2K | $1.05M | — | Held |
| MetLife Investment Management, LLC | 26K | $943.7K | — | Held |
| CenterBook Partners LP | 26K | $943.5K | — | Held |
| DIADEMA PARTNERS LP | 25K | $907.3K | — | Held |
| RAYMOND JAMES FINANCIAL INC | 25K | $906.3K | — | Held |
| Sigma Planning Corp | 24K | $871K | — | Held |
| Atom Investors LP | 22.3K | $810.4K | — | Held |
| Creative Planning | 21.1K | $765.8K | — | Held |
| Maven Securities LTD | 20K | $725.8K | — | Held |
| Bellevue Group AG | 19.8K | $719.5K | — | Held |
| CITIGROUP INC | 18.3K | $664.7K | — | Held |
| Quantinno Capital Management LP | 18.2K | $662K | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 17.3K | $629.6K | — | Held |
| Twin Securities, Inc. | 16.7K | $607.4K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 16.7K | $606.9K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16.2K | $587.2K | — | Held |
| Entropy Technologies, LP | 16.2K | $587K | — | Held |
| State of New Jersey Common Pension Fund D | 15.6K | $565.5K | — | Held |
| PSP Research LLC | 14.8K | $537.7K | — | Held |
| FOX RUN MANAGEMENT, L.L.C. | 14.5K | $527.1K | — | Held |
| Campbell & CO Investment Adviser LLC | 14.4K | $522.7K | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 13K | $471.8K | — | Held |
| China Universal Asset Management Co., Ltd. | 12.9K | $468K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 12.7K | $460.3K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 12.6K | $455.9K | — | Held |
| Optimize Financial Inc | 12.4K | $449.4K | — | Held |
| ProShare Advisors LLC | 12K | $436.9K | — | Held |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 12K | $435.4K | — | Held |
| AlphaQuest LLC | 11.3K | $411.1K | — | Held |
| FORA Capital, LLC | 11.1K | $401K | — | Held |
| CreativeOne Wealth, LLC | 10.8K | $390.1K | — | Held |
| Lion Point Capital, LP | 10.5K | $381K | — | Held |
| Pale Fire Capital SE | 10.4K | $375.7K | — | Held |
| Mariner, LLC | 10.2K | $371.5K | — | Held |
| KLP KAPITALFORVALTNING AS | 9.6K | $348.4K | — | Held |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 9.35K | $339.3K | — | Held |
| SEI INVESTMENTS CO | 8.78K | $318.6K | — | Held |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 7.56K | $274.4K | — | Held |
| BANQUE PICTET & CIE SA | 7.49K | $271.7K | — | Held |
| Persistent Asset Partners Ltd | 7.42K | $269.1K | — | New |
| Virtus Investment Advisers, LLC | 7.21K | $261.6K | — | Held |
| KINGSWOOD WEALTH ADVISORS, LLC | 7.07K | $256.7K | — | Held |
| Cinctive Capital Management LP | 7.04K | $255.4K | — | Held |
| Connor, Clark & Lunn Investment Management Ltd. | 6.86K | $248.9K | — | Held |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 6.78K | $246.1K | — | Held |
| TEMA ETFS LLC | 6.46K | $234.5K | — | Held |
| NEOS Investment Management LLC | 6.46K | $234.5K | — | Held |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 6.38K | $231.7K | — | Held |
| SIMPLEX TRADING, LLC | 4.8K | $174.3K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 3.85K | $139.6K | — | Held |
| Caitong International Asset Management Co., Ltd | 3.82K | $138.7K | — | Held |
| Ameritas Investment Partners, Inc. | 3.8K | $137.8K | — | Held |
| PNC Financial Services Group, Inc. | 2.23K | $81.1K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 1.95K | $70.7K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.55K | $56.4K | — | Held |
| ROYAL BANK OF CANADA | 1.53K | $56K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.33M | $48.1K | — | Held |
| OSAIC HOLDINGS, INC. | 1.16K | $41.9K | — | Held |
| Smartleaf Asset Management LLC | 1K | $35.6K | — | Held |
| Navalign, LLC | 900 | $32.7K | — | Held |
| COMERICA BANK | 781 | $28.3K | — | Held |
| Tower Research Capital LLC (TRC) | 520 | $18.9K | — | Held |
| Versant Capital Management, Inc | 513 | $18.6K | — | Held |
| GAMMA Investing LLC | 451 | $16.4K | — | Held |
| Pinnacle Wealth Planning Services, Inc. | 355 | $12.9K | — | Held |
| MassMutual Private Wealth & Trust, FSB | 319 | $11.6K | — | Held |
| LORD, ABBETT & CO. LLC | 312.4K | $11.3K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 275 | $11.3K | — | Held |
| Sterling Capital Management LLC | 306 | $11.1K | — | Held |
| SG Americas Securities, LLC | 230.8K | $8.38K | — | Held |
| Allworth Financial LP | 219 | $7.95K | −$72 | Added$6.28K |
| Larson Financial Group LLC | 154 | $5.59K | — | Held |
| EverSource Wealth Advisors, LLC | 154 | $5.59K | — | Held |
| Rockefeller Capital Management L.P. | 134 | $4.86K | — | Held |
| SBI Securities Co., Ltd. | 116 | $4.21K | — | Held |
| Arax Advisory Partners | 109 | $3.96K | — | Held |
| HRT FINANCIAL LP | 87.2K | $3.17K | — | Held |
| J.Safra Asset Management Corp | 81 | $2.94K | — | Held |
| US BANCORP \DE\ | 81 | $2.94K | — | Held |
| True Wealth Design, LLC | 76 | $2.76K | — | Held |
| ROTHSCHILD INVESTMENT LLC | 55 | $2K | — | Held |
| ALGERT GLOBAL LLC | 47.5K | $1.72K | — | Held |
| Optiver Holding B.V. | 42 | $1.52K | — | Held |
| Torren Management, LLC | 39 | $1.42K | — | Held |
| Parkside Financial Bank & Trust | 35 | $1.27K | — | Held |
| Farther Finance Advisors, LLC | 35 | $1.27K | — | Held |
| Private Wealth Management Group, LLC | 28 | $1.02K | — | Held |
| MAI Capital Management | 24 | $871 | — | Held |
| Parallel Advisors, LLC | 22 | $798 | — | Held |
| Handelsbanken Fonder AB | 14.1K | $512 | — | Held |
| Clearstead Advisors, LLC | 11 | $400 | — | Held |
| QUADRANT CAPITAL GROUP LLC | 8 | $291 | — | Held |
| IFP Advisors, Inc | 8 | $290 | −$4 | Added$214 |
| CWM, LLC | 5.1K | $185 | — | Held |
| ACADIAN ASSET MANAGEMENT LLC | 2.91K | $104 | — | Held |
| AMALGAMATED BANK | 1.47K | $53 | — | Held |
| Essential Partners LLC | 1 | $36 | −$2 | Cut−$2 |
| Covestor Ltd | 473 | $17 | — | Held |
| Daiwa Securities Group Inc. | 235 | $9 | — | Held |
| BESSEMER GROUP INC | 38 | $1 | — | Held |
| Avion Wealth | 21 | $0 | — | Held |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | $0 | — | Held |