| Paradigm Biocapital Advisors LP | 6.18M | $35.5M | −$20M | Cut−$11.8M |
| BlackRock, Inc. | 5.11M | $29.3M | −$20.6M | Cut−$19.4M |
| Affinity Asset Advisors, LLC | 5.05M | $29M | −$13.4M | Cut−$2.79M |
| RA CAPITAL MANAGEMENT, L.P. | 5M | $28.7M | −$20.9M | Cut−$20.9M |
| JANUS HENDERSON GROUP PLC | 4.98M | $28.5M | −$20.9M | Cut−$26.2M |
| Vestal Point Capital, LP | 4.47M | $25.7M | −$18.8M | Cut−$18.8M |
| Frazier Life Sciences Management, L.P. | 4.42M | $25.4M | −$18.5M | Cut−$18.5M |
| Citadel | 3.83M | $22M | −$15.8M | Cut−$15.5M |
| ORBIMED ADVISORS LLC | 3.6M | $20.7M | −$8.9M | Cut−$423.2K |
| State Street | 3.57M | $20.5M | −$13.4M | Cut−$11.2M |
| VANGUARD CAPITAL MANAGEMENT LLC | 3.01M | $17.3M | — | Held |
| Woodline Partners LP | 2.75M | $15.8M | −$11.5M | Cut−$16M |
| GOLDMAN SACHS GROUP INC | 1.95M | $11.2M | −$3.28M | Added$3.43M |
| Avoro Capital Advisors LLC | 1.88M | $10.8M | −$7.86M | Cut−$22M |
| Point72 Asset Management, L.P. | 1.68M | $9.65M | −$7.04M | Cut−$9.17M |
| MILLENNIUM MANAGEMENT LLC | 1.61M | $9.26M | −$3.8M | Added$240.7K |
| Balyasny Asset Management L.P. | 1.59M | $9.12M | −$6.66M | Cut−$7.11M |
| GEODE CAPITAL MANAGEMENT, LLC | 1.51M | $8.69M | −$6.06M | Cut−$5.67M |
| ADAR1 Capital Management, LLC | 1.47M | $8.42M | −$5.84M | Cut−$5.41M |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1.25M | $7.17M | −$5.24M | Cut−$5.24M |
| 683 Capital Management, LLC | 1.2M | $6.89M | −$4.69M | Cut−$4.23M |
| Nantahala Capital Management, LLC | 1.2M | $6.89M | −$4.19M | Cut−$3.04M |
| DIMENSIONAL FUND ADVISORS LP | 1.1M | $6.33M | −$3.62M | Cut−$2.24M |
| Octagon Capital Advisors LP | 1.1M | $6.31M | −$4.61M | Cut−$10.8M |
| Spruce Street Capital LP | 928.6K | $5.33M | −$733.2K | Added$3.59M |
| Blackstone Inc. | 905K | $5.19M | −$3.79M | Cut−$3.79M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 577.2K | $3.31M | — | Held |
| Ikarian Capital, LLC | 513K | $2.94M | −$2.15M | Cut−$2.15M |
| NORTHERN TRUST CORP | 493.7K | $2.83M | −$1.92M | Cut−$1.7M |
| BANK OF AMERICA CORP /DE/ | 491.5K | $2.82M | −$671.6K | Added$1.23M |
| Qube Research & Technologies Ltd | 465.5K | $2.67M | −$558.3K | Added$1.35M |
| MORGAN STANLEY | 402.9K | $2.31M | −$587.4K | Added$920.8K |
| VANGUARD FIDUCIARY TRUST CO | 384.7K | $2.21M | — | Held |
| DAFNA Capital Management LLC | 377.1K | $2.16M | −$1.43M | Cut−$1.22M |
| Icahn Capital | 339.6K | $1.95M | −$1.41M | Cut−$1.4M |
| UBS Group AG | 321.7K | $1.85M | −$1.18M | Cut−$944.4K |
| Squarepoint Ops LLC | 319.1K | $1.83M | −$388K | Added$912K |
| Aberdeen Group plc | 245.9K | $1.41M | — | New |
| BNP PARIBAS FINANCIAL MARKETS | 228.2K | $1.31M | −$956.2K | Cut−$1.25M |
| Privium Fund Management B.V. | 205K | $1.18M | −$806.8K | Cut−$735.3K |
| Nuveen, LLC | 183K | $1.05M | −$766.7K | Cut−$1.05M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 182.1K | $1.05M | −$762.9K | Cut−$863.6K |
| TWO SIGMA INVESTMENTS, LP | 181.7K | $1.04M | −$761.2K | Cut−$2.93M |
| WELLINGTON MANAGEMENT GROUP LLP | 172.7K | $991.3K | −$348.7K | Added$164.8K |
| Bank of New York Mellon Corp | 158.9K | $912.1K | −$665.8K | Cut−$743.7K |
| Y-Intercept (Hong Kong) Ltd | 142.6K | $818.4K | −$597.4K | Cut−$1.48M |
| BOOTHBAY FUND MANAGEMENT, LLC | 136.4K | $782.8K | −$571.4K | Cut−$571.4K |
| BURKEHILL GLOBAL MANAGEMENT, LP | 125K | $717.5K | −$523.7K | Cut−$523.8K |
| Susquehanna Portfolio Strategies, LLC | 113K | $648.5K | −$109.8K | Added$388.3K |
| ExodusPoint Capital Management, LP | 112.2K | $643.9K | — | New |
| ALLIANCEBERNSTEIN L.P. | 61.8K | $613.8K | $0 | Held |
| Rafferty Asset Management, LLC | 100.9K | $579.1K | −$422.8K | Cut−$435.3K |
| XTX Topco Ltd | 100.6K | $577.5K | −$46.7K | Added$466.8K |
| JPMORGAN CHASE & CO | 93.2K | $491K | −$139.2K | Added$194.4K |
| RHUMBLINE ADVISERS | 72.1K | $413.7K | −$290.7K | Cut−$275.1K |
| Creative Planning | 67.1K | $385K | −$43.4K | Added$282.2K |
| Invesco Ltd. | 63.5K | $364.6K | −$266.1K | Cut−$4.23M |
| DEUTSCHE BANK AG\ | 63.1K | $361.9K | −$239.5K | Cut−$205.7K |
| DRW Securities, LLC | 48K | $275.5K | — | New |
| Bleakley Financial Group, LLC | 48K | $275.3K | — | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 47K | $269.8K | −$155.1K | Cut−$97.7K |
| PROFUND ADVISORS LLC | 45.2K | $259.2K | −$159.4K | Cut−$118.7K |
| Vanguard Global Advisers, LLC | 42.6K | $244.4K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 37.1K | $212.8K | −$42.6K | Added$103.8K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 37.1K | $209.5K | −$149.7K | Cut−$139.5K |
| MetLife Investment Management, LLC | 35.6K | $204.3K | −$149.1K | Cut−$150.5K |
| PANAGORA ASSET MANAGEMENT INC | 34.3K | $196.9K | −$143.7K | Cut−$143.7K |
| D. E. Shaw & Co., Inc. | 30.5K | $174.9K | −$127.7K | Cut−$4.59M |
| Virtus Investment Advisers, LLC | 27.9K | $160.2K | −$114.1K | Cut−$110.2K |
| AXQ CAPITAL, LP | 26.1K | $149.9K | — | New |
| Mitsubishi UFJ Asset Management Co., Ltd. | 25.6K | $146.8K | −$99K | Cut−$105.1K |
| WELLS FARGO & COMPANY/MN | 25K | $143.5K | −$104.7K | Cut−$558.9K |
| Fidelity | 24.4K | $140K | −$56.1K | Added$7.04K |
| Schonfeld Strategic Advisors LLC | 24.2K | $139K | — | New |
| Cerity Partners LLC | 21K | $120.7K | −$88.1K | Cut−$102.1K |
| Soltis Investment Advisors LLC | 20K | $114.8K | −$83.8K | Cut−$83.8K |
| NEW YORK STATE COMMON RETIREMENT FUND | 19.9K | $114.2K | −$83.3K | Cut−$83.3K |
| CWM, LLC | 18.3K | $105.1K | $105K | Added$105K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 17.7K | $101.8K | −$74.3K | Cut−$88.3K |
| Vanguard Personalized Indexing Management, LLC | 17.6K | $100.8K | −$68.9K | Cut−$62.4K |
| EntryPoint Capital, LLC | 16.6K | $95.1K | — | New |
| INTECH INVESTMENT MANAGEMENT LLC | 16.5K | $94.7K | −$59.4K | Cut−$46.2K |
| Police & Firemen's Retirement System of New Jersey | 16.4K | $94K | −$68.6K | Cut−$68.6K |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 16K | $91.5K | −$54.3K | Cut−$44.8K |
| RAYMOND JAMES FINANCIAL INC | 15.6K | $89.5K | −$52.5K | Cut−$35K |
| CAXTON CORP | 13.9K | $80K | −$58.4K | Cut−$58.4K |
| COMMONWEALTH EQUITY SERVICES, LLC | 13.6K | $78.2K | −$47.1K | Cut−$33.4K |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 13.4K | $76.9K | −$56.1K | Cut−$56.1K |
| CITIGROUP INC | 13.3K | $76.5K | −$55.8K | Cut−$75.4K |
| China Universal Asset Management Co., Ltd. | 13K | $74.3K | −$49.8K | Cut−$43.8K |
| ProShare Advisors LLC | 12.9K | $73.8K | −$53.8K | Cut−$72.7K |
| E Fund Management Co., Ltd. | 12.7K | $72.8K | — | Held |
| BARCLAYS PLC | 12.2K | $69.8K | −$51K | Cut−$1.8M |
| Ethic Inc. | 11.1K | $63.9K | −$46.6K | Cut−$49.8K |
| VOYA INVESTMENT MANAGEMENT LLC | 10.7K | $61.4K | −$44.9K | Cut−$47.5K |
| Tower Research Capital LLC (TRC) | 9.48K | $54.4K | −$3.46K | Added$46.2K |
| Russell Investments Group, Ltd. | 6.64K | $38.1K | −$24.6K | Cut−$20.2K |
| Legal & General Group Plc | 5.63K | $32.3K | −$23.6K | Cut−$23.6K |
| ROYAL BANK OF CANADA | 5.3K | $30K | −$22.8K | Cut−$37K |
| Ameritas Investment Partners, Inc. | 5.12K | $29.4K | −$21.5K | Cut−$21.5K |
| NISA INVESTMENT ADVISORS, LLC | 4.87K | $27.9K | −$11.6K | Added$469 |
| Mirae Asset Global Investments Co., Ltd. | 3.81K | $21.9K | −$14.9K | Cut−$13.4K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3.6K | $20.6K | −$15.1K | Cut−$17.9K |
| NATIONAL BANK OF CANADA /FI/ | 2.46K | $14.1K | — | New |
| Sterling Capital Management LLC | 2.19K | $12.6K | −$9.18K | Cut−$23.5K |
| GF FUND MANAGEMENT CO. LTD. | 1.63K | $9.35K | −$6.01K | Cut−$4.89K |
| Larson Financial Group LLC | 1.46K | $8.36K | −$1.01K | Added$5.97K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1.35K | $7.78K | — | New |
| GROUP ONE TRADING LLC | 1.31K | $7.51K | −$5.48K | Cut−$10.5K |
| SIMPLEX TRADING, LLC | 1.24K | $7.12K | −$5.2K | Cut−$122.3K |
| Rockefeller Capital Management L.P. | 1.14K | $6.55K | −$2.93K | Cut−$402 |
| HARBOUR INVESTMENTS, INC. | 1K | $5.74K | — | New |
| EverSource Wealth Advisors, LLC | 801 | $4.6K | −$3.06K | Cut−$2.66K |
| US BANCORP \DE\ | 640 | $3.67K | −$2.32K | Cut−$1.84K |
| Optiver Holding B.V. | 600 | $3.44K | −$1.31K | Added$346 |
| PNC Financial Services Group, Inc. | 505 | $2.9K | −$2.04K | Cut−$1.94K |
| Essential Partners LLC | 471 | $2.7K | −$1.97K | Cut−$2.02K |
| OSAIC HOLDINGS, INC. | 411 | $2.36K | −$239 | Added$1.79K |
| Truvestments Capital LLC | 400 | $2.3K | — | New |
| Allworth Financial LP | 379 | $2.18K | −$1.59K | Cut−$31.4K |
| GAMMA Investing LLC | 331 | $1.9K | −$210 | Added$1.4K |
| True Wealth Design, LLC | 226 | $1.3K | −$947 | Cut−$947 |
| SBI Securities Co., Ltd. | 207 | $1.19K | −$868 | Cut−$967 |
| Fortitude Family Office, LLC | 205 | $1.18K | −$519 | Cut−$54 |
| IFP Advisors, Inc | 203 | $1.17K | −$851 | Cut−$851 |
| SIGNATUREFD, LLC | 200 | $1.15K | −$838 | Cut−$1.73K |
| Key Financial Inc | 200 | $1.15K | — | New |
| Torren Management, LLC | 178 | $1.02K | −$746 | Cut−$2.17K |
| Steward Partners Investment Advisory, LLC | 100 | $574 | −$419 | Cut−$419 |
| Bare Financial Services, Inc | 80 | $459 | — | New |
| Caitong International Asset Management Co., Ltd | 60 | $344 | −$252 | Cut−$36.5K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 56 | $321 | — | New |
| PRICE T ROWE ASSOCIATES INC /MD/ | 43.1K | $248 | −$142 | Cut−$89 |
| GSA CAPITAL PARTNERS LLP | 34.3K | $197 | −$48 | Added$83 |
| Sunbelt Securities, Inc. | 16 | $92 | −$67 | Cut−$67 |
| Virtu Financial LLC | 11.9K | $68 | — | New |
| MAI Capital Management | 11 | $64 | — | New |
| Smartleaf Asset Management LLC | 4 | $21 | −$18 | Cut−$18 |