| JANUS HENDERSON GROUP PLC | 5.51M | $54.7M | — | Held |
| RA CAPITAL MANAGEMENT, L.P. | 5M | $49.6M | — | Held |
| BlackRock, Inc. | 4.91M | $48.7M | — | Held |
| Paradigm Biocapital Advisors LP | 4.76M | $47.3M | — | Held |
| Vestal Point Capital, LP | 4.47M | $44.4M | — | Held |
| Frazier Life Sciences Management, L.P. | 4.42M | $43.9M | — | Held |
| Vanguard | 3.89M | $38.7M | — | Held |
| Citadel | 3.77M | $37.5M | — | Held |
| Avoro Capital Advisors LLC | 3.3M | $32.8M | — | Held |
| Affinity Asset Advisors, LLC | 3.2M | $31.8M | — | Held |
| Woodline Partners LP | 3.2M | $31.8M | — | Held |
| State Street | 3.19M | $31.7M | — | Held |
| ORBIMED ADVISORS LLC | 2.13M | $21.1M | — | Held |
| Point72 Asset Management, L.P. | 1.89M | $18.8M | — | Held |
| Octagon Capital Advisors LP | 1.73M | $17.1M | — | Held |
| Balyasny Asset Management L.P. | 1.64M | $16.2M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 1.45M | $14.4M | — | Held |
| ADAR1 Capital Management, LLC | 1.39M | $13.8M | — | Held |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1.25M | $12.4M | — | Held |
| 683 Capital Management, LLC | 1.12M | $11.1M | — | Held |
| Nantahala Capital Management, LLC | 1M | $9.93M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 908K | $9.02M | — | Held |
| Blackstone Inc. | 905K | $8.99M | — | New |
| DIMENSIONAL FUND ADVISORS LP | 862.9K | $8.57M | — | Held |
| GOLDMAN SACHS GROUP INC | 781.9K | $7.76M | — | Held |
| Siren, L.L.C. | 720.6K | $7.16M | — | Held |
| SILVERARC CAPITAL MANAGEMENT, LLC | 617.6K | $6.13M | — | Held |
| Ikarian Capital, LLC | 513K | $5.09M | — | Held |
| D. E. Shaw & Co., Inc. | 480.2K | $4.77M | — | Held |
| Invesco Ltd. | 463K | $4.6M | — | Held |
| NORTHERN TRUST CORP | 457.1K | $4.54M | — | Held |
| Verition Fund Management LLC | 428.5K | $4.25M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 400.6K | $3.98M | — | Held |
| DAFNA Capital Management LLC | 340.9K | $3.38M | — | Held |
| Icahn Capital | 337.4K | $3.35M | — | Held |
| UBS Group AG | 281.1K | $2.79M | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 257.4K | $2.56M | — | Held |
| AMERIPRISE FINANCIAL INC | 243.3K | $2.42M | — | Held |
| Y-Intercept (Hong Kong) Ltd | 231.2K | $2.3M | — | Held |
| Renaissance Technologies | 217.8K | $2.16M | — | Held |
| Nuveen, LLC | 211.5K | $2.1M | — | Held |
| Privium Fund Management B.V. | 192.6K | $1.91M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 192.2K | $1.91M | — | Held |
| BARCLAYS PLC | 188.8K | $1.87M | $367.1K | Added$1.13M |
| Spruce Street Capital LP | 175K | $1.74M | — | Held |
| Bank of New York Mellon Corp | 166.7K | $1.66M | — | Held |
| BANK OF AMERICA CORP /DE/ | 160.3K | $1.59M | $93K | Added$1.4M |
| MORGAN STANLEY | 140.2K | $1.39M | $322.6K | Added$740.9K |
| JANE STREET GROUP, LLC | 140.1K | $1.39M | — | Held |
| PERCEPTIVE ADVISORS LLC | 139.8K | $1.39M | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 136.4K | $1.35M | — | Held |
| Qube Research & Technologies Ltd | 133.3K | $1.32M | — | Held |
| BURKEHILL GLOBAL MANAGEMENT, LP | 125K | $1.24M | — | Held |
| Rafferty Asset Management, LLC | 102.2K | $1.01M | — | Held |
| Squarepoint Ops LLC | 92.6K | $919.6K | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 83.2K | $826.5K | — | Held |
| TWO SIGMA ADVISERS, LP | 81.3K | $807.3K | — | Held |
| WELLS FARGO & COMPANY/MN | 70.7K | $702.4K | — | Held |
| RHUMBLINE ADVISERS | 69.4K | $688.8K | — | Held |
| Atom Investors LP | 68.5K | $680.1K | — | Held |
| ALLIANCEBERNSTEIN L.P. | 61.8K | $613.8K | — | Held |
| DEUTSCHE BANK AG\ | 57.2K | $567.7K | — | Held |
| AMERICAN CENTURY COMPANIES INC | 46K | $456.7K | — | Held |
| PROFUND ADVISORS LLC | 38.1K | $377.9K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 37K | $367.5K | — | Held |
| MetLife Investment Management, LLC | 35.7K | $354.7K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 35.3K | $349K | — | Held |
| PANAGORA ASSET MANAGEMENT INC | 34.3K | $340.6K | — | Held |
| Graham Capital Management, L.P. | 32.9K | $326.7K | — | Held |
| JPMORGAN CHASE & CO | 29.9K | $296.5K | — | Held |
| Virtus Investment Advisers, LLC | 27.2K | $270.4K | — | Held |
| WINTON GROUP Ltd | 26.9K | $267.1K | — | Held |
| Susquehanna Portfolio Strategies, LLC | 26.2K | $260.2K | — | Held |
| Mitsubishi UFJ Asset Management Co., Ltd. | 26.2K | $251.9K | — | Held |
| IEQ CAPITAL, LLC | 24.7K | $245.2K | — | Held |
| Cerity Partners LLC | 22.4K | $222.8K | — | Held |
| Pale Fire Capital SE | 22.3K | $221.5K | — | Held |
| OMERS ADMINISTRATION Corp | 20.9K | $207.5K | — | Held |
| Soltis Investment Advisors LLC | 20K | $198.6K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 19.9K | $197.5K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 19.1K | $190.1K | — | Held |
| Vanguard Personalized Indexing Management, LLC | 16.4K | $163.2K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 16.4K | $162.6K | — | Held |
| Persistent Asset Partners Ltd | 16K | $159.1K | — | New |
| CITIGROUP INC | 15.3K | $151.9K | — | Held |
| ProShare Advisors LLC | 14.8K | $146.5K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 14.2K | $140.9K | — | Held |
| CAXTON CORP | 13.9K | $138.5K | — | Held |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 14.3K | $136.3K | — | Held |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 13.4K | $133.1K | — | Held |
| Fidelity | 13.4K | $132.9K | — | Held |
| SIMPLEX TRADING, LLC | 13K | $129.4K | — | Held |
| RAYMOND JAMES FINANCIAL INC | 12.5K | $124.5K | — | Held |
| China Universal Asset Management Co., Ltd. | 11.9K | $118.1K | — | Held |
| AlphaQuest LLC | 11.7K | $116.4K | — | Held |
| Ethic Inc. | 11.4K | $113.7K | — | Held |
| COMMONWEALTH EQUITY SERVICES, LLC | 11.2K | $111.5K | — | Held |
| XTX Topco Ltd | 11.1K | $110.7K | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 11K | $109K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 11.6K | $109K | — | Held |
| Creative Planning | 10.4K | $102.9K | — | Held |
| ROYAL BANK OF CANADA | 6.72K | $67K | — | Held |
| Russell Investments Group, Ltd. | 5.87K | $58.3K | — | Held |
| Legal & General Group Plc | 5.63K | $55.9K | — | Held |
| Ameritas Investment Partners, Inc. | 5.12K | $50.9K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3.88K | $38.6K | — | Held |
| Caitong International Asset Management Co., Ltd | 3.71K | $36.9K | — | Held |
| Sterling Capital Management LLC | 3.64K | $36.1K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 3.55K | $35.2K | — | Held |
| Allworth Financial LP | 3.39K | $33.6K | $1.01K | Added$31.6K |
| NISA INVESTMENT ADVISORS, LLC | 2.77K | $27.5K | — | Held |
| GROUP ONE TRADING LLC | 1.82K | $18K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.43K | $14.2K | — | Held |
| Aquatic Capital Management LLC | 1.08K | $10.8K | — | Held |
| Tower Research Capital LLC (TRC) | 826 | $8.2K | — | Held |
| EverSource Wealth Advisors, LLC | 731 | $7.26K | — | Held |
| Rockefeller Capital Management L.P. | 700 | $6.95K | — | Held |
| US BANCORP \DE\ | 555 | $5.51K | — | Held |
| PNC Financial Services Group, Inc. | 487 | $4.84K | — | Held |
| Essential Partners LLC | 476 | $4.73K | $1.55K | Added$1.6K |
| Torren Management, LLC | 321 | $3.19K | — | Held |
| Optiver Holding B.V. | 312 | $3.1K | — | Held |
| SIGNATUREFD, LLC | 290 | $2.88K | — | Held |
| Larson Financial Group LLC | 240 | $2.38K | — | Held |
| True Wealth Design, LLC | 226 | $2.25K | — | Held |
| SBI Securities Co., Ltd. | 217 | $2.15K | — | Held |
| IFP Advisors, Inc | 203 | $2.02K | $668 | Added$668 |
| Fortitude Family Office, LLC | 124 | $1.23K | — | Held |
| Steward Partners Investment Advisory, LLC | 100 | $993 | — | Held |
| OSAIC HOLDINGS, INC. | 57 | $566 | — | Held |
| Farther Finance Advisors, LLC | 57 | $566 | — | Held |
| Rialto Wealth Management, LLC | 53 | $527 | — | Held |
| ACADIAN ASSET MANAGEMENT LLC | 50.9K | $505 | — | Held |
| GAMMA Investing LLC | 50 | $497 | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 33.9K | $337 | — | Held |
| CWM, LLC | 19K | $188 | — | Held |
| SG Americas Securities, LLC | 18.6K | $185 | — | Held |
| Sunbelt Securities, Inc. | 16 | $159 | — | Held |
| GSA CAPITAL PARTNERS LLP | 11.5K | $114 | — | Held |
| Clearstead Advisors, LLC | 4 | $40 | — | Held |
| Smartleaf Asset Management LLC | 4 | $39 | — | Held |
| BESSEMER GROUP INC | 2.38K | $24 | — | Held |
| AMALGAMATED BANK | 1.98K | $20 | — | Held |
| ROTHSCHILD INVESTMENT LLC | 1 | $10 | — | Held |
| Daiwa Securities Group Inc. | 243 | $2 | — | Held |