| Fidelity | 8.71M | $605.9M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 7.12M | $495.3M | — | Held |
| Avoro Capital Advisors LLC | 6.56M | $455.9M | — | Held |
| JANUS HENDERSON GROUP PLC | 5.09M | $354M | — | Held |
| Deep Track Capital, LP | 4.11M | $286M | — | Held |
| BVF INC/IL | 3.48M | $242M | — | Held |
| MORGAN STANLEY | 2.09M | $145.2M | $24M | Added$129M |
| Driehaus Capital Management LLC | 1.64M | $114.2M | — | Held |
| BAKER BROS. ADVISORS LP | 1.43M | $99.6M | — | Held |
| PRINCIPAL FINANCIAL GROUP INC | 1.28M | $89.3M | — | Held |
| Casdin Capital, LLC | 1.18M | $81.7M | — | Held |
| ORBIMED ADVISORS LLC | 1.16M | $80.8M | — | Held |
| Siren, L.L.C. | 1.08M | $75M | — | Held |
| TCG Crossover Management, LLC | 920.9K | $64M | — | Held |
| Capitolis Liquid Global Markets LLC | 878.3K | $61.1M | — | Held |
| FRANKLIN RESOURCES INC | 870.6K | $60.5M | — | Held |
| ALLIANCEBERNSTEIN L.P. | 848.9K | $59M | — | Held |
| DEUTSCHE BANK AG\ | 841.2K | $58.5M | — | Held |
| Citadel | 772.5K | $53.7M | — | Held |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 768K | $53.4M | — | Held |
| Rock Springs Capital Management LP | 748.2K | $52M | — | Held |
| Pacific Heights Asset Management LLC | 700K | $48.7M | — | Held |
| Logos Global Management LP | 600K | $41.7M | — | Held |
| AMERICAN CENTURY COMPANIES INC | 507K | $35.3M | — | Held |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 467.8K | $32.5M | — | Held |
| FARALLON CAPITAL MANAGEMENT LLC | 454K | $31.6M | — | New |
| BlackRock, Inc. | 430.1K | $29.9M | — | Held |
| HSG Holding Ltd | 266.1K | $24.4M | — | Held |
| STEMPOINT CAPITAL LP | 351.1K | $24.4M | — | Held |
| EcoR1 Capital, LLC | 334.4K | $23.3M | — | Held |
| AMERIPRISE FINANCIAL INC | 285.5K | $19.9M | — | Held |
| ArrowMark Colorado Holdings LLC | 271.2K | $18.9M | — | Held |
| NATIONAL BANK OF CANADA /FI/ | 265.4K | $18.5M | — | Held |
| Aberdeen Group plc | 264.9K | $18.4M | — | Held |
| Catalio Capital Management, LP | 252.9K | $17.6M | — | Held |
| Capricorn Fund Managers Ltd | 252.6K | $17.6M | — | Held |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 250K | $17.4M | — | Held |
| Monashee Investment Management LLC | 225K | $15.6M | — | Held |
| GOLDMAN SACHS GROUP INC | 224.3K | $15.6M | — | Held |
| Balyasny Asset Management L.P. | 216.2K | $15M | — | Held |
| UBS Group AG | 202.5K | $14.1M | — | Held |
| Sio Capital Management, LLC | 201.5K | $14M | — | Held |
| HighVista Strategies LLC | 193K | $13.4M | — | Held |
| TD Asset Management Inc | 174.7K | $12.1M | — | Held |
| MARSHALL WACE, LLP | 168.6K | $11.7M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 152.6K | $10.6M | — | Held |
| Rhenman & Partners Asset Management AB | 147.6K | $10.3M | — | Held |
| JANE STREET GROUP, LLC | 147.2K | $10.2M | — | Held |
| Bellevue Group AG | 145.2K | $10.1M | — | Held |
| Eversept Partners, LP | 127.6K | $8.87M | — | Held |
| Woodline Partners LP | 123.9K | $8.62M | — | Held |
| Renaissance Technologies | 115.2K | $8.01M | — | Held |
| Alyeska Investment Group, L.P. | 115K | $8M | — | Held |
| Jefferies Financial Group Inc. | 103K | $7.16M | — | Held |
| RTW INVESTMENTS, LP | 100K | $6.96M | — | Held |
| Jain Global LLC | 100K | $6.95M | — | Held |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 99.6K | $6.93M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 95.5K | $6.65M | — | Held |
| SummitTX Capital, L.P. | 94.7K | $6.58M | — | Held |
| NEXTBio Capital Management LP | 94.4K | $6.57M | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 96.4K | $6.53M | — | Held |
| SIMPLEX TRADING, LLC | 92.7K | $6.45M | — | Held |
| B Group, Inc. | 90K | $6.26M | — | Held |
| Birchview Capital, LP | 90K | $6.26M | — | Held |
| Soleus Capital Management, L.P. | 90K | $6.26M | — | Held |
| Trexquant Investment LP | 89.9K | $6.26M | — | Held |
| PLATINUM INVESTMENT MANAGEMENT LTD | 87.9K | $6.11M | — | Held |
| Brevan Howard Capital Management LP | 86.3K | $5.96M | — | Held |
| PEREGRINE CAPITAL MANAGEMENT LLC | 84.3K | $5.86M | — | Held |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 83.1K | $5.78M | — | Held |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 82.6K | $5.75M | — | Held |
| Verition Fund Management LLC | 78.1K | $5.44M | — | Held |
| Boxer Capital Management, LLC | 75K | $5.22M | — | New |
| PFM Health Sciences, LP | 68.2K | $4.75M | — | Held |
| Susquehanna Portfolio Strategies, LLC | 68.1K | $4.74M | — | Held |
| BURKEHILL GLOBAL MANAGEMENT, LP | 60K | $4.17M | — | Held |
| Longaeva Partners L.P. | 60K | $4.17M | — | Held |
| BANQUE PICTET & CIE SA | 59.9K | $4.16M | — | Held |
| OSAIC HOLDINGS, INC. | 59.2K | $4.12M | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 55.3K | $3.85M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 55.1K | $3.84M | — | Held |
| Parkman Healthcare Partners LLC | 55K | $3.83M | — | Held |
| BANK OF MONTREAL /CAN/ | 54.3K | $3.68M | — | Held |
| SEVEN GRAND MANAGERS, LLC | 50K | $3.48M | — | Held |
| Integral Health Asset Management, LLC | 50K | $3.48M | — | Held |
| Buckland Partners Management Co LLC | 50K | $3.48M | — | Held |
| ALPS ADVISORS INC | 49.7K | $3.46M | — | Held |
| Pier Capital, LLC | 48.8K | $3.39M | — | Held |
| FLAX POND CAPITAL, LLC | 48.7K | $3.39M | — | Held |
| State Street | 48.2K | $3.35M | — | Held |
| ANTIPODES PARTNERS Ltd | 46.3K | $3.25M | — | Held |
| RAYMOND JAMES FINANCIAL INC | 44.4K | $3.09M | — | Held |
| Mariner, LLC | 44.2K | $3.07M | — | Held |
| Headlands Technologies LLC | 43.7K | $3.04M | — | Held |
| SPHERA FUNDS MANAGEMENT LTD. | 41K | $2.85M | — | Held |
| ACT CAPITAL MANAGEMENT, LLC | 38.5K | $2.68M | — | Held |
| Informed Momentum Co LLC | 38.1K | $2.65M | — | Held |
| DAFNA Capital Management LLC | 37K | $2.57M | — | Held |
| TUDOR INVESTMENT CORP ET AL | 35.1K | $2.44M | — | New |
| Vestal Point Capital, LP | 35K | $2.43M | — | Held |
| TrueMark Investments, LLC | 33.9K | $2.36M | — | Held |
| BANK OF AMERICA CORP /DE/ | 31.7K | $2.2M | $572.5K | Added$1.82M |
| DCF Advisers, LLC | 30K | $2.09M | — | Held |
| NOMURA ASSET MANAGEMENT CO LTD | 29.2K | $2.03M | — | Held |
| Russell Investments Group, Ltd. | 26.3K | $1.83M | — | Held |
| EXCHANGE TRADED CONCEPTS, LLC | 26K | $1.81M | — | Held |
| Quinn Opportunity Partners LLC | 25K | $1.74M | — | Held |
| SECTORAL ASSET MANAGEMENT INC | 23.9K | $1.66M | — | Held |
| Maven Securities LTD | 20K | $1.39M | — | Held |
| XTX Topco Ltd | 19.2K | $1.33M | — | Held |
| SEI INVESTMENTS CO | 14.9K | $1.04M | — | Held |
| WEXFORD CAPITAL LP | 14.8K | $1.03M | — | Held |
| J. Goldman & Co LP | 13.6K | $946K | — | Held |
| BRANDYWINE MANAGERS, LLC | 13.4K | $929K | — | Held |
| JPMORGAN CHASE & CO | 13K | $901.1K | — | Held |
| Quadrature Capital Ltd | 12.8K | $887.5K | — | Held |
| DNB Asset Management AS | 12.6K | $879K | — | Held |
| Allianz Asset Management GmbH | 12K | $834.6K | — | Held |
| ENVESTNET ASSET MANAGEMENT INC | 11.6K | $804.7K | — | Held |
| China Universal Asset Management Co., Ltd. | 10.9K | $757.3K | — | Held |
| ROYAL BANK OF CANADA | 10.2K | $709K | — | Held |
| Y-Intercept (Hong Kong) Ltd | 10.1K | $704.7K | — | Held |
| Bleichroeder LP | 10K | $695.5K | — | Held |
| MISSION WEALTH MANAGEMENT, LP | 9.58K | $666.5K | — | Held |
| HighTower Advisors, LLC | 9.32K | $648.2K | — | Held |
| SmartHarvest Portfolios, LLC | 9.06K | $629.8K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 9K | $625.9K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 8.75K | $608.3K | — | Held |
| Schonfeld Strategic Advisors LLC | 8.73K | $607K | — | Held |
| D. E. Shaw & Co., Inc. | 8.62K | $599.7K | — | Held |
| LPL Financial LLC | 8.11K | $564K | — | Held |
| PEAK6 LLC | 7.96K | $553.3K | $330.5K | Added$245.3K |
| BARCLAYS PLC | 7.83K | $544.8K | $156.8K | Added$439.1K |
| MML INVESTORS SERVICES, LLC | 7.83K | $544.2K | — | Held |
| Vestmark Advisory Solutions, Inc. | 7.53K | $524K | — | Held |
| Parallel Advisors, LLC | 7.35K | $511.3K | — | Held |
| Private Capital Advisors, Inc. | 7.35K | $511.1K | — | Held |
| CITIGROUP INC | 7.33K | $510.1K | — | Held |
| PSP Research LLC | 6.72K | $467.3K | — | Held |
| SIGNATUREFD, LLC | 6.65K | $462.5K | — | Held |
| Cetera Investment Advisers | 6.6K | $458.8K | — | Held |
| Gilbert & Cook, Inc. | 5.68K | $395.2K | — | Held |
| WELLS FARGO & COMPANY/MN | 5.66K | $393.9K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 5.27K | $366.3K | — | Held |
| Blueshift Asset Management, LLC | 5.21K | $362.6K | — | Held |
| Quadcap Wealth Management, LLC | 7.48K | $354.8K | — | Held |
| Concurrent Investment Advisors, LLC | 5K | $347.8K | — | Held |
| STIFEL FINANCIAL CORP | 4.83K | $335.9K | — | Held |
| Ikarian Capital, LLC | 4.82K | $335.5K | — | Held |
| Graham Capital Management, L.P. | 4.78K | $332.3K | — | Held |
| Independent Advisor Alliance | 4.54K | $316K | — | Held |
| E. Ohman J:or Asset Management AB | 4.52K | $314.2K | — | Held |
| GABELLI FUNDS LLC | 4K | $278.2K | — | Held |
| Virtus Investment Advisers, LLC | 3.97K | $275.9K | — | Held |
| PNC Financial Services Group, Inc. | 3.93K | $273.1K | — | Held |
| Merit Financial Group, LLC | 3.69K | $256.5K | — | Held |
| NORTHERN TRUST CORP | 3.65K | $253.5K | — | Held |
| Bank of New York Mellon Corp | 3.6K | $250.6K | — | Held |
| PROFUND ADVISORS LLC | 3.51K | $243.9K | — | Held |
| CIBC WORLD MARKET INC. | 3.25K | $225.9K | — | Held |
| Invesco Ltd. | 3.2K | $222.6K | — | Held |
| ProShare Advisors LLC | 2.96K | $205.7K | — | Held |
| Banque Cantonale Vaudoise | 2.94K | $205K | — | Held |
| Steward Partners Investment Advisory, LLC | 2.54K | $176.7K | — | Held |
| Persistent Asset Partners Ltd | 2.44K | $169.4K | — | New |
| ASSETMARK, INC | 2.1K | $145.7K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 1.83K | $127.2K | — | Held |
| State of Wyoming | 1.76K | $122.5K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.67M | $116.2K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.31K | $91.3K | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 1.05K | $72.7K | — | Held |
| GAMMA Investing LLC | 930 | $64.7K | — | Held |
| Rockefeller Capital Management L.P. | 731 | $50.8K | — | Held |
| Farther Finance Advisors, LLC | 690 | $48K | — | Held |
| EverSource Wealth Advisors, LLC | 578 | $40.2K | — | Held |
| COUNTRY TRUST BANK | 500 | $34.8K | — | Held |
| WOLFF WIESE MAGANA LLC | 400 | $27.8K | — | Held |
| SOA Wealth Advisors, LLC. | 350 | $24.3K | — | Held |
| North Star Investment Management Corp. | 330 | $23K | — | Held |
| Private Wealth Management Group, LLC | 196 | $13.6K | — | Held |
| Dynamic Wealth Strategies, LLC | 150 | $10.4K | — | Held |
| SHP Wealth Management | 100 | $6.96K | — | Held |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 60 | $4.17K | — | Held |
| Tower Research Capital LLC (TRC) | 41 | $2.85K | — | Held |
| ACADIAN ASSET MANAGEMENT LLC | 17.6K | $1.22K | — | Held |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 17.3K | $1.2K | — | Held |
| BELLEVUE ASSET MANAGEMENT, LLC | 15 | $1.04K | — | Held |
| SG Americas Securities, LLC | 10.1K | $706 | — | Held |
| Ancora Advisors LLC | 10 | $695 | — | Held |
| Allworth Financial LP | 9 | $626 | — | New |
| Janney Capital Management LLC | 8.51K | $592 | — | Held |
| Cullen/Frost Bankers, Inc. | 8 | $556 | — | Held |
| Larson Financial Group LLC | 5 | $348 | — | Held |
| HUNTINGTON NATIONAL BANK | 2 | $139 | — | Held |
| Walleye Capital LLC | 2 | $139 | — | Held |
| CWM, LLC | 480 | $33 | — | Held |
| Daiwa Securities Group Inc. | 186 | $13 | — | Held |
| BESSEMER GROUP INC | 29 | $2 | — | Held |
| Capital Analysts, LLC | 18 | $1 | — | Held |