| Frazier Life Sciences Management, L.P. | 24.7M | $399.2M | $283.2M | Added$314.7M |
| BlackRock, Inc. | 20.2M | $326M | $194.3M | Added$268M |
| VR ADVISER, LLC | 16.4M | $265.1M | $204.1M | Added$198.6M |
| RTW INVESTMENTS, LP | 16.2M | $261.4M | $1.83M | Added$260.9M |
| Vivo Capital, LLC | 12.2M | $196.6M | $115.5M | Added$162.1M |
| VANGUARD CAPITAL MANAGEMENT LLC | 11.2M | $182M | — | Held |
| Siren, L.L.C. | 11.2M | $181.9M | $109.1M | Added$149.4M |
| Logos Global Management LP | 11.2M | $180.4M | $138.9M | Added$132M |
| Paradigm Biocapital Advisors LP | 10.4M | $168.2M | $129.5M | Added$115.5M |
| State Street | 9.3M | $150.5M | $76.9M | Added$127.5M |
| ARCH Venture Management, LLC | 7.09M | $114.7M | $88.4M | Added$73.6M |
| GEODE CAPITAL MANAGEMENT, LLC | 6M | $97M | $61.4M | Added$78.7M |
| Cormorant Asset Management, LP | 5.8M | $93.8M | — | New |
| Affinity Asset Advisors, LLC | 5.35M | $86.6M | $48.6M | Added$72.1M |
| Balyasny Asset Management L.P. | 5.14M | $83.2M | $1.22M | Added$82.9M |
| GOLDMAN SACHS GROUP INC | 4.88M | $78.9M | $41.5M | Added$66.5M |
| JANUS HENDERSON GROUP PLC | 3.71M | $60M | — | New |
| 5AM Venture Management, LLC | 3.49M | $56.4M | $43.4M | Added$36.3M |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3.43M | $55.6M | $42.8M | Added$1.63M |
| Commodore Capital LP | 3.17M | $51.4M | — | New |
| BANK OF AMERICA CORP /DE/ | 3.06M | $49.4M | $20.1M | Added$43.4M |
| a16z Capital Management, L.L.C. | 2.86M | $46.3M | $35.7M | Added$35.7M |
| Woodline Partners LP | 2.83M | $45.8M | $24.1M | Added$38.6M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2.1M | $34M | — | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1.9M | $30.7M | $20.9M | Added$24.5M |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1.85M | $30M | $16.4M | Added$25.1M |
| UBS Group AG | 1.85M | $29.9M | $2.12M | Added$29.3M |
| DIMENSIONAL FUND ADVISORS LP | 1.79M | $28.9M | $22.1M | Added$22.3M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1.77M | $28.7M | — | Held |
| NORTHERN TRUST CORP | 1.7M | $27.5M | $16.6M | Added$22.6M |
| VICTORY CAPITAL MANAGEMENT INC | 1.65M | $26.8M | $229.2K | Added$26.7M |
| VANGUARD FIDUCIARY TRUST CO | 1.54M | $24.9M | — | Held |
| Fidelity | 1.49M | $24.1M | $6.5M | Added$22.2M |
| Renaissance Technologies | 1.4M | $22.6M | $10.6M | Added$19.5M |
| D. E. Shaw & Co., Inc. | 1.22M | $19.7M | $2.52M | Added$19M |
| Rock Springs Capital Management LP | 1.1M | $17.9M | $11.9M | Added$14.3M |
| BNP PARIBAS FINANCIAL MARKETS | 1.09M | $17.6M | $404.8K | Added$17.5M |
| MORGAN STANLEY | 989.2K | $16M | $10.1M | Added$13M |
| EcoR1 Capital, LLC | 900K | $14.6M | — | New |
| First Turn Management, LLC | 867.6K | $14M | — | New |
| JPMORGAN CHASE & CO | 924.4K | $13.8M | $10.4M | Added$9.52M |
| Holocene Advisors, LP | 760.7K | $12.3M | — | New |
| Invesco Ltd. | 759.9K | $12.3M | $4.11M | Added$11.1M |
| Integral Health Asset Management, LLC | 700K | $11.3M | — | New |
| Point72 Asset Management, L.P. | 693.3K | $11.2M | — | New |
| Icahn Capital | 691.2K | $11.2M | $8.35M | Added$8.69M |
| AMERIPRISE FINANCIAL INC | 670.6K | $10.9M | — | New |
| ALLIANCEBERNSTEIN L.P. | 2.64M | $9.84M | $0 | Added$9.06M |
| WELLINGTON MANAGEMENT GROUP LLP | 595.4K | $9.63M | $6.77M | Added$7.61M |
| MILLENNIUM MANAGEMENT LLC | 576K | $9.32M | $7.18M | Added$994.4K |
| ExodusPoint Capital Management, LP | 575.7K | $9.32M | $7.17M | Added$3.77M |
| Bank of New York Mellon Corp | 559.6K | $9.05M | $6.81M | Added$7.02M |
| Nuveen, LLC | 543K | $8.79M | $5.29M | Added$7.21M |
| Ensign Peak Advisors, Inc | 500.7K | $8.1M | — | New |
| Citadel | 498.4K | $8.06M | $6.21M | Added$4.23M |
| JANE STREET GROUP, LLC | 455K | $7.36M | $5.67M | Added$3.97M |
| MARSHALL WACE, LLP | 426.5K | $6.9M | $772K | Added$6.67M |
| Spruce Street Capital LP | 422.5K | $6.84M | $5.26M | Cut−$7.63M |
| Creative Planning | 418.8K | $6.78M | $4.76M | Added$5.36M |
| PRUDENTIAL FINANCIAL INC | 416.7K | $6.74M | $158.9K | Added$6.7M |
| Parkman Healthcare Partners LLC | 406.7K | $6.58M | — | New |
| TD Asset Management Inc | 394.3K | $6.38M | $2.86M | Added$5.52M |
| AMERICAN CENTURY COMPANIES INC | 381K | $6.16M | $2.06M | Added$5.55M |
| Polymer Capital Management (HK) LTD | 357.7K | $5.79M | — | New |
| ACUTA CAPITAL PARTNERS, LLC | 354.6K | $5.74M | — | New |
| Atom Investors LP | 345.6K | $5.59M | — | New |
| KVP Capital Advisors, LP | 340K | $5.5M | — | New |
| Swiss National Bank | 336.8K | $5.45M | — | New |
| Trexquant Investment LP | 301.1K | $4.87M | — | New |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 259K | $4.19M | — | New |
| VOYA INVESTMENT MANAGEMENT LLC | 253.6K | $4.1M | $413.5K | Added$3.98M |
| SIMPLEX TRADING, LLC | 252.7K | $4.09M | $3.15M | Added$2.8M |
| Rafferty Asset Management, LLC | 252K | $4.08M | $1.63M | Added$3.59M |
| RHUMBLINE ADVISERS | 242.6K | $3.93M | $2.36M | Added$3.22M |
| STEMPOINT CAPITAL LP | 239.9K | $3.88M | — | New |
| FRED ALGER MANAGEMENT, LLC | 236.8K | $3.83M | — | New |
| TEMA ETFS LLC | 226.9K | $3.67M | — | New |
| Tidal Investments LLC | 226.9K | $3.67M | — | New |
| Seven Fleet Capital Management LP | 222.5K | $3.6M | — | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 216.6K | $3.5M | $682.4K | Added$3.3M |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 204.4K | $3.31M | $133.2K | Added$3.27M |
| TANG CAPITAL MANAGEMENT LLC | 200K | $3.24M | $2.49M | Cut−$112K |
| Pictet Asset Management Holding SA | 208.3K | $3.14M | — | New |
| HighVista Strategies LLC | 181.1K | $2.93M | — | New |
| Cinctive Capital Management LP | 171.9K | $2.78M | — | New |
| Longaeva Partners L.P. | 171.2K | $2.77M | — | New |
| DEUTSCHE BANK AG\ | 163.3K | $2.64M | $1.52M | Added$2.19M |
| NATIXIS | 163.2K | $2.64M | — | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 153.6K | $2.49M | $1.91M | Added$1.74M |
| XTX Topco Ltd | 147.6K | $2.39M | $134.5K | Added$2.35M |
| Informed Momentum Co LLC | 137.9K | $2.23M | — | New |
| Legal & General Group Plc | 133.4K | $2.16M | $191.9K | Added$2.1M |
| Vanguard Global Advisers, LLC | 113.6K | $1.84M | — | Held |
| PROFUND ADVISORS LLC | 113.2K | $1.83M | $630.5K | Added$1.64M |
| VANGUARD ASSET MANAGEMENT, Ltd | 111.8K | $1.81M | — | Held |
| WELLS FARGO & COMPANY/MN | 107.2K | $1.73M | $1.34M | Added$915.2K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 106.8K | $1.71M | $1.08M | Added$1.38M |
| MetLife Investment Management, LLC | 103.6K | $1.68M | $1M | Added$1.38M |
| FRANKLIN RESOURCES INC | 101.8K | $1.65M | — | New |
| SEVEN GRAND MANAGERS, LLC | 100K | $1.62M | — | New |
| BURKEHILL GLOBAL MANAGEMENT, LP | 100K | $1.62M | — | New |
| STATE OF WISCONSIN INVESTMENT BOARD | 98.6K | $1.6M | — | New |
| J. Goldman & Co LP | 98K | $1.59M | — | New |
| Squarepoint Ops LLC | 94.7K | $1.53M | $1.18M | Added$571.2K |
| RAYMOND JAMES FINANCIAL INC | 82.7K | $1.34M | — | New |
| Cresset Asset Management, LLC | 80K | $1.29M | $995.7K | Added$996.5K |
| ArrowMark Colorado Holdings LLC | 79.1K | $1.28M | — | New |
| Virtus Investment Advisers, LLC | 75.7K | $1.23M | $920.7K | Added$950.7K |
| Harvest Investment Services, LLC | 73.7K | $1.19M | — | New |
| Schonfeld Strategic Advisors LLC | 68K | $1.1M | — | New |
| Hudson Bay Capital Management LP | 65.3K | $1.06M | $814.3K | Added$469.5K |
| Susquehanna Portfolio Strategies, LLC | 59.1K | $956K | $736.2K | Added$736.2K |
| State of New Jersey Common Pension Fund D | 58.2K | $941.3K | — | New |
| INTECH INVESTMENT MANAGEMENT LLC | 57.5K | $930.9K | $716.9K | Added$593.4K |
| GILDER GAGNON HOWE & CO LLC | 56.6K | $915.7K | — | New |
| Cerity Partners LLC | 55.8K | $902.2K | $694.8K | Added$673.3K |
| Brevan Howard Capital Management LP | 55.1K | $891.6K | $657K | Added$695.4K |
| China Universal Asset Management Co., Ltd. | 54.9K | $888.9K | $576K | Added$716.9K |
| NEW YORK STATE COMMON RETIREMENT FUND | 54.8K | $886K | $682.3K | Added$679.3K |
| Police & Firemen's Retirement System of New Jersey | 51.5K | $832.8K | $548.6K | Added$669K |
| CITIGROUP INC | 49.1K | $794.6K | $611.9K | Added$438.3K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 47.9K | $775.3K | — | New |
| Vanguard Personalized Indexing Management, LLC | 46.9K | $758.8K | $431.9K | Added$629.9K |
| ARIZONA STATE RETIREMENT SYSTEM | 46.8K | $756.5K | — | New |
| Connor, Clark & Lunn Investment Management Ltd. | 45.3K | $733.6K | — | New |
| BARCLAYS PLC | 45.1K | $729.4K | $561.7K | Cut−$769K |
| Vanguard Investments Australia, Ltd. | 44.3K | $716.8K | — | Held |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 42.3K | $685.1K | — | New |
| ProShare Advisors LLC | 41.3K | $669K | $515.2K | Added$504.5K |
| KLP KAPITALFORVALTNING AS | 37.5K | $606.8K | — | New |
| Verdad Advisers, LP | 33.1K | $535.1K | — | New |
| STRS OHIO | 33K | $533.9K | — | New |
| CWM, LLC | 32.8K | $530K | $529.9K | Added$529.9K |
| E Fund Management Co., Ltd. | 32.6K | $527.5K | — | Held |
| Tower Research Capital LLC (TRC) | 32.3K | $522.7K | $85.8K | Added$497.1K |
| SEI INVESTMENTS CO | 31.8K | $513.9K | $207.9K | Added$451.8K |
| Marks Group Wealth Management, Inc | 29.9K | $483.4K | — | New |
| Persistent Asset Partners Ltd | 28.3K | $457.4K | — | New |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 27.8K | $449.4K | — | New |
| FORA Capital, LLC | 26.8K | $433.5K | — | New |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 23.4K | $416.6K | $319.1K | Added$334.9K |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 24.8K | $402K | — | New |
| Quantbot Technologies LP | 23.2K | $375.8K | — | New |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 22.1K | $357.2K | — | New |
| Quadrature Capital Ltd | 21.7K | $350.9K | $164K | Added$301.9K |
| T. Rowe Price Investment Management, Inc. | 21.3M | $344K | $200.7K | Added$284K |
| Allianz Asset Management GmbH | 19.9K | $322K | — | New |
| Mariner, LLC | 18.7K | $303.2K | $135K | Added$263K |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 18.7K | $303.1K | — | New |
| Scientech Research LLC | 18.2K | $294K | $226.4K | Added$25.4K |
| FARALLON CAPITAL MANAGEMENT LLC | 18K | $291.2K | — | New |
| Baader Bank Aktiengesellschaft | 18K | $291.2K | — | New |
| XPONANCE LLC | 17.3K | $280.4K | $168.1K | Added$230.2K |
| Odyssean, LLC | 17.3K | $280.4K | — | New |
| PSP Research LLC | 17.3K | $280.4K | — | New |
| QUADRANT CAPITAL GROUP LLC | 17.1K | $276.2K | $212.7K | Added$211K |
| Abel Hall, LLC | 16.9K | $274.2K | $195.4K | Added$215.9K |
| OXFORD ASSET MANAGEMENT LLP | 16.8K | $271K | — | New |
| Mirae Asset Global Investments Co., Ltd. | 16.1K | $261.3K | $171.8K | Added$210K |
| TWO SIGMA INVESTMENTS, LP | 15.8K | $255.6K | $196.9K | Added$114.2K |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 15.8K | $255.2K | — | New |
| Ameritas Investment Partners, Inc. | 15.5K | $251.2K | $182.5K | Added$196.7K |
| Wealthcare Advisory Partners LLC | 15.2K | $245.4K | $189K | Added$189K |
| Russell Investments Group, Ltd. | 14.3K | $231.3K | $178.1K | Added$177.8K |
| Ballentine Partners, LLC | 14K | $226.6K | $174.4K | Added$174.5K |
| LPL Financial LLC | 13.3K | $215.1K | — | New |
| BAILARD, INC. | 13.1K | $212.7K | $163.8K | Added$81.6K |
| Swiss Life Asset Management Ltd | 12.2K | $197.6K | — | New |
| Pallas Capital Advisors LLC | 12.1K | $196.6K | $151.4K | Added$144.8K |
| STIFEL FINANCIAL CORP | 12K | $194.8K | $128.3K | Added$156.4K |
| NISA INVESTMENT ADVISORS, LLC | 11.6K | $188.4K | $54.9K | Added$171.9K |
| DNB Asset Management AS | 11.5K | $185.7K | — | New |
| WINTON GROUP Ltd | 10.6K | $171.5K | — | New |
| ADAR1 Capital Management, LLC | 10K | $161.8K | — | New |
| JONES FINANCIAL COMPANIES LLLP | 9.63K | $144.2K | — | New |
| SIGNATUREFD, LLC | 7.4K | $119.7K | $88.5K | Added$93.3K |
| GF FUND MANAGEMENT CO. LTD. | 6.37K | $103.1K | $69.5K | Added$82.4K |
| Sterling Capital Management LLC | 6.35K | $102.7K | $79.1K | Added$65.1K |
| State of Wyoming | 5.85K | $94.7K | — | New |
| Sio Capital Management, LLC | 5K | $80.9K | — | New |
| Parallel Advisors, LLC | 4.29K | $69.5K | $52.7K | Added$53.8K |
| EverSource Wealth Advisors, LLC | 4.25K | $68.7K | $29.8K | Added$59.9K |
| Rockefeller Capital Management L.P. | 3.34K | $54.1K | $8.17K | Added$51.6K |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 3.07K | $49.7K | — | New |
| Farther Finance Advisors, LLC | 2.33K | $38.7K | $30K | Added$30.1K |
| Kemnay Advisory Services Inc. | 2.14K | $34.7K | — | New |
| GAMMA Investing LLC | 2K | $32.4K | $20.1K | Added$26.4K |
| Allworth Financial LP | 1.87K | $30.3K | $23.4K | Added$23.1K |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 1.84K | $29.9K | — | New |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.82M | $29.4K | $1.29K | Added$29K |
| PNC Financial Services Group, Inc. | 1.47K | $23.8K | $99 | Added$23.8K |
| Physician Wealth Advisors, Inc. | 1.19K | $19.3K | $14.9K | Added$14.9K |
| True Wealth Design, LLC | 1.12K | $18.1K | $13.9K | Added$13.9K |
| Caitong International Asset Management Co., Ltd | 1.04K | $16.8K | — | New |
| FEDERATED HERMES, INC. | 1K | $16.3K | $12.5K | Added$12.5K |
| E Fund Management (Hong Kong) Co., Ltd. | 932 | $15.1K | — | New |
| ROTHSCHILD INVESTMENT LLC | 503 | $8.14K | $4.91K | Added$6.67K |
| Optiver Holding B.V. | 460 | $7.44K | $5.73K | Added$4.02K |
| Essential Partners LLC | 459 | $7.43K | $5.72K | Added$5.72K |
| Rialto Wealth Management, LLC | 413 | $6.68K | $5.15K | Added$5.15K |
| Cornerstone Financial Management LLC | 338 | $5.47K | $4.21K | Added$4.21K |
| US BANCORP \DE\ | 295 | $4.77K | — | New |
| ROYAL BANK OF CANADA | 239 | $4K | $3.14K | Cut−$14K |
| Fortitude Family Office, LLC | 217 | $3.51K | — | New |
| Steward Partners Investment Advisory, LLC | 200 | $3.24K | $2.49K | Added$2.49K |
| IFP Advisors, Inc | 184 | $2.98K | $1.17K | Added$2.63K |
| Sunbelt Securities, Inc. | 162 | $2.62K | $2.02K | Added$2.02K |
| Bare Financial Services, Inc | 116 | $1.88K | — | New |
| ALGERT GLOBAL LLC | 88K | $1.42K | — | New |
| MassMutual Private Wealth & Trust, FSB | 86 | $1.39K | — | New |
| Arax Advisory Partners | 76 | $1.23K | $299 | Added$1.14K |
| Hughes Financial Services, LLC | 55 | $890 | $685 | Added$98 |
| SG Americas Securities, LLC | 44.7K | $723 | $557 | Added$542 |
| Parkside Financial Bank & Trust | 40 | $648 | — | New |
| SBI Securities Co., Ltd. | 37 | $599 | $461 | Cut−$989 |
| Root Financial Partners, LLC | 34 | $550 | — | New |
| MAI Capital Management | 23 | $373 | — | New |
| Rachor Investment Advisory Services, LLC | 18 | $292 | — | New |
| ACADIAN ASSET MANAGEMENT LLC | 12.4K | $200 | — | New |
| OSAIC HOLDINGS, INC. | 6 | $97 | — | New |
| KBC Group NV | 5K | $81 | — | New |
| FIFTH THIRD BANCORP | 2 | $32 | — | New |
| BESSEMER GROUP INC | 1.59K | $26 | $20 | Added$20 |
| Covestor Ltd | 16 | $0 | $0 | Held |